Combretum micranthum

• Index
• Plant Species
• Natural Activity
• Metabolite list (3)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Combretum micranthum
Genus	Combretum
Family	Combretaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Combretum micranthum
Linked NCBI taxonomy ID	578542
Linked level	species

Family

Family in NCBI taxonomy	Combretaceae
ID	3954

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Natural Activity

List (6)

Species	Activity
Combretum micranthum G. Don	Antibacterial
Combretum micranthum G. Don	Antidote, opium
Combretum micranthum G. Don	Antiemetic
Combretum micranthum G. Don	Astringent
Combretum micranthum G. Don	Choleretic
Combretum micranthum G. Don	Diuretic

Metabolite list (3)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00001345	(-)-Betonicine / 4-Hydroxyproline betaine	CHEMBL1181451 CHEMBL1373466 CHEMBL1996398		7 / 16 / 14		No. 2627	No. 1
C00002074	Stachydrine	CHEMBL394450 CHEMBL1456892 CHEMBL1986864		10 / 8 / 12		No. 2627	No. 1
C00007298	Choline	CHEMBL920	D002794	11 / 5 / 5	51 / 20	No. 5945

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001345 C00002074 C00007298	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001345 C00002074 C00007298	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001345 C00002074 C00007298	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001345 C00002074 C00007298	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001345 C00002074 C00007298	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00001345	3 / 1
P16473	Thyrotropin receptor	Glycohormone receptor	C00002074	3 / 2
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002074	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002074	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001345	11 / 10
P22303	Acetylcholinesterase	Hydrolase	C00007298	1 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00007298	0 / 0
O15244	Solute carrier family 22 member 2	Drug uniporter	C00007298	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00007298	0 / 0
O00255	Menin	Unclassified protein	C00002074	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002074	1 / 2
Q9H015	Solute carrier family 22 member 4	Unclassified protein	C00007298	1 / 1
O76082	Solute carrier family 22 member 5	Unclassified protein	C00007298	1 / 2

51 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
43	ACHE, ACEE, ARACHE, N-ACHE, YT	acetylcholinesterase (EC:3.1.1.7)	C00007298
8854	ALDH1A2, RALDH(II), RALDH2, RALDH2-T	aldehyde dehydrogenase 1 family, member A2 (EC:1.2.1.36)	C00007298
64333	ARHGAP9, 10C, RGL1	Rho GTPase activating protein 9	C00007298
590	BCHE, CHE1, CHE2, E1	butyrylcholinesterase (EC:3.1.1.8)	C00007298
701	BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1	BUB1 mitotic checkpoint serine/threonine kinase B (EC:2.7.11.1)	C00007298
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00007298
9332	CD163, M130, MM130	CD163 molecule	C00007298
948	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3	CD36 molecule (thrombospondin receptor)	C00007298
55143	CDCA8, BOR, BOREALIN, DasraB, MESRGP	cell division cycle associated 8	C00007298
55349	CHDH	choline dehydrogenase (EC:1.1.99.1)	C00007298
1111	CHEK1, CHK1	checkpoint kinase 1 (EC:2.7.11.1)	C00007298
1137	CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	C00007298
1139	CHRNA7, CHRNA7-2, NACHRA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	C00007298
1141	CHRNB2, EFNL3, nAChRB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	C00007298
81035	COLEC12, CLP1, NSR2, SCARA4, SRCL	collectin sub-family member 12	C00007298
1440	CSF3, C17orf33, CSF3OS, GCSF, G-CSF	colony stimulating factor 3 (granulocyte)	C00007298
1471	CST3, ARMD11	cystatin C	C00007298
1514	CTSL, CATL, CTSL1, MEP	cathepsin L (EC:3.4.22.15)	C00007298
1524	CX3CR1, CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28	chemokine (C-X3-C motif) receptor 1	C00007298
1794	DOCK2	dedicator of cytokinesis 2	C00007298
3169	FOXA1, HNF3A, TCF3A	forkhead box A1	C00007298
2632	GBE1, APBD, GBE, GSD4	glucan (1,4-alpha-), branching enzyme 1 (EC:2.4.1.18)	C00007298
3003	GZMK, TRYP2	granzyme K (granzyme 3; tryptase II) (EC:3.4.21.-)	C00007298
3309	HSPA5, BIP, GRP78, MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	C00007298
396742			C00007298
3560	IL2RB, CD122, IL15RB, P70-75	interleukin 2 receptor, beta	C00007298
10112	KIF20A, MKLP2, RAB6KIFL	kinesin family member 20A	C00007298
9493	KIF23, CHO1, KNSL5, MKLP-1, MKLP1	kinesin family member 23	C00007298
51348	KLRF1, CLEC5C, NKp80	killer cell lectin-like receptor subfamily F, member 1	C00007298
114569	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)	C00007298
55016	MARCH1, MARCH-I, RNF171	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	C00007298
4256	MGP, MGLAP, NTI	matrix Gla protein	C00007298
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00007298
4522	MTHFD1, MTHFC, MTHFD	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (EC:1.5.1.5 6.3.4.3 3.5.4.9)	C00007298
9172	MYOM2, TTNAP	myomesin 2	C00007298
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00007298
11333	PDAP1, HASPP28, PAP, PAP1	PDGFA associated protein 1	C00007298
10400	PEMT, PEAMT, PEMPT, PEMT2, PNMT	phosphatidylethanolamine N-methyltransferase (EC:2.1.1.17 2.1.1.71)	C00007298
5329	PLAUR, CD87, U-PAR, UPAR, URKR	plasminogen activator, urokinase receptor	C00007298
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00007298
23532	PRAME, CT130, MAPE, OIP-4, OIP4	preferentially expressed antigen in melanoma	C00007298
5790	PTPRCAP, CD45-AP, LPAP	protein tyrosine phosphatase, receptor type, C-associated protein	C00007298
10287	RGS19, GAIP, RGSGAIP	regulator of G-protein signaling 19	C00007298
57140	RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	C00007298
6422	SFRP1, FRP, FRP-1, FRP1, FrzA, SARP2	secreted frizzled-related protein 1	C00007298
6584	SLC22A5, CDSP, OCTN2, OCTN2VT	solute carrier family 22 (organic cation/carnitine transporter), member 5	C00007298
9056	SLC7A7, LAT3, LPI, MOP-2, Y+LAT1, y+LAT-1	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	C00007298
6594	SMARCA1, ISWI, NURF140, SNF2L, SNF2L1, SNF2LB, SNF2LT, SWI, SWI2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	C00007298
7015	TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT	telomerase reverse transcriptase (EC:2.7.7.49)	C00007298
7128	TNFAIP3, A20, OTUD7C, TNFA1P2	tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)	C00007298
83549	UCK1, URK1	uridine-cytidine kinase 1 (EC:2.7.1.48)	C00007298

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions