PCIDB

KCF-S cluster No. 1536 (7 metabolites)

Corresponding Phytochemical cluster No. 40

Plant Species

Cumulative plant class count

class name count
Spermatophyta 22
asterids 1

Cumulative family count

class name count
Pinaceae 14
Cupressaceae 6
Araucariaceae 2
Asteraceae 1

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Abietanes 2

metabolites link (2)

br08003 Category KEGG ID KNApSAcK ID
Abietanes C11878 C00000868
Abietanes C06087 C00000871

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00000868 External link 512 Abieta-7,13-diene
C00000869 External link 512 Abietal
/ 7,13-Abietadien-18-al
/ Abieta-7,13-diene-18-al
CHEMBL563793
C00000870 External link 512 Abietol
/ Abietinol
/ Abieta-7,13-diene-18-ol
CHEMBL304954
CHEMBL1436063
C026490
9 / 12 / 10
C00000871 External link 512 Abietic acid
/ 7,13-Abietadien-18-oic acid
CHEMBL71893
CHEMBL1336124
CHEMBL1357151
CHEMBL1514489
CHEMBL1552001
C023710
18 / 22 / 25
C00000878 External link 512 ent-Abieta-7,13-diene
C00007631 External link 512 Abietadiene
C00036013 External link 512 4-epi-abietic acid
CHEMBL71893
CHEMBL1336124
CHEMBL1357151
CHEMBL1514489
CHEMBL1552001
18 / 22 / 25

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein C00000870 C00000871 C00036013 11 / 10
Q15120 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial Pdhk C00000870 C00000871 C00036013 1 / 0
Q15119 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial Pdhk C00000870 C00000871 C00036013 0 / 0
Q16654 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial Pdhk C00000870 C00000871 C00036013 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000870 C00000871 C00036013 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000870 C00000871 C00036013 0 / 0
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk C00000870 C00000871 C00036013 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000870 C00000871 C00036013 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000871 C00036013 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000871 C00036013 3 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000871 C00036013 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00000871 C00036013 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000871 C00036013 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000871 C00036013 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000871 C00036013 0 / 3
P11473 Vitamin D3 receptor NR1I1 C00000871 C00036013 2 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000871 C00036013 0 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000871 C00036013 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000870 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#300905 Charcot-marie-tooth disease, x-linked dominant, 6; cmtx6 Q15120
#609535 Drug metabolism, poor, cyp2c19-related P33261
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (25)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)