Frullania solanderiana
Species
KNApSAcK Entry
| Organism name | Frullania solanderiana |
|---|---|
| Genus | Frullania |
| Family | Jubulaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Frullania solanderiana |
|---|---|
| Linked NCBI taxonomy ID | 642363 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Frullaniaceae |
|---|---|
| ID | 400721 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Embryophyta |
|---|---|
| ID | 3193 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00016958
|
gamma-Maaliene
|
No. 149 | No. 38 |
|
||||
|
C00030479
|
Hexadecanoic acid
/ n-Hexadecanoic acid |
CHEMBL82293
|
D019308
|
16 / 8 / 8 | 35 / 1 | No. 184 | No. 68 |
|
|
C00036669
|
9,12-Octadecadienoic acid
|
CHEMBL267476
|
D019787
|
29 / 31 / 28 | 42 / 11 | No. 367 | No. 68 |
|
|
C00032309
|
Tetradecanol
/ 1-Tetradecanol |
CHEMBL24022
|
C020940
|
1 / 0 / 0 | No. 599 |
|
||
|
C00012425
|
Bicyclogermacren
/ Bicyclogermacrene / (+)-Bicyclogermacrene |
CHEMBL509566
|
No. 699 | No. 38 |
|
|||
|
C00036262
|
2-Pentadecanone
|
C012474
|
No. 1606 |
|
||||
|
C00036263
|
2-Tridecanone
|
CHEMBL480097
|
C009541
|
No. 1611 |
|
|||
|
C00030758
|
2-Undecanone
/ Methyl nonyl ketone |
No. 1611 |
|
Human Protein / Gene in interactions
36 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q96RI1 | Bile acid receptor | NR1H4 | C00030479 C00032309 C00036669 | 0 / 0 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00030479 C00036669 | 0 / 0 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00030479 C00036669 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00030479 C00036669 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00030479 C00036669 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00030479 C00036669 | 1 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00030479 C00036669 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00030479 C00036669 | 2 / 2 |
| O75496 | Geminin | Unclassified protein | C00030479 C00036669 | 0 / 0 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00036669 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00030479 | 1 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00030479 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00036669 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00036669 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00036669 | 0 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00036669 | 0 / 0 |
| P12104 | Fatty acid-binding protein, intestinal | Other cytosolic protein | C00030479 | 0 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00036669 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00036669 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00030479 | 0 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00036669 | 3 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00036669 | 5 / 3 |
| P13726 | Tissue factor | Membrane receptor | C00036669 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00030479 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00036669 | 0 / 0 |
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | C00030479 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00036669 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00036669 | 2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00036669 | 11 / 10 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00036669 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00036669 | 0 / 1 |
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | C00036669 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00036669 | 0 / 0 |
| O60603 | Toll-like receptor 2 | Membrane receptor | C00030479 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00036669 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00036669 | 1 / 1 |
72 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00030479
C00036669
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00030479
C00036669
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00030479
C00036669
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00030479
C00036669
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00030479
C00036669
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00036669
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00030479
|
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 |
C00030479
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00030479
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00030479
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00030479
|
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) |
C00030479
|
| 57817 | HAMP, HEPC, HFE2B, LEAP1, PLTR | hepcidin antimicrobial peptide |
C00030479
|
| 3481 | IGF2, C11orf43, IGF-II, PP9974 | insulin-like growth factor 2 (somatomedin A) |
C00030479
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00030479
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00030479
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00030479
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00030479
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00030479
|
| 4493 | MT1E, MT1, MTD | metallothionein 1E |
C00030479
|
| 4494 | MT1F, MT1 | metallothionein 1F |
C00030479
|
| 4496 | MT1H, MT-0, MT-1H, MT-IH, MT1 | metallothionein 1H |
C00030479
|
| 4501 | MT1X, MT-1l, MT1 | metallothionein 1X |
C00030479
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00030479
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00030479
|
| 3651 | PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 | pancreatic and duodenal homeobox 1 |
C00030479
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00030479
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00030479
|
| 29893 | PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP | PSMC3 interacting protein |
C00030479
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00030479
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00030479
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00030479
|
| 23216 | TBC1D1, TBC, TBC1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 |
C00030479
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00030479
|
| 7351 | UCP2, BMIQ4, SLC25A8, UCPH | uncoupling protein 2 (mitochondrial, proton carrier) |
C00030479
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00036669
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00036669
|
| 335 | APOA1 | apolipoprotein A-I |
C00036669
|
| 430 | ASCL2, ASH2, HASH2, MASH2, bHLHa45 | achaete-scute family bHLH transcription factor 2 |
C00036669
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00036669
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00036669
|
| 1082 | CGB, CGB3, CGB5, CGB7, CGB8, hCGB | chorionic gonadotropin, beta polypeptide |
C00036669
|
| 1387 | CREBBP, CBP, KAT3A, RSTS | CREB binding protein (EC:2.3.1.48) |
C00036669
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00036669
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00036669
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00036669
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00036669
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00036669
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00036669
|
| 2168 | FABP1, FABPL, L-FABP | fatty acid binding protein 1, liver |
C00036669
|
| 2170 | FABP3, FABP11, H-FABP, M-FABP, MDGI, O-FABP | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) |
C00036669
|
| 9415 | FADS2, D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13 | fatty acid desaturase 2 (EC:1.14.19.-) |
C00036669
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00036669
|
| 3586 | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF | interleukin 10 |
C00036669
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00030479
|
| 3558 | IL2, IL-2, TCGF, lymphokine | interleukin 2 |
C00036669
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00036669
|
| 3567 | IL5, EDF, IL-5, TRF | interleukin 5 (colony-stimulating factor, eosinophil) |
C00036669
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00036669
|
| 653361 | NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox | neutrophil cytosolic factor 1 |
C00036669
|
| 4688 | NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX | neutrophil cytosolic factor 2 |
C00036669
|
| 8648 | NCOA1, F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74 | nuclear receptor coactivator 1 (EC:2.3.1.48) |
C00036669
|
| 10499 | NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75 | nuclear receptor coactivator 2 |
C00036669
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00036669
|
| 5338 | PLD2 | phospholipase D2 (EC:3.1.4.4) |
C00036669
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00036669
|
| 100136658 |
C00036669
|
||
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00036669
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00036669
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00036669
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00036669
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00036669
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (33)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #246300 | Leprosy, susceptibility to, 3; lprs3 |
O60603
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #601665 | Obesity |
P37231
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (29)
| KEGG | name | UniProt |
|---|---|---|
| H00344 | Leprosy |
O60603
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
12 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003072 | Cognition Disorders |
C00030479
|
| D001321 | Autistic Disorder |
C00036669
|
| D019970 | Cocaine-Related Disorders |
C00036669
|
| D017453 | Dermatitis, Irritant |
C00036669
|
| D005234 | Fatty Liver |
C00036669
|
| D006520 | Hepatitis, Animal |
C00036669
|
| D006526 | Hepatitis C |
C00036669
|
| D006937 | Hypercholesterolemia |
C00036669
|
| D006949 | Hyperlipidemias |
C00036669
|
| D015228 | Hypertriglyceridemia |
C00036669
|
| D007414 | Intestinal Neoplasms |
C00036669
|
| D008175 | Lung Neoplasms |
C00036669
|