phytochemical cluster No. 39 (30 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (3)
• Metabolite list (30)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	35
Spermatophyta	28
Magnoliophyta	24
asterids	19
Liliopsida	17
Embryophyta	12

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Cumulative family count (Top 20)

class name	count
Pinaceae	20
Piperaceae	14
Asteraceae	9
Cistaceae	9
Cupressaceae	7
Poaceae	6
Malvaceae	6
Frullaniaceae	6
Lamiaceae	6
Lauraceae	5
Annonaceae	5
Myrtaceae	5
Zingiberaceae	4
Cyperaceae	4
Meliaceae	4
Acoraceae	3
Gymnomitriaceae	3
Fagaceae	3
Fabaceae	3
Apiaceae	2

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Cadinanes	4

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metabolites link (6)

br08003 Category	KEGG ID	KNApSAcK ID
Cadinanes	C09625	C00003106
Cadinanes	C07667	C00003136
Cadinanes	C06394	C00007636
Cadinanes	C19738	C00030345
Cadinanes	C07667	C00038078
Cadinanes	C07667	C00038103

KCF-S cluster (3)

KCF-S ID	# of metabolite
No. 283	20
No. 1524	7
No. 4111	3

Metabolite list (30)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00003106	gamma-Muurolene / 1beta-Cadina-4,10(15)-diene					No. 283
C00035828	1(10),4-Cadinadiene-3,9-diol / 3,9-Dihydroxy-delta-cadinene					No. 283
C00035520	Cadina-1(10),4-dien					No. 283
C00020041	gamma-Bulgarene					No. 283
C00020042	(-)-Khusol / Cadina-4,10(15)-dien-12-ol					No. 283
C00020044	Khusinol / 1beta,6alpha,7betaH-Cadina-4,10(15)-dien-2beta-ol					No. 283
C00030434	omega-Cadinene / 1(10),3-Cadinadiene					No. 283
C00020049	gamma1-Cadinene					No. 283
C00020051	(-)-epsilon-Bulgarene					No. 283
C00020052	10beta,15-Epoxykhusinol / 1beta,6alpha,7betaH-Cadina-4,10(15)-dien-3alpha-ol					No. 283
C00030345	14-Hydroxy-delta-cadinene					No. 283
C00029866	delta-Cadinene	CHEMBL445759				No. 283
C00020057	alpha-Amorphene					No. 283
C00020058	alpha-Muurolene					No. 283
C00020059	alpha-Cadinene					No. 283
C00029671	delta-Amorphene / (+)-delta-Amorphene	CHEMBL445759				No. 283
C00020130	Sclerosporal / 14-Oxy-alpha-muurolene					No. 283
C00020249	Cubenene / Cadina-1,4-diene / Cadina-1(2),4-diene					No. 283
C00020384	6,9-Guaiadiene					No. 283
C00020128	beta-Cadinene					No. 283
C00029396	Guaia-6,9-diene / (+)-Guaia-6,9-diene					No. 1524
C00020056	beta1-Bulgarene / 4,9-Bulgaradiene					No. 1524
C00020053	4,10(14)-Oplopadien-3-ol					No. 1524
C00020048	gamma2-Cadinene / 3,10(14)-Cadinadiene					No. 1524
C00035061	delta-Cadinen-9-one / 1(10),4-Cadinadien-9-one					No. 1524
C00037022	(R)-(-)-Gossypol	CHEMBL51483		78 / 69 / 87		No. 1524
C00007636	gamma-Cadinene		C054278			No. 1524
C00003136	gamma-Amorphene / (+)-gamma-Amorphene					No. 4111
C00038078	Gossypol	CHEMBL51483	D006072	78 / 69 / 87	17 / 2	No. 4111
C00038103	(+)-Gossypol	CHEMBL51483		78 / 69 / 87		No. 4111

