KCF-S cluster No. 1141 (8 metabolites)
Corresponding Phytochemical cluster No. 68
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 22 |
| eudicotyledons | 11 |
| asterids | 10 |
| Magnoliophyta | 7 |
| Embryophyta | 7 |
| Liliopsida | 4 |
| Spermatophyta | 2 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Brassicaceae
|
11 |
|
Frullaniaceae
|
7 |
|
Asteraceae
|
5 |
|
Lythraceae
|
4 |
|
Caryophyllaceae
|
4 |
|
Saururaceae
|
4 |
|
Crassulaceae
|
4 |
|
Ganodermataceae
|
4 |
|
Saxifragaceae
|
3 |
|
Arecaceae
|
3 |
|
Cistaceae
|
3 |
|
Lauraceae
|
2 |
|
Pinaceae
|
2 |
|
Calophyllaceae
|
2 |
|
Solanaceae
|
2 |
|
Ulmaceae
|
1 |
|
Rubiaceae
|
1 |
|
Verbenaceae
|
1 |
|
Malvaceae
|
1 |
|
Rhodomelaceae
|
1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Saturated fatty acids | 4 |
metabolites link (4)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Saturated fatty acids | C01571 | C00001213 |
| Saturated fatty acids | C02679 | C00001221 |
| Saturated fatty acids | C06424 | C00001228 |
| Saturated fatty acids | C06423 | C00001231 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001213
|
Capric acid
/ Decanoic acid / n-Decanoic acid |
CHEMBL107498
|
C031071
|
8 / 11 / 6 | 4 / 0 |
|
|
C00001219
|
Omega-Hydroxydodecanoic acid
|
CHEMBL55068
|
C031263
|
1 / 0 |
|
|
|
C00001221
|
Lauric acid
/ Docosanoic acid / n-Dodecanoic acid |
CHEMBL108766
|
C030358
|
19 / 25 / 14 | 11 / 0 |
|
|
C00001228
|
Myristic acid
/ Tetradecanoic acid / n-Tetradecanoic acid |
CHEMBL111077
|
D019814
|
17 / 9 / 10 | 3 / 0 |
|
|
C00001231
|
Caprylic acid
/ Octanoic acid / n-Octanoic acid |
CHEMBL324846
|
C031492
|
10 / 14 / 13 | 2 / 1 |
|
|
C00007421
|
Undecanoic acid
|
CHEMBL108030
|
C016173
|
1 / 0 |
|
|
|
C00007422
|
Tridecanoic acid
|
CHEMBL107874
|
|
|||
|
C00030829
|
Pelargonic acid
/ n-Nonanoic acid |
CHEMBL108436
|
C008776
|
4 / 4 / 2 | 3 / 1 |
|
Human Protein / Gene in interactions
37 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00001213 C00001228 C00001231 C00030829 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00001213 C00001221 C00001228 C00001231 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00001213 C00001221 C00001228 C00001231 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001213 C00001221 C00001231 | 3 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00001213 C00001221 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001221 C00001228 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001228 C00030829 | 1 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001221 C00030829 | 3 / 1 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001213 C00001221 | 5 / 3 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001213 C00001231 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001221 C00001228 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001221 C00001231 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00001213 C00001221 | 3 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001221 C00001228 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001228 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001228 | 0 / 0 |
| Q8TCC7 | Solute carrier family 22 member 8 | Antiporter | C00001231 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00001221 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001228 | 2 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001221 | 7 / 3 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001221 | 0 / 0 |
| Q4U2R8 | Solute carrier family 22 member 6 | Antiporter | C00001231 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001228 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001228 | 2 / 3 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001228 | 2 / 2 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001221 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001231 | 11 / 10 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00030829 | 0 / 0 |
| Q05193 | Dynamin-1 | Structural | C00001228 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001221 | 1 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001221 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001221 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001228 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001221 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001228 | 1 / 1 |
| Q9NSA0 | Solute carrier family 22 member 11 | Transporter | C00001231 | 0 / 0 |
| O60603 | Toll-like receptor 2 | Membrane receptor | C00001228 | 1 / 1 |
13 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 128 | ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR | alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) |
C00001213
C00001219
C00001221
C00001231
C00007421 C00030829 |
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001221
C00001228
C00001231
C00030829
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001213
C00001221
C00001228
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00001213
C00001221
|
| 199974 | CYP4Z1, CYP4A20 | cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) |
C00001221
C00001228
|
| 1579 | CYP4A11, CP4Y, CYP4A2, CYP4AII | cytochrome P450, family 4, subfamily A, polypeptide 11 (EC:1.14.15.3) |
C00001221
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00001221
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001221
|
| 64127 | NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1 | nucleotide-binding oligomerization domain containing 2 |
C00001221
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001221
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001221
|
| 942 | CD86, B7-2, B7.2, B70, CD28LG2, LAB72 | CD86 molecule |
C00030829
|
| 9076 | CLDN1, CLD1, ILVASC, SEMP1 | claudin 1 |
C00001213
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (45)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22310
|
| #606785 | Crigler-najjar syndrome, type ii |
P22310
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #143500 | Gilbert syndrome |
P22310
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #246300 | Leprosy, susceptibility to, 3; lprs3 |
O60603
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (33)
| KEGG | name | UniProt |
|---|---|---|
| H00344 | Leprosy |
O60603
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|