Piper nigrum L.
Species
KNApSAcK Entry
| Organism name | Piper nigrum L. |
|---|---|
| Genus | Piper |
| Family | Piperaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Piper nigrum |
|---|---|
| Linked NCBI taxonomy ID | 13216 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Piperaceae |
|---|---|
| ID | 16739 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Natural Activity
List (132)
| Species | Activity |
|---|---|
| Piper nigrum L. | Abortifacient |
| Piper nigrum L. | Alexeteric |
| Piper nigrum L. | Analeptic |
| Piper nigrum L. | Analgesic |
| Piper nigrum L. | Antibacterial |
| Piper nigrum L. | Anticonvulsant |
| Piper nigrum L. | Antidote, fish |
| Piper nigrum L. | Antidote, mushroom |
| Piper nigrum L. | Antidote,shellfish |
| Piper nigrum L. | Antiglucuronidase |
| Piper nigrum L. | Antileishmanic |
| Piper nigrum L. | Antioxidant |
| Piper nigrum L. | Antipyretic |
| Piper nigrum L. | Antiseptic |
| Piper nigrum L. | Aperitif |
| Piper nigrum L. | Carminative |
| Piper nigrum L. | Catarrh |
| Piper nigrum L. | Catecholaminic |
| Piper nigrum L. | Chill |
| Piper nigrum L. | Chokera |
| Piper nigrum L. | Cold |
| Piper nigrum L. | Colic |
| Piper nigrum L. | Coma |
| Piper nigrum L. | Condyloma |
| Piper nigrum L. | Congestion |
| Piper nigrum L. | Constipation |
| Piper nigrum L. | Convulsion |
| Piper nigrum L. | Corn |
| Piper nigrum L. | Cough |
| Piper nigrum L. | Cramp |
| Piper nigrum L. | DebilityDermatosis |
| Piper nigrum L. | Diaphoretic |
| Piper nigrum L. | Diarrhea |
| Piper nigrum L. | Digestive |
| Piper nigrum L. | Diuretic |
| Piper nigrum L. | Dog Bite |
| Piper nigrum L. | Dry Mouth |
| Piper nigrum L. | Dysentery |
| Piper nigrum L. | Dysmenorrhea |
| Piper nigrum L. | Dyspepsia |
| Piper nigrum L. | Dysuria |
| Piper nigrum L. | Emmenagogue |
| Piper nigrum L. | Epididymosis |
| Piper nigrum L. | Epilepsy |
| Piper nigrum L. | Epinephrinogenic |
| Piper nigrum L. | Escherichia |
| Piper nigrum L. | Expectorant |
| Piper nigrum L. | Favus |
| Piper nigrum L. | Fever |
| Piper nigrum L. | Frostbite |
| Piper nigrum L. | Fungicide |
| Piper nigrum L. | Fungus |
| Piper nigrum L. | Furunculosis |
| Piper nigrum L. | Galactorrhea |
| Piper nigrum L. | Gas |
| Piper nigrum L. | Gastrogogue |
| Piper nigrum L. | Gastrosis |
| Piper nigrum L. | Gingivosis |
| Piper nigrum L. | Gonorrhea |
| Piper nigrum L. | Gravel |
| Piper nigrum L. | Hay Fever |
| Piper nigrum L. | Head Cold |
| Piper nigrum L. | Headache |
| Piper nigrum L. | Hemorrhoid |
| Piper nigrum L. | Hepatosis |
| Piper nigrum L. | Hepatotonic |
| Piper nigrum L. | Hiccup |
| Piper nigrum L. | High Blood Pressure |
| Piper nigrum L. | High Cholesterol |
| Piper nigrum L. | HMG-CoA-Reductase Inhibitor |
| Piper nigrum L. | Hypertensive |
| Piper nigrum L. | Hypocholesterolemic |
| Piper nigrum L. | Hypotensive |
| Piper nigrum L. | Induration |
| Piper nigrum L. | Infection |
| Piper nigrum L. | Inflammation |
| Piper nigrum L. | Insecticide |
| Piper nigrum L. | Itch |
| Piper nigrum L. | Larvicide |
| Piper nigrum L. | Leishmaniasis |
| Piper nigrum L. | Lethargy |
| Piper nigrum L. | Malaria |
| Piper nigrum L. | Mucososis |
| Piper nigrum L. | Mutagenic |
| Piper nigrum L. | Mycosis |
| Piper nigrum L. | Nausea |
| Piper nigrum L. | Nervousness |
| Piper nigrum L. | Neuralgia |
| Piper nigrum L. | Onychiosis |
| Piper nigrum L. | Ophthalmia |
| Piper nigrum L. | Pain |
| Piper nigrum L. | Paralysis |
| Piper nigrum L. | Paraplegia |
| Piper nigrum L. | Parturition |
| Piper nigrum L. | Peristaltic |
| Piper nigrum L. | Phymata |
| Piper nigrum L. | Positive Chronotropic |
| Piper nigrum L. | Prolapse |
| Piper nigrum L. | Respiradepressant |
| Piper nigrum L. | Respirosis |
| Piper nigrum L. | Rhinosis |
| Piper nigrum L. | Ringworm |
| Piper nigrum L. | Rubefacient |
| Piper nigrum L. | Scabicide |
| Piper nigrum L. | Scabies |
| Piper nigrum L. | Scarlatina |
| Piper nigrum L. | Scirrhus |
| Piper nigrum L. | Secretagogue |
| Piper nigrum L. | Sialagogue |
| Piper nigrum L. | Sinusosis |
| Piper nigrum L. | Snakebite |
| Piper nigrum L. | Sore Throat |
| Piper nigrum L. | Splenosis |
| Piper nigrum L. | Staphylococcus |
| Piper nigrum L. | Stimulant |
| Piper nigrum L. | Stomachache |
| Piper nigrum L. | Stomachic |
| Piper nigrum L. | Swelling |
| Piper nigrum L. | Taenicide |
| Piper nigrum L. | Tinea |
| Piper nigrum L. | Tonic |
| Piper nigrum L. | Toothache |
| Piper nigrum L. | Tumor |
| Piper nigrum L. | Ulcer |
| Piper nigrum L. | Urethrosis |
| Piper nigrum L. | Urolithiasis |
| Piper nigrum L. | Vertigo |
| Piper nigrum L. | vomiting |
| Piper nigrum L. | Wart |
| Piper nigrum L. | Water Retention |
| Piper nigrum L. | Wen |
| Piper nigrum L. | Yeast |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00032163
|
Sitostanol
/ Stigmastanol / beta-Sitostanol |
CHEMBL305498
CHEMBL252364 |
C021255
|
No. 68 | No. 11 |
|
||
|
C00032087
|
Octadecanoic acid
|
CHEMBL46403
|
C031183
|
15 / 17 / 19 | 6 / 1 | No. 184 | No. 68 |
|
|
C00019308
|
Doursterol
/ Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside |
CHEMBL197711
CHEMBL506678 CHEMBL2304043 |
C011015
|
5 / 4 / 2 | 0 / 3 | No. 520 |
|
|
|
C00031036
|
Pipyahyine
|
No. 638 |
|
|||||
|
C00028813
|
Pellitorine
|
C008778
|
No. 1863 |
|
||||
|
C00031306
|
Sarmentine
|
CHEMBL2205104
|
No. 3056 |
|
||||
|
C00031479
|
[(2E,4E)-Dodecadienoyl]-pyrrolidine
|
No. 3056 |
|
|||||
|
C00031853
|
Hexadecanoylpyrrolidine
/ 1-Hexadecanoylpyrrolidine |
CHEMBL1223443
|
No. 4618 |
|
||||
|
C00031035
|
Pipnoohine
|
No. 4837 |
|
Human Protein / Gene in interactions
34 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00019308 C00023774 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 C00019308 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 C00019308 | 4 / 2 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 C00032087 | 1 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 C00019308 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00019308 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 C00032087 | 3 / 2 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00032087 | 2 / 2 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00032087 | 2 / 3 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00032087 | 0 / 0 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00032087 | 0 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00032087 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00032087 | 0 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00032087 | 3 / 1 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00032087 | 3 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00032087 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00032087 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 | 0 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00032087 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00032087 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00032087 | 1 / 2 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00032087
|
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 |
C00032087
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00032087
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00032087
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00032087
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00032087
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (28)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|