Human Protein / Gene in interactions

78 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003136 C00038078 C00038103	1 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00003136 C00038078 C00038103	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00003136 C00038078 C00038103	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00003136 C00038078 C00038103	7 / 37
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00003136 C00038078 C00038103	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00003136 C00038078 C00038103	4 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00003136 C00038078 C00038103	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00003136 C00038078 C00038103	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003136 C00038078 C00038103	2 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00003136 C00038078 C00038103	0 / 0
P06746	DNA polymerase beta	Enzyme	C00003136 C00038078 C00038103	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00003136 C00038078 C00038103	1 / 1
P29466	Caspase-1	C14	C00003136 C00038078 C00038103	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00003136 C00038078 C00038103	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00003136 C00038078 C00038103	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00003136 C00038078 C00038103	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00003136 C00038078 C00038103	11 / 10
P37840	Alpha-synuclein	Unclassified protein	C00003136 C00038078 C00038103	4 / 2
P10828	Thyroid hormone receptor beta	NR1A2	C00003136 C00038078 C00038103	3 / 1
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00003136 C00038078 C00038103	0 / 0
P02768	Serum albumin	Secreted protein	C00003136 C00038078 C00038103	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003136 C00038078 C00038103	0 / 1
Q92843	Bcl-2-like protein 2	Other cytosolic protein	C00003136 C00038078 C00038103	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00003136 C00038078 C00038103	1 / 2
P51570	Galactokinase	Enzyme	C00003136 C00038078 C00038103	1 / 1
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00003136 C00038078 C00038103	1 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003136 C00038078 C00038103	2 / 3
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00003136 C00038078 C00038103	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00003136 C00038078 C00038103	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003136 C00038078 C00038103	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00003136 C00038078 C00038103	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00003136 C00038078 C00038103	0 / 0
P42858	Huntingtin	Unclassified protein	C00003136 C00038078 C00038103	1 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003136 C00038078 C00038103	2 / 0
O75496	Geminin	Unclassified protein	C00003136 C00038078 C00038103	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00003136 C00038078 C00038103	0 / 0
P15121	Aldose reductase	Enzyme	C00003136 C00038078 C00038103	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00003136 C00038078 C00038103	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00003136 C00038078 C00038103	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00003136 C00038078 C00038103	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00003136 C00038078 C00038103	0 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00003136 C00038078 C00038103	5 / 3
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00003136 C00038078 C00038103	2 / 0
Q96RI1	Bile acid receptor	NR1H4	C00003136 C00038078 C00038103	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00003136 C00038078 C00038103	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003136 C00038078 C00038103	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00003136 C00038078 C00038103	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00003136 C00038078 C00038103	2 / 2
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003136 C00038078 C00038103	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003136 C00038078 C00038103	0 / 0
P03372	Estrogen receptor	NR3A1	C00003136 C00038078 C00038103	1 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00003136 C00038078 C00038103	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00003136 C00038078 C00038103	0 / 0
P55210	Caspase-7	C14	C00003136 C00038078 C00038103	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003136 C00038078 C00038103	1 / 1
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00003136 C00038078 C00038103	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003136 C00038078 C00038103	0 / 1
P52732	Kinesin-like protein KIF11	Other cytosolic protein	C00003136 C00038078 C00038103	1 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00003136 C00038078 C00038103	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00003136 C00038078 C00038103	1 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00003136 C00038078 C00038103	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00003136 C00038078 C00038103	4 / 3
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00003136 C00038078 C00038103	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003136 C00038078 C00038103	0 / 0
P10275	Androgen receptor	NR3C4	C00003136 C00038078 C00038103	3 / 4
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00003136 C00038078 C00038103	0 / 0
Q07817	Bcl-2-like protein 1	Other cytosolic protein	C00003136 C00038078 C00038103	0 / 0
P10415	Apoptosis regulator Bcl-2	Other cytosolic protein	C00003136 C00038078 C00038103	0 / 7
Q9UBT6	DNA polymerase kappa	Enzyme	C00003136 C00038078 C00038103	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00003136 C00038078 C00038103	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00003136 C00038078 C00038103	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00003136 C00038078 C00038103	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00003136 C00038078 C00038103	1 / 1
O00255	Menin	Unclassified protein	C00003136 C00038078 C00038103	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003136 C00038078 C00038103	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00003136 C00038078 C00038103	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00003136 C00038078 C00038103	1 / 4
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00003136 C00038078 C00038103	0 / 0

17 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
27113	BBC3, JFY-1, JFY1, PUMA	BCL2 binding component 3	C00003136
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00003136
10018	BCL2L11, BAM, BIM, BOD	BCL2-like 11 (apoptosis facilitator)	C00003136
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003136
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00003136
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00003136
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00003136
2919	CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	C00003136
2050	EPHB4, HTK, MYK1, TYRO11	EPH receptor B4 (EC:2.7.10.1)	C00003136
2247	FGF2, BFGF, FGF-2, FGFB, HBGF-2	fibroblast growth factor 2 (basic)	C00003136
2261	FGFR3, ACH, CD333, CEK2, HSFGFR3EX, JTK4	fibroblast growth factor receptor 3 (EC:2.7.10.1)	C00003136
3397	ID1, ID, bHLHb24	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	C00003136
3911	LAMA5	laminin, alpha 5	C00003136
4170	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	C00003136
4192	MDK, ARAP, MK, NEGF2	midkine (neurite growth-promoting factor 2)	C00003136
5154	PDGFA, PDGF-A, PDGF1	platelet-derived growth factor alpha polypeptide	C00003136
1890	TYMP, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF	thymidine phosphorylase (EC:2.4.2.4)	C00003136

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions