PCIDB

KNApSAcK Metabolite C00007298

Metabolite

KNApSAcK Entry

id C00007298
Name Choline
CAS RN 62-49-7
Standard InChI InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1
Standard InChI (Main Layer) InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3

Cluster

Phytochemical cluster
KCF-S cluster No. 5945

Link

ChEMBL

By standard InChI CHEMBL920
By standard InChI Main Layer CHEMBL920

KEGG

By LinkDB C00114

CTD

By CAS RN D002794

Human Protein / Gene in interaction

11 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL920 CHEMBL1741321 (1)
1 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter CHEMBL920 CHEMBL2077532 (1) CHEMBL2076311 (1)
CHEMBL2077770 (1) CHEMBL2077776 (1)
CHEMBL2077808 (1)
0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL920 CHEMBL993349 (1) CHEMBL2076204 (1)
CHEMBL2077755 (1) CHEMBL2077767 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL920 CHEMBL1741325 (1)
0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL920 CHEMBL1741322 (1)
0 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL920 CHEMBL641238 (1)
1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL920 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL920 CHEMBL1741324 (1)
0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL920 CHEMBL1738442 (1)
0 / 0
Q9H015 Solute carrier family 22 member 4 Unclassified protein CHEMBL920 CHEMBL2076168 (1)
1 / 1
O76082 Solute carrier family 22 member 5 Unclassified protein CHEMBL920 CHEMBL2078080 (1) CHEMBL2078086 (1)
1 / 2

CTD interaction (58)

