PCIDB

Malva silvestris

Species

KNApSAcK Entry

Organism name Malva silvestris
Genus Malva
Family Malvaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Malva
Linked NCBI taxonomy ID 96479
Linked level genus

Family

Family in NCBI taxonomy Malvaceae
ID 3629

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00000856 External link 512 4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid
CHEMBL441343
C038193
21 / 7 / 16 2 / 1 No. 817 No. 81
C00000206 External link 512 Saligel
/ Salonil
/ Salicylic acid
/ 2-Carboxyphenol
/ o-Hydroxybenzoic acid
CHEMBL424
D020156
124 / 50 / 42 15 / 12 No. 817 No. 81
C00000152 External link 512 p-Coumaric acid
CHEMBL66879
CHEMBL2336752
C032171
23 / 13 / 18 6 / 1 No. 904 No. 6
C00029533 External link 512 Gastrodigenin
/ 4-Methylolphenol
/ p-Hydroxybenzyl alcohol
/ 4-Hydroxybenzyl alcohol
CHEMBL202132
C018966
6 / 3 / 4 0 / 2 No. 936 No. 6
C00034769 External link 512 4-Hydroxy-2-methoxybenzoic acid
No. 1073
C00002743 External link 512 Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
CHEMBL32749
C004999
110 / 52 / 40 16 / 6 No. 1366 No. 6
C00029536 External link 512 p-Anisic acid
/ 4-Methoxybenzoic acid
CHEMBL21932
C004520
3 / 2 / 3 No. 2930
C00029471 External link 512 4-Hydroxydihydrocinnamic acid
/ 3-(4-Hydroxyphenyl)propionic acid
CHEMBL1172560
C008869
1 / 2 / 0 No. 3466
C00034770 External link 512 4-Hydroxy-3-methoxydihydrocinnamic acid
No. 8695

Human Protein / Gene in interactions

150 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00915 Carbonic anhydrase 1 Lyase C00000152 C00000206 C00000856 C00002743 C00029536 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000152 C00000206 C00000856 C00002743 C00029536 1 / 2
P23280 Carbonic anhydrase 6 Lyase C00000152 C00000206 C00000856 C00002743 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000152 C00000206 C00000856 C00002743 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000152 C00000206 C00000856 C00002743 1 / 2
P07451 Carbonic anhydrase 3 Lyase C00000152 C00000206 C00000856 C00002743 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000152 C00000206 C00000856 C00002743 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000152 C00000206 C00000856 C00002743 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000152 C00000206 C00000856 C00002743 1 / 8
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000152 C00000206 C00000856 C00002743 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000152 C00000206 C00000856 C00002743 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000152 C00000206 C00000856 C00002743 0 / 1
P06241 Tyrosine-protein kinase Fyn Src C00000206 C00002743 C00029533 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000152 C00000206 C00002743 0 / 3
P03372 Estrogen receptor NR3A1 C00000152 C00000206 C00002743 1 / 1
P25101 Endothelin-1 receptor Endothelin receptor C00000206 C00002743 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000206 C00002743 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000152 C00002743 3 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000206 C00002743 0 / 0
P08246 Neutrophil elastase S1A C00000206 C00002743 2 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000206 C00002743 0 / 0
P29466 Caspase-1 C14 C00000206 C00002743 0 / 0
P17252 Protein kinase C alpha type Alpha C00000206 C00002743 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000206 C00002743 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000206 C00002743 2 / 2
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000206 C00002743 1 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000206 C00002743 0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00000856 C00029533 1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000206 C00002743 2 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000206 C00002743 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000206 C00002743 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000206 C00002743 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000206 C00002743 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000206 C00002743 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000206 C00002743 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000206 C00002743 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000206 C00002743 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000206 C00002743 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000206 C00002743 1 / 1
P51580 Thiopurine S-methyltransferase Enzyme C00000856 C00029536 1 / 1
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000206 C00002743 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000206 C00002743 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000206 C00002743 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000206 C00002743 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000206 C00002743 0 / 1
P25105 Platelet-activating factor receptor PAF receptor C00000206 C00002743 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000206 C00002743 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000206 C00002743 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00000206 C00002743 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000206 C00002743 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000206 C00002743 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000206 C00002743 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000206 C00002743 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000206 C00002743 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000206 C00002743 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000206 C00002743 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000206 C00002743 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000206 C00002743 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00000206 C00002743 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000206 C00002743 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000206 C00002743 1 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000206 C00002743 1 / 1
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000206 C00002743 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000206 C00002743 0 / 1
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000206 C00002743 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000206 C00002743 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000152 C00002743 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000206 C00002743 1 / 0
O75496 Geminin Unclassified protein C00000206 C00002743 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000206 C00002743 1 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000206 C00000856 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000206 C00002743 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000206 C00002743 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000206 C00002743 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000206 C00002743 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000206 C00002743 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000206 C00002743 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000206 C00002743 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000206 C00002743 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000206 C00002743 0 / 0
P15121 Aldose reductase Enzyme C00000152 C00000206 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000206 C00002743 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000206 C00002743 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000206 C00002743 1 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000206 C00002743 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000206 C00002743 0 / 0
P08311 Cathepsin G S1A C00000206 C00002743 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000206 C00002743 1 / 0
P03956 Interstitial collagenase M10A C00000206 C00002743 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000206 C00002743 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000206 C00002743 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000206 C00002743 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000206 C00002743 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000206 C00002743 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000206 C00002743 0 / 0
P14679 Tyrosinase Oxidoreductase C00000152 C00002743 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000206 C00002743 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000206 C00002743 2 / 0
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00000856 C00029533 1 / 1
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000206 C00002743 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000206 C00002743 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000206 C00002743 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000206 C00002743 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000206 C00002743 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000206 C00002743 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000206 C00002743 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000206 C00002743 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000206 C00002743 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000206 C00002743 0 / 0
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000152 0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00000206 0 / 0
P08253 72 kDa type IV collagenase M10A C00000206 1 / 3
P62993 Growth factor receptor-bound protein 2 Other cytosolic protein C00029533 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000206 2 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000856 0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme C00000206 0 / 0
P36537 UDP-glucuronosyltransferase 2B10 Enzyme C00000206 0 / 0
P46108 Adapter molecule crk Unclassified protein C00029533 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002743 0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00000206 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000206 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000152 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000206 0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00000206 0 / 0
P05067 Amyloid beta A4 protein Membrane receptor C00000206 2 / 2
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00000856 0 / 0
P08236 Beta-glucuronidase Enzyme C00000206 1 / 2
P26358 DNA (cytosine-5)-methyltransferase 1 Transferase C00029471 2 / 0
Q9UQ49 Sialidase-3 Enzyme C00000856 0 / 0
P08183 Multidrug resistance protein 1 drug C00000206 1 / 0
P02768 Serum albumin Secreted protein C00000206 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002743 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002743 1 / 1
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000152 1 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002743 5 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000856 0 / 0
P00519 Tyrosine-protein kinase ABL1 Abl C00029533 1 / 2
P22894 Neutrophil collagenase M10A C00000206 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000206 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000152 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000856 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000206 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000206 4 / 1
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000152 1 / 0
P08254 Stromelysin-1 M10A C00000206 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000206 0 / 0
Q12794 Hyaluronidase-1 Enzyme C00002743 1 / 2
Q9UHC3 Acid-sensing ion channel 3 Unclassified protein C00000206 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002743 3 / 0
Q9NSA0 Solute carrier family 22 member 11 Transporter C00000206 0 / 0

30 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000206 C00002743
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000152 C00000856
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000206 C00002743
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000152 C00002743
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000152 C00002743
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00000206 C00002743
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000206 C00002743
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00000152 C00002743
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000152 C00002743
23621 BACE1, ASP2, BACE, HSPC104 beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) C00002743
6319 SCD, FADS5, MSTP008, SCD1, SCDOS stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) C00002743
5742 PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002743
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002743
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002743
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002743
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002743
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000152
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002743
3952 LEP, LEPD, OB, OBS leptin C00000856
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000206
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00000206
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000206
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00000206
23764 MAFF, U-MAF, hMafF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F C00000206
4489 MT1A, MT1, MT1S, MTC metallothionein 1A C00000206
55867 SLC22A11, OAT4, hOAT4 solute carrier family 22 (organic anion/urate transporter), member 11 C00000206
9356 SLC22A6, HOAT1, OAT1, PAHT, ROAT1 solute carrier family 22 (organic anion transporter), member 6 C00000206
10864 SLC22A7, NLT, OAT2 solute carrier family 22 (organic anion transporter), member 7 C00000206
114571 SLC22A9, HOAT4, OAT4, OAT7, UST3H, ust3 solute carrier family 22 (organic anion transporter), member 9 C00000206
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00000206

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (71)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#104300 Alzheimer disease; ad P05067
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#600807 Asthma, susceptibility to Q13093
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#604121 Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant; adcadn P26358
#605714 Cerebral amyloid angiopathy, app-related P05067
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613163 Gaba-transaminase deficiency P80404
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#608232 Leukemia, chronic myeloid; cml P00519
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#253220 Mucopolysaccharidosis, type vii; mps7 P08236
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#614116 Neuropathy, hereditary sensory, type ie; hsn1e P26358
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#607276 Resting heart rate, variation in P08588
#600852 Retinitis pigmentosa 17; rp17 P22748
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#610460 Thiopurine s-methyltransferase deficiency P51580
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (52)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) P00519 (related)
P00519 (marker)
H00004 Chronic myeloid leukemia (CML) P00519 (related)
P00519 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00056 Alzheimer's disease (AD) P05067 (related)
H01185 Cerebral amyloid angiopathy (CAA) P05067 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00132 Mucopolysaccharidosis type VII (MPS7) P08236 (related)
H00421 Mucopolysaccharidosis (MPS) P08236 (related)
Q12794 (related)
H00100 Neutropenic disorders P08246 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

21 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008545 Melanoma C00002743
C00000152
D003128 COMA C00000206
D007249 Inflammation C00002743
D008106 Liver Cirrhosis, Experimental C00002743
D050197 Atherosclerosis C00002743
D009203 Myocardial Infarction C00002743
D000647 Amnesia C00029533
D007859 Learning Disorders C00029533
D012220 Rhinitis C00000856
D001249 Asthma C00000206
D002252 Carbon Tetrachloride Poisoning C00002743
D004342 Drug Hypersensitivity C00000206
D034381 Hearing Loss C00000206
D006685 Hoarseness C00000206
D007819 Laryngeal Edema C00000206
D009668 Nose Diseases C00000206
D049188 Prenatal Injuries C00000206
D012640 Seizures C00000206
D014012 Tinnitus C00000206
D014581 Urticaria C00000206
D014860 Warts C00000206