Rubia wallichiana DECNE
Species
KNApSAcK Entry
| Organism name | Rubia wallichiana DECNE |
|---|---|
| Genus | Rubia |
| Family | Rubiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Rubia |
|---|---|
| Linked NCBI taxonomy ID | 25473 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Rubiaceae |
|---|---|
| ID | 24966 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (23)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003558
|
Ursolic acid
|
CHEMBL297810
CHEMBL56048 CHEMBL300594 CHEMBL169 CHEMBL176234 CHEMBL491715 CHEMBL1316667 CHEMBL1555307 CHEMBL1593360 CHEMBL1979720 |
C005466
|
47 / 26 / 33 | 15 / 12 | No. 13 | No. 51 |
|
|
C00000659
|
Medioresinol
/ (+)-Medioresinol |
CHEMBL376507
CHEMBL513023 |
2 / 1 / 1 | No. 38 | No. 21 |
|
||
|
C00002857
|
Purpurin
|
CHEMBL294264
|
C410870
|
33 / 27 / 26 | 5 / 0 | No. 41 | No. 62 |
|
|
C00031527
|
Xanthopurpurin 3-methyl ether
/ 1-Hydroxy-3-methoxyanthraquinone |
No. 41 | No. 62 |
|
||||
|
C00002786
|
Alizarin 2-methyl ether
/ 1-Hydroxy-2-methoxyanthraquinone |
CHEMBL451977
|
6 / 9 / 11 | No. 41 | No. 62 |
|
||
|
C00002838
|
Lucidin
|
C039315
|
No. 41 | No. 62 |
|
|||
|
C00002839
|
1,3-Dihydroxy-2-methoxymethylanthraquinone
|
CHEMBL485454
|
No. 41 | No. 62 |
|
|||
|
C00031546
|
6-Hydroxyrubiadin
/ 1,3,6-Trihydroxy-2-methylanthraquinone / 2-Methyl-1,3,6-trihydroxyanthraquinone / 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone |
CHEMBL251491
|
No. 41 | No. 62 |
|
|||
|
C00002862
|
Rubiadin
/ 1,3-Dihydroxy-2-methyl-9,10-anthraquinone |
CHEMBL251251
|
C072500
|
No. 41 | No. 62 |
|
||
|
C00032078
|
Nordamnacanthal
|
No. 41 | No. 62 |
|
||||
|
C00031526
|
1-Hydroxy-2-methylanthraquinone
/ 1-Hydroxy-2-methyl-9,10-anthraquinone |
CHEMBL42302
|
2 / 2 / 1 | No. 41 | No. 62 |
|
||
|
C00031247
|
Rubiawallin C
|
CHEMBL1443601
|
17 / 23 / 44 | No. 41 | No. 62 |
|
||
|
C00031525
|
Lucidin 3-methyl ether
/ 1-Hydroxy-2-hydroxymethyl-3-methoxyanthraquinone / 1-Hydroxy-2-(hydroxymethyl)-3-methoxyanthraquinone |
No. 41 | No. 62 |
|
||||
|
C00031245
|
Rubiawallin A
|
No. 41 | No. 62 |
|
||||
|
C00031246
|
Rubiawallin B
|
No. 41 | No. 62 |
|
||||
|
C00032518
|
Xanthopurpurin
|
CHEMBL372711
|
2 / 0 / 7 | No. 41 | No. 62 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00002499
|
Scopoletin
|
CHEMBL71851
|
D012603
|
48 / 37 / 34 | 9 / 0 | No. 864 | No. 25 |
|
|
C00002498
|
Scoparone
/ 6,7-Dimethoxycoumarin / Aesculetin dimethyl ether |
CHEMBL325864
|
C018145
|
4 / 2 / 2 | 6 / 0 | No. 864 | No. 25 |
|
|
C00001221
|
Lauric acid
/ Docosanoic acid / n-Dodecanoic acid |
CHEMBL108766
|
C030358
|
19 / 25 / 14 | 11 / 0 | No. 1141 | No. 68 |
|
|
C00031985
|
Ophiohayatone B
/ (-)-Ophiohayatone B / Lucidin 3-O-primeveroside / (-)-Lucidin 3-O-beta-primeveroside |
CHEMBL521217
|
C064334
|
No. 1320 | No. 62 |
|
||
|
C00031232
|
Rubiadin primeveroside
|
No. 1320 | No. 62 |
|
Human Protein / Gene in interactions
133 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000659 C00002499 C00002857 C00003558 C00003672 | 0 / 1 |
| O00255 | Menin | Unclassified protein | C00002499 C00002786 C00002857 C00003558 | 2 / 5 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000659 C00002499 C00003558 C00003672 | 1 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002499 C00002786 C00002857 C00003558 | 1 / 2 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002499 C00002857 C00031247 | 1 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00002499 C00003558 C00003672 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002857 C00003558 C00031247 | 1 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002499 C00002857 C00003558 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002499 C00003558 C00003672 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001221 C00002857 C00003558 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002499 C00003558 C00003672 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002499 C00002857 C00003558 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002786 C00002857 C00031247 | 4 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001221 C00002499 C00002857 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003558 C00003672 C00023774 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002499 C00002857 C00031247 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002499 C00003558 C00003672 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003558 C00003672 | 1 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002857 C00003558 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002857 C00031247 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002857 C00031247 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001221 C00002857 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002499 C00002857 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002499 C00003558 | 0 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00001221 C00003672 | 1 / 1 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00001221 C00002499 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002499 C00002857 | 2 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002499 C00002857 | 3 / 3 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003558 C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001221 C00003672 | 3 / 2 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002499 C00031247 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001221 C00003558 | 3 / 1 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001221 C00003558 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002857 C00003558 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002857 C00003672 | 1 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00001221 C00002499 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00002499 C00003558 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001221 C00002499 | 7 / 3 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002857 C00003558 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002786 C00031247 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001221 C00031247 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003558 C00003672 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00001221 C00002499 | 3 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002499 C00003558 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002857 C00031247 | 4 / 2 |
| O75496 | Geminin | Unclassified protein | C00002499 C00031247 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00002857 C00031247 | 1 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002499 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002857 | 0 / 0 |
| Q9UQL6 | Histone deacetylase 5 | Hydrolase | C00003558 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002499 | 1 / 2 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002786 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002499 | 0 / 0 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00003558 | 1 / 1 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002499 | 0 / 0 |
| P50281 | Matrix metalloproteinase-14 | M10A | C00002857 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00001221 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002499 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00003558 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00031526 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002857 | 2 / 3 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001221 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002857 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002857 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002498 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002499 | 1 / 2 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00003558 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001221 | 5 / 3 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002499 | 1 / 1 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002857 | 2 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001221 | 0 / 0 |
| O15379 | Histone deacetylase 3 | Hydrolase | C00003558 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002857 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00002498 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002499 | 1 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002499 | 0 / 1 |
| P55789 | FAD-linked sulfhydryl oxidase ALR | Enzyme | C00002499 | 1 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003558 | 11 / 10 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002786 | 1 / 1 |
| O75030 | Microphthalmia-associated transcription factor | Unclassified protein | C00031247 | 4 / 4 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00001221 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00031247 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003558 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002499 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003558 | 0 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002499 | 1 / 0 |
| P56524 | Histone deacetylase 4 | Hydrolase | C00003558 | 1 / 1 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002499 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003558 | 0 / 0 |
| P30305 | M-phase inducer phosphatase 2 | Ser_Thr_Tyr | C00003558 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002857 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002499 | 0 / 0 |
| P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00003558 | 0 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00002499 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001221 | 0 / 0 |
| Q13547 | Histone deacetylase 1 | Hydrolase | C00003558 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002499 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002499 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002499 | 5 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002499 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00031247 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001221 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003558 | 0 / 0 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00003558 | 0 / 1 |
| Q9UBN7 | Histone deacetylase 6 | Hydrolase | C00003558 | 0 / 0 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00003558 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002499 | 1 / 1 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00032518 | 0 / 7 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002499 | 6 / 4 |
| P08246 | Neutrophil elastase | S1A | C00031526 | 2 / 1 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002499 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00003558 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00031247 | 0 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | C00002499 | 1 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00032518 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00003558 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00003558 | 1 / 4 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00002498 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002498 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00031247 | 7 / 37 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002857 | 2 / 1 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00002857 | 1 / 2 |
43 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001221
C00002498
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00001221
C00002499
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00001221
C00002857
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001221
C00002498
|
| 128 | ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR | alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) |
C00001221
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003558
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00003558
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00003558
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00003558
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00003558
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00003558
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00003558
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00003558
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00003558
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00003558
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002498
|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00003558
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00002498
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002498
|
| 5966 | REL, C-Rel | v-rel avian reticuloendotheliosis viral oncogene homolog |
C00002498
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003558
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003558
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001221
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003558
|
| 1579 | CYP4A11, CP4Y, CYP4A2, CYP4AII | cytochrome P450, family 4, subfamily A, polypeptide 11 (EC:1.14.15.3) |
C00001221
|
| 199974 | CYP4Z1, CYP4A20 | cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) |
C00001221
|
| 64127 | NOD2, ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1 | nucleotide-binding oligomerization domain containing 2 |
C00001221
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001221
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001221
|
| 578 | BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 | BCL2-antagonist/killer 1 |
C00003558
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002857
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002857
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00002857
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002857
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002499
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002499
|
| 54578 | UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F | UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) |
C00002499
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002499
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002499
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002499
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002499
|
| 7508 | XPC, RAD4, XP3, XPCC | xeroderma pigmentosum, complementation group C |
C00002499
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (112)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
O75030
P14679 |
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| %606641 | Body mass index; bmi |
P37231
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #600430 | Brachydactyly-mental retardation syndrome; bdmr |
P56524
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
Q14191 |
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #614456 | Melanoma, cutaneous malignant, susceptibility to, 8; cmm8 |
O75030
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #613076 | Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay |
P55789
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #103500 | Tietz syndrome |
O75030
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #193510 | Waardenburg syndrome, type 2a; ws2a |
O75030
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (112)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00038 | Malignant melanoma |
O75030
(related)
O75030 (marker) P04637 (related) P14679 (marker) |
| H00169 | Ocular albinism |
O75030
(related)
|
| H00759 | Waardenburg syndrome (WS) |
O75030
(related)
|
| H01187 | Tietz syndrome |
O75030
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P10415 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
P10415 (related) |
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
P10415 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
P10415 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
P10415 (related) |
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
P11308 (related) |
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00561 | Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome |
P56524
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
12 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001284 | Atrophy |
C00003558
|
| D006528 | Carcinoma, Hepatocellular |
C00003558
|
| D002471 | Cell Transformation, Neoplastic |
C00003558
|
| D003921 | Diabetes Mellitus, Experimental |
C00003558
|
| D006943 | Hyperglycemia |
C00003558
|
| D006949 | Hyperlipidemias |
C00003558
|
| D006965 | Hyperplasia |
C00003558
|
| D007249 | Inflammation |
C00003558
|
| D008103 | Liver Cirrhosis |
C00003558
|
| D017202 | Myocardial Ischemia |
C00003558
|
| D009369 | Neoplasms |
C00003558
|
| D012878 | Skin Neoplasms |
C00003558
|