KCF-S cluster No. 606 (14 metabolites)

Corresponding Phytochemical cluster No. 25

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	111
rosids	59
Liliopsida	2

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Cumulative family count

class name	count
Apiaceae	108
Rutaceae	28
Moraceae	28
Aspergillaceae	5
Asteraceae	3
Fabaceae	2
Rosaceae	1
Poaceae	1
Cyperaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Furanocoumarins	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Furanocoumarins	C02162	C00000583
Furanocoumarins	C09053	C00002448
Furanocoumarins	C09269	C00002477
Furanocoumarins	C09285	C00002493

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000583	Isopimpinellin	CHEMBL140796	C015304	9 / 3 / 4	2 / 0
C00002448	Alloimperatorin
C00002477	Imperatorin	CHEMBL453805	C031534	18 / 7 / 6	1 / 1
C00002493	Pimpinellin	CHEMBL1491809	C039409	3 / 0 / 1
C00030531	Isogosferol / Isogospherol / (+)-Isogospherol
C00030532	Isoimperatorin	CHEMBL448060	C055542	8 / 13 / 11	3 / 1
C00030987	Phellopterin	CHEMBL452751	C104601	7 / 18 / 10
C00032846	Cnidilin / Knidilin / Isophellopterin	CHEMBL1934194		1 / 0 / 0
C00033282	Pabulenol	CHEMBL1870203
C00037872	Swietenocoumarin B
C00043481	E-Imperatorin acid	CHEMBL487409
C00043493	E-Trichoclin	CHEMBL527099 CHEMBL487408
C00044024	Z-Imperatorin acid	CHEMBL487409
C00044026	Z-Trichoclin	CHEMBL527099 CHEMBL487408

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P56817	Beta-secretase 1	A1A	C00000583 C00002477 C00030532 C00030987 C00032846	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000583 C00002477 C00030532 C00030987	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000583 C00002477 C00002493	0 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00002477 C00002493 C00030532	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002477 C00030532	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000583 C00002477	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002477	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00002477	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00030987	1 / 0
P11473	Vitamin D3 receptor	NR1I1	C00002477	2 / 3
P37840	Alpha-synuclein	Unclassified protein	C00030987	4 / 2
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000583	0 / 0
P11413	Glucose-6-phosphate 1-dehydrogenase	Enzyme	C00030987	1 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002477	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00030987	7 / 3
P83916	Chromobox protein homolog 1	Unclassified protein	C00002477	0 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00002477	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00002477	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00030532	11 / 10
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000583	2 / 2
P22303	Acetylcholinesterase	Hydrolase	C00030532	1 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002493	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002477	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00030532	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002477	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000583	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00030987	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000583	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000583	0 / 0
O00167	Eyes absent homolog 2	Enzyme	C00002477	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00002477	2 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002477	1 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00030532	0 / 0

4 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00000583 C00002477 C00030532
2939	GSTA2, GST2, GSTA2-2, GTA2, GTH2	glutathione S-transferase alpha 2 (EC:2.5.1.18)	C00030532
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00000583
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00030532

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions