| Organism name | Calophyllum inophyllum |
|---|---|
| Genus | Calophyllum |
| Family | Calophyllaceae / Clusiaceae / Clusiaceae-Guttiferae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Calophyllum inophyllum |
|---|---|
| Linked NCBI taxonomy ID | 158927 |
| Linked level | species |
| Family in NCBI taxonomy | Calophyllaceae |
|---|---|
| ID | 703253 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | rosids |
|---|---|
| ID | 71275 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00007247
|
Linolenic acid
/ alpha-Linolenic acid / (Z,Z,Z)-Octadeca-9,12,15-trienoic acid |
D017962
|
22 / 5 |
|
||||
|
C00005732
|
Myricetin 7-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00036393
|
1,7-Dihydroxy-3,6-dimethoxyxanthone
|
No. 3 | No. 15 |
|
||||
|
C00037329
|
Isogentiakochianin
/ 1,3,8-Trihydroxy-7-methoxyxanthone |
No. 3 | No. 15 |
|
||||
|
C00002964
|
Mesuaxanthone A
|
CHEMBL363747
|
1 / 1 / 1 | No. 3 | No. 15 |
|
||
|
C00036378
|
Haploxanthone
/ 1,3,7-Trihydroxy-8-methoxyxanthone |
No. 3 | No. 15 |
|
||||
|
C00002944
|
Calophyllin B
|
No. 15 | No. 15 |
|
||||
|
C00031483
|
1,3,5,6-Tetrahydroxy-2-prenylxanthone
/ 1,3,5,6-Tetrahydroxy-2-(3-methylbut-2-enyl)xanthone |
No. 15 | No. 15 |
|
||||
|
C00035818
|
Caloxanthone A
|
No. 18 | No. 15 |
|
||||
|
C00035841
|
Inoxanthone
|
No. 18 | No. 15 |
|
||||
|
C00002961
|
Macluraxanthone
/ 3-Hydroxyblancoxanthone |
CHEMBL478960
|
5 / 11 / 11 | No. 18 | No. 15 |
|
||
|
C00036862
|
Caloxanthone D
|
No. 18 | No. 15 |
|
||||
|
C00002959
|
Jacareubin
|
CHEMBL1254294
|
No. 24 | No. 15 |
|
|||
|
C00002945
|
Dehydrocycloguanandin
|
No. 24 | No. 15 |
|
||||
|
C00002947
|
6-Deoxyjacareubin
|
CHEMBL457949
|
No. 24 | No. 15 |
|
|||
|
C00001015
|
Amentoflavone
|
CHEMBL63354
|
C011164
|
50 / 39 / 29 | 5 / 0 | No. 34 | No. 18 |
|
|
C00006507
|
Pyranoamentoflavone
|
No. 34 | No. 18 |
|
||||
|
C00035819
|
Caloxanthone B
/ (+)-Caloxanthone B |
No. 47 | No. 15 |
|
||||
|
C00029364
|
Euxanthone
/ 1,7-Dihydroxyxanthone |
CHEMBL389166
|
C404221
|
1 / 0 / 0 | No. 76 | No. 15 |
|
|
|
C00033518
|
1,5-Dihydroxyxanthone
|
CHEMBL185686
|
1 / 1 / 1 | No. 76 | No. 15 |
|
||
|
C00003747
|
Friedelin
/ Friedeline / Friedelanone / (-)-Friedelin / Friedelan-3-one |
CHEMBL485998
CHEMBL1551590 |
C060796
|
2 / 0 / 0 | No. 101 | No. 52 |
|
|
|
C00001238
|
Stearic acid
|
CHEMBL46403
|
C031183
|
15 / 17 / 19 | 6 / 1 | No. 184 | No. 68 |
|
|
C00035628
|
Gondoic acid
|
No. 184 | No. 68 |
|
||||
|
C00001217
|
Erucic acid
/ cis-13-Docosenoic acid |
CHEMBL1173380
|
4 / 3 / 4 | No. 184 | No. 68 |
|
||
|
C00001233
|
Palmitic acid
|
CHEMBL82293
|
D019308
|
16 / 8 / 8 | 35 / 1 | No. 184 | No. 68 |
|
|
C00001209
|
Arachidic acid
/ Eicosanoic acid |
CHEMBL1173381
|
C094477
|
No. 184 | No. 68 |
|
||
|
C00001230
|
Nervonic acid
|
C013147
|
No. 184 | No. 68 |
|
|||
|
C00001232
|
Oleic acid
/ (Z)-9-Octadecenoic acid |
CHEMBL8659
CHEMBL460657 |
D019301
|
30 / 19 / 20 | 26 / 9 | No. 184 | No. 68 |
|
|
C00029354
|
Palmitoleic acid
/ cis-Palmitoleic acid / (Z)-Palmitoleic acid |
CHEMBL453509
|
2 / 5 / 3 | No. 184 | No. 68 |
|
||
|
C00010217
|
Calaustralin
|
No. 266 | No. 17 |
|
||||
|
C00001224
|
Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid |
CHEMBL267476
|
29 / 31 / 28 | No. 367 | No. 68 |
|
||
|
C00002455
|
Calophyllolide
|
C018859
|
No. 464 | No. 17 |
|
|||
|
C00010213
|
Inophyllum E
/ cis-and-trans-Inophyllolide |
CHEMBL334946
CHEMBL336955 |
No. 464 | No. 17 |
|
|||
|
C00035840
|
Inophyllum C
|
CHEMBL334946
CHEMBL336955 |
No. 464 | No. 17 |
|
|||
|
C00010214
|
Inophyllolide chromanol
|
CHEMBL337029
CHEMBL132692 CHEMBL341394 CHEMBL422798 CHEMBL192847 CHEMBL466773 |
2 / 0 / 0 | No. 464 | No. 17 |
|
||
|
C00001211
|
Behenic acid
|
CHEMBL1173474
|
C007547
|
No. 1100 | No. 68 |
|
||
|
C00001223
|
Lignoceric acid
|
CHEMBL1173620
|
C010210
|
1 / 0 | No. 1100 | No. 68 |
|
|
|
C00001228
|
Myristic acid
/ Tetradecanoic acid / n-Tetradecanoic acid |
CHEMBL111077
|
D019814
|
17 / 9 / 10 | 3 / 0 | No. 1141 | No. 68 |
|
|
C00041014
|
Isoinophynone
|
No. 1383 |
|
|||||
|
C00041013
|
Inophynone
/ (+)-Inophynone |
No. 1383 |
|
|||||
|
C00010269
|
Calophyllic acid
|
CHEMBL134236
CHEMBL132827 |
No. 1383 |
|
||||
|
C00035812
|
Brasiliensic acid
|
No. 3088 |
|
|||||
|
C00035839
|
Inophylloidic acid
|
No. 3088 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001015 C00001217 C00001224 C00001232 C00001238 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001224 C00001228 C00001232 C00001233 C00003747 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001224 C00001228 C00001232 C00001233 C00001238 | 2 / 2 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001217 C00001224 C00001228 C00001232 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001217 C00001224 C00001228 C00001238 | 1 / 1 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001224 C00001228 C00001232 C00001233 | 0 / 0 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00001224 C00001232 C00001233 C00001238 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001224 C00001228 C00001232 C00001233 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001015 C00001232 C00001238 C00002961 | 1 / 2 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001224 C00001232 C00001238 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001015 C00001232 C00002961 | 4 / 3 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001217 C00001228 C00001238 | 2 / 3 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00001224 C00001232 C00001233 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001224 C00001232 C00001233 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001224 C00001232 C00001238 | 3 / 3 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00001224 C00001232 C00029364 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001015 C00001238 C00002961 | 2 / 5 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001224 C00001232 C00029354 | 5 / 3 |
| P13726 | Tissue factor | Membrane receptor | C00001224 C00001232 C00029354 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001015 C00001238 | 3 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002964 C00033518 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001224 C00001238 | 3 / 2 |
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | C00001232 C00001233 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001233 C00001238 | 0 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001015 C00001224 | 2 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001228 C00001232 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001015 C00001228 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001224 C00001233 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001224 C00001238 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001015 C00001232 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001015 C00001228 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001232 C00001238 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001224 C00001233 | 3 / 4 |
| O60603 | Toll-like receptor 2 | Membrane receptor | C00001228 C00001233 | 1 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001015 C00001224 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001015 C00001228 | 2 / 2 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00001232 C00001233 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001228 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001015 | 2 / 0 |
| P47712 | Cytosolic phospholipase A2 | Enzyme | C00001015 | 0 / 0 |
| P43235 | Cathepsin K | C1A | C00001015 | 1 / 2 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001015 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001015 | 0 / 0 |
| P12104 | Fatty acid-binding protein, intestinal | Other cytosolic protein | C00001233 | 0 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00001232 | 0 / 0 |
| P14555 | Phospholipase A2, membrane associated | Enzyme | C00001015 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001015 | 7 / 3 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001015 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001015 | 1 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001224 | 0 / 0 |
| P49763 | Placenta growth factor | Unclassified protein | C00001015 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001232 | 1 / 2 |
| O15496 | Group 10 secretory phospholipase A2 | Enzyme | C00001015 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00001233 | 1 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00001224 | 0 / 0 |
| P15692 | Vascular endothelial growth factor A | Secreted protein | C00001015 | 1 / 2 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001224 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00001233 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00001224 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00001015 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00001015 | 1 / 3 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001224 | 11 / 10 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003747 | 0 / 0 |
| P07148 | Fatty acid-binding protein, liver | Unclassified protein | C00001232 | 0 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00001232 | 1 / 4 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00001232 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001232 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00001228 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001015 | 0 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00010214 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001015 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001015 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001238 | 0 / 0 |
| P19174 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Enzyme | C00001015 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001224 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001224 | 0 / 1 |
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | C00001224 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001015 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001232 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001232 | 0 / 0 |
| Q05193 | Dynamin-1 | Structural | C00001228 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00010214 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001232 | 2 / 2 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00001228 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002961 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002961 | 4 / 1 |
| P55072 | Transitional endoplasmic reticulum ATPase | Unclassified protein | C00001015 | 2 / 1 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00001015 | 0 / 0 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001015 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001015 | 1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001015 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001015 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001015 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001015 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001015 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001015 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001015 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001015 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001015 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001015 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001015 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001015 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001015 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001015 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001015 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001015 | 2 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001228 | 1 / 1 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001228
C00001232
C00001233
C00001238
C00007247 |
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00001223
C00001232
C00001233
C00001238
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001228
C00001233
C00001238
|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00001232
C00001233
C00001238
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001232
C00001233
C00001238
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001232
C00001233
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00001015
C00007247
|
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 |
C00001233
C00001238
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00001015
C00001233
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00001232
C00001233
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001232
C00001233
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00001232
C00001233
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00001233
C00007247
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00001232
C00007247
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00001232
C00007247
|
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00001232
C00007247
|
| 100136658 |
C00001232
C00007247
|
||
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00001233
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00007247
|
| 3992 | FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12 | fatty acid desaturase 1 (EC:1.14.19.-) |
C00007247
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00007247
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00007247
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00007247
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00007247
|
| 3827 | KNG1, BDK, BK, KNG | kininogen 1 |
C00007247
|
| 9971 | NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 | nuclear receptor subfamily 1, group H, member 4 |
C00007247
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00007247
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00007247
|
| 1591 | CYP24A1, CP24, CYP24, HCAI, P450-CC24 | cytochrome P450, family 24, subfamily A, polypeptide 1 (EC:1.14.13.126) |
C00007247
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00007247
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00007247
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00001232
|
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 |
C00001232
|
| 8647 | ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
