KCF-S cluster No. 2627 (4 metabolites)
Corresponding Phytochemical cluster No. 1
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 19 |
| rosids | 15 |
| Liliopsida | 1 |
Cumulative family count
| class name | count |
|---|---|
| Lamiaceae | 16 |
| Capparaceae | 8 |
| Fabaceae | 4 |
| Asteraceae | 3 |
| Combretaceae | 2 |
| Rutaceae | 1 |
| Xanthorrhoeaceae | 1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Pyrrolidine alkaloids | 3 |
metabolites link (3)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Pyrrolidine alkaloids | C08283 | C00001367 |
| Pyrrolidine alkaloids | C10151 | C00002045 |
| Pyrrolidine alkaloids | C10172 | C00002074 |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001345
|
(-)-Betonicine
/ 4-Hydroxyproline betaine |
CHEMBL1181451
CHEMBL1373466 CHEMBL1996398 |
7 / 16 / 14 |
|
||
|
C00001367
|
Homostachydrine
|
CHEMBL1184551
|
|
|||
|
C00002045
|
3-Hydroxystachydrine
|
|
||||
|
C00002074
|
Stachydrine
|
CHEMBL394450
CHEMBL1456892 CHEMBL1986864 |
10 / 8 / 12 |
|
Human Protein / Gene in interactions
12 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001345 C00002074 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001345 C00002074 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001345 C00002074 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001345 C00002074 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001345 C00002074 | 0 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002074 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002074 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001345 | 3 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002074 | 3 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001345 | 11 / 10 |
| O00255 | Menin | Unclassified protein | C00002074 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002074 | 1 / 2 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (22)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (23)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|