Species

KNApSAcK Entry

Organism name Ligusticum chuanxiong HORT.
Genus Ligusticum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ligusticum
Linked NCBI taxonomy ID 49551
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002743 External link 512 Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
CHEMBL32749
C004999
110 / 52 / 40 16 / 6 No. 1366 No. 6
C00031173 External link 512 Riligustilide
/ (-)-Riligustilide
CHEMBL2047346
No. 3614
C00029489 External link 512 3-Butylidenephthalide
CHEMBL249592
CHEMBL1765390
C026105
1 / 0 / 0 16 / 1 No. 3810
C00032553 External link 512 Z-Ligustilide
CHEMBL481246
1 / 0 / 0 No. 7258
C00031368 External link 512 Senkyunolide A
/ (-)-Senkyunolide A
No. 8549

Human Protein / Gene in interactions

110 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002743 C00029489 C00032553 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002743 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002743 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002743 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002743 2 / 2
P08246 Neutrophil elastase S1A C00002743 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00002743 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002743 3 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002743 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002743 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00002743 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00002743 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002743 0 / 0
P29466 Caspase-1 C14 C00002743 0 / 0
P17252 Protein kinase C alpha type Alpha C00002743 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002743 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002743 2 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002743 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00002743 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002743 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002743 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002743 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002743 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002743 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002743 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002743 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002743 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002743 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002743 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002743 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002743 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002743 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002743 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00002743 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002743 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002743 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002743 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002743 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002743 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002743 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002743 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002743 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002743 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002743 1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002743 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002743 1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002743 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00002743 0 / 0
O75496 Geminin Unclassified protein C00002743 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002743 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002743 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002743 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002743 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002743 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002743 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002743 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002743 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002743 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002743 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002743 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002743 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00002743 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002743 0 / 0
P08311 Cathepsin G S1A C00002743 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002743 1 / 0
P03956 Interstitial collagenase M10A C00002743 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002743 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002743 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002743 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002743 0 / 0
P14679 Tyrosinase Oxidoreductase C00002743 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002743 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002743 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002743 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002743 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002743 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002743 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002743 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002743 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002743 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002743 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002743 2 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002743 3 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002743 0 / 1
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002743 0 / 0
P03372 Estrogen receptor NR3A1 C00002743 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002743 1 / 0
P22303 Acetylcholinesterase Hydrolase C00002743 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002743 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002743 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002743 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002743 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002743 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002743 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002743 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002743 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002743 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002743 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002743 5 / 1
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002743 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002743 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002743 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002743 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002743 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00002743 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002743 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002743 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00002743 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00002743 1 / 2
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002743 0 / 0

29 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002743 C00029489
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002743 C00029489
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002743 C00029489
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002743
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002743
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002743
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002743
5742 PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002743
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002743
23621 BACE1, ASP2, BACE, HSPC104 beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) C00002743
6319 SCD, FADS5, MSTP008, SCD1, SCDOS stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) C00002743
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00002743
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002743
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002743
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002743
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002743
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00029489
581 BAX, BCL2L4 BCL2-associated X protein C00029489
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00029489
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00029489
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00029489
898 CCNE1, CCNE cyclin E1 C00029489
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00029489
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00029489
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00029489
1029 CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 cyclin-dependent kinase inhibitor 2A C00029489
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00029489
4288 MKI67, KIA, MIB-1 marker of proliferation Ki-67 C00029489
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00029489

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (52)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#600807 Asthma, susceptibility to Q13093
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#607276 Resting heart rate, variation in P08588
#600852 Retinitis pigmentosa 17; rp17 P22748
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (40)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D050197 Atherosclerosis C00002743
D002252 Carbon Tetrachloride Poisoning C00002743
D007249 Inflammation C00002743
D008106 Liver Cirrhosis, Experimental C00002743
D008545 Melanoma C00002743
D009203 Myocardial Infarction C00002743
D005909 Glioblastoma C00029489