Species

KNApSAcK Entry

Organism name Aristolochia heterophylla Hemsl
Genus Aristolochia
Family Aristolochiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Aristolochia
Linked NCBI taxonomy ID 12947
Linked level genus

Family

Family in NCBI taxonomy Aristolochiaceae
ID 16727

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (62)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005538 External link 512 Isorhamnetin 3-robinobioside
/ Isorhamnetin 3-O-robinobioside
CHEMBL84174
CHEMBL258394
CHEMBL1711509
CHEMBL2165403
7 / 1 / 2 No. 1 No. 15
C00002843 External link 512 Morindaparvin A
CHEMBL452754
C035011
No. 41 No. 62
C00003674 External link 512 Stigmasterol
/ beta-Stigmasterol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00031394 External link 512 Stigmast 4-ene 3,6-dione
/ (-)-Stigmast 4-ene 3,6-dione
C017726
No. 53 No. 11
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00032725 External link 512 Aristolactam IIIa
CHEMBL607579
1 / 0 / 0 No. 125
C00027515 External link 512 Aristolactam
/ Aristolactam I
CHEMBL479127
C121135
1 / 0 / 0 No. 125
C00027470 External link 512 Piperolactam A
CHEMBL387864
C457227
No. 125
C00027141 External link 512 Noraristolodione
/ Dioxodehydroasimilobine
/ 4,5-Dioxodehydroasimilobine
CHEMBL390369
No. 125
C00027122 External link 512 Aristolactam AIIIa
CHEMBL388956
5 / 1 / 3 No. 125
C00025787 External link 512 Cepharadione A
CHEMBL235921
No. 125
C00021676 External link 512 9-Methoxyaristolactam I
/ 9-Methoxyaristololactam I
No. 125
C00025791 External link 512 Cepharanone B
/ Aristolactam BII
/ Aristololactam B II
CHEMBL226772
C064674
No. 125
C00027121 External link 512 Aristolactam AII
/ Aristololactam A II
CHEMBL390368
No. 125
C00032724 External link 512 Aristofolin B
No. 291 No. 4
C00032726 External link 512 Aristolic acid
CHEMBL486801
C018834
No. 291 No. 4
C00021671 External link 512 Aristolochic acid B
/ Aristolochic acid II
CHEMBL602280
C042310
1 / 0 / 0 No. 291 No. 4
C00032729 External link 512 Aristolochate C
/ Aristolochate IIIa
CHEMBL603494
1 / 0 / 0 No. 291 No. 4
C00032730 External link 512 Aristolochate I
CHEMBL93353
13 / 11 / 12 No. 291 No. 4
C00027125 External link 512 Aristolochic acid D
/ Aristolochic acid IVa
CHEMBL604748
3 / 0 / 0 No. 291 No. 4
C00027519 External link 512 Aristolochic acid C
/ Aristolochic acid IIIa
CHEMBL603494
C092652
1 / 0 / 0 No. 291 No. 4
C00032766 External link 512 Aristolochate IVa
CHEMBL604748
3 / 0 / 0 No. 291 No. 4
C00032732 External link 512 Aristolochic acid II methyl ester
No. 291 No. 4
C00033192 External link 512 Methyl aristolochate
No. 291 No. 4
C00033191 External link 512 Methyl aristolate
CHEMBL520680
C020920
No. 291 No. 4
C00032731 External link 512 Aristolochate II
CHEMBL602280
1 / 0 / 0 No. 291 No. 4
C00025334 External link 512 trans-Feruloyltyramine
/ N-trans-Feruloyltyramine
/ trans-N-Feruloyltyramine
CHEMBL206555
CHEMBL451720
1 / 4 / 2 No. 499
C00025324 External link 512 N-cis-Feruloyltyramine
