PCIDB

KNApSAcK Metabolite C00001221

Metabolite

KNApSAcK Entry

id C00001221
Name Lauric acid / Docosanoic acid / n-Dodecanoic acid
CAS RN 143-07-7
Standard InChI InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
Standard InChI (Main Layer) InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)

Cluster

Phytochemical cluster No. 68
KCF-S cluster No. 1141

Link

ChEMBL

By standard InChI CHEMBL108766
By standard InChI Main Layer CHEMBL108766

KEGG

By LinkDB C02679

CTD

By CAS RN C030358

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL108766 CHEMBL1908081 (1)
3 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL108766 CHEMBL1908087 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL108766 CHEMBL1614281 (2) CHEMBL1614361 (2)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL108766 CHEMBL1794399 (1) CHEMBL1794561 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL108766 CHEMBL1794371 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL108766 CHEMBL1614458 (1)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL108766 CHEMBL2114835 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL108766 CHEMBL2114788 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL108766 CHEMBL2114810 (1)
7 / 3
Q9UGP5 DNA polymerase lambda Enzyme CHEMBL108766 CHEMBL1921596 (1) CHEMBL1920071 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL108766 CHEMBL1794401 (1)
0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL108766 CHEMBL1794510 (2)
5 / 3
Q96RI1 Bile acid receptor NR1H4 CHEMBL108766 CHEMBL1794437 (1)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL108766 CHEMBL2114842 (2)
0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL108766 CHEMBL1908085 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL108766 CHEMBL1794542 (1)
1 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL108766 CHEMBL1743271 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL108766 CHEMBL1794560 (2)
3 / 4
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL108766 CHEMBL1921592 (1) CHEMBL1921595 (1)
0 / 0

CTD interaction (18)

compound gene gene name gene description interaction interaction type form reference
pmid
C030358 128 ADH5
ADH-3
ADHX
FALDH
FDH
GSH-FDH
GSNOR
alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] decreases reaction
/ increases reduction
protein 19428350
C030358 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) CYP2C9 gene polymorphism results in decreased hydroxylation of lauric acid decreases hydroxylation
gene 11455026
C030358 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) CYP2C9 protein results in increased hydroxylation of lauric acid increases hydroxylation
protein 9241660
11455026
C030358 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased metabolism of lauric acid increases metabolic processing
protein 12464242
C030358 1579 CYP4A11
CP4Y
CYP4A2
CYP4AII
cytochrome P450, family 4, subfamily A, polypeptide 11 (EC:1.14.15.3) CYP4A11 protein results in increased metabolism of lauric acid increases metabolic processing
protein 16712844
C030358 199974 CYP4Z1
CYP4A20
cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) CYP4Z1 protein results in decreased abundance of lauric acid decreases abundance
protein 22841774
C030358 199974 CYP4Z1
CYP4A20
cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [CYP4Z1 protein results in decreased abundance of lauric acid] decreases abundance
/ decreases reaction
protein 22841774
C030358 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Curcumin inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of IL8 protein] decreases reaction
/ increases expression
/ increases secretion
protein 18413660
C030358 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 lauric acid results in increased expression of and results in increased secretion of IL8 protein increases expression
/ increases secretion
protein 18413660
C030358 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 parthenolide inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of IL8 protein] decreases reaction
/ increases expression
/ increases secretion
protein 18413660
C030358 64127 NOD2
ACUG
BLAU
CARD15
CD
CLR16.3
IBD1
NLRC2
NOD2B
PSORAS1
nucleotide-binding oligomerization domain containing 2 Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]] affects binding
/ decreases reaction
/ increases reaction
protein 18413660
C030358 64127 NOD2
ACUG
BLAU
CARD15
CD
CLR16.3
IBD1
NLRC2
NOD2B
PSORAS1
nucleotide-binding oligomerization domain containing 2 lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein] affects binding
/ increases reaction
protein 18413660
C030358 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha lauric acid binds to PPARA protein affects binding
protein 10403814
C030358 10891 PPARGC1A
LEM6
PGC-1(alpha)
PGC-1v
PGC1
PGC1A
PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha lauric acid results in increased expression of PPARGC1A mRNA increases expression
mRNA 23056435
C030358 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 18413660
C030358 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A lauric acid results in increased activity of RELA protein increases activity
protein 18413660
C030358 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 18413660
C030358 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of lauric acid increases glucuronidation
protein 16051554

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#615363 Estrogen resistance; estrr P03372
#143500 Gilbert syndrome P22310
#137800 Glioma susceptibility 1; glm1 P37231
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#174800 Mccune-albright syndrome; mas P63092
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (14)

KEGG disease name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)