compound gene gene name gene description interaction interaction type form reference
pmid
D002794 43 ACHE
ACEE
ARACHE
N-ACHE
YT
acetylcholinesterase (EC:3.1.1.7) ACHE protein alternative form inhibits the reaction [Choline binds to CHRNA7 protein] affects binding
/ decreases reaction
protein 19287501
D002794 43 ACHE
ACEE
ARACHE
N-ACHE
YT
acetylcholinesterase (EC:3.1.1.7) Choline analog results in decreased activity of ACHE protein decreases activity
protein 17980356
D002794 8854 ALDH1A2
RALDH(II)
RALDH2
RALDH2-T
aldehyde dehydrogenase 1 family, member A2 (EC:1.2.1.36) Choline affects the expression of ALDH1A2 mRNA affects expression
mRNA 17616785
D002794 64333 ARHGAP9
10C
RGL1
Rho GTPase activating protein 9 Choline affects the expression of ARHGAP9 mRNA affects expression
mRNA 17616785
D002794 590 BCHE
CHE1
CHE2
E1
butyrylcholinesterase (EC:3.1.1.8) Choline analog results in decreased activity of BCHE protein decreases activity
protein 17980356
D002794 701 BUB1B
BUB1beta
BUBR1
Bub1A
MAD3L
MVA1
SSK1
hBUBR1
BUB1 mitotic checkpoint serine/threonine kinase B (EC:2.7.11.1) Choline affects the expression of BUB1B mRNA affects expression
mRNA 17616785
D002794 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Choline affects the expression of CCL2 mRNA affects expression
mRNA 17616785
D002794 9332 CD163
M130
MM130
CD163 molecule Choline affects the expression of CD163 mRNA affects expression
mRNA 17616785
D002794 948 CD36
BDPLT10
CHDS7
FAT
GP3B
GP4
GPIV
PASIV
SCARB3
CD36 molecule (thrombospondin receptor) Choline affects the expression of CD36 mRNA affects expression
mRNA 17616785
D002794 55143 CDCA8
BOR
BOREALIN
DasraB
MESRGP
cell division cycle associated 8 Choline affects the expression of CDCA8 mRNA affects expression
mRNA 17616785
D002794 55349 CHDH
choline dehydrogenase (EC:1.1.99.1) CHDH gene SNP affects the susceptibility to Choline affects response to substance
gene 17616785
D002794 1111 CHEK1
CHK1
checkpoint kinase 1 (EC:2.7.11.1) Choline affects the expression of CHEK1 mRNA affects expression
mRNA 17616785
D002794 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Choline affects the activity of [CHRNA4 protein binds to CHRNB2 protein] affects activity
/ affects binding
protein 14645658
D002794 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
D002794 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) ACHE protein alternative form inhibits the reaction [Choline binds to CHRNA7 protein] affects binding
/ decreases reaction
protein 19287501
D002794 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Choline binds to and results in increased activity of CHRNA7 protein affects binding
/ increases activity
protein 12626641
D002794 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Choline binds to CHRNA7 protein affects binding
protein 19287501
D002794 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Choline results in increased activity of CHRNA7 protein increases activity
protein 10082212
D002794 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA7 protein mutant form results in increased susceptibility to Choline increases response to substance
protein 10082212
D002794 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Choline affects the activity of [CHRNA4 protein binds to CHRNB2 protein] affects activity
/ affects binding
protein 14645658
D002794 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
D002794 81035 COLEC12
CLP1
NSR2
SCARA4
SRCL
collectin sub-family member 12 Choline affects the expression of COLEC12 mRNA affects expression
mRNA 17616785
D002794 1440 CSF3
C17orf33
CSF3OS
GCSF
G-CSF
colony stimulating factor 3 (granulocyte) [CSF3 protein co-treated with Paclitaxel] results in decreased abundance of Choline affects cotreatment
/ decreases abundance
protein 9018096
D002794 1471 CST3
ARMD11
cystatin C Choline affects the expression of CST3 mRNA affects expression
mRNA 17616785
D002794 1514 CTSL
CATL
CTSL1
MEP
cathepsin L (EC:3.4.22.15) Choline affects the expression of CTSL mRNA affects expression
mRNA 17616785
D002794 1524 CX3CR1
CCRL1
CMKBRL1
CMKDR1
GPR13
GPRV28
V28
chemokine (C-X3-C motif) receptor 1 Choline affects the expression of CX3CR1 mRNA affects expression
mRNA 17616785
D002794 1794 DOCK2
dedicator of cytokinesis 2 Choline affects the expression of DOCK2 mRNA affects expression
mRNA 17616785
D002794 3169 FOXA1
HNF3A
TCF3A
forkhead box A1 Choline affects the expression of FOXA1 mRNA affects expression
mRNA 17616785
D002794 2632 GBE1
APBD
GBE
GSD4
glucan (1,4-alpha-), branching enzyme 1 (EC:2.4.1.18) Choline affects the expression of GBE1 mRNA affects expression
mRNA 17616785
D002794 3003 GZMK
TRYP2
granzyme K (granzyme 3; tryptase II) (EC:3.4.21.-) Choline affects the expression of GZMK mRNA affects expression
mRNA 17616785
D002794 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Choline affects the expression of HSPA5 mRNA affects expression
mRNA 17616785
D002794 396742 Choline affects the expression of HSPCB mRNA affects expression
mRNA 17616785
D002794 3560 IL2RB
CD122
IL15RB
P70-75
interleukin 2 receptor, beta Choline affects the expression of IL2RB mRNA affects expression
mRNA 17616785
D002794 10112 KIF20A
MKLP2
RAB6KIFL
kinesin family member 20A Choline affects the expression of KIF20A mRNA affects expression
mRNA 17616785
D002794 9493 KIF23
CHO1
KNSL5
MKLP-1
MKLP1
kinesin family member 23 Choline affects the expression of KIF23 mRNA affects expression
mRNA 17616785
D002794 51348 KLRF1
CLEC5C
NKp80
killer cell lectin-like receptor subfamily F, member 1 Choline affects the expression of KLRF1 mRNA affects expression
mRNA 17616785
D002794 114569 MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene) Choline affects the expression of MAL2 mRNA affects expression
mRNA 17616785
D002794 55016 MARCH1
MARCH-I
RNF171
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase Choline affects the expression of MARCH1 mRNA affects expression
mRNA 17616785
D002794 4256 MGP
MGLAP
NTI
matrix Gla protein Choline affects the expression of MGP mRNA affects expression
mRNA 17616785
D002794 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Choline affects the expression of MMP2 mRNA affects expression
mRNA 17616785
D002794 4522 MTHFD1
MTHFC
MTHFD
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (EC:1.5.1.5 6.3.4.3 3.5.4.9) MTHFD1 gene SNP affects the susceptibility to Choline affects response to substance
gene 17616785
D002794 9172 MYOM2
TTNAP
myomesin 2 Choline affects the expression of MYOM2 mRNA affects expression
mRNA 17616785
D002794 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Choline affects the expression of NFKBIA mRNA affects expression
mRNA 17616785
D002794 11333 PDAP1
HASPP28
PAP
PAP1
PDGFA associated protein 1 Choline affects the expression of PDAP1 mRNA affects expression
mRNA 17616785
D002794 10400 PEMT
PEAMT
PEMPT
PEMT2
PNMT
phosphatidylethanolamine N-methyltransferase (EC:2.1.1.17 2.1.1.71) PEMT gene SNP affects the susceptibility to Choline affects response to substance
gene 17616785
D002794 5329 PLAUR
CD87
U-PAR
UPAR
URKR
plasminogen activator, urokinase receptor Choline affects the expression of PLAUR mRNA affects expression
mRNA 17616785
D002794 10891 PPARGC1A
LEM6
PGC-1(alpha)
PGC-1v
PGC1
PGC1A
PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Choline results in increased expression of PPARGC1A mRNA increases expression
mRNA 23056435
D002794 23532 PRAME
CT130
MAPE
OIP-4
OIP4
preferentially expressed antigen in melanoma Choline affects the expression of PRAME mRNA affects expression
mRNA 17616785
D002794 5790 PTPRCAP
CD45-AP
LPAP
protein tyrosine phosphatase, receptor type, C-associated protein Choline affects the expression of PTPRCAP mRNA affects expression
mRNA 17616785
D002794 10287 RGS19
GAIP
RGSGAIP
regulator of G-protein signaling 19 Choline affects the expression of RGS19 mRNA affects expression
mRNA 17616785
D002794 57140 RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1 Choline affects the expression of RNPEPL1 mRNA affects expression
mRNA 17616785
D002794 6422 SFRP1
FRP
FRP-1
FRP1
FrzA
SARP2
secreted frizzled-related protein 1 Choline affects the expression of SFRP1 mRNA affects expression
mRNA 17616785
D002794 6584 SLC22A5
CDSP
OCTN2
OCTN2VT
solute carrier family 22 (organic cation/carnitine transporter), member 5 Choline inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] decreases reaction
/ increases uptake
protein 16928358
D002794 9056 SLC7A7
LAT3
LPI
MOP-2
Y+LAT1
y+LAT-1
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 Choline affects the expression of SLC7A7 mRNA affects expression
mRNA 17616785
D002794 6594 SMARCA1
ISWI
NURF140
SNF2L
SNF2L1
SNF2LB
SNF2LT
SWI
SWI2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Choline affects the expression of SMARCA1 mRNA affects expression
mRNA 17616785
D002794 7015 TERT
CMM9
DKCA2
DKCB4
EST2
PFBMFT1
TCS1
TP2
TRT
hEST2
hTRT
telomerase reverse transcriptase (EC:2.7.7.49) Choline affects the expression of TERT mRNA affects expression
mRNA 17616785
D002794 7128 TNFAIP3
A20
OTUD7C
TNFA1P2
tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) Choline affects the expression of TNFAIP3 mRNA affects expression
mRNA 17616785
D002794 83549 UCK1
URK1
uridine-cytidine kinase 1 (EC:2.7.1.48) Choline affects the expression of UCK1 mRNA affects expression
mRNA 17616785

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#212140 Carnitine deficiency, systemic primary; cdsp O76082
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#180300 Rheumatoid arthritis; ra Q9H015
#112100 Yt blood group antigen P22303

KEGG DISEASE (5)

KEGG disease name UniProt
H00286 Crohn's disease O76082 (related)
Q9H015 (related)
H00525 Disorders of fatty-acid oxidation O76082 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

20 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000647 D002794 Amnesia therapeutic
20600432
D001321 D002794 Autistic Disorder marker/mechanism
16818868
D006528 D002794 Carcinoma, Hepatocellular marker/mechanism
therapeutic
2387015
2396046
D003072 D002794 Cognition Disorders therapeutic
11823105
D003866 D002794 Depressive Disorder marker/mechanism
9018096
D002658 D002794 Developmental Disabilities marker/mechanism
16818868
D056486 D002794 Drug-Induced Liver Injury marker/mechanism
20548288
22330258
D005234 D002794 Fatty Liver marker/mechanism
therapeutic
894741
17825453
20008134
20196952
20350562
20368703
20697377
23038002
D005235 D002794 Fatty Liver, Alcoholic therapeutic
20118189
D006505 D002794 Hepatitis marker/mechanism
20368703
D007249 D002794 Inflammation marker/mechanism
20008134
D007859 D002794 Learning Disorders therapeutic
20381573
D008103 D002794 Liver Cirrhosis marker/mechanism
17825453
20196952
D008113 D002794 Liver Neoplasms marker/mechanism
3554467
D008569 D002794 Memory Disorders therapeutic
20381573
C541083 D002794 Non-alcoholic Fatty Liver Disease marker/mechanism
20548288
D010195 D002794 Pancreatitis marker/mechanism
1713672
D016137 D002794 Spina Bifida Cystica therapeutic
22473653
D013226 D002794 Status Epilepticus marker/mechanism
1815138
3612132
D052878 D002794 Urolithiasis marker/mechanism
16941950