/ cis-N-Feruloyltyramine
CHEMBL206555
CHEMBL451720
1 / 4 / 2 No. 499
C00033139 External link 512 Madolin B
No. 500
C00033138 External link 512 Madolin A
/ (+)-Madolin A
CHEMBL1224785
3 / 1 / 0 No. 500
C00032576 External link 512 1,10-Epoxylepidozenal
No. 500
C00033146 External link 512 Madolin K
/ (+)-Madolin K
CHEMBL2333549
No. 699 No. 38
C00002683 External link 512 Vanillin
CHEMBL13883
18 / 8 / 9 No. 1003
C00002674 External link 512 Syringic acid
/ 4-Hydroxy-3,5-dimethoxybenzoic acid
CHEMBL1414
C001945
12 / 3 / 5 No. 1073
C00032734 External link 512 Aristoloterpenate IV
/ (-)-Aristoloterpenate IV
CHEMBL463405
CHEMBL463406
No. 1255
C00027292 External link 512 Aristoloterpenate III
/ (-)-Aristoloterpenate III
CHEMBL505464
CHEMBL508460
No. 1255
C00032733 External link 512 Aristoloterpenate II
/ (-)-Aristoloterpenate II
CHEMBL463405
CHEMBL463406
No. 1255
C00027291 External link 512 Aristoloterpenate I
/ (-)-Aristoloterpenate I
CHEMBL505464
CHEMBL508460
No. 1255
C00002743 External link 512 Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
CHEMBL32749
C004999
110 / 52 / 40 16 / 6 No. 1366 No. 6
C00033140 External link 512 Madolin E
/ (+)-Madolin E
No. 1542
C00032808 External link 512 Cepharanone A N-beta-D-glucoside
/ (-)-Cepharanone A N-beta-D-glucoside
No. 1580
C00027123 External link 512 Aristolactam Ia N-beta-glucoside
/ Aristolactam C N-beta-D-glucoside
/ Aristolactam-Ia-N-beta-D-glucoside
/ Aristolactam Ia N-beta-D-glucopyranoside
No. 1580
C00027286 External link 512 Aristolactam I N-beta-glucoside
C062008
No. 1580
C00030768 External link 512 Methyl vanillate
CHEMBL486214
No. 1936
C00033193 External link 512 Methyl isovanillate
No. 1936
C00030771 External link 512 Methylparaben
/ p-Methoxycarbonylphenol
CHEMBL325372
C015358
102 / 49 / 57 3 / 0 No. 2169
C00032864 External link 512 Cumin alcohol
/ Cuminyl alcohol
/ p-Isopropylbenzyl alcohol
No. 2172 No. 35
C00033148 External link 512 Madolin M
/ (-)-Madolin M
No. 2666
C00033147 External link 512 Madolin L
/ (-)-Madolin L
No. 2666
C00033142 External link 512 Madolin G
No. 3183
C00033143 External link 512 Madolin H
/ (-)-Madolin H
No. 3183
C00033144 External link 512 Madolin I
/ (+)-Madolin I
No. 3231
C00011727 External link 512 Aristolactone
CHEMBL2333547
2 / 0 / 0 No. 3231
C00012469 External link 512 Manshurolide
CHEMBL2333551
2 / 0 / 0 No. 3231
C00033141 External link 512 Madolin F
/ (+)-Madolin F
No. 3631
C00032727 External link 512 Aristolide A
/ (-)-Aristolide A
No. 4907
C00032728 External link 512 Aristolide B
/ (+)-Aristolide B
No. 4907
C00033472 External link 512 Versicolactone D
C064535
No. 5789
C00033471 External link 512 Versicolactone C
C050785
No. 6951
C00033470 External link 512 Versicolactone B
CHEMBL2333545
C050784
No. 7076
C00033145 External link 512 Madolin J
/ (+)-Madolin J
No. 8389
C00007468 External link 512 Allantoin
CHEMBL593429
CHEMBL1230080
D000481
12 / 12 / 14 No. 8950

Human Protein / Gene in interactions

163 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P24941 Cyclin-dependent kinase 2 Cdc2 C00021671 C00027122 C00027125 C00027515 C00027519 C00032725 C00032729 C00032730 C00032731 C00032766 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002743 C00003672 C00005538 C00007468 C00030771 C00032730 0 / 1
P27361 Mitogen-activated protein kinase 3 Erk C00002743 C00011727 C00012469 C00030771 C00033138 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002743 C00011727 C00012469 C00030771 C00033138 0 / 0
O75496 Geminin Unclassified protein C00002743 C00005538 C00027125 C00032730 C00032766 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002743 C00003672 C00007468 C00030771 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002743 C00003672 C00007468 C00030771 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002743 C00003672 C00007468 C00030771 0 / 1
P14679 Tyrosinase Oxidoreductase C00002743 C00003672 C00025324 C00025334 4 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002743 C00003672 C00007468 C00030771 1 / 1
P03372 Estrogen receptor NR3A1 C00002743 C00003672 C00005538 C00030771 1 / 1
Q9ULX7 Carbonic anhydrase 14 Lyase C00002674 C00002743 C00030771 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002674 C00002743 C00030771 1 / 2
P22303 Acetylcholinesterase Hydrolase C00002743 C00030771 C00033138 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00002674 C00002743 C00030771 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002674 C00002743 C00030771 0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002683 C00030771 C00032730 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002683 C00002743 C00003674 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00002674 C00002743 C00030771 1 / 2
P43166 Carbonic anhydrase 7 Lyase C00002674 C00002743 C00030771 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002683 C00030771 C00032730 0 / 0
P17252 Protein kinase C alpha type Alpha C00002743 C00030771 0 / 0
P29466 Caspase-1 C14 C00002743 C00030771 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002743 C00030771 2 / 2
Q92731 Estrogen receptor beta NR3A2 C00002743 C00030771 0 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002683 C00003672 1 / 1
P22748 Carbonic anhydrase 4 Lyase C00002674 C00002743 1 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002743 C00030771 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002743 C00030771 0 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00003672 C00007468 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002743 C00030771 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00002674 C00002743 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002743 C00030771 1 / 1
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00002674 C00002743 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002743 C00030771 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002743 C00030771 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002743 C00030771 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002743 C00030771 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002743 C00030771 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002743 C00030771 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002743 C00030771 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002743 C00030771 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00002674 C00002743 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002743 C00030771 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002743 C00030771 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002743 C00030771 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002743 C00030771 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002743 C00030771 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002743 C00030771 0 / 0
P06746 DNA polymerase beta Enzyme C00003672 C00003674 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002743 C00030771 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002743 C00030771 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002743 C00030771 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002743 C00030771 1 / 8
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002683 C00030771 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00002743 C00030771 2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002743 C00030771 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002743 C00030771 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002743 C00030771 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002743 C00030771 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002743 C00030771 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002674 C00002743 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002743 C00030771 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002743 C00030771 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002743 C00030771 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002743 C00030771 1 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002743 C00030771 5 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00002683 C00032730 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00005538 C00030771 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002743 C00030771 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002743 C00030771 0 / 0
P39748 Flap endonuclease 1 Enzyme C00027125 C00032766 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00002743 C00030771 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002683 C00030771 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002743 C00030771 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002743 C00030771 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002743 C00030771 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002743 C00030771 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002743 C00030771 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002743 C00030771 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002743 C00030771 0 / 0
P08246 Neutrophil elastase S1A C00002743 C00030771 2 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002743 C00030771 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002743 C00030771 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002743 C00030771 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002743 C00030771 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002743 C00030771 1 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002743 C00030771 2 / 2
P25103 Substance-P receptor Neurokinin receptor C00002743 C00030771 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002743 C00030771 0 / 0
P08311 Cathepsin G S1A C00002743 C00030771 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002743 C00030771 1 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002743 C00030771 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00005538 C00032730 0 / 0
P03956 Interstitial collagenase M10A C00002743 C00030771 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002743 C00030771 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002743 C00030771 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002743 C00030771 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002743 C00030771 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002743 C00030771 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002743 C00030771 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002743 C00030771 0 / 3
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002743 C00030771 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002743 C00030771 2 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002743 C00030771 0 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002743 C00030771 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002743 C00030771 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002743 C00030771 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002743 C00030771 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002743 C00030771 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002743 C00030771 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002743 C00030771 1 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002743 C00030771 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002743 C00030771 1 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002743 C00030771 2 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002743 C00030771 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002683 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005538 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00002683 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00002683 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002683 0 / 0
Q96GD4 Aurora kinase B Aur C00027122 0 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase C00003674 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00032730 4 / 1
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00002683 1 / 1
P00734 Prothrombin S1A C00003672 4 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00007468 0 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme C00002683 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P15121 Aldose reductase Enzyme C00002674 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002743 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00030771 7 / 37
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00002743 0 / 0
P78527 DNA-dependent protein kinase catalytic subunit Atypical serine/threonine protein kinase PIKK subfamily C00002683 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002743 3 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00032730 4 / 3
P11473 Vitamin D3 receptor NR1I1 C00007468 2 / 3
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002743 3 / 0
P10275 Androgen receptor NR3C4 C00002683 3 / 4
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00002683 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005538 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00027122 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00002683 1 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002683 0 / 0
P37840 Alpha-synuclein Unclassified protein C00007468 4 / 2
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
O14924 Regulator of G-protein signaling 12 Unclassified protein C00007468 0 / 0
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00027122 1 / 3
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00002743 1 / 2
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002743 0 / 0
O14965 Aurora kinase A Aur C00027122 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00032730 0 / 0
O00255 Menin Unclassified protein C00032730 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00032730 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00007468 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00007468 1 / 4
P11388 DNA topoisomerase 2-alpha Isomerase C00003674 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00003674 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00032730 0 / 0

20 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
23621 BACE1, ASP2, BACE, HSPC104 beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) C00002743
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002743
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002743
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002743
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002743
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002743
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002743
5742 PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002743
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002743
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002743
6319 SCD, FADS5, MSTP008, SCD1, SCDOS stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) C00002743
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00002743
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002743
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002743
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002743
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002743
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00030771
3952 LEP, LEPD, OB, OBS leptin C00030771
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00030771
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00003674

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (96)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#600807 Asthma, susceptibility to Q13093
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#127750 Dementia, lewy body; dlb P37840
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613163 Gaba-transaminase deficiency P80404
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607276 Resting heart rate, variation in P08588
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (92)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
P11802 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P11802 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P11802 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D050197 Atherosclerosis C00002743
D002252 Carbon Tetrachloride Poisoning C00002743
D007249 Inflammation C00002743
D008106 Liver Cirrhosis, Experimental C00002743
D008545 Melanoma C00002743
D009203 Myocardial Infarction C00002743