Neolitsea sericea
Species
KNApSAcK Entry
| Organism name | Neolitsea sericea |
|---|---|
| Genus | Neolitsea |
| Family | Lauraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Neolitsea sericea |
|---|---|
| Linked NCBI taxonomy ID | 128655 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lauraceae |
|---|---|
| ID | 3433 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (9)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00027433
|
Laurolitsine
/ (+)-Norboldine / (+)-Laurolitsine |
CHEMBL487388
|
C109133
|
No. 20 | No. 4 |
|
||
|
C00027281
|
Anonaine
|
CHEMBL401798
|
C098138
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00025625
|
Roemerine
/ (-)-Remerine / (-)-Aporheine / (-)-Roemerine |
CHEMBL36654
CHEMBL483825 |
C030169
|
23 / 10 / 13 | No. 20 | No. 4 |
|
|
|
C00001221
|
Lauric acid
/ Docosanoic acid / n-Dodecanoic acid |
CHEMBL108766
|
C030358
|
19 / 25 / 14 | 11 / 0 | No. 1141 | No. 68 |
|
|
C00012346
|
Sericenic acid
|
No. 1832 |
|
|||||
|
C00012349
|
Neosericenin
|
No. 1832 |
|
|||||
|
C00012347
|
Sericenin
|
No. 1832 |
|
|||||
|
C00012049
|
Sericealactone
|
No. 2358 |
|
|||||
|
C00012039
|
Isosericenin
|
No. 3193 |
|
Human Protein / Gene in interactions
41 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Enzyme | C00025625 C00027281 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001221 C00025625 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001221 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00025625 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00025625 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00025625 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001221 | 3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001221 | 3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001221 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00025625 | 1 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00001221 | 3 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001221 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00025625 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00025625 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00025625 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00025625 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00001221 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001221 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001221 | 7 / 3 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001221 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00001221 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001221 | 5 / 3 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001221 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00025625 | 1 / 1 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00001221 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00025625 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00001221 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001221 | 1 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001221 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00025625 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00025625 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00025625 | 0 / 0 |
| O14727 | Apoptotic protease-activating factor 1 | Unclassified protein | C00025625 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001221 | 3 / 4 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00025625 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00025625 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00025625 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00025625 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00025625 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00025625 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00025625 | 0 / 0 |
11 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 128 | ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR | alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) |
C00001221
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001221
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00001221
|
| 1579 | CYP4A11, CP4Y, CYP4A2, CYP4AII | cytochrome P450, family 4, subfamily A, polypeptide 11 (EC:1.14.15.3) |
C00001221
|
| 199974 | CYP4Z1, CYP4A20 | cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) |
C00001221
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001221
|
| 64127 | NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1 | nucleotide-binding oligomerization domain containing 2 |
C00001221
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001221
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001221
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001221
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00001221
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (35)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #218800 | Crigler-najjar syndrome, type i |
P22310
|
| #606785 | Crigler-najjar syndrome, type ii |
P22310
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #143500 | Gilbert syndrome |
P22310
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (27)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|