Nectria galligena
Species
KNApSAcK Entry
| Organism name | Nectria galligena |
|---|---|
| Genus | Nectria |
| Family | Hypocreaceae |
| Kingdom | Fungi |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Neonectria galligena |
|---|---|
| Linked NCBI taxonomy ID | 56674 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Nectriaceae |
|---|---|
| ID | 110618 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Fungi |
|---|---|
| ID | 4751 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003648
|
Cholesterol
/ Cholesterin / Cholest-5-en-3beta-ol |
CHEMBL112570
CHEMBL1597825 CHEMBL1867358 |
D002784
|
20 / 28 / 24 | 45 / 23 | No. 53 | No. 11 |
|
|
C00003652
|
Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol |
CHEMBL222608
CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225 |
D004875
|
12 / 14 / 11 | No. 111 | No. 11 |
|
|
|
C00023747
|
7-Dehydrocholesterol
/ Provitamin D3,Cholesta-5,7-dien-3beta-ol |
CHEMBL1480760
CHEMBL1797131 |
C016705
|
5 / 6 / 13 | 1 / 1 | No. 111 | No. 11 |
|
|
C00023744
|
Lathosterol
/ Cholest-7-en-3beta-ol |
CHEMBL1515367
|
C001521
|
7 / 7 / 10 | 0 / 3 | No. 111 | No. 11 |
|
|
C00003658
|
Lichesterol
/ Ergosta-5,8,22-trien-3beta-ol / (24S)24-Methylcholesta-5,8,22-trien-3beta-ol |
C014640
|
No. 768 |
|
||||
|
C00002352
|
Mycosporine
|
CHEMBL1210424
|
No. 6212 |
|
Human Protein / Gene in interactions
35 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11473 | Vitamin D3 receptor | NR1I1 | C00003648 C00003652 C00023747 | 2 / 3 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003652 C00023744 | 4 / 3 |
| O00255 | Menin | Unclassified protein | C00023744 C00023747 | 2 / 5 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003648 C00023744 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00023744 C00023747 | 1 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003652 C00023744 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003652 C00023744 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003652 C00023744 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003652 | 1 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003648 | 1 / 0 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00003648 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00003648 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00003648 | 0 / 1 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00003648 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003652 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00003648 | 2 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00003648 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003652 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003652 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003652 | 0 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003652 | 5 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003648 | 11 / 10 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003648 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00003648 | 3 / 4 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | C00003652 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003648 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00003648 | 0 / 0 |
| O00204 | Sulfotransferase family cytosolic 2B member 1 | Enzyme | C00003648 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00023747 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00023747 | 1 / 4 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003648 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00003648 | 0 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00003648 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00003648 | 2 / 2 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00003648 | 3 / 2 |
45 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1717 | DHCR7, SLOS | 7-dehydrocholesterol reductase (EC:1.3.1.21) |
C00003648
C00023747
|
| 2773 | GNAI3, 87U6, ARCND1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
C00003648
|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00003648
|
| 64240 | ABCG5, STSL | ATP-binding cassette, sub-family G (WHITE), member 5 |
C00003648
|
| 64241 | ABCG8, GBD4, STSL | ATP-binding cassette, sub-family G (WHITE), member 8 |
C00003648
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00003648
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003648
|
| 335 | APOA1 | apolipoprotein A-I |
C00003648
|
| 857 | CAV1, BSCL3, CGL3, MSTP085, PPH3, VIP21, CAV | caveolin 1, caveolae protein, 22kDa |
C00003648
|
| 859 | CAV3, LGMD1C, LQT9, VIP-21, VIP21 | caveolin 3 |
C00003648
|
| 1050 | CEBPA, C/EBP-alpha, CEBP | CCAAT/enhancer binding protein (C/EBP), alpha |
