KNApSAcK Metabolite C00030479
Metabolite
KNApSAcK Entry
| id | C00030479 |
|---|---|
| Name | Hexadecanoic acid / n-Hexadecanoic acid |
| CAS RN | 57-10-3 |
| Standard InChI | InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18) |
| Standard InChI (Main Layer) | InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18) |
Cluster
| Phytochemical cluster | No. 68 |
|---|---|
| KCF-S cluster | No. 184 |
Link
ChEMBL
| By standard InChI | CHEMBL82293 |
|---|---|
| By standard InChI Main Layer | CHEMBL82293 |
KEGG
| By LinkDB | C00249 |
|---|
CTD
| By CAS RN | D019308 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 3 |
| Magnoliophyta | 2 |
| Embryophyta | 2 |
| eudicotyledons | 1 |
| asterids | 1 |
| Liliopsida | 1 |
Family
| family name | count |
|---|---|
| Frullaniaceae | 2 |
| Crassulaceae | 1 |
| Rutaceae | 1 |
| Rosaceae | 1 |
| Asteraceae | 1 |
| Saururaceae | 1 |
| Cistaceae | 1 |
| Piperaceae | 1 |
| Acoraceae | 1 |
List (10)
* NCBI
Human Protein / Gene in interaction
16 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| O60603 | Toll-like receptor 2 | Membrane receptor | CHEMBL82293 |
CHEMBL867222
(2)
|
1 / 1 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | CHEMBL82293 |
CHEMBL641280
(1)
CHEMBL832621
(1)
CHEMBL887934 (1) |
0 / 0 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | CHEMBL82293 |
CHEMBL830870
(1)
CHEMBL887935
(1)
|
0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | CHEMBL82293 |
CHEMBL1058704
(1)
|
0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | CHEMBL82293 |
CHEMBL2076221
(1)
|
1 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | CHEMBL82293 |
CHEMBL1008117
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL82293 |
CHEMBL2114780
(1)
|
0 / 0 |
| P12104 | Fatty acid-binding protein, intestinal | Other cytosolic protein | CHEMBL82293 |
CHEMBL684424
(1)
CHEMBL833476
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL82293 |
CHEMBL1794467
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL82293 |
CHEMBL1794456
(1)
|
0 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | CHEMBL82293 |
CHEMBL976708
(1)
|
2 / 2 |
| Q96RI1 | Bile acid receptor | NR1H4 | CHEMBL82293 |
CHEMBL1794415
(1)
|
0 / 0 |
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | CHEMBL82293 |
CHEMBL833475
(1)
CHEMBL869162
(1)
CHEMBL887936 (1) |
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL82293 |
CHEMBL1794364
(1)
|
1 / 1 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL82293 |
CHEMBL1794321
(1)
|
3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | CHEMBL82293 |
CHEMBL2114915
(1)
|
0 / 0 |
CTD interaction (103)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D019308 | 9619 |
ABCG1
ABC8 WHITE1 |
ATP-binding cassette, sub-family G (WHITE), member 1 | Palmitic Acid results in increased expression of ABCG1 mRNA |
increases expression
|
mRNA |
16730733
|
| D019308 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | Palmitic Acid inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
22683933
|
| D019308 | 213 |
ALB
PRO0883 PRO0903 PRO1341 |
albumin | Palmitic Acid binds to ALB protein |
affects binding
|
protein |
12044178
|
| D019308 | 213 |
ALB
PRO0883 PRO0903 PRO1341 |
albumin | Palmitic Acid inhibits the reaction [Fenoprofen binds to ALB protein] |
affects binding
/ decreases reaction |
protein |
9470966
|
| D019308 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Palmitic Acid results in increased expression of BAX |
increases expression
|
15945276
|
|
| D019308 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Palmitic Acid results in decreased expression of BCL2 |
decreases expression
|
15945276
|
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [alpidem results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Cyclosporine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [fipexide results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Flecainide results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Fluoxetine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [nefazodone results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Phentolamine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Propranolol results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Pyrimethamine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [troglitazone results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP3 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [alpidem results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Cyclosporine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [fipexide results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Flecainide results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Fluoxetine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [nefazodone results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Phentolamine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Pyrimethamine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [troglitazone results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP7 protein] |
increases activity
/ increases reaction |
protein |
22700542
|
| D019308 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| D019308 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | Bezafibrate inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| D019308 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | Capsaicin inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| D019308 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [Capsaicin inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA]] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| D019308 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | Palmitic Acid results in increased expression of CCL3 mRNA |
increases expression
|
mRNA |
21745629
|
| D019308 | 1374 |
CPT1A
CPT1 CPT1-L L-CPT1 |
carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) | Capsaicin promotes the reaction [Palmitic Acid results in increased expression of CPT1A mRNA] |
increases expression
/ increases reaction |
mRNA |
21745629
|
| D019308 | 1374 |
CPT1A
CPT1 CPT1-L L-CPT1 |
carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) | Palmitic Acid results in increased expression of CPT1A mRNA |
increases expression
|
mRNA |
21745629
|
| D019308 | 1906 |
EDN1
ET1 HDLCQ7 PPET1 |
endothelin 1 | Palmitic Acid results in increased expression of EDN1 mRNA |
increases expression
|
mRNA |
16895544
|
| D019308 | 1906 |
EDN1
ET1 HDLCQ7 PPET1 |
endothelin 1 | Palmitic Acid results in increased expression of EDN1 protein |
increases expression
|
protein |
16895544
|
| D019308 | 2876 |
GPX1
GPXD GSHPX1 |
glutathione peroxidase 1 (EC:1.11.1.9) | Palmitic Acid results in decreased expression of GPX1 mRNA |
decreases expression
|
mRNA |
18155663
|
| D019308 | 2876 |
GPX1
GPXD GSHPX1 |
glutathione peroxidase 1 (EC:1.11.1.9) | rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of GPX1 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
18155663
|
| D019308 | 3034 |
HAL
HIS HSTD |
histidine ammonia-lyase (EC:4.3.1.3) | Palmitic Acid results in increased expression of HAL mRNA |
increases expression
|
mRNA |
17658692
|
| D019308 | 57817 |
HAMP
HEPC HFE2B LEAP1 PLTR |
hepcidin antimicrobial peptide | Palmitic Acid results in increased expression of HAMP mRNA |
increases expression
|
mRNA |
17658692
|
| D019308 | 3481 |
IGF2
C11orf43 IGF-II PP9974 |
insulin-like growth factor 2 (somatomedin A) | Palmitic Acid results in increased expression of IGF2 mRNA |
increases expression
|
mRNA |
17658692
|
| D019308 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| D019308 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | Bezafibrate inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| D019308 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | Capsaicin inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| D019308 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [Capsaicin inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA]] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| D019308 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | Palmitic Acid results in increased expression of IL8 mRNA |
increases expression
|
mRNA |
21745629
|
| D019308 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | 2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of INS protein]] |
decreases expression
/ decreases reaction |
protein |
18155663
|
| D019308 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | Palmitic Acid results in decreased expression of INS protein |
decreases expression
|
protein |
18155663
|
| D019308 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of INS protein] |
decreases expression
/ decreases reaction |
protein |
18155663
|
| D019308 | 1432 |
MAPK14
CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA |
mitogen-activated protein kinase 14 (EC:2.7.11.24) | Capsaicin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK14 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21745629
|
| D019308 | 1432 |
MAPK14
CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA |
mitogen-activated protein kinase 14 (EC:2.7.11.24) | Palmitic Acid results in increased phosphorylation of MAPK14 protein |
increases phosphorylation
|
protein |
21745629
|
| D019308 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | Capsaicin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21745629
|
| D019308 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | Palmitic Acid results in increased phosphorylation of MAPK8 protein |
increases phosphorylation
|
protein |
21745629
|
| D019308 | 5601 |
MAPK9
JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK |
mitogen-activated protein kinase 9 (EC:2.7.11.24) | Capsaicin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK9 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21745629
|
| D019308 | 5601 |
MAPK9
JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK |
mitogen-activated protein kinase 9 (EC:2.7.11.24) | Palmitic Acid results in increased phosphorylation of MAPK9 protein |
increases phosphorylation
|
protein |
21745629
|
| D019308 | 4493 |
MT1E
MT1 MTD |
metallothionein 1E | Palmitic Acid results in decreased expression of MT1E mRNA |
decreases expression
|
mRNA |
17658692
|
| D019308 | 4494 |
MT1F
MT1 |
metallothionein 1F | Palmitic Acid results in decreased expression of MT1F mRNA |
decreases expression
|
mRNA |
17658692
|
| D019308 | 4496 |
MT1H
MT-0 MT-1H MT-IH MT1 |
metallothionein 1H | Palmitic Acid results in decreased expression of MT1H mRNA |
decreases expression
|
mRNA |
17658692
|
| D019308 | 4501 |
MT1X
MT-1l MT1 |
metallothionein 1X | Palmitic Acid results in decreased expression of MT1X mRNA |
decreases expression
|
mRNA |
17658692
|
| D019308 | 4502 |
MT2A
MT2 |
metallothionein 2A | Palmitic Acid results in decreased expression of MT2A mRNA |
decreases expression
|
mRNA |
17658692
|
| D019308 | 4843 |
NOS2
HEP-NOS INOS NOS NOS2A |
nitric oxide synthase 2, inducible (EC:1.14.13.39) | Palmitic Acid results in increased expression of NOS2 mRNA |
increases expression
|
mRNA |
18155663
|
| D019308 | 4843 |
NOS2
HEP-NOS INOS NOS NOS2A |
nitric oxide synthase 2, inducible (EC:1.14.13.39) | rosiglitazone inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
18155663
|
| D019308 | 3651 |
PDX1
GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1 |
pancreatic and duodenal homeobox 1 | Palmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] |
affects localization
/ decreases reaction |
protein |
22558381
|
| D019308 | 3651 |
PDX1
GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1 |
pancreatic and duodenal homeobox 1 | Palmitic Acid results in decreased expression of PDX1 mRNA |
decreases expression
|
mRNA |
18155663
|
| D019308 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Palmitic Acid binds to and results in increased activity of PPARA protein |
affects binding
/ increases activity |
protein |
10403814
|
| D019308 | 10891 |
PPARGC1A
LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1 |
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | Palmitic Acid results in increased expression of PPARGC1A mRNA |
increases expression
|
mRNA |
23056435
|
| D019308 | 29893 |
PSMC3IP
GT198 HOP2 HUMGT198A ODG3 TBPIP |
PSMC3 interacting protein | Palmitic Acid results in increased expression of PSMC3IP mRNA |
increases expression
|
mRNA |
17658692
|
| D019308 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | Palmitic Acid results in increased phosphorylation of RELA protein |
increases phosphorylation
|
protein |
21745629
|
| D019308 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Palmitic Acid results in increased expression of SERPINE1 mRNA |
increases expression
|
mRNA |
17658692
|
| D019308 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | Palmitic Acid results in decreased expression of SOD1 mRNA |
decreases expression
|
mRNA |
18155663
|
| D019308 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of SOD1 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
18155663
|
| D019308 | 23216 |
TBC1D1
TBC TBC1 |
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 | TBC1D1 protein results in decreased uptake of and results in decreased oxidation of Palmitic Acid |
decreases oxidation
/ decreases uptake |
protein |
18931681
|
| D019308 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Palmitic Acid inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
22683933
|
| D019308 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Palmitic Acid results in increased susceptibility to TNF protein |
increases response to substance
|
protein |
22683933
|
| D019308 | 7351 |
UCP2
BMIQ4 SLC25A8 UCPH |
uncoupling protein 2 (mitochondrial, proton carrier) | Palmitic Acid results in increased activity of UCP2 protein |
increases activity
|
protein |
12858170
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #246300 | Leprosy, susceptibility to, 3; lprs3 |
O60603
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
KEGG DISEASE (8)
| KEGG | disease name | UniProt |
|---|---|---|
| H00344 | Leprosy |
O60603
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|