Ganoderma lucidum

• Index
• Plant Species
• Natural Activity
• Metabolite list (150)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Ganoderma lucidum
Genus	Ganoderma
Family	Ganodermataceae
Kingdom	Fungi

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Ganoderma lucidum
Linked NCBI taxonomy ID	5315
Linked level	species

Family

Family in NCBI taxonomy	Ganodermataceae
ID	5313

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Fungi
ID	4751

Plant class

Plant class
ID

Natural Activity

List (23)

Species	Activity
Ganoderma lucidum	Adaptogen
Ganoderma lucidum	Analgesic
Ganoderma lucidum	Antiaggregant
Ganoderma lucidum	Antiaging
Ganoderma lucidum	Antiallergic
Ganoderma lucidum	Antibacterial
Ganoderma lucidum	Anticonvulsant
Ganoderma lucidum	Antihistaminic
Ganoderma lucidum	Antiinflammatory
Ganoderma lucidum	Antioxidant
Ganoderma lucidum	Antitumor
Ganoderma lucidum	Antiviral
Ganoderma lucidum	Cytotoxic
Ganoderma lucidum	Expectorant
Ganoderma lucidum	Hepatoprotective
Ganoderma lucidum	Hypertensive
Ganoderma lucidum	Hypoglycemic
Ganoderma lucidum	Hypotensive
Ganoderma lucidum	Hypotriglyceridemic
Ganoderma lucidum	Immunostimulant
Ganoderma lucidum	Myorelaxant
Ganoderma lucidum	Radioprotective
Ganoderma lucidum	Sedative

Metabolite list (150)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00031805	Ganoderic acid theta / (+)-Ganoderic acid theta.	CHEMBL2205005				No. 55
C00045318	Ganoderic acid AM1	CHEMBL2205003				No. 55
C00045168	20-Hydroxyganoderic acid G / (+)-20-Hydroxyganoderic acid G					No. 55
C00045153	12-Deacetylganoderic acid H	CHEMBL1922170		1 / 0 / 0		No. 55
C00044932	Methyl lucidenate Q / (+)-Methyl lucidenate Q	CHEMBL460968				No. 55
C00044931	Methyl lucidenate P / (+)-Methyl lucidenate P	CHEMBL511952				No. 55
C00044890	Lucidenic acid P / (+)-Lucidenic acid P	CHEMBL469283				No. 55
C00043677	Lucidenic acid N / (+)-Lucidenic acid N	CHEMBL465487		2 / 1 / 0		No. 55
C00043530	Ganoderic acid beta	CHEMBL474065				No. 55
C00040962	Ganoderic acid alpha / (-)-Ganoderic acid alpha					No. 55
C00035104	Ganoderic acid V1					No. 55
C00023877	Lucidenic acid C / 11,15-Dioxo-3beta,7beta,12beta-trhydroxy-5alpha-lanost-8-en-24-oic acid	CHEMBL465369				No. 55
C00023878	Lucidenic acid F / 3,7,11,15-Tetraoxo-5alpha-lanost-8-en-24-oic acid					No. 55
C00023879	Lucidenic acid G / 3,11-dioxo-4beta,7beta,15alpha-trihydroxy-5alpha-lanost-8-en-24-oic acid					No. 55
C00023845	Ganoderic acid O / 20-Hydroxy-3,7,11,15,23-pentaoxo-5alpha-lanost-8-en-26-oic acid					No. 55
C00023843	Ganoderic acid M / 7beta,12alpha-Dihydroxy-3,11,15,23-tetraoxo-5alpha-lanost-8-en-26-oic acid	CHEMBL2203606				No. 55
C00023870	Ganolucidic acid A	CHEMBL1087131		2 / 1 / 0		No. 55
C00023871	Ganolucidic acid B	CHEMBL1922176		1 / 0 / 0		No. 55
C00031804	Ganoderic acid eta / (+)-Ganoderic acid eta.					No. 55
C00031803	Ganoderic acid epsilon / (+)-Ganoderic acid epsilon					No. 55
C00023875	(+)-Lucidenic acid A / 3,11,15-Trioxo-7beta-hydroxy-5alpha-lanost-8-en-24-oic acid	CHEMBL460969		2 / 1 / 0		No. 55
C00023876	(+)-Lucidenic acid B / 3,11,15-Trioxo-7beta,12beta-dihydroxy-5alpha-lanost-8-en-24-oic acid					No. 55
C00030352	Ganoderenic acid G / (+)-Ganoderenic acid G					No. 55
C00023831	Ganoderic acid L / 3beta,7beta,15alpha,20-Tetrahydroxy-11,23-dioxo-5alpha-lanost-8-en-26-oic acid					No. 55
C00024054	Ganoderic acid G	CHEMBL1922175		1 / 0 / 0		No. 55
C00023885	Lucidenic acid M / 11-Oxo-3beta,7alpha,15alpha-trihydroxy-5alpha-lanost-8-en-24-oic acid					No. 55
C00023884	Lucidenic acid L / 7,11,15-Trioxo-3beta,12beta-dihydroxy-5alpha-lanost-8-en-24-oic acid					No. 55
C00023883	Lucidenic acid K / 3,7,11,15-Tetraoxo-12alpha-hydroxy-5alpha-lanost-8-en-24-oic acid					No. 55
C00023882	Lucidenic acid J / 3,11,15-Trioxo-3beta,12beta-dihydroxy-5alpha-lanost-8-en-24-oic acid					No. 55
C00023881	Lucidenic acid I / 7,11,15-Trioxo-3beta-hydroxy-5alpha-lanost-8-en-24-oic acid					No. 55
C00023880	Lucidenic acid H / 11,15-dioxo-3beta,7beta-dihydroxy-5alpha-lanost-8-en-24-oic acid					No. 55
C00023820	Ganoderic acid A / 7beta,15alpha-Dihydroxy-3,11,23-trioxo-5alpha-lanost-8-en-26-oic acid	CHEMBL602899		3 / 2 / 2		No. 55
C00023821	Ganoderic acid B	CHEMBL1087180		3 / 1 / 0		No. 55
C00023822	Ganoderic acid C / Ganoderic acid C1 / 7beta-Hydroxy-3,11,15,23-tetraoxo-5alpha-lanost-8-en-26-oic acid	CHEMBL1922180 CHEMBL2205002		1 / 0 / 0		No. 55
C00023823	Ganoderic acid D / 7beta,12alpha-Dihydroxy-3,11,23-tetraoxo-5alpha-lanost-8-en-26-oic acid	CHEMBL1922180 CHEMBL2205002		1 / 0 / 0		No. 55
C00023824	Ganoderic acid E / 3,7,11,15,23-pentaoxo-5alpha-lanost-8-en-26-oic acid	CHEMBL465514		2 / 1 / 0		No. 55
C00023825	Ganoderic acid F / 3,7,11,15,23-pentaoxo-12-acetoxy-5alpha-lanost-8-en-26-oic acid	CHEMBL453981				No. 55
C00023826	Ganoderic acid G	CHEMBL1922175		1 / 0 / 0		No. 55
C00023827	Ganoderic acid H / 3beta-Hydroxy-7,11,15,23-tetraoxo-12beta-acetoxy-5alpha-lanost-8-en-26-oic acid	CHEMBL1922178		1 / 0 / 0		No. 55
C00023828	Ganoderic acid I					No. 55
C00023829	Ganoderic acid J	CHEMBL1922172		1 / 0 / 0		No. 55
C00023830	(+)-Ganoderic acid K / 3beta,15alpha-Dihydroxy-7,11,23-trioxo-5alpha-lanost-8-en-26-oic acid	CHEMBL1922177		1 / 0 / 0		No. 55
C00030351	Ganoderenic acid D	CHEMBL1922179		1 / 0 / 0		No. 55
C00023849	Ganoderic acid U					No. 86	No. 51
C00023850	Ganoderic acid V					No. 86	No. 51
C00023854	Ganoderic acid Z	CHEMBL223317				No. 86	No. 51
C00045319	Ganoderic acid DM	CHEMBL1099224		1 / 3 / 4		No. 91
C00030693	Lucidumol B	CHEMBL1915762		2 / 1 / 0		No. 91
C00023874	Ganolucidic acid E / 15alpha-Hydroxy-3,11-dioxo-5alpha-lanosta-8,24E-dien-26-oic acid	CHEMBL2203593				No. 91
C00023873	(+)-Ganolucidic acid D / 15alpha,23-Dihydroxy-3,11-dioxo-5alpha-lanosta-8,24E-dien-26-oic acid					No. 91
C00030692	Lucidumol A / (+)-Lucidumol A	CHEMBL1917739		1 / 0 / 0		No. 91
C00033123	Lucialdehyde A	CHEMBL515080				No. 91
C00023869	Ganodermatriol		C050247			No. 91
C00023868	Ganodermadiol / 5alpha-Lanosta-7,9(11),24-triene-3beta,26-one	CHEMBL240972	C050246	3 / 4 / 4		No. 91
C00033124	Lucialdehyde B / (+)-Lucialdehyde B	CHEMBL463372				No. 91
C00023867	Ganodermanontriol / 24(S),25,26-Trihydroxy-5alpha-lanosta-7,9(11)-dien-3-one	CHEMBL1915763 CHEMBL1921821 CHEMBL1923792 CHEMBL1923793		3 / 1 / 0		No. 91
C00033125	Lucialdehyde C / (+)-Lucialdehyde C					No. 91
C00023862	Ganoderiol F	CHEMBL1915761		5 / 1 / 0		No. 91
C00023847	Ganoderic acid S / (22S,24E)-22-Acetoxy-3alpha-hydroxy-5alpha-lanosta-7,9(11),24-trien-26-oic acid	CHEMBL1097154				No. 91
C00023865	Ganoderiol I					No. 91
C00033850	Ganoderal A / (+)-Ganoderal A	CHEMBL463972				No. 91
C00033851	Ganoderal B / (+)-Ganoderal B					No. 91
C00023864	(+)-Ganoderiol H					No. 91
C00023863	Ganoderiol G					No. 91
C00023853	Ganoderic acid Y / 3beta-Hydroxy-5alpha-lanosta-7,9(11),24-trien-26-oic acid	CHEMBL1915760		2 / 1 / 0		No. 91
C00033852	Ganoderic aldehyde A / (+)-Ganoderic aldehyde A	CHEMBL490377				No. 91
C00023857	Ganoderiol A / (+)-Ganoderiol A / 5alpha-Lanosta-7,9(11)-diene-3beta,24,25,26-tetraol					No. 91
C00023858	Ganoderiol B / 15alpha,26,27-Trihydroxy-5alpha-lanosta-7,9(11),24-trien-3-one					No. 91
C00023859	Ganoderiol C					No. 91
C00023860	Ganoderiol D					No. 91
C00023861	Ganoderiol E					No. 91
C00023866	(+)-Ganodermanondiol / 24(S),25-Dihydroxy-5alpha-lanosta-7,9(11)-dien-3-one	CHEMBL1098479		2 / 1 / 0		No. 91
C00023754	5,6-Dehydroergosterol / Ergosta-7,22-dien-3beta-ol / 24-Methylcholesta-7,22-dien-3beta-ol	CHEMBL463973 CHEMBL560819				No. 111	No. 11
C00003652	Ergosterol / Ergosta-5,7,22-trien-3beta-ol	CHEMBL222608 CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225	D004875	12 / 14 / 11		No. 111	No. 11
C00023765	Ergosta-7,22-dien-3-one / (24S)24-Methylcholesta-7,22-dien-3-one	CHEMBL516711 CHEMBL1514671	C059439	1 / 0 / 1		No. 111	No. 11
C00003112	Cedrol / (+)-Cedrol / alpha-Cedrol	CHEMBL1592444 CHEMBL1974890	C078669	5 / 14 / 11		No. 161	No. 38
C00007423	Pentadecanoic acid / n-Pentadecanoic acid	CHEMBL460025		1 / 2 / 2		No. 184	No. 68
C00023836	(-)-Ganoderic acid Me / 3alpha,15alpha-Diacetoxy-5alpha-lanosta-7,9(11),24E-trien-26-oic acid					No. 268
C00023841	Ganoderic acid Mj / 22-Acetoxy-3alpha-hydroxy-7alpha-methoxy-5alpha-lanosta-8,24E-dien-26-oic acid					No. 268
C00023840	Ganoderic acid Mi / 3alpha-Acetoxy-7alpha-methoxy-5alpha-lanosta-8,24E-dien-26-oic acid					No. 268
C00023839	Ganoderic acid Mh / 3alpha,22-Diacetoxy-7alpha,15alpha-dihydroxy-5alpha-lanosta-8,24E-dien-26-oic acid					No. 268
C00023838	Ganoderic acid Mg / 3alpha,22-Diacetoxy-15alpha-hydroxy-7alpha-methoxy-5alpha-lanosta-8,24E-dien-26-oic acid					No. 268
C00023837	(+)-Ganoderic acid Mf / 3alpha-Acetoxy-15alpha-hydroxy-5alpha-lanosta-7,9(11),24E-trien-26-oic acid					No. 268
C00023842	Ganoderic acid Mk / 3alpha,22-Diacetoxy-15alpha-hydroxy-5alpha-lanosta-7,9(11),24E-dien-26-oic acid					No. 268
C00023835	(-)-Ganoderic acid Md / 3alpha,22-Diacetoxy-7alpha-methoxy-5alpha-lanosta-8,24E-dien-26-oic acid					No. 268
C00035103	Ganoderic acid Q					No. 268
C00023833	(-)-Ganoderic acid Mb / 3alpha,15alpha,22-Triacetoxy-7alpha-hydroxy-5alpha-lanosta-8,24E-dien-26-oic acid					No. 268
C00023832	(-)-Ganoderic acid Ma / 3alpha,7alpha-Diacetoxy-15alpha-hydroxy-5alpha-lanosta-8,24E-dien-26-oic acid					No. 268
C00023844	Ganoderic acid N / 7beta,20-Dihydroxy-3,11,15,23-tetraoxo-5alpha-lanost-8-en-26-oic acid	CHEMBL2205004		2 / 0 / 0		No. 268
C00023846	Ganoderic acid R / (22S,24E)-3alpha,22-Diacetoxy-5alpha-lanosta-7,9(11),24-trien-26-oic acid					No. 268
C00023848	Ganoderic acid T / (22S,24E)3alpha,15alpha,22-Triacetoxy-5alpha-lanosta-7,9(11),24-trien-26-oic acid	CHEMBL2205006				No. 268
C00035031	7-O-Methyl-ganoderic acid O					No. 268
C00035102	Ganoderic acid P					No. 268
C00023851	Ganoderic acid W					No. 268
C00023852	Ganoderic acid X	CHEMBL2205004		2 / 0 / 0		No. 268
C00023834	(-)-Ganoderic acid Mc / 3alpha,7alpha,22-Triacetoxy-15alpha-hydroxy-5alpha-lanosta-8,24E-dien-26-oic acid					No. 268
C00012508	Cuparene / (+)-Cuparene / (R)-Cuparene / (R)-1-Methyl-4-(1,2,2-trimethylcyclopentyl)-benzene					No. 309
C00003203	alpha-Ylangene					No. 333	No. 38
C00001224	Linoleic acid / (Z,Z)-9,12-Octadecadienoic acid	CHEMBL267476		29 / 31 / 28		No. 367	No. 68
C00003131	beta-Farnesene / (E)-beta-Farnesene / beta-trans-Farnesene		C062671			No. 404	No. 38
C00012602	Bazzanene / beta-Bazzanene / (+)-beta-Bazzanene / [R-(R*,S*)]-1,4-Dimethyl-4-(1-methyl-2-methylenecyclopentyl)cyclohexene					No. 451	No. 38
C00034861	Isobazzanene					No. 451	No. 38
C00011617	AR-Curcumene / (R)-(-)-alpha-Curcumene	CHEMBL469717				No. 456	No. 38
C00000805	alpha-Pinene	CHEMBL442565	C005451	3 / 3 / 2	0 / 1	No. 476	No. 35
C00000829	trans-Pinocarveol					No. 476	No. 35
C00007242	beta-Bisabolene / l-beta-Bisabolene / (-)-beta-Bisabolene	CHEMBL444389 CHEMBL1077088 CHEMBL2001434				No. 701	No. 38
C00029339	E-Nerolidol / (E)-Nerolidol / trans-Nerolidol	CHEMBL25424 CHEMBL508801 CHEMBL561014 CHEMBL1923157		3 / 3 / 1		No. 726	No. 38
C00007535	Phenylacetaldehyde / Benzeneacetaldehyde / Phenylacetic aldehyde		C013192		3 / 0	No. 885
C00010301	Coriandrol / (S)-Linalool / S-(+)-Linalool / (+)-S-Linalool / (S)-3,7-Dimethyl-1,6-octadien-3-ol	CHEMBL25306 CHEMBL235672		6 / 8 / 2		No. 958	No. 34
C00034888	-(-)-Linalool / (-)-R-Linalool	CHEMBL25306 CHEMBL235672		6 / 8 / 2		No. 958	No. 34
C00029674	alpha-Terpineol	CHEMBL447597 CHEMBL449810	C016775	3 / 16 / 11		No. 983	No. 35
C00001228	Myristic acid / Tetradecanoic acid / n-Tetradecanoic acid	CHEMBL111077	D019814	17 / 9 / 10	3 / 0	No. 1141	No. 68
C00030829	Pelargonic acid / n-Nonanoic acid	CHEMBL108436	C008776	4 / 4 / 2	3 / 1	No. 1141	No. 68
C00001221	Lauric acid / Docosanoic acid / n-Dodecanoic acid	CHEMBL108766	C030358	19 / 25 / 14	11 / 0	No. 1141	No. 68
C00001231	Caprylic acid / Octanoic acid / n-Octanoic acid	CHEMBL324846	C031492	10 / 14 / 13	2 / 1	No. 1141	No. 68
C00033822	Ergosta-7,22-dien-3beta-yl palmitate					No. 1152
C00034795	alpha-Thujone	CHEMBL1444078		2 / 3 / 2		No. 1161	No. 35