C00003648
|
| 1066 | CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 | carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) |
C00003648
|
| 1583 | CYP11A1, CYP11A, CYPXIA1, P450SCC | cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) |
C00003648
|
| 1593 | CYP27A1, CP27, CTX, CYP27 | cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) |
C00003648
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00003648
|
| 10858 | CYP46A1, CP46, CYP46 | cytochrome P450, family 46, subfamily A, polypeptide 1 (EC:1.14.13.98) |
C00003648
|
| 1581 | CYP7A1, CP7A, CYP7, CYPVII | cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) |
C00003648
|
| 1718 | DHCR24, DCE, Nbla03646, SELADIN1, seladin-1 | 24-dehydrocholesterol reductase (EC:1.3.1.72) |
C00003648
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00003648
|
| 2222 | FDFT1, DGPT, ERG9, SQS, SS | farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21) |
C00003648
|
| 2252 | FGF7, HBGF-7, KGF | fibroblast growth factor 7 |
C00003648
|
| 2264 | FGFR4, CD334, JTK2, TKF | fibroblast growth factor receptor 4 (EC:2.7.10.1) |
C00003648
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00003648
|
| 2778 | GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH | GNAS complex locus |
C00003648
|
| 338442 | HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g | hydroxycarboxylic acid receptor 2 |
C00003648
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003648
|
| 3667 | IRS1, HIRS-1 | insulin receptor substrate 1 |
C00003648
|
| 3931 | LCAT | lecithin-cholesterol acyltransferase (EC:2.3.1.43) |
C00003648
|
| 3949 | LDLR, FH, FHC, LDLCQ2 | low density lipoprotein receptor |
C00003648
|
| 4481 | MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2 | macrophage scavenger receptor 1 |
C00003648
|
| 4864 | NPC1, NPC | Niemann-Pick disease, type C1 |
C00003648
|
| 7376 | NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR | nuclear receptor subfamily 1, group H, member 2 |
C00003648
|
| 10062 | NR1H3, LXR-a, LXRA, RLD-1 | nuclear receptor subfamily 1, group H, member 3 |
C00003648
|
| 9970 | NR1I3, CAR, CAR1, MB67 | nuclear receptor subfamily 1, group I, member 3 |
C00003648
|
| 5338 | PLD2 | phospholipase D2 (EC:3.1.4.4) |
C00003648
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00003648
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00003648
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00003648
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00003648
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00003648
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00003648
|
| 6721 | SREBF2, SREBP-2, SREBP2, bHLHd2 | sterol regulatory element binding transcription factor 2 |
C00003648
|
| 6770 | STAR, STARD1 | steroidogenic acute regulatory protein |
C00003648
|
| 27346 | TMEM97, MAC30 | transmembrane protein 97 |
C00003648
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00003648
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (44)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608688 | Aicar transformylase/imp cyclohydrolase deficiency |
P31939
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #143500 | Gilbert syndrome |
P22309
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (42)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00966 | AICA-ribosiduria |
P31939
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
Diseases related to CTD interactions
27 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D008607 | Intellectual Disability |
C00023744
|
| C537880 | Lathosterolosis |
C00023744
|
| D008107 | Liver Diseases |
C00023744
|
| D019082 | Smith-Lemli-Opitz Syndrome |
C00023747
|
| D001161 | Arteriosclerosis |
C00003648
|
| D050197 | Atherosclerosis |
C00003648
|
| D006528 | Carcinoma, Hepatocellular |
C00003648
|
| D002779 | Cholestasis |
C00003648
|
| D003327 | Coronary Disease |
C00003648
|
| D056486 | Drug-Induced Liver Injury |
C00003648
|
| D050171 | Dyslipidemias |
C00003648
|
| D005234 | Fatty Liver |
C00003648
|
| D006471 | Gastrointestinal Hemorrhage |
C00003648
|
| D006529 | Hepatomegaly |
C00003648
|
| D006937 | Hypercholesterolemia |
C00003648
|
| D006949 | Hyperlipidemias |
C00003648
|
| D006951 | Hyperlipoproteinemias |
C00003648
|
| D006965 | Hyperplasia |
C00003648
|
| D015228 | Hypertriglyceridemia |
C00003648
|
| D007037 | Hypothyroidism |
C00003648
|
| D007680 | Kidney Neoplasms |
C00003648
|
| D007859 | Learning Disorders |
C00003648
|
| D009336 | Necrosis |
C00003648
|
| D009369 | Neoplasms |
C00003648
|
| D052556 | Niemann-Pick Disease, Type C |
C00003648
|
| D058226 | Plaque, Atherosclerotic |
C00003648
|
| D014456 | Ulcer |
C00003648
|