Isatis tinctoria
Species
KNApSAcK Entry
| Organism name | Isatis tinctoria |
|---|---|
| Genus | Isatis |
| Family | Cruciferae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Isatis tinctoria |
|---|---|
| Linked NCBI taxonomy ID | 161756 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Brassicaceae |
|---|---|
| ID | 3700 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (10)
| Species | Activity |
|---|---|
| Isatis tinctoria L. | Antiaggregant |
| Isatis tinctoria L. | Antidermatophytic |
| Isatis tinctoria L. | Antifeedant |
| Isatis tinctoria L. | Antileukemic |
| Isatis tinctoria L. | Antipyretic |
| Isatis tinctoria L. | Antiseptic |
| Isatis tinctoria L. | Fungicide |
| Isatis tinctoria L. | Immunostimulant |
| Isatis tinctoria L. | Insecticide |
| Isatis tinctoria L. | Termiticide |
Metabolite list (34)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001058
|
Isoscoparin
/ Isoorientin 3'-methyl ether |
No. 22 | No. 15 |
|
||||
|
C00035776
|
(9Z)-Lutein
|
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
4 / 2 / 3 | No. 26 | No. 59 |
|
||
|
C00035777
|
(9'Z)-Lutein
|
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
4 / 2 / 3 | No. 26 | No. 59 |
|
||
|
C00003776
|
Lutein
/ (all-E)-Lutein / all-trans-(+)-Xanthophyll / (3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol |
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
D014975
|
4 / 2 / 3 | 7 / 2 | No. 26 | No. 59 |
|
|
C00007864
|
Epiprogoitrin
/ 2(S)-2-Hydroxy-3-butenyl glucosinolate |
No. 46 | No. 76 |
|
||||
|
C00007545
|
Glucoraphanin
/ 4-Methylsulphinylbutyl glucosinolate |
No. 46 | No. 76 |
|
||||
|
C00007586
|
Gluconapin
/ 3-Butyl glucosinolate |
No. 46 | No. 76 |
|
||||
|
C00001486
|
Progoitrin
/ 2(R)-2-Hydroxy 3-butenyl glucosinolate |
C009048
|
No. 46 | No. 76 |
|
|||
|
C00001473
|
Glucoiberverin
/ 3-(Methylthio)propyl glucosinolate |
No. 46 | No. 76 |
|
||||
|
C00001489
|
(N-Sulfoindol-3-yl)methylglucosinolate
|
No. 158 | No. 77 |
|
||||
|
C00000125
|
Glucobrassicin
/ Glucobrassicine / 3-Indolylmethylglucosinolate |
C048308
|
2 / 0 | No. 158 | No. 77 |
|
||
|
C00007861
|
Glucobrassicin-1-sulfate
/ 1-Sulfo-indol-3-ylmethyl glucosinolate |
No. 158 | No. 77 |
|
||||
|
C00007805
|
Glucosinalbate
/ 4-Hydroxybenzyl glucosinolate |
No. 158 | No. 77 |
|
||||
|
C00000128
|
4-Methoxyglucobrassicin
/ 4-Methoxy-3-indolylmethylglucosinolate |
C036025
|
No. 158 | No. 77 |
|
|||
|
C00000127
|
4-Hydroxyglucobrassicin
/ 4-Hydroxy-3-indolylmethylglucosinolate |
C036021
|
No. 158 | No. 77 |
|
|||
|
C00000126
|
Neoglucobrassicin
/ 1-Methoxy-3-indolylmethylglucosinolate |
C064701
|
2 / 0 | No. 158 | No. 77 |
|
||
|
C00029633
|
Ursolic acid
/ Acetylursolic acid |
CHEMBL55086
CHEMBL410525 |
4 / 2 / 2 | No. 177 |
|
|||
|
C00029354
|
Palmitoleic acid
/ cis-Palmitoleic acid / (Z)-Palmitoleic acid |
CHEMBL453509
|
2 / 5 / 3 | No. 184 | No. 68 |
|
||
|
C00001209
|
Arachidic acid
/ Eicosanoic acid |
CHEMBL1173381
|
C094477
|
No. 184 | No. 68 |
|
||
|
C00001233
|
Palmitic acid
|
CHEMBL82293
|
D019308
|
16 / 8 / 8 | 35 / 1 | No. 184 | No. 68 |
|
|
C00001232
|
Oleic acid
/ (Z)-9-Octadecenoic acid |
CHEMBL8659
CHEMBL460657 |
D019301
|
30 / 19 / 20 | 26 / 9 | No. 184 | No. 68 |
|
|
C00001238
|
Stearic acid
|
CHEMBL46403
|
C031183
|
15 / 17 / 19 | 6 / 1 | No. 184 | No. 68 |
|
|
C00048303
|
9-Hydroxy-(10E,12Z,15Z)-octadecatrienoic acid
|
C062142
|
No. 300 | No. 68 |
|
|||
|
C00001224
|
Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid |
CHEMBL267476
|
29 / 31 / 28 | No. 367 | No. 68 |
|
||
|
C00048505
|
Phaeophorbide a
|
CHEMBL510103
|
C032623
|
No. 990 |
|
|||
|
C00002743
|
Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid |
CHEMBL32749
|
C004999
|
110 / 52 / 40 | 16 / 6 | No. 1366 | No. 6 |
|
|
C00002776
|
Sinapic acid
|
CHEMBL109341
|
C073734
|
5 / 5 / 5 | 0 / 5 | No. 1366 | No. 6 |
|
|
C00001541
|
Indican
|
CHEMBL1561942
CHEMBL2063300 |
C066596
|
4 / 3 / 7 | No. 2078 |
|
||
|
C00048361
|
Corchorifatty acid B
|
CHEMBL1668472
|
No. 2892 |
|
||||
|
C00002150
|
Deoxyvasicinone
|
CHEMBL456881
|
C025696
|
25 / 13 / 9 | No. 3142 | No. 7 |
|
|
|
C00048436
|
Isoindigo
|
CHEMBL515155
|
C049010
|
4 / 0 / 0 | No. 4840 |
|
||
|
C00001542
|
Isotan B
|
No. 6094 |
|
|||||
|
C00048293
|
5-Hydroxyoxindole
|
No. 7479 |
|
|||||
|
C00042287
|
Bisindigotin
|
CHEMBL474468
|
No. 8524 |
|
Human Protein / Gene in interactions
177 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00001224 C00001232 C00001233 C00001541 C00002743 C00003776 C00035776 C00035777 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001224 C00001232 C00001233 C00003776 C00035776 C00035777 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001238 C00001541 C00003776 C00035776 C00035777 | 2 / 3 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001224 C00001232 C00001233 C00001238 C00029633 | 2 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001224 C00001232 C00001238 C00002150 | 3 / 3 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00001224 C00001232 C00001233 C00001238 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001224 C00001238 C00002150 | 1 / 1 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001232 C00001238 C00002743 | 0 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001224 C00001232 C00001238 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001224 C00001232 C00001233 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00003776 C00035776 C00035777 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001233 C00001238 C00002743 | 0 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001224 C00002743 C00002776 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001224 C00001232 C00001238 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001224 C00001232 C00029354 | 5 / 3 |