C00023766	Cerevisterol / (-)-Cerevisteri / Ergosta-7,22-diene-5alpha,6beta,7beta-triol / (22E)-Ergosta-7,22-diene-3beta,5alpha,6beta-triol	CHEMBL263108 CHEMBL491545 CHEMBL491546	C006954			No. 1193
C00020282	Drimenol / delta7(8)-15-Hydroxyiresane					No. 1202	No. 38
C00007636	delta-Cadinene	CHEMBL445759				No. 1524	No. 39
C00003035	Geranial / (E)-alpha-Citral	CHEMBL1080997		6 / 7 / 9		No. 1575	No. 34
C00030758	2-Undecanone / Methyl nonyl ketone					No. 1611
C00021903	alpha-trans-Bergamotene / trans-alpha-Bergamotene					No. 1653	No. 38
C00000807	(R)-(-)-Carvone	CHEMBL15676 CHEMBL501949		8 / 9 / 9		No. 1740	No. 35
C00010891	(S)-(+)-Carvone	CHEMBL15676 CHEMBL501949		8 / 9 / 9		No. 1740	No. 35
C00034882	Nonane / n-Nonane	CHEMBL335900	C017573	1 / 3 / 2	3 / 2	No. 1749
C00030830	Nonanol / n-Nonanol	CHEMBL24563	C014713		1 / 0	No. 1749
C00030804	n-Decanal		C021170		2 / 0	No. 1993
C00032442	Undecanal					No. 1993
C00030828	Nonanal / n-Nonanal		C008664		1 / 1	No. 1993
C00029330	(E)-2-Decenal	CHEMBL507518				No. 2140
C00010974	o-Cymol / 0-Isopropyltoluene / 1-Isopropyl-2-methylbenzene		C046257			No. 2172	No. 35
C00029341	(E,E)-2,4-Decadienal / 2-trans,4-trans-Decadienal	CHEMBL443949		8 / 12 / 42		No. 2201
C00010927	Terpinene-4-ol / (-)-Terpinene-4-ol / (R)-(-)-p-Menth-1-en-4-ol	CHEMBL507795		1 / 3 / 0		No. 2215
C00030200	Ergosterol peroxide / Ergosterol 5,8-peroxide / (-)-Ergosterol 5,8-peroxide / 5alpha,8alpha-Epidioxyergosta-6,22-dien-3beta-ol / (-)-5alpha,8alpha-Epidioxyergosta-6,22-dien-3beta-ol	CHEMBL434750 CHEMBL515808 CHEMBL1801968 CHEMBL1969254	C036071	1 / 0 / 0	1 / 4	No. 2300
C00034801	beta-Irone					No. 2480	No. 38
C00029334	(E)-Anethol / trans-Anethol / trans-1-(4-Methoxyphenyl)-1-propene	CHEMBL452630 CHEMBL1468832		6 / 21 / 49		No. 2748	No. 6
C00034802	Bisabolol oxide B					No. 2789
C00029316	(2E)-Octenal / (E)-2-Octenal / trans-Oct-2-en-1-al	CHEMBL448058				No. 2883
C00034763	2-Amylfuran / 2-Pentylfuran					No. 3145
C00023886	Lucidone A	CHEMBL2203600				No. 3165
C00023888	Lucidone C / 3beta,7beta,15alpha-Trihydroxy-4,4,14alpha-trimethyl-11,20-dioxo-5alpha-pregn-8-ene					No. 3165
C00023887	Lucidone B / 7beta-Hydroxy-4,4,14alpha-trimethyl-3,11,15,20-tetraoxo-5alpha-pregn-8-ene					No. 3165
C00034880	n-Heptanal	CHEMBL18104	C046204	2 / 3 / 2	1 / 0	No. 3593
C00001218	Caproic acid / Hexanoic acid / 1-Hexanoic acid / n-Hexanoic acid	CHEMBL14184	C037652	5 / 0 / 0		No. 3692	No. 68
C00021380	Daucene					No. 4056	No. 38
C00034775	6-Methyl-5-hepten-2-one	CHEMBL46340	C029750			No. 5297
C00000136	1,8-Cineole	CHEMBL485259 CHEMBL1397305		99 / 57 / 50		No. 5413	No. 35
C00034794	alpha-Pinene epoxide	CHEMBL274511	C053997			No. 7690	No. 35
C00045197	8beta,9alpha-Dihydroganoderic acid J / (+)-8beta,9alpha-Dihydroganoderic acid J					No. 8256

Human Protein / Gene in interactions

158 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P15121	Aldose reductase	Enzyme	C00001218 C00023820 C00023821 C00023822 C00023823 C00023826 C00023827 C00023829 C00023830 C00023871 C00024054 C00030351 C00045153	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00000136 C00023821 C00023824 C00023853 C00023862 C00023866 C00023867 C00023868 C00023870 C00023875 C00030693 C00043677	1 / 0
P06276	Cholinesterase	Hydrolase	C00023821 C00023824 C00023853 C00023862 C00023866 C00023867 C00023868 C00023870 C00023875 C00030693 C00043677	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000136 C00000805 C00001221 C00001224 C00001231 C00029334 C00029341 C00034795 C00034880 C00034882	3 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00000807 C00001221 C00001224 C00001231 C00003035 C00003112 C00003652 C00010891 C00029334 C00029341	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00000807 C00001221 C00003035 C00003112 C00010301 C00010891 C00029339 C00030829 C00034888	3 / 1
Q96RI1	Bile acid receptor	NR1H4	C00001221 C00001224 C00001228 C00023862 C00023867 C00030200 C00030692	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000136 C00001221 C00001228 C00010301 C00034795 C00034888	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001224 C00003112 C00003652 C00010301 C00029339 C00034888	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000136 C00001224 C00001231 C00003112 C00029334 C00029674	11 / 10
P10275	Androgen receptor	NR3C4	C00000136 C00001221 C00001224 C00003035 C00023868 C00045319	3 / 4
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00000805 C00000807 C00001221 C00010891 C00029341	0 / 0
O75496	Geminin	Unclassified protein	C00000136 C00001224 C00001228 C00001231 C00030829	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00001221 C00010301 C00010927 C00029674 C00034888	3 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000136 C00001224 C00003652 C00023765 C00029334	0 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000807 C00001228 C00010891 C00030829	1 / 1
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00003652 C00010301 C00029674 C00034888	5 / 1
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00001218 C00001221 C00001228 C00001231	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00001218 C00001221 C00001228 C00001231	0 / 0
Q9UGP5	DNA polymerase lambda	Enzyme	C00001218 C00001221 C00001224	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00023844 C00023852 C00023862	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000807 C00010891 C00029341	0 / 0
P03372	Estrogen receptor	NR3A1	C00000136 C00001221 C00001224	1 / 1
P11388	DNA topoisomerase 2-alpha	Isomerase	C00023844 C00023852 C00023862	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001224 C00003652 C00029339	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00001224 C00001228 C00007423	2 / 2
Q9UBT6	DNA polymerase kappa	Enzyme	C00001218 C00001221 C00001224	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00001228 C00003652 C00029341	2 / 3
P28482	Mitogen-activated protein kinase 1	Erk	C00000136 C00000805 C00003112	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00001221 C00001224	5 / 3
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001224 C00001228	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000807 C00010891	2 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00001221 C00001224	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000136 C00003652	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00000136 C00001221	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000136 C00001231	0 / 1
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00001224 C00001228	0 / 0
O00255	Menin	Unclassified protein	C00000807 C00010891	2 / 5
Q9Y4X1	UDP-glucuronosyltransferase 2A1	Enzyme	C00010301 C00034888	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001221 C00001228	0 / 0
O00519	Fatty-acid amide hydrolase 1	Enzyme	C00003035 C00034880	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000136 C00003652	0 / 1
P10145	Interleukin-8	Secreted protein	C00001221 C00029341	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00001224 C00029341	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000136 C00003652	4 / 3
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000136 C00003652	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00029334 C00029341	7 / 37
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000136 C00001224	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000807 C00010891	1 / 2
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001224 C00001228	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000136 C00003652	1 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00000136	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00000136	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00000136	1 / 1
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001228	0 / 0
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00000136	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00000136	1 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00000136	0 / 0
P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	C00023820	1 / 1
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00001228	2 / 2
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000136	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001228	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000136	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00000136	0 / 0
Q8TCC7	Solute carrier family 22 member 8	Antiporter	C00001231	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00000136	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00000136	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00000136	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00000136	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00000136	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000136	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000136	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00000136	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00000136	2 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00000136	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00000136	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000136	1 / 8
P32245	Melanocortin receptor 4	Melanocortin receptor	C00000136	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00000136	0 / 0
