KCF-S cluster No. 57 (70 metabolites)

Corresponding Phytochemical cluster No. 18

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (70)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	82
Embryophyta	5
Spermatophyta	3
asterids	1
Magnoliophyta	1

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Cumulative family count

class name	count
Thymelaeaceae	32
Clusiaceae	16
Anacardiaceae	12
Rhamnaceae	11
Ochnaceae	9
Hypnaceae	4
Cycadaceae	2
Brachytheciaceae	1
Pinaceae	1
Fabaceae	1
Calophyllaceae	1
Paracryphiaceae	1
Annonaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Biflavonoids and polyflavonoids	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Biflavonoids and polyflavonoids	C09758	C00000972
Biflavonoids and polyflavonoids	C09761	C00000976
Biflavonoids and polyflavonoids	C09763	C00000978

Metabolite list (70)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000972	Isochamaejasmin	CHEMBL467196 CHEMBL452374		1 / 0 / 0
C00000976	Kolaflavanone
C00000978	Manniflavanone / Garciniflavanone
C00006420	Chamaejasmin	CHEMBL467196 CHEMBL452374		1 / 0 / 0
C00006421	Neochamaejasmin B	CHEMBL467196 CHEMBL452374		1 / 0 / 0
C00006422	Neochamaejasmin A	CHEMBL467196 CHEMBL452374		1 / 0 / 0
C00006423	7-Methylchamaejasmin
C00006424	Sikokianin C	CHEMBL1172171 CHEMBL1172216
C00006425	Sikokianin B	CHEMBL1172171 CHEMBL1172216
C00006426	Sikokianin A / (+)-Sikokianin A	CHEMBL1172171 CHEMBL1172216
C00006427	Chamaejasmenin A	CHEMBL1545093		18 / 28 / 19
C00006428	Chamaejasmenin B	CHEMBL1545093		18 / 28 / 19
C00006429	Chamaejasmenin C / Ruixianglangdusu A
C00006439	GB1a	CHEMBL63292 CHEMBL456859
C00006441	GB1	CHEMBL504319	C055015
C00006442	GB-2a / (-)-GB-2a	CHEMBL63792 CHEMBL445452 CHEMBL446790
C00006443	GB2	CHEMBL510563 CHEMBL508885	C055016
C00006451	Succedaneaflavanone	CHEMBL66266 CHEMBL456858
C00006458	Rhusflavanone	CHEMBL303495
C00006467	Neorhusflavanone
C00006481	Tetrahydrorobustaflavone
C00006482	3,5,7,4',3'',5'',7'',3''',4'''-Nonahydroxy-3',6''-biflavonone
C00006516	Tetrahydroamentoflavone
C00006517	Biflavanone C
C00006518	Biflavanone A
C00006519	Semecarpuflavanone
C00006520	Jeediflavanone
C00006521	Galluflavanone
C00006522	7''-O-Methyltetrahydroamentoflavone
C00006529	3',3'''-Binaringenin	CHEMBL1779459
C00006530	Hypnogenol B
C00006531	Hypnogenol A
C00006532	[5',5']-Bisdihydroquercetin
C00006546	3,5,7,4',3'',5'',7''-Heptahydroxy-3'-O-4'''-biflavanone
C00006550	Zeyherin
C00006568	Hexaspermone A
C00006569	Hexaspermone B
C00006570	Hexaspermone C
C00006577	Mucronulatol-(4->6)-naringenin
C00008795	Daphnodorin C		C055029
C00008797	Daphnodorin E	CHEMBL2048507		6 / 5 / 4
C00013286	Genkwanol A / [2'R-(2'alpha,3'beta,8'alpha,9'alpha)]-3',4'-Dihydro-3',4,5',6-tetrahydroxy-2',8'-bis(4-hydroxyphenyl)-spiro[benzofuran-2(3H),9'(8'H)-[2H]furo[2,3-h][1]benzopyran]-3-one	CHEMBL1362112	C054406	14 / 20 / 16
C00013287	Daphnodorin G / [2S-(2alpha,3beta,7aalpha,13abeta)]-3,4,7a,13a-Tetrahydro-3,5,10,12,13a-pentahydroxy-2,7a-bis(4-hydroxyphenyl)-2H,13H-furo[2,3-b:5,4-h']bis[1]benzopyran-13-one
C00014530	Daphnodorin I	CHEMBL1362112		14 / 20 / 16
C00014674	(2S)-2-Deoxymaesopsin-(2->7)-(2R)-maesopsin
C00014675	(2R)-2-Deoxymaesopsin-(2->7)-(2S)-maesopsin
C00014676	(2R)-2-Deoxymaesopsin-(2->7)-(2R)-maesopsin
C00014677	(2S)-2-Deoxymaesopsin-(2->7)-(2S)-maesopsin
C00014678	(2S,3R)-Dihydrogenistein-(2alpha->7)-(2R)-maesopsin
C00014679	(2S,3R)-Dihydrogenistein-(2alpha->7)-(2S)-maesopsin
C00014686	(I-2S,II-2S)-I-7,II-7-Di-O-methyltetrahydroamentoflavone
C00014704	Dehydroxyhexaspermone C
C00014706	Ruixianglangdusu B / (2R,2'R,3S,3'S)-rel-(+)-2,2',3,3'-Tetrahydro-5,5',7-trihydroxy-7'-methoxy-2,2'-bis(4-methoxyphenyl)-[3,3'-bi-4H-1-benzopyran]-4,4'-dione
C00014708	(2R,3S)-Naringenin-(3alpha->5)-(2R)-maesopsin
C00014709	(2R,3S)-Naringenin-(3alpha->5)-(2S)-maesopsin
C00014710	[2R-[2alpha,3beta(R*)]]-3-[2,3-Dihydro-2,4,6-trihydroxy-2-[(4-hydroxyphenyl)methyl]-3-oxo-7-benzofuranyl]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00014711	[2R-[2alpha,3beta(S*)]]-3-[2,3-Dihydro-2,4,6-trihydroxy-2-[(4-hydroxyphenyl)methyl]-3-oxo-7-benzofuranyl]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00014718	Gnidia biflavonoid 4 / (2R,2'R,3S,3'R)-2,2',3,3'-Tetrahydro-3',5,5',7,7'-pentahydroxy-2-(4-hydroxyphenyl)-2'-(3,4,5-trihydroxyphenyl)-[3,8'-bi-4H-1-benzopyran]-4,4'-dione
C00014719	Gnidia biflavonoid 4a / (2S,2'R,3R,3'R)-2,2',3,3'-Tetrahydro-3',5,5',7,7'-pentahydroxy-2-(4-hydroxyphenyl)-2'-(3,4,5-trihydroxyphenyl)-[3,8'-bi-4H-1-benzopyran]-4,4'-dione
C00014720	7,7''-Di-O-Methyltetrahydrohinokiflavone
C00014726	7-O-Methyltetrahydroochnaflavone	CHEMBL451877
C00014727	7,7''Di-O-methyl-2,3,2'',3''-tetrahydroochnaflavone	CHEMBL448630
C00030090	Daphnogirin A	CHEMBL2048507		6 / 5 / 4
C00030091	Daphnogirin B	CHEMBL2048507		6 / 5 / 4
C00031675	Chamaejasmenin D / (+)-Chamaejasmenin D
C00031893	Isochamaejasmenin B	CHEMBL1545093		18 / 28 / 19
C00036030	Afzelone A
C00036031	Afzelone B
C00036356	(rel)-1beta,2alpha-di-(2,4-dihydroxy-6-methoxybenzoyl)-3beta,4alpha-di-(4-methoxyphenyl)-cyclobutane
C00037902	Tetrahydrohinokiflavone / (-)-Tetrahydrohinokiflavone

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00006427 C00006428 C00013286 C00014530 C00031893	1 / 1
O00255	Menin	Unclassified protein	C00006427 C00006428 C00013286 C00014530 C00031893	2 / 5
P10636	Microtubule-associated protein tau	Unclassified protein	C00006427 C00006428 C00013286 C00014530 C00031893	4 / 3
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00006427 C00006428 C00013286 C00014530 C00031893	1 / 2
P39748	Flap endonuclease 1	Enzyme	C00006427 C00006428 C00013286 C00014530 C00031893	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00006427 C00006428 C00013286 C00014530 C00031893	2 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00006427 C00006428 C00013286 C00014530 C00031893	7 / 3
P05412	Transcription factor AP-1	Transcription Factor	C00000972 C00006420 C00006421 C00006422	0 / 0
P03956	Interstitial collagenase	M10A	C00008797 C00030090 C00030091	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00006427 C00006428 C00031893	1 / 2
P17861	X-box-binding protein 1	Unclassified protein	C00006427 C00006428 C00031893	1 / 0
P42858	Huntingtin	Unclassified protein	C00006427 C00006428 C00031893	1 / 1
P14780	Matrix metalloproteinase-9	M10A	C00008797 C00030090 C00030091	2 / 2
O75496	Geminin	Unclassified protein	C00006427 C00006428 C00031893	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00006427 C00006428 C00031893	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00006427 C00006428 C00031893	3 / 1
P39900	Macrophage metalloelastase	M10A	C00008797 C00030090 C00030091	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00006427 C00006428 C00031893	0 / 0
P45452	Collagenase 3	M10A	C00008797 C00030090 C00030091	1 / 1
P37840	Alpha-synuclein	Unclassified protein	C00006427 C00006428 C00031893	4 / 2
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00006427 C00006428 C00031893	1 / 0
P08254	Stromelysin-1	M10A	C00008797 C00030090 C00030091	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00006427 C00006428 C00031893	0 / 0
P06746	DNA polymerase beta	Enzyme	C00006427 C00006428 C00031893	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00008797 C00030090 C00030091	1 / 3
Q9UNA4	DNA polymerase iota	Enzyme	C00013286 C00014530	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00013286 C00014530	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00013286 C00014530	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00013286 C00014530	2 / 2
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00013286 C00014530	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00013286 C00014530	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00013286 C00014530	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions