KNApSAcK Metabolite C00023747
Metabolite
KNApSAcK Entry
| id | C00023747 |
|---|---|
| Name | 7-Dehydrocholesterol / Provitamin D3,Cholesta-5,7-dien-3beta-ol |
| CAS RN | 434-16-2 |
| Standard InChI | InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3 |
Cluster
| Phytochemical cluster | No. 11 |
|---|---|
| KCF-S cluster | No. 111 |
Link
ChEMBL
| By standard InChI | CHEMBL1797131 |
|---|---|
| By standard InChI Main Layer | CHEMBL1480760 CHEMBL1797131 |
KEGG
| By LinkDB | C01164 |
|---|
CTD
| By CAS RN | C016705 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Russulaceae | 3 |
| Nectriaceae | 1 |
List (4)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Lactarius sp. | 5401 | Russulaceae | Fungi | |
| Nectria galligena | 56674 | Nectriaceae | Fungi | |
| Russula aeruginosa | 5402 | Russulaceae | Fungi | |
| Russula decolorans | 152956 | Russulaceae | Fungi |
Human Protein / Gene in interaction
5 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL1480760 |
CHEMBL1794311
(1)
CHEMBL1963865
(1)
CHEMBL1963915 (1) CHEMBL1963934 (1) |
2 / 3 |
| O00255 | Menin | Unclassified protein | CHEMBL1480760 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1480760 |
CHEMBL1614531
(1)
|
1 / 3 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL1480760 |
CHEMBL1613933
(1)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL1480760 |
CHEMBL1613933
(1)
|
1 / 6 |
CTD interaction (2)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C016705 | 1717 |
DHCR7
SLOS |
7-dehydrocholesterol reductase (EC:1.3.1.21) | DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol |
increases abundance
|
mutant form |
16446309
|
| C016705 | 1717 |
DHCR7
SLOS |
7-dehydrocholesterol reductase (EC:1.3.1.21) | DHCR7 results in increased reduction of 7-dehydrocholesterol |
increases reduction
|
15896653
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (6)
| OMIM | preferred title | UniProt |
|---|---|---|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (13)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|