PCIDB

KNApSAcK Metabolite C00003648

Metabolite

KNApSAcK Entry

id C00003648
Name Cholesterol / Cholesterin / Cholest-5-en-3beta-ol
CAS RN 57-88-5
Standard InChI InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
Standard InChI (Main Layer) InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3

Cluster

Phytochemical cluster No. 11
KCF-S cluster No. 53

Link

ChEMBL

By standard InChI CHEMBL112570
By standard InChI Main Layer CHEMBL112570 CHEMBL1597825 CHEMBL1867358

KEGG

By LinkDB C00187

CTD

By CAS RN D002784

Species

Summary

Plant class

class name count
rosids 9
asterids 5
Liliopsida 3

Family (Top 10)

family name count
Blastocladiaceae 3
Fabaceae 3
Solanaceae 2
Glomeraceae 2
Malvaceae 2
Kickxellaceae 2
Brassicaceae 2
Melanthiaceae 1
Poaceae 1
Leptosphaeriaceae 1

List (46)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acaulospora laevis 78545 Acaulosporaceae Fungi
Achlya bisexualis 4766 Saprolegniaceae Eukaryota
Allomyces macrogynus 28583 Blastocladiaceae Fungi
Allomyces spp. 28581 Blastocladiaceae Fungi
Amoebidium parasiticum 4881 Amoebidiaceae Eukaryota
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Aspergillus oryzae 5062 Aspergillaceae Fungi
Aureoumbra lagunensis 44058 Eukaryota
Bauhinia candicans 72379 Fabaceae rosids Viridiplantae
Blastocladia ramosa 945685 Blastocladiaceae Fungi
Chattonella marina 90936 Chattonellaceae Eukaryota
Chloromorum toxicum 299907 Eukaryota
Chorisia insignis 874444 Malvaceae rosids Viridiplantae
Chorisia speciosa 82382 Malvaceae rosids Viridiplantae
Clerodendron neutens 13432 Lamiaceae asterids Viridiplantae
Collectotrichum dematium
Conyza aegyptica 41552 Asteraceae asterids Viridiplantae
Crotone hieronymi
Digitalis lanata Ehrh. 49450 Plantaginaceae asterids Viridiplantae
Dipsacomyces acuminosporus 4866 Kickxellaceae Fungi
Dynamena pumila 308606 Sertulariidae Metazoa
Erysimum carniolicum 65352 Brassicaceae rosids Viridiplantae
Furcellaria fastigiata
Glomus mosseae 27381 Glomeraceae Fungi
Glomus sp. 4875 Glomeraceae Fungi
Glycine max 3847 Fabaceae rosids Viridiplantae
Gnomonia leptostyla 187235 Gnomoniaceae Fungi
Haplophyllum acutifolium 452768 Rutaceae rosids Viridiplantae
Hordeum vulgare L.cv Mammut 4512 Poaceae Liliopsida Viridiplantae
Hyrtios gumminae
Lanurocerasus officinalis
Laurencia aldingensis 1167835 Rhodomelaceae Eukaryota
Leptosphaeria typhae 5021 Leptosphaeriaceae Fungi
Linderina pennispora 61395 Kickxellaceae Fungi
Monoblepharella sp.
Nectria galligena 56674 Nectriaceae Fungi
Nicotiana benthamiana 4100 Solanaceae asterids Viridiplantae
Phoenix dactylifera 42345 Arecaceae Liliopsida Viridiplantae
Phycomyces blakesleeanus 4837 Phycomycetaceae Fungi
Prosopis spicigera 1217432 Fabaceae rosids Viridiplantae
Rhizophlyctis rosea 64517 Rhizophlyctidaceae Fungi
Schleichera trijuga 290995 Sapindaceae rosids Viridiplantae
Smittium sp.
Solanum tuberosum 4113 Solanaceae asterids Viridiplantae
Ustilago maydis 5270 Ustilaginaceae Fungi
Veratrum grandiflorum 203092 Melanthiaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O00204 Sulfotransferase family cytosolic 2B member 1 Enzyme CHEMBL112570 CHEMBL1743312 (1)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL112570 CHEMBL1794524 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1597825 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL112570 CHEMBL1614544 (1)
11 / 10
P37840 Alpha-synuclein Unclassified protein CHEMBL112570 CHEMBL1250260 (1) CHEMBL1250261 (1)
CHEMBL1250262 (1) CHEMBL1250263 (1)
CHEMBL1250264 (1) CHEMBL1250265 (1)
CHEMBL1250266 (1) CHEMBL1250267 (1)
CHEMBL1250268 (1) CHEMBL1250269 (1)
CHEMBL1250270 (1)
4 / 2
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 CHEMBL112570 CHEMBL934981 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL112570 CHEMBL2075511 (1)
1 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1867358 CHEMBL1794311 (1)
2 / 3
P04150 Glucocorticoid receptor NR3C1 CHEMBL112570 CHEMBL1794382 (1)
0 / 1
Q13133 Oxysterols receptor LXR-alpha NR1H3 CHEMBL112570 CHEMBL712591 (1)
0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL112570 CHEMBL2078553 (1)
2 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase CHEMBL112570 CHEMBL830331 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL112570 CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL112570 CHEMBL1794321 (1)
3 / 4
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1867358 CHEMBL1794536 (1)
0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL112570 CHEMBL830332 (1)
0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase CHEMBL112570 CHEMBL830332 (1)
0 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL112570 CHEMBL806153 (1)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL112570 CHEMBL806153 (1)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL112570 CHEMBL806153 (1)
3 / 2

CTD interaction (121)

compound gene gene name gene description interaction interaction type form reference
pmid
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]] decreases reaction
/ increases export
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 ABCA1 protein results in increased export of Cholesterol increases export
protein 15983222
20655299
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 ABCA1 protein results in increased transport of Cholesterol increases transport
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol] affects reaction
/ increases transport
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 APOA1 protein promotes the reaction [ABCA1 protein results in increased export of Cholesterol] increases export
/ increases reaction
protein 15983222
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 glycolaldehyde inhibits the reaction [ABCA1 protein results in increased export of Cholesterol] decreases reaction
/ increases export
protein 15983222
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol] decreases reaction
/ increases export
protein 15983222
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 [HCAR2 protein results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol decreases export
/ decreases expression
protein 20655299
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol] decreases reaction
/ increases export
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]] affects reaction
/ decreases reaction
/ increases export
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]] affects reaction
/ increases export
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] affects reaction
/ decreases reaction
/ increases export
protein 16118212
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 [resveratrol results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol increases expression
/ increases secretion
protein 20372816
D002784 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]] decreases reaction
/ increases transport
protein 16118212
D002784 9619 ABCG1
ABC8
WHITE1
ATP-binding cassette, sub-family G (WHITE), member 1 [resveratrol results in increased expression of ABCG1 protein] which results in increased secretion of Cholesterol increases expression
/ increases secretion
protein 20372816
D002784 64240 ABCG5
STSL
ATP-binding cassette, sub-family G (WHITE), member 5 ABCG5 protein affects the export of Cholesterol affects export
protein 15696852
D002784 64241 ABCG8
GBD4
STSL
ATP-binding cassette, sub-family G (WHITE), member 8 ABCG8 protein affects the export of Cholesterol affects export
protein 15696852
D002784 177 AGER
RAGE
advanced glycosylation end product-specific receptor AGER protein affects the abundance of Cholesterol affects abundance
protein 20372816
D002784 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Cholesterol results in increased expression of and results in increased phosphorylation of AKT1 protein increases expression
/ increases phosphorylation
protein 19672739
D002784 335 APOA1
apolipoprotein A-I 1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 335 APOA1
apolipoprotein A-I [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 335 APOA1
apolipoprotein A-I [Acrolein affects the metabolism of APOA1 protein] which results in decreased secretion of Cholesterol affects metabolic processing
/ decreases secretion
protein 16126721
D002784 335 APOA1
apolipoprotein A-I Acrolein inhibits the reaction [APOA1 protein affects the transport of Cholesterol] affects transport
/ decreases reaction
protein 16037261
D002784 335 APOA1
apolipoprotein A-I APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol] affects reaction
/ increases transport
protein 16118212
D002784 335 APOA1
apolipoprotein A-I APOA1 protein promotes the reaction [ABCA1 protein results in increased export of Cholesterol] increases export
/ increases reaction
protein 15983222
D002784 335 APOA1
apolipoprotein A-I APOA1 protein results in increased export of Cholesterol increases export
protein 23041272
D002784 335 APOA1
apolipoprotein A-I APOA1 protein results in increased secretion of Cholesterol increases secretion
protein 12531903
20056921
D002784 335 APOA1
apolipoprotein A-I Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 335 APOA1
apolipoprotein A-I [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 335 APOA1
apolipoprotein A-I CYP27A1 protein promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] increases reaction
/ increases secretion
protein 12531903
D002784 335 APOA1
apolipoprotein A-I fingolimod promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] increases reaction
/ increases secretion
protein 20056921
D002784 335 APOA1
apolipoprotein A-I Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 335 APOA1
apolipoprotein A-I mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]] affects reaction
/ decreases reaction
/ increases export
protein 16118212
D002784 335 APOA1
apolipoprotein A-I Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 335 APOA1
apolipoprotein A-I palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] affects reaction
/ decreases reaction
/ increases transport
protein 16118212
D002784 335 APOA1
apolipoprotein A-I [pirinixic acid binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 335 APOA1
apolipoprotein A-I PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]] affects reaction
/ increases export
protein 16118212
D002784 335 APOA1
apolipoprotein A-I PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] affects reaction
/ decreases reaction
/ increases export
protein 16118212
D002784 335 APOA1
apolipoprotein A-I resveratrol inhibits the reaction [APOA1 protein results in increased export of Cholesterol] decreases reaction
/ increases export
protein 23041272
D002784 857 CAV1
BSCL3
CGL3
MSTP085
PPH3
VIP21
CAV
caveolin 1, caveolae protein, 22kDa CAV1 protein results in increased transport of Cholesterol increases transport
protein 12640124
D002784 859 CAV3
LGMD1C
LQT9
VIP-21
VIP21
caveolin 3 CAV3 protein affects the import of Cholesterol affects import
protein 19221014
D002784 1050 CEBPA
C/EBP-alpha
CEBP
CCAAT/enhancer binding protein (C/EBP), alpha [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol decreases chemical synthesis
/ decreases expression
mRNA 23063590
D002784 1066 CES1
ACAT
CE-1
CEH
CES2
HMSE
HMSE1
PCE-1
REH
SES1
TGH
hCE-1
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) CES1 protein results in increased metabolism of Cholesterol increases metabolic processing
protein 8049197
11015575
12773168
D002784 1066 CES1
ACAT
CE-1
CEH
CES2
HMSE
HMSE1
PCE-1
REH
SES1
TGH
hCE-1
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) Cholesterol results in increased expression of CES1 mRNA increases expression
mRNA 8049197
D002784 1583 CYP11A1
CYP11A
CYPXIA1
P450SCC
cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) CYP11A1 protein affects the metabolism of Cholesterol affects metabolic processing
protein 16054388
D002784 1583 CYP11A1
CYP11A
CYPXIA1
P450SCC
cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) CYP11A1 protein results in increased metabolism of Cholesterol increases metabolic processing
protein 19900470
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) CYP27A1 protein promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] increases reaction
/ increases secretion
protein 12531903
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) CYP27A1 protein results in decreased chemical synthesis of Cholesterol decreases chemical synthesis
protein 12531903
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) [CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol] increases chemical synthesis
/ increases reaction
/ increases uptake
protein 16477808
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) CYP27A1 protein results in increased hydroxylation of and results in decreased abundance of Cholesterol decreases abundance
/ increases hydroxylation
protein 11714861
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol increases chemical synthesis
/ increases hydroxylation
protein 9660774
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 25-hydroxycholesterol increases chemical synthesis
/ increases metabolic processing
protein 8078928
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol increases chemical synthesis
/ increases metabolic processing
protein 9215552
11408283
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein increases activity
/ increases chemical synthesis
/ increases metabolic processing
protein 11408283
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid increases chemical synthesis
/ increases metabolic processing
protein 8078928
9215552
D002784 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) CYP27A1 protein results in increased secretion of Cholesterol increases secretion
protein 12117727
D002784 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) [CYP3A4 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-ene-3,4-diol increases chemical synthesis
/ increases oxidation
protein 11514559
D002784 10858 CYP46A1
CP46
CYP46
cytochrome P450, family 46, subfamily A, polypeptide 1 (EC:1.14.13.98) CYP46A1 gene SNP affects the metabolism of and affects the abundance of Cholesterol affects abundance
/ affects metabolic processing
gene 19286353
D002784 10858 CYP46A1
CP46
CYP46
cytochrome P450, family 46, subfamily A, polypeptide 1 (EC:1.14.13.98) CYP46A1 protein results in increased hydroxylation of Cholesterol increases hydroxylation
protein 14640697
D002784 1581 CYP7A1
CP7A
CYP7
CYPVII
cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) CYP7A1 protein affects the metabolism of Cholesterol affects metabolic processing
protein 15696852
D002784 1581 CYP7A1
CP7A
CYP7
CYPVII
cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) CYP7A1 protein results in increased metabolism of Cholesterol increases metabolic processing
protein 7925343
11013305
D002784 1718 DHCR24
DCE
Nbla03646
SELADIN1
seladin-1
24-dehydrocholesterol reductase (EC:1.3.1.72) [DHCR24 protein results in increased metabolism of Desmosterol] which results in increased abundance of Cholesterol increases abundance
/ increases metabolic processing
protein 23042211
D002784 1717 DHCR7
SLOS
7-dehydrocholesterol reductase (EC:1.3.1.21) DHCR7 mutant form affects the susceptibility to Cholesterol affects response to substance
mutant form 19365639
D002784 1717 DHCR7
SLOS
7-dehydrocholesterol reductase (EC:1.3.1.21) DHCR7 mutant form results in decreased abundance of Cholesterol decreases abundance
mutant form 16446309
D002784 1717 DHCR7
SLOS
7-dehydrocholesterol reductase (EC:1.3.1.21) DHCR7 results in increased chemical synthesis of Cholesterol increases chemical synthesis
15896653
D002784 1717 DHCR7
SLOS
7-dehydrocholesterol reductase (EC:1.3.1.21) Simvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol] increases chemical synthesis
/ increases reaction
15896653
D002784 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Cholesterol inhibits the reaction [FGF7 protein results in increased expression of FAS mRNA] decreases reaction
/ increases expression
mRNA 16162944
D002784 2222 FDFT1
DGPT
ERG9
SQS
SS
farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21) FDFT1 protein results in increased chemical synthesis of Cholesterol increases chemical synthesis
protein 17483544
D002784 2252 FGF7
HBGF-7
KGF
fibroblast growth factor 7 Cholesterol inhibits the reaction [FGF7 protein results in increased expression of FAS mRNA] decreases reaction
/ increases expression
protein 16162944
D002784 2252 FGF7
HBGF-7
KGF
fibroblast growth factor 7 Cholesterol inhibits the reaction [FGF7 protein results in increased expression of SCD mRNA] decreases reaction
/ increases expression
protein 16162944
D002784 2264 FGFR4
CD334
JTK2
TKF
fibroblast growth factor receptor 4 (EC:2.7.10.1) FGFR4 protein results in decreased metabolism of Cholesterol decreases metabolic processing
protein 15750181
D002784 2773 GNAI3
87U6
ARCND1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 Cholesterol inhibits the reaction [Progesterone results in decreased expression of GNAI3 protein] decreases expression
/ decreases reaction
protein 19221014
D002784 2778 GNAS
AHO
C20orf45
GNAS1
GPSA
GSA
GSP
NESP
PHP1A
PHP1B
PHP1C
POH
GNAS complex locus Cholesterol inhibits the reaction [Progesterone results in increased expression of GNAS protein] decreases reaction
/ increases expression
protein 19221014
D002784 338442 HCAR2
GPR109A
HCA2
HM74a
HM74b
NIACR1
PUMAG
Puma-g
hydroxycarboxylic acid receptor 2 [HCAR2 protein results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol decreases export
/ decreases expression
protein 20655299
D002784 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol decreases chemical synthesis
/ decreases expression
mRNA 23063590
D002784 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) [artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol decreases chemical synthesis
/ decreases expression
protein 23063590
D002784 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) Cholesterol results in decreased activity of HMGCR protein decreases activity
protein 18024962
D002784 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) Cholesterol results in decreased expression of HMGCR mRNA decreases expression
mRNA 17516993
D002784 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol increases abundance
/ increases activity
protein 16027736
D002784 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein increases activity
/ increases chemical synthesis
/ increases metabolic processing
protein 11408283
D002784 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol increases abundance
/ increases activity
protein 16027736
D002784 3667 IRS1
HIRS-1
insulin receptor substrate 1 IRS1 gene polymorphism affects the abundance of Cholesterol affects abundance
gene 10591678
D002784 3931 LCAT
lecithin-cholesterol acyltransferase (EC:2.3.1.43) LCAT protein results in increased acylation of Cholesterol increases acylation
protein 4847537
D002784 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor [CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol] increases chemical synthesis
/ increases reaction
/ increases uptake
protein 16477808
D002784 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor LDLR protein results in increased uptake of Cholesterol increases uptake
protein 16477808
D002784 4481 MSR1
CD204
SCARA1
SR-A
SRA
phSR1
phSR2
macrophage scavenger receptor 1 [resveratrol results in decreased expression of MSR1 protein] which results in decreased uptake of Cholesterol decreases expression
/ decreases uptake
protein 20372816
D002784 4864 NPC1
NPC
Niemann-Pick disease, type C1 NPC1 protein results in increased secretion of Cholesterol increases secretion
protein 16174794
D002784 4864 NPC1
NPC
Niemann-Pick disease, type C1 Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Cholesterol] decreases reaction
/ increases secretion
protein 16174794
D002784 7376 NR1H2
LXR-b
LXRB
NER
NER-I
RIP15
UNR
nuclear receptor subfamily 1, group H, member 2 Cholesterol results in increased activity of NR1H2 protein increases activity
protein 21543282
D002784 10062 NR1H3
LXR-a
LXRA
RLD-1
nuclear receptor subfamily 1, group H, member 3 [25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol affects binding
/ increases activity
/ increases transport
protein 12595494
D002784 10062 NR1H3
LXR-a
LXRA
RLD-1
nuclear receptor subfamily 1, group H, member 3 [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 10062 NR1H3
LXR-a
LXRA
RLD-1
nuclear receptor subfamily 1, group H, member 3 [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 9970 NR1I3
CAR
CAR1
MB67
nuclear receptor subfamily 1, group I, member 3 Cholesterol metabolite binds to NR1I3 protein affects binding
protein 16051528
D002784 5338 PLD2
phospholipase D2 (EC:3.1.4.4) PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]] affects reaction
/ increases export
protein 16118212
D002784 5338 PLD2
phospholipase D2 (EC:3.1.4.4) PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] affects reaction
/ decreases reaction
/ increases export
protein 16118212
D002784 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) PON1 protein results in decreased chemical synthesis of Cholesterol decreases chemical synthesis
protein 12615663
D002784 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) PON1 protein results in increased export of Cholesterol increases export
protein 16229851
16331452
D002784 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] affects binding
/ decreases reaction
/ increases activity
/ increases reaction
protein 11779144
D002784 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha [pirinixic acid binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [resveratrol results in decreased abundance of Cholesterol] affects binding
/ decreases abundance
/ decreases activity
/ decreases reaction
protein 20372816
D002784 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol] affects binding
/ increases activity
/ increases reaction
/ increases transport
protein 12595494
D002784 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Pravastatin inhibits the reaction [[troglitazone binds to and results in increased activity of PPARG protein] which results in increased abundance of Cholesterol] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 12044893
D002784 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [troglitazone binds to and results in increased activity of PPARG protein] which results in decreased abundance of Cholesterol affects binding
/ decreases abundance
/ increases activity
protein 16946405
D002784 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol affects binding
/ decreases abundance
/ decreases expression
/ increases activity
protein 16946405
D002784 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma [troglitazone binds to and results in increased activity of PPARG protein] which results in increased abundance of Cholesterol affects binding
/ increases abundance
/ increases activity
protein 12044893
D002784 5879 RAC1
Rac-1
TC-25
p21-Rac1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Cholesterol inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RAC1 protein] affects localization
/ decreases activity
/ decreases reaction
protein 21334995
D002784 6256 RXRA
NR2B1
retinoid X receptor, alpha Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] affects binding
/ decreases reaction
/ increases activity
/ increases reaction
protein 11779144
D002784 6319 SCD
FADS5
MSTP008
SCD1
SCDOS
stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) Cholesterol inhibits the reaction [FGF7 protein results in increased expression of SCD mRNA] decreases reaction
/ increases expression
mRNA 16162944
D002784 6721 SREBF2
SREBP-2
SREBP2
bHLHd2
sterol regulatory element binding transcription factor 2 [[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol affects binding
/ decreases abundance
/ decreases expression
/ increases activity
protein 16946405
D002784 6770 STAR
STARD1
steroidogenic acute regulatory protein STAR protein affects the transport of Cholesterol affects transport
protein 15819722
D002784 6770 STAR
STARD1
steroidogenic acute regulatory protein STAR protein results in increased transport of Cholesterol increases transport
protein 19900470
D002784 27346 TMEM97
MAC30
transmembrane protein 97 TMEM97 protein affects the metabolism of Cholesterol affects metabolic processing
protein 18070364
D002784 7421 VDR
NR1I1
vitamin D (1,25- dihydroxyvitamin D3) receptor Cholesterol metabolite binds to VDR protein affects binding
protein 16051528

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#127750 Dementia, lewy body; dlb P37840
#607208 Dravet syndrome P35498
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#275210 Restrictive dermopathy, lethal P02545
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (24)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)

Diseases related to CTD interactions

23 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001161 D002784 Arteriosclerosis marker/mechanism
8320874
18049428
18442015
D050197 D002784 Atherosclerosis marker/mechanism
223374
413557
9601935
10559523
16632123
18302760
19028402
D006528 D002784 Carcinoma, Hepatocellular marker/mechanism
21147110
D002779 D002784 Cholestasis marker/mechanism
1942649
12700418
D003327 D002784 Coronary Disease marker/mechanism
619758
D056486 D002784 Drug-Induced Liver Injury marker/mechanism
22310181
D050171 D002784 Dyslipidemias marker/mechanism
18230960
D005234 D002784 Fatty Liver marker/mechanism
21535835
D006471 D002784 Gastrointestinal Hemorrhage marker/mechanism
18049428
18442015
D006529 D002784 Hepatomegaly marker/mechanism
22570273
D006937 D002784 Hypercholesterolemia marker/mechanism
8245718
16933029
17611329
21052790
21269478
21535835
22570273
D006949 D002784 Hyperlipidemias marker/mechanism
17124636
D006951 D002784 Hyperlipoproteinemias marker/mechanism
17611329
D006965 D002784 Hyperplasia marker/mechanism
16148612
D015228 D002784 Hypertriglyceridemia marker/mechanism
16549462
D007037 D002784 Hypothyroidism marker/mechanism
11177166
D007680 D002784 Kidney Neoplasms marker/mechanism
8221684
D007859 D002784 Learning Disorders marker/mechanism
17134702
D009336 D002784 Necrosis marker/mechanism
20484746
D009369 D002784 Neoplasms marker/mechanism
6061664
D052556 D002784 Niemann-Pick Disease, Type C marker/mechanism
9802331
20557099
D058226 D002784 Plaque, Atherosclerotic marker/mechanism
16148612
D014456 D002784 Ulcer marker/mechanism
18049428
18442015