PCIDB

Aristolochia manshuriensis

Species

KNApSAcK Entry

Organism name Aristolochia manshuriensis
Genus Aristolochia
Family Aristolochiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Aristolochia manshuriensis
Linked NCBI taxonomy ID 158555
Linked level species

Family

Family in NCBI taxonomy Aristolochiaceae
ID 16727

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (22)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00027121 External link 512 Aristolactam AII
/ Aristololactam A II
CHEMBL390368
No. 125
C00021676 External link 512 9-Methoxyaristolactam I
/ 9-Methoxyaristololactam I
No. 125
C00044532 External link 512 Aristomanoside
CHEMBL502608
No. 152
C00027516 External link 512 Aristolochic acid
/ Aristolochic acid I
CHEMBL93353
C000228
13 / 11 / 12 21 / 10 No. 291 No. 4
C00044531 External link 512 Aristolochic acid IVa methyl ester
No. 291 No. 4
C00032732 External link 512 Aristolochic acid II methyl ester
No. 291 No. 4
C00044699 External link 512 Demethylaristofolin E
CHEMBL512559
No. 291 No. 4
C00027517 External link 512 Aristolochic acid B
/ Aristolochic acid II
CHEMBL602280
C042310
1 / 0 / 0 No. 291 No. 4
C00044530 External link 512 Aristofolin E
No. 291 No. 4
C00034085 External link 512 N-p-Coumaroyltyramine
CHEMBL64286
No. 499
C00012431 External link 512 (+)-Isobicyclogermacrenal
CHEMBL2333548
2 / 0 / 0 No. 699 No. 38
C00000856 External link 512 4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid
CHEMBL441343
C038193
21 / 7 / 16 2 / 1 No. 817 No. 81
C00000152 External link 512 p-Coumaric acid
CHEMBL66879
CHEMBL2336752
C032171
23 / 13 / 18 6 / 1 No. 904 No. 6
C00002682 External link 512 Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid
CHEMBL120568
D014641
5 / 3 / 3 5 / 0 No. 1073
C00044698 External link 512 Dehydrooxoperezinone
CHEMBL526125
No. 1178
C00002743 External link 512 Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
CHEMBL32749
C004999
110 / 52 / 40 16 / 6 No. 1366 No. 6
C00030768 External link 512 Methyl vanillate
CHEMBL486214
No. 1936
C00044700 External link 512 Demethylsonodione
No. 2415
C00012469 External link 512 Manshurolide
CHEMBL2333551
2 / 0 / 0 No. 3231
C00027127 External link 512 Aristoloside
C104942
No. 5170

Human Protein / Gene in interactions

151 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P03372 Estrogen receptor NR3A1 C00000152 C00002682 C00002743 C00003672 1 / 1
P23280 Carbonic anhydrase 6 Lyase C00000152 C00000856 C00002743 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000152 C00000856 C00002743 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002743 C00003672 C00027516 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00002743 C00012431 C00012469 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000152 C00000856 C00002743 1 / 8
P00918 Carbonic anhydrase 2 Lyase C00000152 C00000856 C00002743 1 / 2
Q16790 Carbonic anhydrase 9 Lyase C00000152 C00000856 C00002743 0 / 1
P22748 Carbonic anhydrase 4 Lyase C00000152 C00000856 C00002743 1 / 1
P27361 Mitogen-activated protein kinase 3 Erk C00002743 C00012431 C00012469 0 / 0
P14679 Tyrosinase Oxidoreductase C00000152 C00002743 C00003672 4 / 2
P00915 Carbonic anhydrase 1 Lyase C00000152 C00000856 C00002743 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000152 C00000856 C00002743 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000152 C00000856 C00002743 1 / 2
P43166 Carbonic anhydrase 7 Lyase C00000152 C00000856 C00002743 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000152 C00000856 C00002743 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000152 C00000856 C00002743 0 / 0
P06746 DNA polymerase beta Enzyme C00003672 C00023774 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000152 C00002743 0 / 0
O75496 Geminin Unclassified protein C00002743 C00027516 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000152 C00002743 3 / 0
P15121 Aldose reductase Enzyme C00000152 C00002682 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000152 C00002743 0 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002743 C00003672 0 / 0
P51580 Thiopurine S-methyltransferase Enzyme C00000856 C00002682 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002743 C00003672 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002743 C00003672 0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00027516 C00027517 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002743 C00023774 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002743 C00003672 1 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002743 1 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002743 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002743 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002743 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002743 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002743 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002743 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002743 0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00000856 1 / 1
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002743 0 / 0
Q9UQ49 Sialidase-3 Enzyme C00000856 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002743 1 / 1
P06241 Tyrosine-protein kinase Fyn Src C00002743 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002743 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00000856 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00027516 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00002743 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002743 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002743 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002743 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002743 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002743 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002743 2 / 2
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002743 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002743 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002743 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002743 1 / 0
P17252 Protein kinase C alpha type Alpha C00002743 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00027516 0 / 0
P29466 Caspase-1 C14 C00002743 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002743 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000152 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002743 0 / 0
P42858 Huntingtin Unclassified protein C00002682 1 / 1
Q16539 Mitogen-activated protein kinase 14 p38 C00002743 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000856 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002743 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002743 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002743 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002743 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002743 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002743 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002743 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002743 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002743 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00002743 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002743 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002743 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002743 1 / 0
P08246 Neutrophil elastase S1A C00002743 2 / 1
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002743 0 / 0
P08311 Cathepsin G S1A C00002743 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002743 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00027516 0 / 0
P03956 Interstitial collagenase M10A C00002743 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002743 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P04150 Glucocorticoid receptor NR3C1 C00002743 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002743 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002743 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002743 2 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002743 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002743 2 / 0
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00000856 1 / 1
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002743 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002743 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002743 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002743 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002743 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002743 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002743 1 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002743 2 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00002743 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000152 0 / 0
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000152 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000856 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002743 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002743 0 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P22303 Acetylcholinesterase Hydrolase C00002743 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002743 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002743 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002743 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002743 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002743 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002743 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002743 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000856 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00027516 4 / 1
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000152 1 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002743 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002682 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000152 1 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002743 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00027516 4 / 3
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000856 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00027516 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002743 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002743 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002743 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002743 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002743 1 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002743 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002743 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002743 3 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00002743 1 / 2
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002743 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00027516 0 / 0
O00255 Menin Unclassified protein C00027516 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00027516 1 / 2
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00027516 0 / 0

37 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000152 C00002743 C00027516
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000152 C00002743 C00027516
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002682 C00002743
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002682 C00002743
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002682 C00002743
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000152 C00000856
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000152 C00002682
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002682 C00002743
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00000152 C00002743
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000152 C00002743
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002743 C00027516
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002743 C00027516
4093 SMAD9, MADH6, MADH9, PPH2, SMAD8, SMAD8A, SMAD8B SMAD family member 9 C00027516
55867 SLC22A11, OAT4, hOAT4 solute carrier family 22 (organic anion/urate transporter), member 11 C00027516
9356 SLC22A6, HOAT1, OAT1, PAHT, ROAT1 solute carrier family 22 (organic anion transporter), member 6 C00027516
9376 SLC22A8, OAT3 solute carrier family 22 (organic anion transporter), member 8 C00027516
4086 SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 SMAD family member 1 C00027516
4090 SMAD5, DWFC, JV5-1, MADH5 SMAD family member 5 C00027516
3309 HSPA5, BIP, GRP78, MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) C00027516
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00027516
7494 XBP1, TREB5, XBP-1, XBP2 X-box binding protein 1 C00027516
23621 BACE1, ASP2, BACE, HSPC104 beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) C00002743
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002743
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002743
5742 PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002743
26585 GREM1, CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2 gremlin 1, DAN family BMP antagonist C00027516
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002743
6319 SCD, FADS5, MSTP008, SCD1, SCDOS stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) C00002743
2034 EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 endothelial PAS domain protein 1 C00027516
1965 EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa C00027516
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00027516
59 ACTA2, AAT6, ACTSA, MYMY5 actin, alpha 2, smooth muscle, aorta C00027516
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00027516
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00027516
655 BMP7, OP-1 bone morphogenetic protein 7 C00027516
3952 LEP, LEPD, OB, OBS leptin C00000856
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (80)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#218030 Apparent mineralocorticoid excess; ame P80365
#600807 Asthma, susceptibility to Q13093
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613163 Gaba-transaminase deficiency P80404
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607276 Resting heart rate, variation in P08588
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#610460 Thiopurine s-methyltransferase deficiency P51580
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (61)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007249 Inflammation C00027516
C00002743
D008545 Melanoma C00002743
C00000152
D051437 Renal Insufficiency C00027516
D001284 Atrophy C00027516
D007674 Kidney Diseases C00027516
D007680 Kidney Neoplasms C00027516
D007683 Kidney Tubular Necrosis, Acute C00027516
D009369 Neoplasms C00027516
D018376 Cardiovascular Abnormalities C00027516
D014571 Urologic Neoplasms C00027516
D050197 Atherosclerosis C00002743
D002252 Carbon Tetrachloride Poisoning C00002743
D008106 Liver Cirrhosis, Experimental C00002743
D001449 Balkan Nephropathy C00027516
D009203 Myocardial Infarction C00002743
D012220 Rhinitis C00000856