Digitalis lanata Ehrh.
Species
KNApSAcK Entry
| Organism name | Digitalis lanata Ehrh. |
|---|---|
| Genus | Digitalis |
| Family | Plantaginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Digitalis lanata |
|---|---|
| Linked NCBI taxonomy ID | 49450 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Plantaginaceae |
|---|---|
| ID | 156152 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (7)
| Species | Activity |
|---|---|
| Digitalis lanata Ehrh. | Antidote |
| Digitalis lanata Ehrh. | Cardiotonic |
| Digitalis lanata Ehrh. | Diuretic |
| Digitalis lanata Ehrh. | Myocardiocontractant |
| Digitalis lanata Ehrh. | Negative Chronotropic |
| Digitalis lanata Ehrh. | Poison |
| Digitalis lanata Ehrh. | Positive Inotropic |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003574
|
Digitonin
|
CHEMBL404811
CHEMBL509531 CHEMBL2005540 |
D004072
|
105 / 60 / 67 | No. 21 | No. 11 |
|
|
|
C00003647
|
Campesterol
/ 24alpha-Methylcholesterol / (24R)24-Methylcholest-5-en-3beta-ol |
CHEMBL520535
CHEMBL485421 CHEMBL1836653 |
C021273
|
No. 53 | No. 11 |
|
||
|
C00003648
|
Cholesterol
/ Cholesterin / Cholest-5-en-3beta-ol |
CHEMBL112570
CHEMBL1597825 CHEMBL1867358 |
D002784
|
20 / 28 / 24 | 45 / 23 | No. 53 | No. 11 |
|
|
C00003650
|
Cycloartenol
|
CHEMBL119938
CHEMBL225815 CHEMBL226036 CHEMBL393145 CHEMBL2007217 |
C100089
|
0 / 1 | No. 129 | No. 11 |
|
|
|
C00003573
|
Digitogenin
|
No. 171 | No. 11 |
|
Human Protein / Gene in interactions
120 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00003574 C00003648 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00003574 C00003648 | 3 / 4 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003574 C00003648 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00003574 C00003648 | 0 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003574 C00003648 | 2 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00003574 | 1 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00003574 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00003574 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00003574 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00003574 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00003574 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00003574 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00003574 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00003574 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003574 | 1 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00003574 | 2 / 2 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003648 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003648 | 11 / 10 |
| P37840 | Alpha-synuclein | Unclassified protein | C00003648 | 4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003574 | 3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003574 | 3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00003574 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00003574 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00003574 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00003574 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00003574 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00003574 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00003574 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00003574 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00003574 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00003574 | 0 / 0 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00003648 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003648 | 1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00003574 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00003574 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00003574 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003574 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00003574 | 1 / 8 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00003574 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00003574 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00003574 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00003574 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00003574 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00003574 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00003574 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00003574 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00003574 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00003574 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00003574 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003574 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00003574 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003574 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00003574 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00003574 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00003574 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00003574 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00003574 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00003574 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00003574 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00003574 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00003574 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00003574 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00003574 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00003574 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00003574 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00003574 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00003574 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00003574 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00003574 | 0 / 0 |
| O00204 | Sulfotransferase family cytosolic 2B member 1 | Enzyme | C00003648 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00003574 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00003574 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00003574 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00003574 | 2 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00003574 | 5 / 3 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00003574 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00003574 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00003574 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00003574 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00003574 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00003574 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003574 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00003648 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00003574 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003574 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00003574 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003574 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00003648 | 2 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00003574 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00003574 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003574 | 0 / 3 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00003574 | 1 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00003648 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00003574 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00003574 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00003574 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00003574 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00003574 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00003574 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00003574 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00003574 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003574 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003574 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003574 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00003574 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003574 | 4 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00003574 | 7 / 37 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00003574 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00003574 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00003574 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00003574 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00003574 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00003574 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00003574 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003648 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003648 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00003648 | 0 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00003648 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00003648 | 2 / 2 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00003648 | 3 / 2 |
45 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00003648
|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00003648
|
| 64240 | ABCG5, STSL | ATP-binding cassette, sub-family G (WHITE), member 5 |
C00003648
|
| 64241 | ABCG8, GBD4, STSL | ATP-binding cassette, sub-family G (WHITE), member 8 |
C00003648
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00003648
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003648
|
| 335 | APOA1 | apolipoprotein A-I |
C00003648
|
| 857 | CAV1, BSCL3, CGL3, MSTP085, PPH3, VIP21, CAV | caveolin 1, caveolae protein, 22kDa |
C00003648
|
| 859 | CAV3, LGMD1C, LQT9, VIP-21, VIP21 | caveolin 3 |
C00003648
|
| 1050 | CEBPA, C/EBP-alpha, CEBP | CCAAT/enhancer binding protein (C/EBP), alpha |
C00003648
|
| 1066 | CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 | carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) |
C00003648
|
| 1583 | CYP11A1, CYP11A, CYPXIA1, P450SCC | cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) |
C00003648
|
| 1593 | CYP27A1, CP27, CTX, CYP27 | cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) |
C00003648
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00003648
|
| 10858 | CYP46A1, CP46, CYP46 | cytochrome P450, family 46, subfamily A, polypeptide 1 (EC:1.14.13.98) |
C00003648
|
| 1581 | CYP7A1, CP7A, CYP7, CYPVII | cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) |
C00003648
|
| 1718 | DHCR24, DCE, Nbla03646, SELADIN1, seladin-1 | 24-dehydrocholesterol reductase (EC:1.3.1.72) |
C00003648
|
| 1717 | DHCR7, SLOS | 7-dehydrocholesterol reductase (EC:1.3.1.21) |
C00003648
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00003648
|
| 2222 | FDFT1, DGPT, ERG9, SQS, SS | farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21) |
C00003648
|
| 2252 | FGF7, HBGF-7, KGF | fibroblast growth factor 7 |
C00003648
|
| 2264 | FGFR4, CD334, JTK2, TKF | fibroblast growth factor receptor 4 (EC:2.7.10.1) |
C00003648
|
| 2773 | GNAI3, 87U6, ARCND1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
C00003648
|
| 2778 | GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH | GNAS complex locus |
C00003648
|
| 338442 | HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g | hydroxycarboxylic acid receptor 2 |
C00003648
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00003648
|
| 3667 | IRS1, HIRS-1 | insulin receptor substrate 1 |
C00003648
|
| 3931 | LCAT | lecithin-cholesterol acyltransferase (EC:2.3.1.43) |
C00003648
|
| 3949 | LDLR, FH, FHC, LDLCQ2 | low density lipoprotein receptor |
C00003648
|
| 4481 | MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2 | macrophage scavenger receptor 1 |
C00003648
|
| 4864 | NPC1, NPC | Niemann-Pick disease, type C1 |
C00003648
|
| 7376 | NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR | nuclear receptor subfamily 1, group H, member 2 |
C00003648
|
| 10062 | NR1H3, LXR-a, LXRA, RLD-1 | nuclear receptor subfamily 1, group H, member 3 |
C00003648
|
| 9970 | NR1I3, CAR, CAR1, MB67 | nuclear receptor subfamily 1, group I, member 3 |
C00003648
|
| 5338 | PLD2 | phospholipase D2 (EC:3.1.4.4) |
C00003648
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00003648
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00003648
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00003648
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00003648
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00003648
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00003648
|
| 6721 | SREBF2, SREBP-2, SREBP2, bHLHd2 | sterol regulatory element binding transcription factor 2 |
C00003648
|
| 6770 | STAR, STARD1 | steroidogenic acute regulatory protein |
C00003648
|
| 27346 | TMEM97, MAC30 | transmembrane protein 97 |
C00003648
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00003648
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (83)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
P37231 |
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (82)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
Diseases related to CTD interactions
24 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D012878 | Skin Neoplasms |
C00003650
|
| D001161 | Arteriosclerosis |
C00003648
|
| D050197 | Atherosclerosis |
C00003648
|
| D006528 | Carcinoma, Hepatocellular |
C00003648
|
| D002779 | Cholestasis |
C00003648
|
| D003327 | Coronary Disease |
C00003648
|
| D056486 | Drug-Induced Liver Injury |
C00003648
|
| D050171 | Dyslipidemias |
C00003648
|
| D005234 | Fatty Liver |
C00003648
|
| D006471 | Gastrointestinal Hemorrhage |
C00003648
|
| D006529 | Hepatomegaly |
C00003648
|
| D006937 | Hypercholesterolemia |
C00003648
|
| D006949 | Hyperlipidemias |
C00003648
|
| D006951 | Hyperlipoproteinemias |
C00003648
|
| D006965 | Hyperplasia |
C00003648
|
| D015228 | Hypertriglyceridemia |
C00003648
|
| D007037 | Hypothyroidism |
C00003648
|
| D007680 | Kidney Neoplasms |
C00003648
|
| D007859 | Learning Disorders |
C00003648
|
| D009336 | Necrosis |
C00003648
|
| D009369 | Neoplasms |
C00003648
|
| D052556 | Niemann-Pick Disease, Type C |
C00003648
|
| D058226 | Plaque, Atherosclerotic |
C00003648
|
| D014456 | Ulcer |
C00003648
|