Cedrus libani

• Index
• Plant Species
• Natural Activity
• Metabolite list (43)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Cedrus libani
Genus	Cedrus
Family	Pinaceae
Kingdom	Plantae

---

NCBI taxonomy

Entry

Linked NCBI taxonomy name	Cedrus libani
Linked NCBI taxonomy ID	93692
Linked level	species

Family

Family in NCBI taxonomy	Pinaceae
ID	3318

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Spermatophyta
ID	58024

Natural Activity

List (4)

Species	Activity
Cedrus libani A. Rich.	Diuretic
Cedrus libani A. Rich.	Expectorant
Cedrus libani A. Rich.	Fungicide
Cedrus libani A. Rich.	Insecticide

Metabolite list (43)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00003162	Longifolene	CHEMBL519092	C035607			No. 149	No. 38
C00029421	epi-Cubenol / 1-epi-Cubenol / (+)-ent-Epicubenol					No. 205	No. 38
C00022712	Manool	CHEMBL561922				No. 256	No. 46
C00029866	Cubenene / Cadina-1,4-diene / Cadina-1(2),4-diene					No. 283	No. 39
C00030345	gamma-Cadinene		C054278			No. 283	No. 39
C00029671	alpha-Muurolene					No. 283	No. 39
C00020130	gamma-Muurolene / 1beta-Cadina-4,10(15)-diene					No. 283	No. 39
C00035828	gamma-Amorphene / (+)-gamma-Amorphene					No. 283	No. 39
C00003203	alpha-Ylangene					No. 333	No. 38
C00048329	beta-Copaene					No. 333	No. 38
C00003120	alpha-Cubebene					No. 333	No. 38
C00003118	Copaene / alpha-Copaene / (-)-alpha-Copaene					No. 333	No. 38
C00029977	cis-Verbenol					No. 476	No. 35
C00000805	alpha-Pinene	CHEMBL442565	C005451	3 / 3 / 2	0 / 1	No. 476	No. 35
C00000816	beta-Pinene	CHEMBL501351	C010789			No. 476	No. 35
C00000829	trans-Pinocarveol					No. 476	No. 35
C00021309	alpha-Himachalene					No. 478	No. 38
C00003110	Caryophyllene / (E)-Caryophyllene / beta-Caryophyllene / (-)-(E)-Caryophyllene / (E)-beta-Caryophyllene	CHEMBL445740 CHEMBL448700		2 / 3 / 7		No. 478	No. 38
C00021310	gamma-Himachalene					No. 478	No. 38
C00003145	Himachalol		C010185		0 / 2	No. 615	No. 38
C00000823	Limonene	CHEMBL15799 CHEMBL449062	C008281	7 / 21 / 48	6 / 6	No. 848	No. 35
C00029674	alpha-Terpineol	CHEMBL447597 CHEMBL449810	C016775	3 / 16 / 11		No. 983	No. 35
C00001221	Lauric acid / Docosanoic acid / n-Dodecanoic acid	CHEMBL108766	C030358	19 / 25 / 14	11 / 0	No. 1141	No. 68
C00021899	Allohimachalol					No. 1295
C00050259	trans-alpha-Bisabolene					No. 1323	No. 38
C00003147	Humulene / alpha-Caryophyllene / (+/-)-alpha-Humulene	CHEMBL251280	C042686			No. 1421	No. 38
C00050265	Z-gamma-Atlantone					No. 1469	No. 38
C00050146	Longiborneol		C412581			No. 1507
C00007631	Abietadiene					No. 1536	No. 40
C00010872	beta-Phellandrene / (+/-)-beta-Phellandrene	CHEMBL444254	C058582			No. 1898	No. 35
C00029544	4-Terpineol / Terpin-4-ol / Terpineol-4 / Terpinen-4-ol	CHEMBL507795	C034019	1 / 3 / 0		No. 2215
C00011897	Atlantonic acid					No. 2249
C00000853	Myrcene	CHEMBL455491	C008574	3 / 3 / 3		No. 2285	No. 34
C00003029	Camphene	CHEMBL506889 CHEMBL510535	C019286			No. 2460	No. 35
C00003061	gamma-Terpinene / 1-Methyl-4-(1-methylethyl)-1,4-cyclohexadiene	CHEMBL449693	C018669			No. 2468	No. 35
C00003060	alpha-Terpinene					No. 2468	No. 35
C00011720	Germacrene D / (-)-Germacrene D	CHEMBL105432 CHEMBL1836650				No. 2639	No. 38
C00011045	delta-3-Carene / (-)-Carene(-)-3-Carene	CHEMBL506854				No. 2690	No. 35
C00011903	(+)-Todomatuic acid					No. 2790
C00011891	Libanotic acid					No. 2790
C00000861	Terpinolene	CHEMBL454697	C027009		1 / 0	No. 3725
C00050104	gamma-Dehydro-ar-himachalene					No. 4291
C00021308	beta-Himachalene					No. 7393

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00001221 C00029544 C00029674	3 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000805 C00000853 C00001221	3 / 2
Q96RI1	Bile acid receptor	NR1H4	C00000853 C00001221	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00000805 C00001221	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00000823 C00001221	3 / 1
P02545	Prelamin-A/C	Unclassified protein	C00000823 C00029674	11 / 10
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00000823 C00001221	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001221	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000823	0 / 3
P00352	Retinal dehydrogenase 1	Enzyme	C00001221	0 / 0
P10145	Interleukin-8	Secreted protein	C00001221	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001221	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00001221	7 / 3
Q9UGP5	DNA polymerase lambda	Enzyme	C00001221	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00000823	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000853	0 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00001221	5 / 3
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00001221	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000805	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00000823	7 / 37
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00001221	0 / 0
P03372	Estrogen receptor	NR3A1	C00001221	1 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00001221	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00029674	5 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000823	0 / 0
P10275	Androgen receptor	NR3C4	C00001221	3 / 4
Q9UBT6	DNA polymerase kappa	Enzyme	C00001221	0 / 0
O00255	Menin	Unclassified protein	C00003110	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003110	1 / 2

18 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00000823
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000823
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00000823
3265	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1	Harvey rat sarcoma viral oncogene homolog	C00000823
4852	NPY, PYY4	neuropeptide Y	C00000823
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000823
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000861
128	ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR	alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284)	C00001221
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00001221
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00001221
1579	CYP4A11, CP4Y, CYP4A2, CYP4AII	cytochrome P450, family 4, subfamily A, polypeptide 11 (EC:1.14.15.3)	C00001221
199974	CYP4Z1, CYP4A20	cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1)	C00001221
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001221
64127	NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1	nucleotide-binding oligomerization domain containing 2	C00001221
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00001221
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00001221
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001221
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00001221

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions