Haplophyllum acutifolium
Species
KNApSAcK Entry
| Organism name | Haplophyllum acutifolium |
|---|---|
| Genus | Haplophyllum |
| Family | Rutaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Haplophyllum acutifolium |
|---|---|
| Linked NCBI taxonomy ID | 452768 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Rutaceae |
|---|---|
| ID | 23513 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (18)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000640
|
(+)-Eudesmin
|
CHEMBL519099
CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879 |
C105875
|
2 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00000698
|
(+)-Epieudesmin
|
CHEMBL519099
CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879 |
2 / 0 / 0 | No. 38 | No. 21 |
|
||
|
C00003648
|
Cholesterol
/ Cholesterin / Cholest-5-en-3beta-ol |
CHEMBL112570
CHEMBL1597825 CHEMBL1867358 |
D002784
|
20 / 28 / 24 | 45 / 23 | No. 53 | No. 11 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00030479
|
Hexadecanoic acid
/ n-Hexadecanoic acid |
CHEMBL82293
|
D019308
|
16 / 8 / 8 | 35 / 1 | No. 184 | No. 68 |
|
|
C00034356
|
Kusunokinin
/ (-)-Kusunokinin |
No. 223 | No. 21 |
|
||||
|
C00002198
|
Skimmianine
|
CHEMBL21396
|
C035932
|
18 / 32 / 62 | No. 368 | No. 7 |
|
|
|
C00002158
|
Evoxine
/ 7-(2,3-Dihydroxy-3-methyl-butyl)oxy-8-methyldictamnine |
CHEMBL1317300
CHEMBL1395597 CHEMBL1416006 |
14 / 9 / 9 | No. 600 | No. 7 |
|
||
|
C00026394
|
Haplamine
/ 6-Methoxyflindersine |
CHEMBL1488010
|
23 / 37 / 65 | No. 799 | No. 7 |
|
||
|
C00002162
|
Flindersine
|
CHEMBL1507844
|
1 / 3 / 3 | No. 799 | No. 7 |
|
||
|
C00026438
|
Haplophytin A
|
No. 799 | No. 7 |
|
||||
|
C00048277
|
2-Nonylquinolin-4(1H)-one
|
No. 884 |
|
|||||
|
C00048306
|
Acutine
|
No. 1001 |
|
|||||
|
C00048396
|
Haplacutine A
|
No. 1001 |
|
|||||
|
C00048397
|
Haplacutine B
|
No. 1001 |
|
|||||
|
C00048398
|
Haplacutine C
|
No. 1001 |
|
|||||
|
C00048399
|
Haplacutine D
|
No. 1001 |
|
|||||
|
C00048401
|
Haplacutine F
|
No. 1001 |
|
Human Protein / Gene in interactions
67 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000640 C00000698 C00002158 C00002198 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002158 C00002198 C00003672 C00026394 | 0 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002158 C00002162 C00002198 C00026394 | 3 / 3 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002158 C00002198 C00003672 C00026394 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002158 C00002198 C00026394 | 2 / 2 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002158 C00002198 C00026394 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000640 C00000698 C00003648 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002158 C00002198 C00026394 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002198 C00026394 C00030479 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002158 C00002198 C00003672 | 0 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00003648 C00003672 C00030479 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002158 C00002198 C00003672 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002158 C00002198 C00026394 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002198 C00003672 C00026394 | 3 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002198 C00003648 C00026394 | 11 / 10 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002158 C00002198 C00003672 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002198 C00026394 | 7 / 37 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002158 C00026394 | 1 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 C00030479 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00002198 C00026394 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002198 C00026394 | 1 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002198 C00026394 | 1 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00003648 C00030479 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003648 C00026394 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00003648 C00030479 | 3 / 4 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00030479 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00026394 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00026394 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00026394 | 2 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003648 | 2 / 3 |
| P12104 | Fatty acid-binding protein, intestinal | Other cytosolic protein | C00030479 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00026394 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00026394 | 2 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00030479 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00030479 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00030479 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00030479 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00003648 | 0 / 0 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00003648 | 0 / 0 |
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | C00030479 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00003648 | 4 / 2 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00003648 | 2 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003648 | 0 / 0 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00030479 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002158 | 0 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00003648 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00003648 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002158 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 | 0 / 0 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00030479 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00030479 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| O00204 | Sulfotransferase family cytosolic 2B member 1 | Enzyme | C00003648 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00026394 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00026394 | 0 / 0 |
| O60603 | Toll-like receptor 2 | Membrane receptor | C00030479 | 1 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003648 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00003648 | 0 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00003648 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00003648 | 2 / 2 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00003648 | 3 / 2 |
77 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00003648
C00030479
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00003648
C00030479
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003648
C00030479
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00030479
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00003648
|
| 64240 | ABCG5, STSL | ATP-binding cassette, sub-family G (WHITE), member 5 |
C00003648
|
| 335 | APOA1 | apolipoprotein A-I |
C00003648
|
| 857 | CAV1, BSCL3, CGL3, MSTP085, PPH3, VIP21, CAV | caveolin 1, caveolae protein, 22kDa |
C00003648
|
| 859 | CAV3, LGMD1C, LQT9, VIP-21, VIP21 | caveolin 3 |
C00003648
|
| 1050 | CEBPA, C/EBP-alpha, CEBP | CCAAT/enhancer binding protein (C/EBP), alpha |
C00003648
|
| 1066 | CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 | carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) |
C00003648
|
| 1583 | CYP11A1, CYP11A, CYPXIA1, P450SCC | cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) |
C00003648
|
| 1593 | CYP27A1, CP27, CTX, CYP27 | cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) |
C00003648
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00003648
|
| 10858 | CYP46A1, CP46, CYP46 | cytochrome P450, family 46, subfamily A, polypeptide 1 (EC:1.14.13.98) |
C00003648
|
| 1581 | CYP7A1, CP7A, CYP7, CYPVII | cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) |
C00003648
|
| 1718 | DHCR24, DCE, Nbla03646, SELADIN1, seladin-1 | 24-dehydrocholesterol reductase (EC:1.3.1.72) |
C00003648
|
| 1717 | DHCR7, SLOS | 7-dehydrocholesterol reductase (EC:1.3.1.21) |
C00003648
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00003648
|
| 2222 | FDFT1, DGPT, ERG9, SQS, SS | farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21) |
C00003648
|
| 2252 | FGF7, HBGF-7, KGF | fibroblast growth factor 7 |
C00003648
|
| 2264 | FGFR4, CD334, JTK2, TKF | fibroblast growth factor receptor 4 (EC:2.7.10.1) |
C00003648
|
| 2773 | GNAI3, 87U6, ARCND1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
C00003648
|
| 2778 | GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH | GNAS complex locus |
C00003648
|
| 338442 | HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g | hydroxycarboxylic acid receptor 2 |
C00003648
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003648
|
| 3667 | IRS1, HIRS-1 | insulin receptor substrate 1 |
C00003648
|
| 3931 | LCAT | lecithin-cholesterol acyltransferase (EC:2.3.1.43) |
C00003648
|
| 3949 | LDLR, FH, FHC, LDLCQ2 | low density lipoprotein receptor |
C00003648
|
| 4481 | MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2 | macrophage scavenger receptor 1 |
C00003648
|
| 4864 | NPC1, NPC | Niemann-Pick disease, type C1 |
C00003648
|
| 7376 | NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR | nuclear receptor subfamily 1, group H, member 2 |
C00003648
|
| 10062 | NR1H3, LXR-a, LXRA, RLD-1 | nuclear receptor subfamily 1, group H, member 3 |
C00003648
|
| 9970 | NR1I3, CAR, CAR1, MB67 | nuclear receptor subfamily 1, group I, member 3 |
C00003648
|
| 5338 | PLD2 | phospholipase D2 (EC:3.1.4.4) |
C00003648
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00003648
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00003648
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00003648
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00003648
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00003648
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00003648
|
| 6721 | SREBF2, SREBP-2, SREBP2, bHLHd2 | sterol regulatory element binding transcription factor 2 |
C00003648
|
| 6770 | STAR, STARD1 | steroidogenic acute regulatory protein |
C00003648
|
| 27346 | TMEM97, MAC30 | transmembrane protein 97 |
C00003648
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00003648
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00030479
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00030479
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00030479
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00030479
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00030479
|
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 |
C00030479
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00030479
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00030479
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00030479
|
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) |
C00030479
|
| 57817 | HAMP, HEPC, HFE2B, LEAP1, PLTR | hepcidin antimicrobial peptide |
C00030479
|
| 3481 | IGF2, C11orf43, IGF-II, PP9974 | insulin-like growth factor 2 (somatomedin A) |
C00030479
|
| 64241 | ABCG8, GBD4, STSL | ATP-binding cassette, sub-family G (WHITE), member 8 |
C00003648
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00030479
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00030479
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00030479
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00030479
|
| 4493 | MT1E, MT1, MTD | metallothionein 1E |
C00030479
|
| 4494 | MT1F, MT1 | metallothionein 1F |
C00030479
|
| 4496 | MT1H, MT-0, MT-1H, MT-IH, MT1 | metallothionein 1H |
C00030479
|
| 4501 | MT1X, MT-1l, MT1 | metallothionein 1X |
C00030479
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00030479
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00030479
|
| 3651 | PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 | pancreatic and duodenal homeobox 1 |
C00030479
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00030479
|
| 29893 | PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP | PSMC3 interacting protein |
C00030479
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00030479
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00030479
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00030479
|
| 23216 | TBC1D1, TBC, TBC1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 |
C00030479
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00030479
|
| 7351 | UCP2, BMIQ4, SLC25A8, UCPH | uncoupling protein 2 (mitochondrial, proton carrier) |
C00030479
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (72)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #246300 | Leprosy, susceptibility to, 3; lprs3 |
O60603
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (87)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00344 | Leprosy |
O60603
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
24 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001161 | Arteriosclerosis |
C00003648
|
| D050197 | Atherosclerosis |
C00003648
|
| D006528 | Carcinoma, Hepatocellular |
C00003648
|
| D002779 | Cholestasis |
C00003648
|
| D003327 | Coronary Disease |
C00003648
|
| D056486 | Drug-Induced Liver Injury |
C00003648
|
| D050171 | Dyslipidemias |
C00003648
|
| D005234 | Fatty Liver |
C00003648
|
| D006471 | Gastrointestinal Hemorrhage |
C00003648
|
| D006529 | Hepatomegaly |
C00003648
|
| D006937 | Hypercholesterolemia |
C00003648
|
| D006949 | Hyperlipidemias |
C00003648
|
| D006951 | Hyperlipoproteinemias |
C00003648
|
| D006965 | Hyperplasia |
C00003648
|
| D015228 | Hypertriglyceridemia |
C00003648
|
| D007037 | Hypothyroidism |
C00003648
|
| D007680 | Kidney Neoplasms |
C00003648
|
| D007859 | Learning Disorders |
C00003648
|
| D009336 | Necrosis |
C00003648
|
| D009369 | Neoplasms |
C00003648
|
| D052556 | Niemann-Pick Disease, Type C |
C00003648
|
| D058226 | Plaque, Atherosclerotic |
C00003648
|
| D014456 | Ulcer |
C00003648
|
| D003072 | Cognition Disorders |
C00030479
|