KCF-S cluster No. 368 (20 metabolites)

Corresponding Phytochemical cluster No. 7

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (20)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	177
asterids	2
eudicotyledons	2

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Cumulative family count

class name	count
Rutaceae	177
Notodontidae	6
Ranunculaceae	2
Apocynaceae	2
Sertulariidae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Quinoline alkaloids	10

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metabolites link (10)

br08003 Category	KEGG ID	KNApSAcK ID
Quinoline alkaloids	C10631	C00002129
Quinoline alkaloids	C10660	C00002151
Quinoline alkaloids	C10676	C00002159
Quinoline alkaloids	C10678	C00002161
Quinoline alkaloids	C10694	C00002172
Quinoline alkaloids	C10701	C00002177
Quinoline alkaloids	C10714	C00002183
Quinoline alkaloids	C10716	C00002184
Quinoline alkaloids	C10736	C00002195
Quinoline alkaloids	C10740	C00002198

Metabolite list (20)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002129	Acronycidine / 5,7,8-Trimethoxydictamnine
C00002151	Dictamine / Dictamnine	CHEMBL22533	C026398
C00002159	gamma-Fagarine / 4,8-Dimethoxyfuro[2,3-b]quinoline	CHEMBL252925	C049193	8 / 14 / 7
C00002161	Flindersiamine / 8-Methoxy-6,7-methylenedioxydictamnine	CHEMBL503519	C012321
C00002172	Haplopine	CHEMBL455007	C012345	3 / 8 / 3
C00002177	Kokusaginine	CHEMBL278779		9 / 7 / 3
C00002183	Maculine	CHEMBL503675
C00002184	Maculosidine	CHEMBL1966898
C00002195	Robustine / (-)-Rutacridone	CHEMBL402862
C00002198	Skimmianine	CHEMBL21396	C035932	18 / 32 / 62
C00026391	5-Methoxymaculine	CHEMBL461610
C00026410	Confusameline / 7-Hydroxydictamnine / 7-O-Demethylevolitrine	CHEMBL503574
C00026415	Delbine / Delbine (Monnieria)
C00026434	Halfordinine / 6,7,8-Trimethoxydictamnine
C00026440	Heliparvifoline / 7-Hydroxy-6-methoxydictamnine
C00026452	Kokusagine / 7,8-Methylenedioxydictamnine	CHEMBL491782
C00026468	O-Ethylnordictamnine
C00026477	Ptelein / Pteleine / 6-Methoxydictamnine	CHEMBL486165
C00026492	Tecleine
C00037133	Evolitrin / Evolitrine	CHEMBL401536		2 / 0 / 0

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002159 C00002172 C00002177 C00002198	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002159 C00002198	2 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002159 C00002198	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00002159 C00002198	1 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00002159 C00002172	7 / 3
P00352	Retinal dehydrogenase 1	Enzyme	C00002159 C00002198	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002177	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002198	3 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002198	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002198	1 / 0
P55789	FAD-linked sulfhydryl oxidase ALR	Enzyme	C00002172	1 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00037133	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002198	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002177	2 / 0
O75496	Geminin	Unclassified protein	C00002198	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002159	4 / 2
P37840	Alpha-synuclein	Unclassified protein	C00002177	4 / 2
P02545	Prelamin-A/C	Unclassified protein	C00002198	11 / 10
P83916	Chromobox protein homolog 1	Unclassified protein	C00002177	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002198	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002198	3 / 3
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002177	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002198	7 / 37
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002198	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002198	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002177	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002177	0 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00037133	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002159	0 / 0
O00255	Menin	Unclassified protein	C00002198	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002198	1 / 2
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002177	1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions