PCIDB

KNApSAcK Metabolite C00002743

Metabolite

KNApSAcK Entry

id C00002743
Name Ferulic acid / 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
CAS RN 1135-24-6
Standard InChI InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+
Standard InChI (Main Layer) InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)

Cluster

Phytochemical cluster No. 6
KCF-S cluster No. 1366

Link

ChEMBL

By standard InChI CHEMBL32749
By standard InChI Main Layer CHEMBL32749

KEGG

By LinkDB C01494

CTD

By CAS RN C004999

Species

Summary

Plant class

class name count
asterids 18
rosids 13
Liliopsida 9
eudicotyledons 7
Spermatophyta 6
Magnoliophyta 4
Euphyllophyta 1

Family (Top 10)

family name count
Apiaceae 8
Poaceae 5
Pinaceae 4
Asteraceae 2
Ranunculaceae 2
Lauraceae 2
Malvaceae 2
Lamiaceae 2
Brassicaceae 2
Aristolochiaceae 2

List (62)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Actaea racemosa 64040 Ranunculaceae eudicotyledons Viridiplantae
Aeschynanthus bracteatus 175969 Gesneriaceae asterids Viridiplantae
Aganosma caryophyllata
Ajuga iva 38595 Lamiaceae asterids Viridiplantae
Andrographis paniculata 175694 Acanthaceae asterids Viridiplantae
Angelica furcijuga KITAGAWA 40948 Apiaceae asterids Viridiplantae
Angelica sinensis 165353 Apiaceae asterids Viridiplantae
Antitoxicum scanden
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Aristolochia heterophylla Hemsl 12947 Aristolochiaceae Magnoliophyta Viridiplantae
Aristolochia manshuriensis 158555 Aristolochiaceae Magnoliophyta Viridiplantae
Aruncus diocus 23143 Rosaceae rosids Viridiplantae
Beta vulgaris 161934 Amaranthaceae eudicotyledons Viridiplantae
Calligonum leucocladum 1202986 Polygonaceae eudicotyledons Viridiplantae
Catalpa ovata 265497 Bignoniaceae asterids Viridiplantae
Chamaecyparis formosensis 187461 Cupressaceae Spermatophyta Viridiplantae
Cinnamomum subavenium 977953 Lauraceae Magnoliophyta Viridiplantae
Cinnamomum tenuifolium 13428 Lauraceae Magnoliophyta Viridiplantae
Citrus sudachi 558546 Rutaceae rosids Viridiplantae
Colubrina faralaotra subsp.trichocarpa. 106663 Rhamnaceae rosids Viridiplantae
Conyza schimperi 41552 Asteraceae asterids Viridiplantae
Cyperus rotundus L. 512623 Cyperaceae Liliopsida Viridiplantae
Equsetum arvense
Eriocaulon buergerianum 26021 Eriocaulaceae Liliopsida Viridiplantae
Falcaria vulgaris 52469 Apiaceae asterids Viridiplantae
Ferula assa-foetida 52471 Apiaceae asterids Viridiplantae
Ferula foetida 371345 Apiaceae asterids Viridiplantae
Gymnadenia conopsea R.BR. 59323 Orchidaceae Liliopsida Viridiplantae
Gynerium sagittatum 42053 Poaceae Liliopsida Viridiplantae
Hibiscus taiwanensis 47605 Malvaceae rosids Viridiplantae
Isatis tinctoria 161756 Brassicaceae rosids Viridiplantae
Lens esculenta 3864 Fabaceae rosids Viridiplantae
Ligusticum chuanxiong HORT. 49551 Apiaceae asterids Viridiplantae
Ligusticum multivittatum 49551 Apiaceae asterids Viridiplantae
Macaranga triloba 109851 Euphorbiaceae rosids Viridiplantae
Maize bran 4479 Poaceae Liliopsida Viridiplantae
Malva silvestris 96479 Malvaceae rosids Viridiplantae
Opopanax chironicum 63018 Apiaceae asterids Viridiplantae
Opuntia ficus-indica var.saboten 106975 Cactaceae eudicotyledons Viridiplantae
Oryza sativa 4530 Poaceae Liliopsida Viridiplantae
Periploca graeca 63485 Apocynaceae asterids Viridiplantae
Phellodendron amurense 68554 Rutaceae rosids Viridiplantae
Phleum pratense 15957 Poaceae Liliopsida Viridiplantae
Phyllostachys edulis 38705 Poaceae Liliopsida Viridiplantae
Picea ajanensis 3328 Pinaceae Spermatophyta Viridiplantae
Picea obovata 331118 Pinaceae Spermatophyta Viridiplantae
Pinus laricio 3318 Pinaceae Spermatophyta Viridiplantae
Plantago lanceolata 39414 Plantaginaceae asterids Viridiplantae
Plantago media 101992 Plantaginaceae asterids Viridiplantae
Populus pseudosimonii 3689 Salicaceae rosids Viridiplantae
Posidonia oceanica 55489 Posidoniaceae Liliopsida Viridiplantae
Pseudomonas pseudoalcaligenes 330 Pseudomonadaceae Bacteria
Ranunculus baudotii 568534 Ranunculaceae eudicotyledons Viridiplantae
Reseda muricata C.Presl. 26963 Resedaceae rosids Viridiplantae
Rhaponticum carthamoides 362630 Asteraceae asterids Viridiplantae
Salvia officinalis 38868 Lamiaceae asterids Viridiplantae
Sedum takesimense Nakai 904691 Crassulaceae eudicotyledons Viridiplantae
Taxus baccata 25629 Taxaceae Spermatophyta Viridiplantae
Tribulus terrestris 210369 Zygophyllaceae rosids Viridiplantae
Tsuga heterophylla 3359 Pinaceae Spermatophyta Viridiplantae
Viscum coloratum 3971 Viscaceae eudicotyledons Viridiplantae
Vittaria anguste-elongata 38724 Pteridaceae Euphyllophyta Viridiplantae

Human Protein / Gene in interaction

110 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL32749 CHEMBL1909136 (2)
1 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL32749 CHEMBL1908082 (1)
3 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL32749 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL32749 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL32749 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL32749 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL32749 CHEMBL1909215 (2)
0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme CHEMBL32749 CHEMBL1032505 (1)
3 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL32749 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL32749 CHEMBL1909176 (2)
0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL32749 CHEMBL1074270 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL32749 CHEMBL1074269 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL32749 CHEMBL1074272 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL32749 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL32749 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL32749 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL32749 CHEMBL1909197 (2)
2 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL32749 CHEMBL1036024 (1)
1 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL32749 CHEMBL1074266 (1) CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL32749 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL32749 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL32749 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL32749 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL32749 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL32749 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL32749 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL32749 CHEMBL1909093 (2)
0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor CHEMBL32749 CHEMBL977664 (1)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL32749 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL32749 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL32749 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL32749 CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL32749 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL32749 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL32749 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL32749 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL32749 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL32749 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL32749 CHEMBL1909214 (2)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL32749 CHEMBL1074271 (1)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL32749 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL32749 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL32749 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL32749 CHEMBL1909166 (2)
1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL32749 CHEMBL1074276 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL32749 CHEMBL1074274 (1)
1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL32749 CHEMBL1909133 (2)
0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor CHEMBL32749 CHEMBL1772554 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL32749 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL32749 CHEMBL1908090 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL32749 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL32749 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL32749 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL32749 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL32749 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL32749 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL32749 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL32749 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL32749 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL32749 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL32749 CHEMBL1909167 (2)
1 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL32749 CHEMBL1074265 (1)
0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL32749 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL32749 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL32749 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL32749 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL32749 CHEMBL1909119 (2)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL32749 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL32749 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL32749 CHEMBL1909170 (2)
0 / 0
P14679 Tyrosinase Oxidoreductase CHEMBL32749 CHEMBL870666 (1)
4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL32749 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL32749 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL32749 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL32749 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL32749 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL32749 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL32749 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL32749 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL32749 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL32749 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL32749 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL32749 CHEMBL1909132 (2)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL32749 CHEMBL1074273 (1)
0 / 1
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL32749 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL32749 CHEMBL1909145 (2) CHEMBL1941568 (1)
CHEMBL1941569 (1)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL32749 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL32749 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL32749 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL32749 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL32749 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL32749 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL32749 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL32749 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL32749 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL32749 CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL32749 CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL32749 CHEMBL1909137 (2)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL32749 CHEMBL1908080 (1)
5 / 1
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL32749 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL32749 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL32749 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL32749 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL32749 CHEMBL1909116 (2)
1 / 1
P07451 Carbonic anhydrase 3 Lyase CHEMBL32749 CHEMBL1074267 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL32749 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL32749 CHEMBL1909128 (2)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL32749 CHEMBL1074268 (1)
1 / 1
Q12794 Hyaluronidase-1 Enzyme CHEMBL32749 CHEMBL1111859 (1)
1 / 2
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL32749 CHEMBL1613914 (1)
0 / 0

CTD interaction (17)

compound gene gene name gene description interaction interaction type form reference
pmid
C004999 23621 BACE1
ASP2
BACE
HSPC104
beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) ferulic acid inhibits the reaction [Copper results in increased expression of BACE1 mRNA] decreases reaction
/ increases expression
mRNA 18583042
C004999 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 ferulic acid results in decreased expression of CCND1 protein decreases expression
protein 15486966
C004999 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) ferulic acid results in increased expression of CDKN1A protein increases expression
protein 15486966
C004999 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) ferulic acid results in decreased activity of CYP1A1 protein decreases activity
protein 15841493
C004999 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) ferulic acid results in decreased activity of CYP1A2 protein decreases activity
protein 15841493
C004999 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) ferulic acid results in decreased activity of MAPK1 protein decreases activity
protein 15486966
C004999 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) ferulic acid results in decreased activity of MAPK3 protein decreases activity
protein 15486966
C004999 5742 PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) ferulic acid results in decreased expression of PTGS1 mRNA decreases expression
mRNA 20816778
C004999 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) ferulic acid results in decreased expression of PTGS2 protein decreases expression
protein 15841493
C004999 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 ferulic acid results in decreased phosphorylation of RB1 protein decreases phosphorylation
protein 15486966
C004999 6319 SCD
FADS5
MSTP008
SCD1
SCDOS
stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) ferulic acid results in decreased expression of SCD mRNA decreases expression
mRNA 20816778
C004999 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) TYR protein results in increased oxidation of ferulic acid increases oxidation
protein 20685355
C004999 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) [TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione decreases abundance
/ increases oxidation
protein 20685355
C004999 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of ferulic acid increases glucuronidation
protein 15117964
C004999 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of ferulic acid increases glucuronidation
protein 15117964
C004999 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of ferulic acid increases glucuronidation
protein 15117964
C004999 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of ferulic acid increases glucuronidation
protein 15117964

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (52)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#600807 Asthma, susceptibility to Q13093
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#607276 Resting heart rate, variation in P08588
#600852 Retinitis pigmentosa 17; rp17 P22748
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (40)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

6 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D050197 C004999 Atherosclerosis therapeutic
20573577
D002252 C004999 Carbon Tetrachloride Poisoning therapeutic
16011737
D007249 C004999 Inflammation therapeutic
18068289
D008106 C004999 Liver Cirrhosis, Experimental therapeutic
16011737
D008545 C004999 Melanoma therapeutic
20685355
D009203 C004999 Myocardial Infarction therapeutic
16444596
16635105