KNApSAcK Metabolite C00003136
Metabolite
KNApSAcK Entry
| id | C00003136 |
|---|---|
| Name | Gossypol |
| CAS RN | 303-45-7 |
| Standard InChI | InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 |
| Standard InChI (Main Layer) | InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 |
Cluster
| Phytochemical cluster | No. 39 |
|---|---|
| KCF-S cluster | No. 4111 |
Link
ChEMBL
| By standard InChI | CHEMBL51483 |
|---|---|
| By standard InChI Main Layer | CHEMBL51483 |
KEGG
| By LinkDB | C07667 |
|---|
CTD
| By CAS RN | D006072 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 4 |
Family
| family name | count |
|---|---|
| Malvaceae | 3 |
| Combretaceae | 1 |
| Plectosphaerellaceae | 1 |
List (5)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Calycopteris floribunda | 134915 | Combretaceae | rosids | Viridiplantae |
| Gossypium sp. | 3633 | Malvaceae | rosids | Viridiplantae |
| Montezuma speciosissima | 3629 | Malvaceae | rosids | Viridiplantae |
| Thespesia populnea | 3638 | Malvaceae | rosids | Viridiplantae |
| Verticillium albo-atrum | 27335 | Plectosphaerellaceae | Fungi |
Human Protein / Gene in interaction
78 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL51483 |
CHEMBL1614110
(1)
CHEMBL1741321
(2)
|
1 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | CHEMBL51483 |
CHEMBL1614316
(1)
CHEMBL1613805
(1)
CHEMBL1614009 (1) CHEMBL1614293 (1) |
0 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | CHEMBL51483 |
CHEMBL957998
(1)
CHEMBL957999
(1)
|
0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL51483 |
CHEMBL1613992
(2)
CHEMBL1613995
(1)
CHEMBL2114895 (1) |
7 / 44 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | CHEMBL51483 |
CHEMBL909447
(1)
CHEMBL888455
(1)
CHEMBL1055758 (1) CHEMBL1274442 (1) CHEMBL1614529 (1) CHEMBL2318343 (1) CHEMBL2320593 (1) CHEMBL2320594 (2) CHEMBL2320595 (2) CHEMBL2345532 (2) |
0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL51483 |
CHEMBL1613842
(2)
|
4 / 2 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL51483 |
CHEMBL1738312
(1)
|
0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL51483 |
CHEMBL1794367
(1)
CHEMBL2114784
(2)
|
1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL51483 |
CHEMBL1794499
(1)
|
2 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | CHEMBL51483 |
CHEMBL1737859
(1)
CHEMBL1738565
(1)
|
0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | CHEMBL51483 |
CHEMBL1614079
(1)
|
0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | CHEMBL51483 |
CHEMBL1614076
(1)
|
1 / 1 |
| P29466 | Caspase-1 | C14 | CHEMBL51483 |
CHEMBL1614523
(1)
CHEMBL1614278
(1)
CHEMBL1613961 (1) CHEMBL1614158 (1) CHEMBL1613851 (1) |
0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL51483 |
CHEMBL1794524
(1)
CHEMBL1794552
(1)
|
0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | CHEMBL51483 |
CHEMBL1738600
(1)
CHEMBL2114875
(1)
CHEMBL2114824 (1) |
0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | CHEMBL51483 |
CHEMBL1614331
(2)
CHEMBL1614474
(1)
CHEMBL1613927 (1) |
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL51483 |
CHEMBL1614544
(1)
|
11 / 10 |
| P37840 | Alpha-synuclein | Unclassified protein | CHEMBL51483 |
CHEMBL2354282
(2)
|
4 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL51483 |
CHEMBL1614554
(3)
CHEMBL1613776
(6)
CHEMBL1794399 (1) |
3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | CHEMBL51483 |
CHEMBL1794471
(1)
|
0 / 0 |
| P02768 | Serum albumin | Secreted protein | CHEMBL51483 |
CHEMBL1953042
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL51483 |
CHEMBL1614027
(2)
CHEMBL1741325
(2)
|
0 / 1 |
| Q92843 | Bcl-2-like protein 2 | Other cytosolic protein | CHEMBL51483 |
CHEMBL891870
(1)
|
0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL51483 |
CHEMBL1614067
(5)
|
1 / 2 |
| P51570 | Galactokinase | Enzyme | CHEMBL51483 |
CHEMBL1613821
(1)
|
1 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | CHEMBL51483 |
CHEMBL1614166
(1)
|
1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL51483 |
CHEMBL1794311
(3)
CHEMBL1794376
(1)
CHEMBL1794339 (1) |
2 / 3 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | CHEMBL51483 |
CHEMBL1613800
(3)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL51483 |
CHEMBL1614458
(2)
|
0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL51483 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL51483 |
CHEMBL1613922
(1)
CHEMBL1794486
(2)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL51483 |
CHEMBL1738606
(3)
|
0 / 0 |
| P42858 | Huntingtin | Unclassified protein | CHEMBL51483 |
CHEMBL1613918
(1)
|
1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL51483 |
CHEMBL1794584
(1)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL51483 |
CHEMBL2114780
(1)
|
0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL51483 |
CHEMBL1613838
(1)
|
0 / 0 |
| P15121 | Aldose reductase | Enzyme | CHEMBL51483 |
CHEMBL643119
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL51483 |
CHEMBL1738610
(1)
|
0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | CHEMBL51483 |
CHEMBL1963893
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL51483 |
CHEMBL1794467
(3)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL51483 |
CHEMBL1794382
(1)
CHEMBL1794456
(1)
|
0 / 1 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | CHEMBL51483 |
CHEMBL1794293
(1)
CHEMBL1794510
(1)
|
5 / 3 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | CHEMBL51483 |
CHEMBL1614252
(4)
|
2 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | CHEMBL51483 |
CHEMBL1794415
(1)
CHEMBL1794437
(1)
|
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL51483 |
CHEMBL1614521
(2)
CHEMBL1613808
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL51483 |
CHEMBL1741322
(2)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL51483 |
CHEMBL1613910
(2)
CHEMBL1614227
(2)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL51483 |
CHEMBL1614038
(5)
|
2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | CHEMBL51483 |
CHEMBL1614342
(1)
|
1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL51483 |
CHEMBL1738675
(1)
CHEMBL1738317
(1)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL51483 |
CHEMBL1614199
(1)
CHEMBL1794542
(1)
|
1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | CHEMBL51483 |
CHEMBL2114853
(1)
|
0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL51483 |
CHEMBL1614240
(2)
|
0 / 0 |
| P55210 | Caspase-7 | C14 | CHEMBL51483 |
CHEMBL1614340
(1)
CHEMBL1613779
(1)
CHEMBL1613931 (1) |
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL51483 |
CHEMBL1613777
(1)
CHEMBL1741323
(2)
|
1 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | CHEMBL51483 |
CHEMBL958788
(1)
CHEMBL958789
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL51483 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
CHEMBL1741324 (2) |
0 / 1 |
| P52732 | Kinesin-like protein KIF11 | Other cytosolic protein | CHEMBL51483 |
CHEMBL942113
(1)
CHEMBL2353359
(1)
|
1 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL51483 |
CHEMBL1794483
(1)
|
0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | CHEMBL51483 |
CHEMBL1614052
(1)
|
1 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL51483 |
CHEMBL1614211
(5)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL51483 |
CHEMBL1614250
(5)
CHEMBL1614421
(5)
CHEMBL1614502 (5) |
4 / 3 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | CHEMBL51483 |
CHEMBL1738402
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL51483 |
CHEMBL1737980
(1)
CHEMBL2114890
(1)
|
0 / 0 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL51483 |
CHEMBL1794321
(1)
CHEMBL1794560
(1)
|
3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | CHEMBL51483 |
CHEMBL2114915
(1)
|
0 / 0 |
| Q07817 | Bcl-2-like protein 1 | Other cytosolic protein | CHEMBL51483 |
CHEMBL647263
(1)
CHEMBL909446
(1)
CHEMBL1002038 (1) CHEMBL1002039 (1) CHEMBL1031065 (1) CHEMBL1106536 (2) CHEMBL1274437 (1) |
0 / 0 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | CHEMBL51483 |
CHEMBL909444
(1)
CHEMBL909445
(1)
CHEMBL888453 (1) CHEMBL891868 (1) CHEMBL937576 (1) CHEMBL1106537 (2) CHEMBL1274438 (1) CHEMBL2320592 (1) |
0 / 7 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL51483 |
CHEMBL1794536
(6)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL51483 |
CHEMBL1613914
(5)
|
0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | CHEMBL51483 |
CHEMBL1613829
(6)
CHEMBL1613928
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL51483 |
CHEMBL1738442
(3)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL51483 |
CHEMBL1614364
(5)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL51483 |
CHEMBL1614257
(6)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL51483 |
CHEMBL1614257
(6)
|
1 / 3 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL51483 |
CHEMBL1613933
(4)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL51483 |
CHEMBL1613933
(4)
|
1 / 6 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | CHEMBL51483 |
CHEMBL2114738
(1)
|
0 / 0 |
CTD interaction (26)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D006072 | 27113 |
BBC3
JFY-1 JFY1 PUMA |
BCL2 binding component 3 | Gossypol results in increased expression of BBC3 protein |
increases expression
|
protein |
18840529
|
| D006072 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | Gossypol analog binds to and affects the activity of BCL2L1 protein |
affects activity
/ affects binding |
protein |
16020667
|
| D006072 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | Gossypol results in decreased expression of BCL2L1 protein |
decreases expression
|
protein |
18840529
|
| D006072 | 10018 |
BCL2L11
BAM BIM BOD |
BCL2-like 11 (apoptosis facilitator) | Gossypol results in increased expression of BCL2L11 protein |
increases expression
|
protein |
18840529
|
| D006072 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Gossypol results in increased activity of CASP3 protein |
increases activity
|
protein |
19825521
|
| D006072 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Gossypol results in increased cleavage of CASP3 protein |
increases cleavage
|
protein |
18840529
|
| D006072 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | [zoledronic acid co-treated with Gossypol] results in increased activity of CASP3 protein |
affects cotreatment
/ increases activity |
protein |
19825521
|
| D006072 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Gossypol results in increased activity of CASP7 protein |
increases activity
|
protein |
19825521
|
| D006072 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | [zoledronic acid co-treated with Gossypol] results in increased activity of CASP7 protein |
affects cotreatment
/ increases activity |
protein |
19825521
|
| D006072 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | Gossypol results in increased cleavage of CASP9 protein |
increases cleavage
|
protein |
18840529
|
| D006072 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | Gossypol results in decreased expression of CCL2 mRNA |
decreases expression
|
mRNA |
19825521
|
| D006072 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | zoledronic acid promotes the reaction [Gossypol results in decreased expression of CCL2 mRNA] |
decreases expression
/ increases reaction |
mRNA |
19825521
|
| D006072 | 2919 |
CXCL1
FSP GRO1 GROa MGSA MGSA-a NAP-3 SCYB1 |
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | [zoledronic acid co-treated with Gossypol] results in decreased expression of CXCL1 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
19825521
|
| D006072 | 2050 |
EPHB4
HTK MYK1 TYRO11 |
EPH receptor B4 (EC:2.7.10.1) | [zoledronic acid co-treated with Gossypol] results in decreased expression of EPHB4 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
19825521
|
| D006072 | 2247 |
FGF2
BFGF FGF-2 FGFB HBGF-2 |
fibroblast growth factor 2 (basic) | Gossypol results in decreased expression of FGF2 mRNA |
decreases expression
|
mRNA |
19825521
|
| D006072 | 2247 |
FGF2
BFGF FGF-2 FGFB HBGF-2 |
fibroblast growth factor 2 (basic) | zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGF2 mRNA] |
decreases expression
/ increases reaction |
mRNA |
19825521
|
| D006072 | 2261 |
FGFR3
ACH CD333 CEK2 HSFGFR3EX JTK4 |
fibroblast growth factor receptor 3 (EC:2.7.10.1) | Gossypol results in decreased expression of FGFR3 mRNA |
decreases expression
|
mRNA |
19825521
|
| D006072 | 2261 |
FGFR3
ACH CD333 CEK2 HSFGFR3EX JTK4 |
fibroblast growth factor receptor 3 (EC:2.7.10.1) | zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGFR3 mRNA] |
decreases expression
/ increases reaction |
mRNA |
19825521
|
| D006072 | 3397 |
ID1
ID bHLHb24 |
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | Gossypol results in decreased expression of ID1 mRNA |
decreases expression
|
mRNA |
19825521
|
| D006072 | 3397 |
ID1
ID bHLHb24 |
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | zoledronic acid promotes the reaction [Gossypol results in decreased expression of ID1 mRNA] |
decreases expression
/ increases reaction |
mRNA |
19825521
|
| D006072 | 3911 |
LAMA5
|
laminin, alpha 5 | [zoledronic acid co-treated with Gossypol] results in decreased expression of LAMA5 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
19825521
|
| D006072 | 4170 |
MCL1
BCL2L3 EAT MCL1-ES MCL1L MCL1S Mcl-1 TM bcl2-L-3 mcl1/EAT |
myeloid cell leukemia sequence 1 (BCL2-related) | Gossypol results in decreased expression of MCL1 protein |
decreases expression
|
protein |
18840529
20587533 |
| D006072 | 4192 |
MDK
ARAP MK NEGF2 |
midkine (neurite growth-promoting factor 2) | Gossypol results in decreased expression of MDK mRNA |
decreases expression
|
mRNA |
19825521
|
| D006072 | 4192 |
MDK
ARAP MK NEGF2 |
midkine (neurite growth-promoting factor 2) | zoledronic acid promotes the reaction [Gossypol results in decreased expression of MDK mRNA] |
decreases expression
/ increases reaction |
mRNA |
19825521
|
| D006072 | 5154 |
PDGFA
PDGF-A PDGF1 |
platelet-derived growth factor alpha polypeptide | [zoledronic acid co-treated with Gossypol] results in decreased expression of PDGFA mRNA |
affects cotreatment
/ decreases expression |
mRNA |
19825521
|
| D006072 | 1890 |
TYMP
ECGF ECGF1 MEDPS1 MNGIE MTDPS1 PDECGF TP hPD-ECGF |
thymidine phosphorylase (EC:2.4.2.4) | Gossypol inhibits the reaction [zoledronic acid results in increased expression of TYMP mRNA] |
decreases reaction
/ increases expression |
mRNA |
19825521
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (69)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 |
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #230200 | Galactokinase deficiency |
P51570
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #152950 | Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; mclmr |
P52732
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (87)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P10415 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
P10415 (related) |
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
P10415 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
P10415 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
P10415 (related) |
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00070 | Galactosemia |
P51570
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|