P08311	Cathepsin G	S1A	C00000136	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00000136	1 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00000136	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00000136	0 / 0
P03956	Interstitial collagenase	M10A	C00000136	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00000136	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00001221	7 / 3
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00000136	0 / 0
Q4U2R8	Solute carrier family 22 member 6	Antiporter	C00001231	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00001224	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000136	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00000136	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00000136	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00000136	0 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00000136	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000136	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00000136	2 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00000136	1 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00000136	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00000136	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00000136	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00000136	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00000136	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00000136	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00000136	0 / 0
P13726	Tissue factor	Membrane receptor	C00001224	0 / 0
P25021	Histamine H2 receptor	Histamine receptor	C00000136	0 / 0
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00000136	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00001224	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00000136	1 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000136	1 / 1
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00000136	2 / 1
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000136	0 / 1
P55055	Oxysterols receptor LXR-beta	NR1H3	C00000136	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001224	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00001224	2 / 2
P00918	Carbonic anhydrase 2	Lyase	C00000136	1 / 2
P05413	Fatty acid-binding protein, heart	Other cytosolic protein	C00001224	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00030829	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000136	2 / 2
P27361	Mitogen-activated protein kinase 3	Erk	C00000136	0 / 0
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000136	1 / 0
P17252	Protein kinase C alpha type	Alpha	C00000136	0 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00000136	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00000136	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000136	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00000136	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00000136	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00000136	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00000136	0 / 0
P29466	Caspase-1	C14	C00000136	0 / 0
Q05193	Dynamin-1	Structural	C00001228	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00000136	0 / 0
P15090	Fatty acid-binding protein, adipocyte	Other cytosolic protein	C00001224	0 / 0
O14842	Free fatty acid receptor 1	Free fatty acid receptor	C00001224	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000136	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00000136	0 / 0
P08246	Neutrophil elastase	S1A	C00000136	2 / 1
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000136	2 / 2
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00000136	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00000136	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00000136	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000136	0 / 3
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00000136	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00000136	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000136	0 / 1
P31939	Bifunctional purine biosynthesis protein PURH	Enzyme	C00003652	1 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00000136	0 / 0
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00023820	1 / 1
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000136	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00029334	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000136	0 / 0
Q7Z2W7	Transient receptor potential cation channel subfamily M member 8	Unclassified protein	C00000136	0 / 0
O60603	Toll-like receptor 2	Membrane receptor	C00001228	1 / 1
P35610	Sterol O-acyltransferase 1	Enzyme	C00001224	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00003035	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00003035	1 / 4
Q9NSA0	Solute carrier family 22 member 11	Transporter	C00001231	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00000136	0 / 0

20 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00001221 C00001228 C00001231 C00030829
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00030804 C00030828 C00034880
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001221 C00007535 C00034882
128	ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR	alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284)	C00001221 C00001231 C00030829
199974	CYP4Z1, CYP4A20	cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1)	C00001221 C00001228
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00001221 C00001228
217	ALDH2, ALDH-E2, ALDHI, ALDM	aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)	C00030804
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00030830
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00034882
5241	PGR, NR3C3, PR	progesterone receptor	C00034882
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00007535
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00001221
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00001221
1579	CYP4A11, CP4Y, CYP4A2, CYP4AII	cytochrome P450, family 4, subfamily A, polypeptide 11 (EC:1.14.15.3)	C00001221
1646	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	C00007535
64127	NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1	nucleotide-binding oligomerization domain containing 2	C00001221
942	CD86, B7-2, B7.2, B70, CD28LG2, LAB72	CD86 molecule	C00030829
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001221
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00001221
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00030200

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions