Angelica sinensis
Species
KNApSAcK Entry
| Organism name | Angelica sinensis |
|---|---|
| Genus | Angelica |
| Family | Apiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Angelica sinensis |
|---|---|
| Linked NCBI taxonomy ID | 165353 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Apiaceae |
|---|---|
| ID | 4037 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (45)
| Species | Activity |
|---|---|
| Angelica sinensis (Oliv.) Diels | Alterative |
| Angelica sinensis (Oliv.) Diels | Analgesic |
| Angelica sinensis (Oliv.) Diels | Antiaggregant |
| Angelica sinensis (Oliv.) Diels | Antiallergic |
| Angelica sinensis (Oliv.) Diels | Antianemic |
| Angelica sinensis (Oliv.) Diels | Antiarrhythmic |
| Angelica sinensis (Oliv.) Diels | Antiasthmatic |
| Angelica sinensis (Oliv.) Diels | Antiatherosclerotic |
| Angelica sinensis (Oliv.) Diels | Antiinflammatory |
| Angelica sinensis (Oliv.) Diels | Antiproliferative |
| Angelica sinensis (Oliv.) Diels | Antiseptic |
| Angelica sinensis (Oliv.) Diels | Antiserotonin |
| Angelica sinensis (Oliv.) Diels | Antispasmodic |
| Angelica sinensis (Oliv.) Diels | Aphrodisiac |
| Angelica sinensis (Oliv.) Diels | Bitter |
| Angelica sinensis (Oliv.) Diels | Circulostimulant |
| Angelica sinensis (Oliv.) Diels | CNS-Depressant |
| Angelica sinensis (Oliv.) Diels | CNS-Stimulant |
| Angelica sinensis (Oliv.) Diels | Deobstruent |
| Angelica sinensis (Oliv.) Diels | Depurative |
| Angelica sinensis (Oliv.) Diels | Diuretic |
| Angelica sinensis (Oliv.) Diels | Emmenagogue |
| Angelica sinensis (Oliv.) Diels | Estrogenic |
| Angelica sinensis (Oliv.) Diels | Fmale Tonic |
| Angelica sinensis (Oliv.) Diels | Hemopoietic |
| Angelica sinensis (Oliv.) Diels | Hepatoprotective |
| Angelica sinensis (Oliv.) Diels | Hepatotonic |
| Angelica sinensis (Oliv.) Diels | Hypertensive |
| Angelica sinensis (Oliv.) Diels | Hypocholesterolemic |
| Angelica sinensis (Oliv.) Diels | Hypotensive |
| Angelica sinensis (Oliv.) Diels | Immunodepressant |
| Angelica sinensis (Oliv.) Diels | Immunomodulator |
| Angelica sinensis (Oliv.) Diels | Immunostimulant |
| Angelica sinensis (Oliv.) Diels | Laxative |
| Angelica sinensis (Oliv.) Diels | Leukocytogenic |
| Angelica sinensis (Oliv.) Diels | Myorelaxant |
| Angelica sinensis (Oliv.) Diels | Myostimulant |
| Angelica sinensis (Oliv.) Diels | Phagoytotic |
| Angelica sinensis (Oliv.) Diels | Radioprotective |
| Angelica sinensis (Oliv.) Diels | Sedative |
| Angelica sinensis (Oliv.) Diels | Tonic |
| Angelica sinensis (Oliv.) Diels | Tranquilizer |
| Angelica sinensis (Oliv.) Diels | Uterocontractant |
| Angelica sinensis (Oliv.) Diels | Uterorelaxant |
| Angelica sinensis (Oliv.) Diels | Vasodilator |
Metabolite list (16)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002477
|
Imperatorin
|
CHEMBL453805
|
C031534
|
18 / 7 / 6 | 1 / 1 | No. 606 | No. 25 |
|
|
C00041228
|
(3R,8S)-Falcarindiol
|
CHEMBL69018
CHEMBL1094112 |
3 / 0 / 0 | No. 940 | No. 69 |
|
||
|
C00041713
|
Oplopandiol
/ (+)-Oplopandiol |
CHEMBL463219
|
1 / 0 / 0 | No. 940 | No. 69 |
|
||
|
C00002683
|
Vanillin
|
CHEMBL13883
|
18 / 8 / 9 | No. 1003 |
|
|||
|
C00041337
|
Angeliferulate
/ (+)-Angeliferulate |
CHEMBL480460
|
1 / 0 / 0 | No. 1298 |
|
|||
|
C00002743
|
Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid |
CHEMBL32749
|
C004999
|
110 / 52 / 40 | 16 / 6 | No. 1366 | No. 6 |
|
|
C00041758
|
p-Hydroxyphenethyl trans-ferulate
/ p-Hydroxyphenylethyl-trans-ferulate |
CHEMBL481245
|
1 / 0 / 0 | No. 1829 |
|
|||
|
C00041229
|
(9Z,11S,16R)-Dihydroxyoctadeca-9,17-dien-12,14-diyn-1-yl acetate
|
CHEMBL511705
CHEMBL490698 CHEMBL2204415 |
1 / 0 / 0 | No. 2971 |
|
|||
|
C00041976
|
Z-Butylidenephthalide
|
CHEMBL249592
CHEMBL1765390 |
1 / 0 / 0 | No. 3810 |
|
|||
|
C00041867
|
Sinaspirolide
/ (+)-Sinaspirolide |
No. 3928 |
|
|||||
|
C00041348
|
Ansaspirolide
|
CHEMBL482223
|
1 / 0 / 0 | No. 3928 |
|
|||
|
C00041231
|
10-Angeloylbutylphthalide
|
CHEMBL500589
|
1 / 0 / 0 | No. 6180 |
|
|||
|
C00041687
|
N-Butylbenzenesulfonamide
|
CHEMBL479880
|
C065565
|
1 / 0 / 0 | 0 / 1 | No. 6206 |
|
|
|
C00032553
|
Z-Ligustilide
|
CHEMBL481246
|
1 / 0 / 0 | No. 7258 |
|
|||
|
C00031368
|
Senkyunolide A
/ (-)-Senkyunolide A |
No. 8549 |
|
|||||
|
C00041295
|
8-Hydroxy-1-methoxy-Z-9-heptadecene-4,6-diyn-3-one
|
CHEMBL479891
|
1 / 0 / 0 | No. 8770 |
|
Human Protein / Gene in interactions
142 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00002477 C00002683 C00002743 C00032553 C00041228 C00041229 C00041231 C00041295 C00041337 C00041348 C00041687 C00041713 C00041758 C00041976 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002477 C00002683 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002477 C00002743 | 0 / 1 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002743 C00041228 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002743 C00041228 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002743 | 1 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002743 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00002743 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002743 | 0 / 0 |
| P78527 | DNA-dependent protein kinase catalytic subunit | Atypical serine/threonine protein kinase PIKK subfamily | C00002683 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002743 | 3 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002743 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002743 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002477 | 1 / 1 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002743 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002743 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002743 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002743 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002743 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002743 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002743 | 2 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002743 | 1 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002683 | 0 / 0 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002683 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002743 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002743 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002743 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002743 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002743 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002743 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002743 | 1 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00002477 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002743 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002743 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002743 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002743 | 0 / 1 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00002683 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002743 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002477 | 2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002743 | 2 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002743 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002743 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002477 | 2 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002743 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002743 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002743 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002743 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002743 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002743 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002743 | 1 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002743 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002683 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002743 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002743 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00002743 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002743 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002683 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002743 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002743 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002743 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002743 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002743 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002743 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002743 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002743 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002743 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002743 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002743 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002743 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002743 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002743 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002743 | 1 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00002683 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002477 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002743 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002743 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002477 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002477 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002743 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002743 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002743 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00002743 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002743 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002743 | 2 / 0 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00002683 | 1 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002743 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002743 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002743 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002743 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002743 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002743 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002683 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00002477 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002743 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002743 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002743 | 2 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00002477 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002743 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002743 | 0 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002683 | 2 / 2 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002683 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002743 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002743 | 0 / 3 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002743 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002743 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002743 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002743 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002743 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002743 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002743 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002743 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002743 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002743 | 1 / 1 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002743 | 3 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002743 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002477 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002477 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002743 | 5 / 1 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002683 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002683 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002683 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002743 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002743 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002743 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002743 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002743 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002743 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002743 | 1 / 1 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00002743 | 1 / 2 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002743 | 0 / 0 |
| O00167 | Eyes absent homolog 2 | Enzyme | C00002477 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002477 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002683 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002477 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002683 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00002477 | 1 / 1 |
17 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 23621 | BACE1, ASP2, BACE, HSPC104 | beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) |
C00002743
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002743
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002743
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002743
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002743
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002743
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002743
|
| 5742 | PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002743
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002743
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00002743
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00002743
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002743
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002743
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002743
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002743
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002743
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00002477
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (66)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (54)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
Q12794
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
8 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D050197 | Atherosclerosis |
C00002743
|
| D002252 | Carbon Tetrachloride Poisoning |
C00002743
|
| D007249 | Inflammation |
C00002743
|
| D008106 | Liver Cirrhosis, Experimental |
C00002743
|
| D008545 | Melanoma |
C00002743
|
| D009203 | Myocardial Infarction |
C00002743
|
| D056486 | Drug-Induced Liver Injury |
C00002477
|
| D020258 | Neurotoxicity Syndromes |
C00041687
|