C00007247
|
| 335 | APOA1 | apolipoprotein A-I |
C00001232
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00001232
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00001232
|
| 1401 | CRP, PTX1 | C-reactive protein, pentraxin-related |
C00001232
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00001232
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00001015
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00001232
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001232
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00001232
|
| 778733 |
C00001232
|
||
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00001232
|
| 1638 | DCT, TRP-2, TYRP2 | dopachrome tautomerase (EC:5.3.3.12) |
C00001015
|
| 6514 | SLC2A2, GLUT2 | solute carrier family 2 (facilitated glucose transporter), member 2 |
C00001232
|
| 6720 | SREBF1, SREBP-1c, SREBP1, bHLHd1 | sterol regulatory element binding transcription factor 1 |
C00001232
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001015
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00001233
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001233
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001233
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001233
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00001233
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00007247
|
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) |
C00001233
|
| 57817 | HAMP, HEPC, HFE2B, LEAP1, PLTR | hepcidin antimicrobial peptide |
C00001233
|
| 3481 | IGF2, C11orf43, IGF-II, PP9974 | insulin-like growth factor 2 (somatomedin A) |
C00001233
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00001233
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00001233
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00001233
|
| 4493 | MT1E, MT1, MTD | metallothionein 1E |
C00001233
|
| 4494 | MT1F, MT1 | metallothionein 1F |
C00001233
|
| 4496 | MT1H, MT-0, MT-1H, MT-IH, MT1 | metallothionein 1H |
C00001233
|
| 4501 | MT1X, MT-1l, MT1 | metallothionein 1X |
C00001233
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00001233
|
| 3651 | PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 | pancreatic and duodenal homeobox 1 |
C00001233
|
| 29893 | PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP | PSMC3 interacting protein |
C00001233
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001233
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00001233
|
| 23216 | TBC1D1, TBC, TBC1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 |
C00001233
|
| 7351 | UCP2, BMIQ4, SLC25A8, UCPH | uncoupling protein 2 (mitochondrial, proton carrier) |
C00001233
|
| 199974 | CYP4Z1, CYP4A20 | cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) |
C00001228
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103780 | Alcohol dependence |
P47869
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613954 | Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 |
P55072
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #167320 | Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 |
P55072
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #246300 | Leprosy, susceptibility to, 3; lprs3 |
O60603
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #603933 | Microvascular complications of diabetes, susceptibility to, 1; mvcd1 |
P15692
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #265800 | Pycnodysostosis |
P43235
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00344 | Leprosy |
O60603
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00025 | Penile cancer |
P08253
(related)
|
| H00028 | Choriocarcinoma |
P08253
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
P55072 (related) |
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00018 | Gastric cancer |
P15692
(related)
|
| H00021 | Renal cell carcinoma |
P15692
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00273 | Pycnodysostosis |
P43235
(related)
|
| H00425 | Lysosomal cysteine protease deficiencies |
P43235
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
Q13315 (related) |
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003072 | Cognition Disorders |
C00001238
C00001232 C00001233 |
| D000860 | Anoxia |
C00001232
|
| D003866 | Depressive Disorder |
C00007247
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00007247
|
| D007249 | Inflammation |
C00007247
|
| D009422 | Nervous System Diseases |
C00007247
|
| D055371 | Acute Lung Injury |
C00001232
|
| D001930 | Brain Injuries |
C00007247
|
| D005234 | Fatty Liver |
C00001232
|
| D006520 | Hepatitis, Animal |
C00001232
|
| D007333 | Insulin Resistance |
C00001232
|
| D055370 | Lung Injury |
C00001232
|
| D011654 | Pulmonary Edema |
C00001232
|
| D012128 | Respiratory Distress Syndrome, Adult |
C00001232
|