| P13726 | Tissue factor | Membrane receptor | C00001224 C00001232 C00029354 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001224 C00002150 C00002743 | 0 / 1 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001224 C00001232 C00001233 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001224 C00001238 C00002150 | 0 / 0 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00001224 C00001232 C00001233 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001224 C00001233 C00002743 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002150 C00002743 | 1 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001232 C00002743 | 0 / 0 |
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | C00001232 C00001233 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002150 C00002743 | 1 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00001232 C00001541 | 1 / 4 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002150 C00002743 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002150 C00002743 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001541 C00002150 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001224 C00001238 | 3 / 2 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001232 C00002150 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001232 C00029633 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002743 C00002776 | 3 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001224 C00001233 | 3 / 4 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001232 C00001238 | 1 / 2 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001232 C00002743 | 2 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002743 C00002776 | 0 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002150 C00002743 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001224 C00001232 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001224 C00002150 | 0 / 0 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00001224 C00001232 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002150 C00002776 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00001232 C00001233 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002150 C00002743 | 0 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002743 | 1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002743 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002743 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002743 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00001224 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001232 | 1 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002150 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002743 | 1 / 8 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00002743 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002743 | 2 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002743 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002743 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002743 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002743 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002743 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002743 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002743 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002743 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002743 | 1 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002743 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002743 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002776 | 2 / 2 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002743 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002743 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00002743 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002150 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002743 | 1 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002743 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002743 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002743 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002743 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002743 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002743 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002743 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002743 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002743 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002743 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002743 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002743 | 1 / 0 |
| P12104 | Fatty acid-binding protein, intestinal | Other cytosolic protein | C00001233 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002743 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002743 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002743 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002743 | 1 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00001232 | 0 / 0 |
| P21980 | Protein-glutamine gamma-glutamyltransferase 2 | Enzyme | C00048436 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002743 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002743 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002743 | 1 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002150 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002150 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001232 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002743 | 1 / 2 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001224 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002743 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002743 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001238 | 3 / 1 |
| P14679 | Tyrosinase | Oxidoreductase | C00002743 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002743 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002743 | 2 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002743 | 1 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002743 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002743 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002743 | 0 / 0 |
| P06276 | Cholinesterase | Hydrolase | C00002150 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002743 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002743 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002743 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00001233 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001224 | 11 / 10 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00001224 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002743 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002743 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002743 | 2 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002150 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002743 | 0 / 1 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002743 | 2 / 2 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001224 | 0 / 0 |
| P07148 | Fatty acid-binding protein, liver | Unclassified protein | C00001232 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001224 | 2 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00001232 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001232 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002743 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002743 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00001233 | 1 / 0 |
| P29466 | Caspase-1 | C14 | C00002743 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002743 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002743 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002743 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002743 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002743 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002743 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002743 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001238 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002743 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002743 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002743 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002743 | 0 / 0 |
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | C00001224 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002743 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00029633 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002743 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002743 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001232 | 4 / 3 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002743 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002743 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002743 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00002743 | 2 / 1 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002743 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002743 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002743 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002743 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002743 | 1 / 1 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00002743 | 1 / 2 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002743 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002150 | 1 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00029633 | 0 / 0 |
| Q2TB90 | Putative hexokinase HKDC1 | Enzyme | C00002150 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002150 | 0 / 0 |
| O60603 | Toll-like receptor 2 | Membrane receptor | C00001233 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002150 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00001238 | 2 / 5 |
| P20248 | Cyclin-A2 | Other cytosolic protein | C00048436 | 0 / 0 |
| P78396 | Cyclin-A1 | Other cytosolic protein | C00048436 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00048436 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002743 | 3 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002150 | 2 / 1 |
73 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00001232
C00001233
C00001238
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00001232
C00001233
C00001238
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001232
C00001233
C00001238
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001232
C00001233
C00001238
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002743
C00003776
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001233
C00003776
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00001232
C00003776
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001233
C00003776
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00001232
C00001233
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00001232
C00002743
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001233
C00003776
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001233
C00001238
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001232
C00001233
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00001232
C00001233
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001232
C00001233
|
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 |
C00001233
C00001238
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002743
C00003776
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00001233
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002743
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002743
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002743
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002743
|
| 2877 | GPX2, GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2 | glutathione peroxidase 2 (gastrointestinal) (EC:1.11.1.9) |
C00000125
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00000125
|
| 3251 | HPRT1, HGPRT, HPRT | hypoxanthine phosphoribosyltransferase 1 (EC:2.4.2.8) |
C00000126
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000126
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00002743
|
| 5742 | PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002743
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00003776
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002743
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002743
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00001232
|
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 |
C00001232
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002743
|
| 335 | APOA1 | apolipoprotein A-I |
C00001232
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00001232
|
| 1401 | CRP, PTX1 | C-reactive protein, pentraxin-related |
C00001232
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00001232
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002743
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00001232
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001232
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00001232
|
| 778733 |
C00001232
|
||
| 100136658 |
C00001232
|
||
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00001232
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00001232
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00001232
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002743
|
| 6514 | SLC2A2, GLUT2 | solute carrier family 2 (facilitated glucose transporter), member 2 |
C00001232
|
| 6720 | SREBF1, SREBP-1c, SREBP1, bHLHd1 | sterol regulatory element binding transcription factor 1 |
C00001232
|
| 23621 | BACE1, ASP2, BACE, HSPC104 | beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) |
C00002743
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00001233
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001233
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00001233
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002743
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00001233
|
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) |
C00001233
|
| 57817 | HAMP, HEPC, HFE2B, LEAP1, PLTR | hepcidin antimicrobial peptide |
C00001233
|
| 3481 | IGF2, C11orf43, IGF-II, PP9974 | insulin-like growth factor 2 (somatomedin A) |
C00001233
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00001233
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00001233
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00001233
|
| 4493 | MT1E, MT1, MTD | metallothionein 1E |
C00001233
|
| 4494 | MT1F, MT1 | metallothionein 1F |
C00001233
|
| 4496 | MT1H, MT-0, MT-1H, MT-IH, MT1 | metallothionein 1H |
C00001233
|
| 4501 | MT1X, MT-1l, MT1 | metallothionein 1X |
C00001233
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00001233
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00001233
|
| 3651 | PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 | pancreatic and duodenal homeobox 1 |
C00001233
|
| 29893 | PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP | PSMC3 interacting protein |
C00001233
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00001233
|
| 23216 | TBC1D1, TBC, TBC1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 |
C00001233
|
| 7351 | UCP2, BMIQ4, SLC25A8, UCPH | uncoupling protein 2 (mitochondrial, proton carrier) |
C00001233
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (103)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #246300 | Leprosy, susceptibility to, 3; lprs3 |
O60603
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (87)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00344 | Leprosy |
O60603
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00094 | DNA repair defects |
P54132
(related)
Q13315 (related) |
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
Q12794
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
21 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003072 | Cognition Disorders |
C00001238
C00001232 C00001233 |
| D000860 | Anoxia |
C00002776
C00001232 |
| D056486 | Drug-Induced Liver Injury |
C00002776
|
| D008106 | Liver Cirrhosis, Experimental |
C00002743
|
| D008545 | Melanoma |
C00002743
|
| D009203 | Myocardial Infarction |
C00002743
|
| D050197 | Atherosclerosis |
C00002743
|
| D000647 | Amnesia |
C00002776
|
| D002252 | Carbon Tetrachloride Poisoning |
C00002743
|
| D001930 | Brain Injuries |
C00002776
|
| D007249 | Inflammation |
C00002743
|
| D004487 | Edema |
C00002776
|
| D007939 | Leukemia L1210 |
C00003776
|
| D014605 | Uveitis |
C00003776
|
| D055371 | Acute Lung Injury |
C00001232
|
| D005234 | Fatty Liver |
C00001232
|
| D006520 | Hepatitis, Animal |
C00001232
|
| D007333 | Insulin Resistance |
C00001232
|
| D055370 | Lung Injury |
C00001232
|
| D011654 | Pulmonary Edema |
C00001232
|
| D012128 | Respiratory Distress Syndrome, Adult |
C00001232
|