Species

KNApSAcK Entry

Organism name Houttuynia emeiensis
Genus Houttuynia
Family Saururaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Houttuynia
Linked NCBI taxonomy ID 16751
Linked level genus

Family

Family in NCBI taxonomy Saururaceae
ID 16748

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (42)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003130 External link 512 alpha.-Farnesene
/ trans-alpha-Farnesene
/ (E,E)-alpha-Farnesene
C062672
No. 404 No. 38
C00003131 External link 512 beta-Farnesene
/ (E)-beta-Farnesene
/ beta-trans-Farnesene
C062671
No. 404 No. 38
C00000805 External link 512 alpha-Pinene
CHEMBL442565
C005451
3 / 3 / 2 0 / 1 No. 476 No. 35
C00000816 External link 512 beta-Pinene
CHEMBL501351
C010789
No. 476 No. 35
C00003110 External link 512 Caryophyllene
/ (E)-Caryophyllene
/ beta-Caryophyllene
/ (-)-(E)-Caryophyllene
/ (E)-beta-Caryophyllene
CHEMBL445740
CHEMBL448700
2 / 3 / 7 No. 478 No. 38
C00032308 External link 512 Tetradecanal
C019102
No. 599
C00029339 External link 512 E-Nerolidol
/ (E)-Nerolidol
/ trans-Nerolidol
CHEMBL25424
CHEMBL508801
CHEMBL561014
CHEMBL1923157
3 / 3 / 1 No. 726 No. 38
C00030224 External link 512 Ethyl tridecanoate
No. 793
C00010868 External link 512 D-Limonene
/ (+)-S-Carvone
/ d-(+)-Limonene
CHEMBL15799
CHEMBL449062
7 / 21 / 48 No. 848 No. 35
C00030152 External link 512 Dodecanol
/ 1-Dodecanol
CHEMBL24722
D007851
No. 877
C00030100 External link 512 Decanol
/ 1-Decanol
/ n-Decanol
CHEMBL25363
C029383
1 / 0 / 0 1 / 0 No. 877
C00030153 External link 512 Dodecene
/ n-Dodecene
CHEMBL30959
1 / 0 / 0 No. 877
C00000156 External link 512 Carvacrol
CHEMBL281202
C073316
10 / 6 / 1 4 / 2 No. 969 No. 35
C00029674 External link 512 alpha-Terpineol
CHEMBL447597
CHEMBL449810
C016775
3 / 16 / 11 No. 983 No. 35
C00001228 External link 512 Myristic acid
/ Tetradecanoic acid
/ n-Tetradecanoic acid
CHEMBL111077
D019814
17 / 9 / 10 3 / 0 No. 1141 No. 68
C00001213 External link 512 Capric acid
/ Decanoic acid
/ n-Decanoic acid
CHEMBL107498
C031071
8 / 11 / 6 4 / 0 No. 1141 No. 68
C00030758 External link 512 2-Undecanone
/ Methyl nonyl ketone
No. 1611
C00029545 External link 512 4-Tridecanone
CHEMBL1922860
No. 1611
C00029455 External link 512 2-Dodecanone
No. 1611
C00000862 External link 512 trans-beta-Ocimene
No. 1698 No. 34
C00000843 External link 512 cis-beta-Ocimene
No. 1698 No. 34
C00030830 External link 512 Nonanol
/ n-Nonanol
CHEMBL24563
C014713
1 / 0 No. 1749
C00030644 External link 512 Lauraldehyde
No. 1993
C00030804 External link 512 n-Decanal
C021170
2 / 0 No. 1993
C00032442 External link 512 Undecanal
No. 1993
C00032377 External link 512 trans-Pinocarvyl acetate
No. 2017
C00030810 External link 512 Neodihydrocarveol
No. 2058 No. 35
C00029344 External link 512 (Z)-2-Nonen-1-ol
No. 2140
C00003046 External link 512 Geranyl acetate
/ trans-Geranyl acetate
/ Acetic acid geraniol ester
CHEMBL1369384
5 / 3 / 4 No. 2157 No. 34
C00029544 External link 512 4-Terpineol
/ Terpin-4-ol
/ Terpineol-4
/ Terpinen-4-ol
CHEMBL507795
C034019
1 / 3 / 0 No. 2215
C00029524 External link 512 4-Carene
CHEMBL326172
CHEMBL2007486
No. 2246
C00000853 External link 512 Myrcene
CHEMBL455491
C008574
3 / 3 / 3 No. 2285 No. 34
C00003061 External link 512 gamma-Terpinene
/ 1-Methyl-4-(1-methylethyl)-1,4-cyclohexadiene
CHEMBL449693
C018669
No. 2468 No. 35
C00003060 External link 512 alpha-Terpinene
No. 2468 No. 35
C00029453 External link 512 2-Decanol
/ 2-Hydroxydecane
CHEMBL46477
No. 2473
C00029452 External link 512 2-Carene
No. 2690 No. 35
C00029844 External link 512 Bornyl acetate
CHEMBL1439452
C071528
4 / 1 / 4 No. 4140 No. 35
C00010344 External link 512 Perillene
/ 3-(4-Methyl-3-pentenyl)furan
C090823
No. 5618
C00029506 External link 512 3-Methyleneundecane
/ 3-Methylene-undecane
No. 5852
C00029590 External link 512 7-Methoxy-3,7-dimethyl-octanal
No. 7426
C00029517 External link 512 4,4,6,6-Tetramethyl-bicyclo[3.1.0]hex-2-ene
No. 7602
C00029668 External link 512 alpha-Cyclogeraniol acetate
No. 8279

Human Protein / Gene in interactions

46 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000156 C00001213 C00029544 C00029674 3 / 0
Q96RI1 Bile acid receptor NR1H4 C00000853 C00001228 C00003046 C00030100 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000805 C00000853 C00001213 3 / 2
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000156 C00001213 C00001228 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000156 C00001213 C00001228 0 / 0
P02545 Prelamin-A/C Unclassified protein C00010868 C00029674 11 / 10
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000156 C00029674 5 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00003046 C00029339 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003046 C00010868 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00010868 C00029339 3 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000805 C00001213 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00029844 C00030153 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000853 C00001213 0 / 1
O75496 Geminin Unclassified protein C00001213 C00001228 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001228 C00029844 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00029339 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001228 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003046 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001228 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000156 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000156 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001228 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001228 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001228 2 / 2
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000156 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001228 2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001213 5 / 3
P11473 Vitamin D3 receptor NR1I1 C00001228 2 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00000805 0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00000156 1 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00010868 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00010868 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00000156 0 / 0
Q05193 Dynamin-1 Structural C00001228 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00010868 0 / 3
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000156 0 / 0
O60603 Toll-like receptor 2 Membrane receptor C00001228 1 / 1
P10275 Androgen receptor NR3C4 C00003046 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001228 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00010868 7 / 37
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001228 1 / 1
O00255 Menin Unclassified protein C00003110 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003110 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00029844 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00029844 1 / 4
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001228 1 / 1

14 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00001213 C00001228
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00001213
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) C00030804
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00030100
128 ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) C00001213
9076 CLDN1, CLD1, ILVASC, SEMP1 claudin 1 C00001213
9970 NR1I3, CAR, CAR1, MB67 nuclear receptor subfamily 1, group I, member 3 C00030830
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) C00030804
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000156
8989 TRPA1, ANKTM1, FEPS transient receptor potential cation channel, subfamily A, member 1 C00000156
162514 TRPV3, OLMS, VRL3 transient receptor potential cation channel, subfamily V, member 3 C00000156
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000156
199974 CYP4Z1, CYP4A20 cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) C00001228
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001228

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (51)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#133239 Esophageal cancer P04637
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#246300 Leprosy, susceptibility to, 3; lprs3 O60603
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (74)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00344 Leprosy O60603 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003877 Dermatitis, Contact C00000805
D003866 Depressive Disorder C00000156
D010146 Pain C00000156