PCIDB

KNApSAcK Metabolite C00001228

Metabolite

KNApSAcK Entry

id C00001228
Name Myristic acid / Tetradecanoic acid / n-Tetradecanoic acid
CAS RN 544-63-8
Standard InChI InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)
Standard InChI (Main Layer) InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)

Cluster

Phytochemical cluster No. 68
KCF-S cluster No. 1141

Link

ChEMBL

By standard InChI CHEMBL111077
By standard InChI Main Layer CHEMBL111077

KEGG

By LinkDB C06424

CTD

By CAS RN D019814

Species

Summary

Plant class

class name count
Embryophyta 6
rosids 6
eudicotyledons 3
Magnoliophyta 3
asterids 2
Liliopsida 1

Family (Top 10)

family name count
Frullaniaceae 6
Brassicaceae 2
Calophyllaceae 2
Saururaceae 2
Myristicaceae 1
Cistaceae 1
Iridaceae 1
Crassulaceae 1
Saxifragaceae 1
Malvaceae 1

List (28)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Anthemis aciphylla BOISS.var.discoidea BOISS 99027 Asteraceae asterids Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Brassica hirta 3728 Brassicaceae rosids Viridiplantae
Calophyllum calaba 883767 Calophyllaceae rosids Viridiplantae
Calophyllum inophyllum 158927 Calophyllaceae rosids Viridiplantae
Cistus creticus 191224 Cistaceae rosids Viridiplantae
Diascia cordata
Diascia integerrima
Diascia megathura
Diascia purpurea
Diascia vigilis
Drymaria cordata 191453 Caryophyllaceae eudicotyledons Viridiplantae
Frullania anomala 642275 Frullaniaceae Embryophyta Viridiplantae
Frullania incumbens 642320 Frullaniaceae Embryophyta Viridiplantae
Frullania lobulata 642327 Frullaniaceae Embryophyta Viridiplantae
Frullania probosciphora 95763 Frullaniaceae Embryophyta Viridiplantae
Frullania scandens 642360 Frullaniaceae Embryophyta Viridiplantae
Frullania spinifera 642367 Frullaniaceae Embryophyta Viridiplantae
Ganoderma lucidum 5315 Ganodermataceae Fungi
Houttuynia cordata 16752 Saururaceae Magnoliophyta Viridiplantae
Houttuynia emeiensis 16751 Saururaceae Magnoliophyta Viridiplantae
Iris florentina 26339 Iridaceae Liliopsida Viridiplantae
Mandragora autumnalis 389206 Solanaceae asterids Viridiplantae
Myristica fragrans 51089 Myristicaceae Magnoliophyta Viridiplantae
Rhodiola rosea L. 203015 Crassulaceae eudicotyledons Viridiplantae
Saxifraga stolonifera Meerb. 3798 Saxifragaceae eudicotyledons Viridiplantae
Spongiporus leucomallellus (Murril)
Tilia cordata Mill. 172266 Malvaceae rosids Viridiplantae

Human Protein / Gene in interaction

17 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O60603 Toll-like receptor 2 Membrane receptor CHEMBL111077 CHEMBL867222 (2)
1 / 1
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL111077 CHEMBL1908087 (1)
0 / 0
Q05193 Dynamin-1 Structural CHEMBL111077 CHEMBL673521 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL111077 CHEMBL1794339 (1)
2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL111077 CHEMBL1613800 (1)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL111077 CHEMBL1794495 (1)
2 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL111077 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL111077 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL111077 CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL111077 CHEMBL2114788 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL111077 CHEMBL1794401 (1)
0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL111077 CHEMBL976708 (1)
2 / 2
Q96RI1 Bile acid receptor NR1H4 CHEMBL111077 CHEMBL1794415 (1)
0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL111077 CHEMBL1908085 (1)
0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL111077 CHEMBL2114915 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL111077 CHEMBL1614364 (1)
1 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL111077 CHEMBL2354287 (1)
1 / 1

CTD interaction (4)

compound gene gene name gene description interaction interaction type form reference
pmid
D019814 199974 CYP4Z1
CYP4A20
cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) CYP4Z1 protein results in decreased abundance of Myristic Acid decreases abundance
protein 22841774
D019814 199974 CYP4Z1
CYP4A20
cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [CYP4Z1 protein results in decreased abundance of Myristic Acid] decreases abundance
/ decreases reaction
protein 22841774
D019814 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Myristic Acid binds to PPARA protein affects binding
protein 10403814
D019814 10891 PPARGC1A
LEM6
PGC-1(alpha)
PGC-1v
PGC1
PGC1A
PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Myristic Acid results in increased expression of PPARGC1A mRNA increases expression
mRNA 23056435

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#246300 Leprosy, susceptibility to, 3; lprs3 O60603
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (10)

KEGG disease name UniProt
H00344 Leprosy O60603 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)