KCF-S cluster No. 848 (10 metabolites)

Corresponding Phytochemical cluster No. 35

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (10)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	33
rosids	21
Spermatophyta	11
Liliopsida	6
Magnoliophyta	5
Embryophyta	3
eudicotyledons	2

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Cumulative family count

class name	count
Rutaceae	16
Lamiaceae	15
Pinaceae	11
Asteraceae	7
Apiaceae	7
Verbenaceae	4
Poaceae	3
Piperaceae	3
Cistaceae	2
Saururaceae	2
Crassulaceae	2
Zingiberaceae	2
Plagiochilaceae	2
Gymnomitriaceae	1
Formicidae	1
Anacardiaceae	1
Acoraceae	1
Fabaceae	1
Salticidae	1
Meliaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Cyclic monoterpenes	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Cyclic monoterpenes	C00521	C00000803
Cyclic monoterpenes	C02576	C00003050
Cyclic monoterpenes	C06099	C00010868
Cyclic monoterpenes	C02452	C00010885

Metabolite list (10)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000803	(-)-Limonene	CHEMBL15799 CHEMBL449062		7 / 21 / 48
C00000823	Limonene	CHEMBL15799 CHEMBL449062	C008281	7 / 21 / 48	6 / 6
C00003043	Dipentene	CHEMBL15799 CHEMBL449062		7 / 21 / 48
C00003050	Perilla aldehyde / (R)-(+)-Perillaldehyde	CHEMBL442913 CHEMBL469537	C033342	2 / 1 / 0	9 / 0
C00010868	D-Limonene / (+)-S-Carvone / d-(+)-Limonene	CHEMBL15799 CHEMBL449062		7 / 21 / 48
C00010871	(S)-(-)-Perillaldehyde	CHEMBL442913 CHEMBL469537		2 / 1 / 0
C00010884	(R)-(+)-Perilla alcohol / (R)-(+)-Perillyl alcohol	CHEMBL236687 CHEMBL444711 CHEMBL1593539		5 / 1 / 1
C00010885	(S)-(-)-Perilla alcohol / (S)-(-)-Perillyl alcohol	CHEMBL236687 CHEMBL444711 CHEMBL1593539		5 / 1 / 1
C00031978	Limonen-10-al	CHEMBL52959
C00035132	m-Mentha-6,8-diene

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P04637	Cellular tumor antigen p53	Transcription Factor	C00000803 C00000823 C00003043 C00010868	7 / 37
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000803 C00000823 C00003043 C00010868	0 / 3
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00000803 C00000823 C00003043 C00010868	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000803 C00000823 C00003043 C00010868	11 / 10
P10828	Thyroid hormone receptor beta	NR1A2	C00000803 C00000823 C00003043 C00010868	3 / 1
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00000803 C00000823 C00003043 C00010868	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000803 C00000823 C00003043 C00010868	0 / 0
O75496	Geminin	Unclassified protein	C00010884 C00010885	0 / 0
O00519	Fatty-acid amide hydrolase 1	Enzyme	C00003050 C00010871	0 / 0
O75762	Transient receptor potential cation channel subfamily A member 1	Unclassified protein	C00003050 C00010871	1 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00010884 C00010885	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00010884 C00010885	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00010884 C00010885	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00010884 C00010885	1 / 1

15 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00000823
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000823
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00000823
3265	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1	Harvey rat sarcoma viral oncogene homolog	C00000823
4852	NPY, PYY4	neuropeptide Y	C00000823
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000823
1555	CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450	cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1)	C00003050
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00003050
9817	KEAP1, INrf2, KLHL19	kelch-like ECH-associated protein 1	C00003050
23764	MAFF, U-MAF, hMafF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F	C00003050
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00003050
5906	RAP1A, KREV-1, KREV1, RAP1, SMGP21	RAP1A, member of RAS oncogene family	C00003050
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00003050
388	RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6	ras homolog family member B	C00003050
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00003050

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions