Bauhinia candicans

• Index
• Plant Species
• Metabolite list (8)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Bauhinia candicans
Genus	Bauhinia
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Bauhinia forficata subsp. pruinosa
Linked NCBI taxonomy ID	72379
Linked level	subspecies

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (8)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005169	Nicotiflorin / Nicotifloroside / Kaempferol 3-O-rutinoside / Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside / (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside	CHEMBL431610 CHEMBL79790 CHEMBL255020 CHEMBL501550 CHEMBL498879 CHEMBL1419228 CHEMBL1875691		22 / 10 / 12		No. 1	No. 15
C00005240	Kaempferol 3-rutinoside-7-rhamnoside					No. 5	No. 15
C00003647	Campesterol / 24alpha-Methylcholesterol / (24R)24-Methylcholest-5-en-3beta-ol	CHEMBL520535 CHEMBL485421 CHEMBL1836653	C021273			No. 53	No. 11
C00003672	Sitosterol / beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol	CHEMBL221542 CHEMBL1398443 CHEMBL1875388		17 / 19 / 12		No. 53	No. 11
C00003648	Cholesterol / Cholesterin / Cholest-5-en-3beta-ol	CHEMBL112570 CHEMBL1597825 CHEMBL1867358	D002784	20 / 28 / 24	45 / 23	No. 53	No. 11
C00023774	Fucostanol / Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol	CHEMBL66943 CHEMBL186373 CHEMBL400247 CHEMBL1568947	D013265	5 / 0 / 0	1 / 0	No. 53	No. 11
C00001555	Trigonelline	CHEMBL350675	C009560	3 / 1 / 0		No. 3681	No. 1
C00007298	Choline	CHEMBL920	D002794	11 / 5 / 5	51 / 20	No. 5945

Human Protein / Gene in interactions

64 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P06746	DNA polymerase beta	Enzyme	C00003672 C00005169 C00023774	0 / 0
P09884	DNA polymerase alpha catalytic subunit	Transferase	C00003648 C00023774	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00003648 C00023774	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00003648 C00005169	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003672 C00007298	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003672 C00007298	1 / 1
Q02880	DNA topoisomerase 2-beta	Isomerase	C00003648 C00023774	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003672 C00007298	1 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003672 C00007298	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003648 C00005169	2 / 3
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003672 C00007298	0 / 1
P08183	Multidrug resistance protein 1	drug	C00003648 C00003672	1 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00001555 C00003648	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00003648	0 / 1
P08047	Transcription factor Sp1	Unclassified protein	C00003672	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00003648	4 / 2
P16473	Thyrotropin receptor	Glycohormone receptor	C00003672	3 / 2
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00005169	1 / 1
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00023774	0 / 0
Q16850	Lanosterol 14-alpha demethylase	Cytochrome P450 51A1	C00003648	0 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00007298	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00005169	0 / 0
P07237	Protein disulfide-isomerase	Enzyme	C00005169	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00005169	1 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00003648	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00005169	0 / 0
O75496	Geminin	Unclassified protein	C00005169	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003672	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00005169	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00005169	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001555	0 / 0
P00734	Prothrombin	S1A	C00003672	4 / 2
P02545	Prelamin-A/C	Unclassified protein	C00003648	11 / 10
P14679	Tyrosinase	Oxidoreductase	C00003672	4 / 2
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00003648	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00005169	1 / 1
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00003648	2 / 0
P03372	Estrogen receptor	NR3A1	C00003672	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003672	2 / 0
P22303	Acetylcholinesterase	Hydrolase	C00007298	1 / 0
Q99700	Ataxin-2	Unclassified protein	C00005169	1 / 1
O00204	Sulfotransferase family cytosolic 2B member 1	Enzyme	C00003648	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00005169	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00005169	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00005169	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003648	0 / 0
P10275	Androgen receptor	NR3C4	C00003648	3 / 4
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003672	1 / 1
O15244	Solute carrier family 22 member 2	Drug uniporter	C00007298	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00005169	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00007298	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00003672	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00001555	1 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00005169	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00005169	1 / 4
Q9H015	Solute carrier family 22 member 4	Unclassified protein	C00007298	1 / 1
O76082	Solute carrier family 22 member 5	Unclassified protein	C00007298	1 / 2
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00005169	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003672	0 / 0
Q9NY46	Sodium channel protein type 3 subunit alpha	SCN alpha, NaV1.x	C00003648	0 / 0
Q99250	Sodium channel protein type 2 subunit alpha	SCN alpha, NaV1.x	C00003648	2 / 2
P35498	Sodium channel protein type 1 subunit alpha	SCN alpha, NaV1.x	C00003648	3 / 2
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00005169	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00005169	2 / 1

97 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
19	ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD	ATP-binding cassette, sub-family A (ABC1), member 1	C00003648
9619	ABCG1, ABC8, WHITE1	ATP-binding cassette, sub-family G (WHITE), member 1	C00003648
64240	ABCG5, STSL	ATP-binding cassette, sub-family G (WHITE), member 5	C00003648
64241	ABCG8, GBD4, STSL	ATP-binding cassette, sub-family G (WHITE), member 8	C00003648
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00003648
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00003648
335	APOA1	apolipoprotein A-I	C00003648
857	CAV1, BSCL3, CGL3, MSTP085, PPH3, VIP21, CAV	caveolin 1, caveolae protein, 22kDa	C00003648
859	CAV3, LGMD1C, LQT9, VIP-21, VIP21	caveolin 3	C00003648
1050	CEBPA, C/EBP-alpha, CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	C00003648
1066	CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1	carboxylesterase 1 (EC:3.1.1.1 3.1.1.56)	C00003648
1583	CYP11A1, CYP11A, CYPXIA1, P450SCC	cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6)	C00003648
1593	CYP27A1, CP27, CTX, CYP27	cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15)	C00003648
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00003648
10858	CYP46A1, CP46, CYP46	cytochrome P450, family 46, subfamily A, polypeptide 1 (EC:1.14.13.98)	C00003648
1581	CYP7A1, CP7A, CYP7, CYPVII	cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17)	C00003648
1718	DHCR24, DCE, Nbla03646, SELADIN1, seladin-1	24-dehydrocholesterol reductase (EC:1.3.1.72)	C00003648
1717	DHCR7, SLOS	7-dehydrocholesterol reductase (EC:1.3.1.21)	C00003648
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00003648
2222	FDFT1, DGPT, ERG9, SQS, SS	farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21)	C00003648
2252	FGF7, HBGF-7, KGF	fibroblast growth factor 7	C00003648
2264	FGFR4, CD334, JTK2, TKF	fibroblast growth factor receptor 4 (EC:2.7.10.1)	C00003648
2773	GNAI3, 87U6, ARCND1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	C00003648
2778	GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH	GNAS complex locus	C00003648
338442	HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g	hydroxycarboxylic acid receptor 2	C00003648
3156	HMGCR, LDLCQ3	3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)	C00003648
3667	IRS1, HIRS-1	insulin receptor substrate 1	C00003648
3931	LCAT	lecithin-cholesterol acyltransferase (EC:2.3.1.43)	C00003648
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00003648
4481	MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2	macrophage scavenger receptor 1	C00003648
4864	NPC1, NPC	Niemann-Pick disease, type C1	C00003648
7376	NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR	nuclear receptor subfamily 1, group H, member 2	C00003648
10062	NR1H3, LXR-a, LXRA, RLD-1	nuclear receptor subfamily 1, group H, member 3	C00003648
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00003648
5338	PLD2	phospholipase D2 (EC:3.1.4.4)	C00003648
5444	PON1, ESA, MVCD5, PON	paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81)	C00003648
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00003648
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00003648
5879	RAC1, Rac-1, TC-25, p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	C00003648
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00003648
6319	SCD, FADS5, MSTP008, SCD1, SCDOS	stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1)	C00003648
6721	SREBF2, SREBP-2, SREBP2, bHLHd2	sterol regulatory element binding transcription factor 2	C00003648
6770	STAR, STARD1	steroidogenic acute regulatory protein	C00003648
27346	TMEM97, MAC30	transmembrane protein 97	C00003648
7421	VDR, NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	C00003648
43	ACHE, ACEE, ARACHE, N-ACHE, YT	acetylcholinesterase (EC:3.1.1.7)	C00007298
8854	ALDH1A2, RALDH(II), RALDH2, RALDH2-T	aldehyde dehydrogenase 1 family, member A2 (EC:1.2.1.36)	C00007298
64333	ARHGAP9, 10C, RGL1	Rho GTPase activating protein 9	C00007298
590	BCHE, CHE1, CHE2, E1	butyrylcholinesterase (EC:3.1.1.8)	C00007298
701	BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1	BUB1 mitotic checkpoint serine/threonine kinase B (EC:2.7.11.1)	C00007298
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00007298
9332	CD163, M130, MM130	CD163 molecule	C00007298
948	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3	CD36 molecule (thrombospondin receptor)	C00007298
55143	CDCA8, BOR, BOREALIN, DasraB, MESRGP	cell division cycle associated 8	C00007298
55349	CHDH	choline dehydrogenase (EC:1.1.99.1)	C00007298
1111	CHEK1, CHK1	checkpoint kinase 1 (EC:2.7.11.1)	C00007298
1137	CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	C00007298
1139	CHRNA7, CHRNA7-2, NACHRA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	C00007298
1141	CHRNB2, EFNL3, nAChRB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	C00007298
81035	COLEC12, CLP1, NSR2, SCARA4, SRCL	collectin sub-family member 12	C00007298
1440	CSF3, C17orf33, CSF3OS, GCSF, G-CSF	colony stimulating factor 3 (granulocyte)	C00007298
1471	CST3, ARMD11	cystatin C	C00007298
1514	CTSL, CATL, CTSL1, MEP	cathepsin L (EC:3.4.22.15)	C00007298
1524	CX3CR1, CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28	chemokine (C-X3-C motif) receptor 1	C00007298
1794	DOCK2	dedicator of cytokinesis 2	C00007298
3169	FOXA1, HNF3A, TCF3A	forkhead box A1	C00007298
2632	GBE1, APBD, GBE, GSD4	glucan (1,4-alpha-), branching enzyme 1 (EC:2.4.1.18)	C00007298
3003	GZMK, TRYP2	granzyme K (granzyme 3; tryptase II) (EC:3.4.21.-)	C00007298
3309	HSPA5, BIP, GRP78, MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	C00007298
396742			C00007298
3560	IL2RB, CD122, IL15RB, P70-75	interleukin 2 receptor, beta	C00007298
10112	KIF20A, MKLP2, RAB6KIFL	kinesin family member 20A	C00007298
9493	KIF23, CHO1, KNSL5, MKLP-1, MKLP1	kinesin family member 23	C00007298
51348	KLRF1, CLEC5C, NKp80	killer cell lectin-like receptor subfamily F, member 1	C00007298
114569	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)	C00007298
55016	MARCH1, MARCH-I, RNF171	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	C00007298
4256	MGP, MGLAP, NTI	matrix Gla protein	C00007298
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00007298
4522	MTHFD1, MTHFC, MTHFD	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (EC:1.5.1.5 6.3.4.3 3.5.4.9)	C00007298
9172	MYOM2, TTNAP	myomesin 2	C00007298
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00007298
11333	PDAP1, HASPP28, PAP, PAP1	PDGFA associated protein 1	C00007298
10400	PEMT, PEAMT, PEMPT, PEMT2, PNMT	phosphatidylethanolamine N-methyltransferase (EC:2.1.1.17 2.1.1.71)	C00007298
5329	PLAUR, CD87, U-PAR, UPAR, URKR	plasminogen activator, urokinase receptor	C00007298
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00007298
23532	PRAME, CT130, MAPE, OIP-4, OIP4	preferentially expressed antigen in melanoma	C00007298
5790	PTPRCAP, CD45-AP, LPAP	protein tyrosine phosphatase, receptor type, C-associated protein	C00007298
10287	RGS19, GAIP, RGSGAIP	regulator of G-protein signaling 19	C00007298
57140	RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	C00007298
6422	SFRP1, FRP, FRP-1, FRP1, FrzA, SARP2	secreted frizzled-related protein 1	C00007298
6584	SLC22A5, CDSP, OCTN2, OCTN2VT	solute carrier family 22 (organic cation/carnitine transporter), member 5	C00007298
9056	SLC7A7, LAT3, LPI, MOP-2, Y+LAT1, y+LAT-1	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	C00007298
6594	SMARCA1, ISWI, NURF140, SNF2L, SNF2L1, SNF2LB, SNF2LT, SWI, SWI2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	C00007298
7015	TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT	telomerase reverse transcriptase (EC:2.7.7.49)	C00007298
7128	TNFAIP3, A20, OTUD7C, TNFA1P2	tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)	C00007298
83549	UCK1, URK1	uridine-cytidine kinase 1 (EC:2.7.1.48)	C00007298
10599	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6	solute carrier organic anion transporter family, member 1B1	C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions