Andrographis paniculata
Species
KNApSAcK Entry
| Organism name | Andrographis paniculata |
|---|---|
| Genus | Andrographis |
| Family | Acanthaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Andrographis paniculata |
|---|---|
| Linked NCBI taxonomy ID | 175694 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Acanthaceae |
|---|---|
| ID | 4185 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (37)
| Species | Activity |
|---|---|
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Abortifacient |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Adaptogen |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Adrenocortical Stimulant |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Alterative |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Analgesic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Anthelminthic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Anti-HIV |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiaggregant |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiandrogenic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiatherosclerotic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antibacterial |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antifertility |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiinflammatory |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiischemic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antileukemic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antioxidant |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antipyretic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiradicular |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiseptic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiserotonin |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antispermatogenic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antityphoid |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Antiulcer |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Bitter |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Cholagogue |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Choleretic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Contraceptive |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Depurative |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Fibrinolytic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Fungicide |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Hepatoprotective |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Hypoglycemic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Hypotensive |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Immunostimulant |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Phagocytotic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Stomachic |
| Andrographis paniculata (Burm. F.) Wall. Ex Nees. | Tonic |
Metabolite list (46)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00004450
|
5-Hydroxy-7,8,2',3'-tetramethoxyflavone 5-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00004477
|
5,4'-Dihidroxy-7,8,2',3'-tetramethoxy flavone 5-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00013653
|
Skullcapflavone I 2'-O-glucoside
/ Skullcapflavone 1,2'-O-beta-D-glucopyranoside / 2-[2-(beta-D-Glucopyranosyloxy)phenyl]-5-hydroxy-7,8-dimethoxy-4H-1-benzopyran-4-one |
No. 2 | No. 15 |
|
||||
|
C00004449
|
5,2',3'-Trihydroxy-7,8-dimethoxyflavone 3'-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00004260
|
5-Hydroxy-7,8,2'-trimethoxyflavone 5-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00004129
|
Wogonin 5-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00004132
|
5-Hydroxy-7,8-dimethoxyflavone 5-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00001016
|
7-O-Methylacacetin
/ Acacetin 7-methyl ether / Genkwanin 4'-methyl ether / Apigenin 7,4'-dimethyl ether / 5-Hydroxy-4',7-dimethoxyflavone / 5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL350958
|
C044998
|
1 / 0 / 0 | No. 3 | No. 15 |
|
|
|
C00003952
|
5,4'-Dihidroxy-7,8,2',3'-tetramethoxyflavone
|
No. 8 | No. 15 |
|
||||
|
C00004610
|
5-Hydroxy-3,7,8,2'-tetramethoxyflavone
|
No. 8 | No. 15 |
|
||||
|
C00008449
|
Andrographidin A
|
No. 12 | No. 14 |
|
||||
|
C00035826
|
(-)-
/ Dihydroskullcapflavone I |
No. 25 | No. 14 |
|
||||
|
C00008154
|
5-Hydroxy-7,8-dimethoxyflavanone
|
CHEMBL1082119
CHEMBL1253998 |
1 / 5 / 5 | No. 25 | No. 14 |
|
||
|
C00003810
|
Moslosooflavone
/ 7-O-Methylwogonin / 7-O-Methylwogonine / 5-Hydroxy-7,8-dimethoxyflavone |
C035064
|
No. 35 | No. 15 |
|
|||
|
C00013310
|
5-Hydroxy-7,2',6'-trimethoxyflavone
/ 2-(2,6-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one |
No. 35 | No. 15 |
|
||||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00035795
|
5,7,2',3'-Tetramethoxyflavanone
|
No. 77 | No. 14 |
|
||||
|
C00022415
|
Andrograpanin
/ 3,14-Dideoxyandrographolide |
CHEMBL327771
CHEMBL518137 CHEMBL497243 |
No. 294 |
|
||||
|
C00002724
|
Heriguard
/ Chlorogenic acid / 3-O-Caffeoylquinic acid |
CHEMBL284616
CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319 |
D002726
|
30 / 19 / 22 | 37 / 9 | No. 314 | No. 6 |
|
|
C00022416
|
Neoandrographolide
|
CHEMBL480853
CHEMBL1316546 CHEMBL1951640 |
C082497
|
1 / 0 / 0 | No. 454 |
|
||
|
C00022233
|
Andropanoside
/ Ninandrographolide |
CHEMBL482237
|
C036456
|
No. 454 |
|
|||
|
C00041274
|
3-O-beta-D-Glucopyranosylandrographolide
/ (-)-3-O-beta-D-Glucopyranosylandrographolide |
CHEMBL472835
|
No. 454 |
|
||||
|
C00041335
|
Andrographiside
|
CHEMBL519275
|
C036457
|
No. 454 |
|
|||
|
C00038156
|
12S,13S-Hydroxyandrographolide
|
CHEMBL518455
CHEMBL467963 CHEMBL467946 |
No. 660 | No. 46 |
|
|||
|
C00022255
|
14-Deoxy-11-oxoandrographolide
|
No. 660 | No. 46 |
|
||||
|
C00022232
|
14-Deoxyandrographolide
|
CHEMBL415768
|
No. 660 | No. 46 |
|
|||
|
C00041244
|
14-Deoxy-17-hydroxyandrographolide
/ (-)-14-Deoxy-17-hydroxyandrographolide |
CHEMBL479489
|
No. 660 | No. 46 |
|
|||
|
C00023362
|
Andrographolide
|
CHEMBL186141
CHEMBL191892 CHEMBL364257 CHEMBL479285 CHEMBL466345 CHEMBL1317036 CHEMBL1317931 CHEMBL1599649 CHEMBL1705045 CHEMBL1951638 |
C030419
|
21 / 28 / 58 | 22 / 5 | No. 660 | No. 46 |
|
|
C00041241
|
12S-Hydroxyandrographolide
/ (-)-12S-Hydroxyandrographolide |
CHEMBL518455
CHEMBL467963 CHEMBL467946 |
No. 660 | No. 46 |
|
|||
|
C00041336
|
Andropanolide
/ (-)-Andropanolide |
CHEMBL186141
CHEMBL191892 CHEMBL364257 CHEMBL479285 CHEMBL466345 CHEMBL1317036 CHEMBL1317931 CHEMBL1599649 CHEMBL1705045 CHEMBL1951638 |
21 / 28 / 58 | No. 660 | No. 46 |
|
||
|
C00038326
|
7S-Hydroxy-14-deoxyandrographolide
|
CHEMBL466745
CHEMBL512623 |
No. 660 | No. 46 |
|
|||
|
C00038325
|
7R-Hydroxy-14-deoxyandrographolide
|
CHEMBL466745
CHEMBL512623 |
No. 660 | No. 46 |
|
|||
|
C00038155
|
12R,13R-Hydroxyandrographolide
|
CHEMBL518455
CHEMBL467963 CHEMBL467946 |
No. 660 | No. 46 |
|
|||
|
C00029961
|
Cinnamic acid
/ .beta-Phenylacrylic acid |
CHEMBL27246
|
C029010
|
5 / 2 / 2 | 16 / 2 | No. 904 | No. 6 |
|
|
C00000615
|
Caffeic acid
|
CHEMBL145
CHEMBL1320034 |
68 / 64 / 63 | No. 904 | No. 6 |
|
||
|
C00041603
|
isoandrographolide
|
No. 1300 | No. 46 |
|
||||
|
C00002743
|
Ferulic acid
/ 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid |
CHEMBL32749
|
C004999
|
110 / 52 / 40 | 16 / 6 | No. 1366 | No. 6 |
|
|
C00022240
|
14-Deoxy-11,14-didehydroandrographolide
|
CHEMBL361568
CHEMBL192725 CHEMBL1326087 |
11 / 1 / 1 | No. 1413 |
|
|||
|
C00011908
|
Paniculide B
|
No. 4283 |
|
|||||
|
C00011909
|
Paniculide C
|
No. 4283 |
|
|||||
|
C00011907
|
Paniculide A
|
No. 4283 |
|
|||||
|
C00034370
|
14-Acetylandrographolide
|
No. 5076 |
|
|||||
|
C00034369
|
14-Acetyl-3,19-isopropylideneandrographolide
|
No. 5076 |
|
|||||
|
C00041378
|
Bisandrographolide C
|
No. 5318 |
|
|||||
|
C00041377
|
Bisandrographolide B
|
No. 5318 |
|
|||||
|
C00029683
|
Andrographic acid
|
No. 7720 |
|
Human Protein / Gene in interactions
179 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000615 C00002724 C00002743 C00003672 C00023362 C00041336 | 0 / 1 |
| O75496 | Geminin | Unclassified protein | C00002724 C00002743 C00022240 C00023362 C00041336 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000615 C00002743 C00003672 C00029961 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000615 C00002724 C00002743 C00003672 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000615 C00002724 C00002743 C00003672 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000615 C00002724 C00002743 C00003672 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002724 C00022240 C00023362 C00041336 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000615 C00002724 C00002743 C00003672 | 0 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000615 C00002724 C00003672 C00022240 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00022416 C00023362 C00041336 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00000615 C00002724 C00029961 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000615 C00002724 C00002743 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000615 C00002724 C00002743 | 2 / 2 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000615 C00002724 C00002743 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00022240 C00023362 C00041336 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000615 C00002724 C00002743 | 3 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00000615 C00002743 C00003672 | 4 / 2 |
| O00255 | Menin | Unclassified protein | C00000615 C00023362 C00041336 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000615 C00023362 C00041336 | 1 / 2 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00000615 C00002743 C00029961 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000615 C00003672 C00029961 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000615 C00002724 C00022240 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000615 C00002743 C00029961 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000615 C00002724 C00003672 | 3 / 2 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000615 C00002724 C00022240 | 0 / 0 |
| O43451 | Maltase-glucoamylase, intestinal | Hydrolase | C00022240 C00023362 C00041336 | 0 / 0 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00022240 C00023362 C00041336 | 0 / 0 |
| Q9H227 | Cytosolic beta-glucosidase | Enzyme | C00022240 C00023362 C00041336 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000615 C00023362 C00041336 | 11 / 10 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00023362 C00041336 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000615 C00002743 | 2 / 2 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000615 C00002743 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002724 C00002743 | 0 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000615 C00002743 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000615 C00002743 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000615 C00002743 | 1 / 2 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000615 C00002743 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000615 C00002743 | 1 / 1 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00023362 C00041336 | 4 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000615 C00002724 | 0 / 0 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00000615 C00002743 | 1 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00023362 C00041336 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000615 C00002724 | 3 / 3 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000615 C00002743 | 0 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00000615 C00003672 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000615 C00002743 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000615 C00022240 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002724 C00002743 | 0 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00023362 C00041336 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001016 C00002743 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000615 C00002724 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00000615 C00002724 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000615 C00002743 | 1 / 8 |
| P03956 | Interstitial collagenase | M10A | C00000615 C00002743 | 0 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000615 C00002743 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000615 C00002743 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00023362 C00041336 | 1 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00023362 C00041336 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00023362 C00041336 | 2 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000615 C00002743 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00023362 C00041336 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00023362 C00041336 | 7 / 37 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000615 C00002724 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000615 C00002743 | 1 / 2 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000615 C00002743 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00023362 C00041336 | 0 / 3 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002743 | 1 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002743 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002743 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000615 | 0 / 0 |
