PCIDB

KNApSAcK Metabolite C00003050

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00003050
Name	Perilla aldehyde / (R)-(+)-Perillaldehyde
CAS RN	2111-75-3
Standard InChI	InChI=1S/C10H14O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,7,10H,1,4-6H2,2H3/t10-/m1/s1
Standard InChI (Main Layer)	InChI=1S/C10H14O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,7,10H,1,4-6H2,2H3

Cluster

Phytochemical cluster	No. 35
KCF-S cluster	No. 848

Link

ChEMBL

By standard InChI	CHEMBL442913
By standard InChI Main Layer	CHEMBL442913 CHEMBL469537

KEGG

By LinkDB	C02576

CTD

By CAS RN	C033342

Species

Summary

Plant class

class name	count
asterids	2
eudicotyledons	1
rosids	1

Family

family name	count
Salticidae	1
Apiaceae	1
Crassulaceae	1
Rutaceae	1
Lamiaceae	1

List (5)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Citrus reticulata	85571	Rutaceae	rosids	Viridiplantae
Perilla arguta	381201	Lamiaceae	asterids	Viridiplantae
Rhodiola rosea L.	203015	Crassulaceae	eudicotyledons	Viridiplantae
Siler trilobum	1112553	Salticidae		Metazoa
Sium latifolium	52573	Apiaceae	asterids	Viridiplantae

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
O00519	Fatty-acid amide hydrolase 1	Enzyme	CHEMBL469537	CHEMBL1099470 (1)	0 / 0
O75762	Transient receptor potential cation channel subfamily A member 1	Unclassified protein	CHEMBL469537	CHEMBL1118242 (1)	1 / 0

CTD interaction (15)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C033342	1555	CYP2B6 CPB6 CYP2B CYP2B7 CYP2B7P CYPIIB6 EFVM IIB1 P450	cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1)	perillaldehyde inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]	decreases reaction / increases hydrolysis	protein	18611395
C033342	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	perillaldehyde results in increased expression of IL8 mRNA	increases expression	mRNA	20491607
C033342	9817	KEAP1 INrf2 KLHL19	kelch-like ECH-associated protein 1	KEAP1 protein inhibits the reaction [perillaldehyde results in increased expression of TXN mRNA]	decreases reaction / increases expression	protein	19123792
C033342	23764	MAFF U-MAF hMafF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F	perillaldehyde results in increased expression of MAFF mRNA	increases expression	mRNA	20491607
C033342	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	perillaldehyde promotes the reaction [NFE2L2 protein binds to TXN enhancer]	affects binding / increases reaction	protein	19123792
C033342	5906	RAP1A KREV-1 KREV1 RAP1 SMGP21	RAP1A, member of RAS oncogene family	Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RAP1A protein]	affects reaction / increases expression	protein	12671036
C033342	5906	RAP1A KREV-1 KREV1 RAP1 SMGP21	RAP1A, member of RAS oncogene family	perillaldehyde results in increased expression of RAP1A protein	increases expression	protein	12671036
C033342	387	RHOA ARH12 ARHA RHO12 RHOH12	ras homolog family member A	Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOA protein]	affects reaction / increases expression	protein	12671036
C033342	387	RHOA ARH12 ARHA RHO12 RHOH12	ras homolog family member A	perillaldehyde results in increased expression of RHOA protein	increases expression	protein	12671036
C033342	388	RHOB ARH6 ARHB MST081 MSTP081 RHOH6	ras homolog family member B	Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOB protein]	affects reaction / increases expression	protein	12671036
C033342	388	RHOB ARH6 ARHB MST081 MSTP081 RHOH6	ras homolog family member B	perillaldehyde results in increased expression of RHOB protein	increases expression	protein	12671036
C033342	7295	TXN TRDX TRX TRX1	thioredoxin	KEAP1 protein inhibits the reaction [perillaldehyde results in increased expression of TXN mRNA]	decreases reaction / increases expression	mRNA	19123792
C033342	7295	TXN TRDX TRX TRX1	thioredoxin	perillaldehyde promotes the reaction [NFE2L2 protein binds to TXN enhancer]	affects binding / increases reaction	enhancer	19123792
C033342	7295	TXN TRDX TRX TRX1	thioredoxin	perillaldehyde results in increased expression of TXN mRNA	increases expression	mRNA	19123792
C033342	7295	TXN TRDX TRX TRX1	thioredoxin	perillaldehyde results in increased expression of TXN protein	increases expression	protein	19123792

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM	preferred title	UniProt
#615040	Episodic pain syndrome, familial, 1; feps1	O75762