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | C00000615 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002743 | 1 / 1 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002743 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002743 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002743 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002724 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002743 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002743 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002743 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002743 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002743 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002743 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002743 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002743 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002743 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002743 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002743 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002724 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002743 | 1 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002743 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002743 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002743 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002743 | 1 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002724 | 1 / 2 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002743 | 2 / 0 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002743 | 0 / 0 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00000615 | 1 / 1 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002743 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002743 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002743 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002743 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002743 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002743 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002743 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002743 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002743 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002743 | 0 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002724 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002743 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002743 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002743 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00000615 | 1 / 1 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00000615 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002743 | 1 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00000615 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002743 | 2 / 1 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00002743 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00000615 | 1 / 3 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002724 | 1 / 1 |
| Q04828 | Aldo-keto reductase family 1 member C1 | Enzyme | C00000615 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000615 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000615 | 5 / 2 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002743 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002743 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002743 | 1 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002743 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002743 | 1 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002743 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002743 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002743 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002743 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002743 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002743 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002743 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000615 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002743 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002743 | 1 / 1 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002743 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00022240 | 0 / 0 |
| P52895 | Aldo-keto reductase family 1 member C2 | Enzyme | C00000615 | 1 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000615 | 3 / 1 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002743 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000615 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002724 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002743 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002743 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002743 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002743 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002743 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002743 | 1 / 1 |
| P29466 | Caspase-1 | C14 | C00002743 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00000615 | 4 / 2 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002743 | 0 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00008154 | 5 / 5 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000615 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002743 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002743 | 0 / 0 |
| P24298 | Alanine aminotransferase 1 | Enzyme | C00000615 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00002743 | 2 / 1 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002724 | 3 / 3 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002743 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000615 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000615 | 0 / 0 |
| P17516 | Aldo-keto reductase family 1 member C4 | Enzyme | C00000615 | 1 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00000615 | 0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | C00000615 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002743 | 3 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002743 | 0 / 0 |
74 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002724
C00002743
C00029961
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002724
C00002743
C00029961
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002724
C00002743
C00029961
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002724
C00002743
C00029961
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002724
C00002743
C00029961
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00023362
C00029961
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002743
C00023362
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00023362
C00029961
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002743
C00023362
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00002743
C00023362
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002724
C00029961
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002743
C00023362
|
| 2201 | FBN2, CCA, DA9 | fibrillin 2 |
C00002724
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002743
|
| 5742 | PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002743
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002743
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00029961
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00029961
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00029961
|
| 1558 | CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 | cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) |
C00029961
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002743
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00029961
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00029961
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002743
|
| 338442 | HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g | hydroxycarboxylic acid receptor 2 |
C00029961
|
| 3284 | HSD3B2, HSD3B, HSDB, SDR11E2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) |
C00029961
|
| 23621 | BACE1, ASP2, BACE, HSPC104 | beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) |
C00002743
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00023362
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00023362
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00023362
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00023362
|
| 890 | CCNA2, CCN1, CCNA | cyclin A2 |
C00023362
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00023362
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00023362
|
| 54583 | EGLN1, C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6 | egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29) |
C00023362
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00023362
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00023362
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00023362
|
| 4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00023362
|
| 259296 | TAS2R50, T2R50, T2R51, TAS2R51 | taste receptor, type 2, member 50 |
C00023362
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00023362
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00023362
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00023362
|
| 47 | ACLY, ACL, ATPCL, CLATP | ATP citrate lyase (EC:2.3.3.8) |
C00002724
|
| 358 | AQP1, AQP-CHIP, CHIP28, CO | aquaporin 1 |
C00002724
|
| 360 | AQP3, AQP-3, GIL | aquaporin 3 (Gill blood group) |
C00002724
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00002724
|
| 960 | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 | CD44 molecule (Indian blood group) |
C00002724
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002724
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002724
|
| 4512 | COX1, COI, MTCO1, MT-CO1 | cytochrome c oxidase subunit I |
C00002724
|
| 114757 | CYGB, HGB, STAP | cytoglobin |
C00002724
|
| 1830 | DSG3, CDHF6, PVA | desmoglein 3 |
C00002724
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002724
|
| 2200 | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 | fibrillin 1 |
C00002724
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00002743
|
| 2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00002724
|
| 2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00002724
|
| 3036 | HAS1, HAS | hyaluronan synthase 1 (EC:2.4.1.212) |
C00002724
|
| 3315 | HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 | heat shock 27kDa protein 1 |
C00002724
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002724
|
| 3852 | KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A | keratin 5 |
C00002724
|
| 4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00002724
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00002724
|
| 8985 | PLOD3, LH3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) |
C00002724
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002724
|
| 5886 | RAD23A, HHR23A, HR23A | RAD23 homolog A (S. cerevisiae) |
C00002724
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00002724
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00002724
|
| 6649 | SOD3, EC-SOD | superoxide dismutase 3, extracellular (EC:1.15.1.1) |
C00002724
|
| 6716 | SRD5A2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) |
C00002724
|
| 7178 | TPT1, HRF, TCTP, p02, p23 | tumor protein, translationally-controlled 1 |
C00002724
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00002724
|
| 7306 | TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN | tyrosinase-related protein 1 (EC:1.14.18.-) |
C00002724
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (126)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614279 | 46,xy sex reversal 8; srxy8 |
P17516
P52895 |
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #609135 | Aplastic anemia |
O14746
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #114480 | Breast cancer |
P31749
|
| #300615 | Brunner syndrome |
P21397
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P31749
P84022 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #176920 | Proteus syndrome |
P31749
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (110)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P00533 (related) P04626 (related) P04637 (related) |
| H00024 | Prostate cancer |
O14746
(marker)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) P08253 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
P16473 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
Q12794
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|
Diseases related to CTD interactions
20 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D008545 | Melanoma |
C00002743
C00029961 C00002724 |
| D008103 | Liver Cirrhosis |
C00023362
|
| D007249 | Inflammation |
C00002743
|
| D008106 | Liver Cirrhosis, Experimental |
C00002743
|
| D050197 | Atherosclerosis |
C00002743
|
| D009203 | Myocardial Infarction |
C00002743
|
| D003384 | Coxsackievirus Infections |
C00029961
|
| D002277 | Carcinoma |
C00023362
|
| D015179 | Colorectal Neoplasms |
C00023362
|
| C535854 | Heavy Metal Toxicity |
C00023362
|
| D002252 | Carbon Tetrachloride Poisoning |
C00002743
|
| D008114 | Liver Neoplasms, Experimental |
C00023362
|
| D000647 | Amnesia |
C00002724
|
| D056486 | Drug-Induced Liver Injury |
C00002724
|
| D006937 | Hypercholesterolemia |
C00002724
|
| D006951 | Hyperlipoproteinemias |
C00002724
|
| D015228 | Hypertriglyceridemia |
C00002724
|
| D052456 | Hypoalphalipoproteinemias |
C00002724
|
| D009336 | Necrosis |
C00002724
|
| D015431 | Weight Loss |
C00002724
|