PCIDB

KNApSAcK Metabolite C00029961

Metabolite

KNApSAcK Entry

id C00029961
Name Cinnamic acid / .beta-Phenylacrylic acid
CAS RN 621-82-9
Standard InChI InChI=1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+
Standard InChI (Main Layer) InChI=1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)

Cluster

Phytochemical cluster No. 6
KCF-S cluster No. 904

Link

ChEMBL

By standard InChI CHEMBL27246
By standard InChI Main Layer CHEMBL27246

KEGG

By LinkDB C10438

CTD

By CAS RN C029010

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL27246 CHEMBL1106811 (1)
0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL27246 CHEMBL2051343 (1) CHEMBL2051344 (1)
1 / 1
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor CHEMBL27246 CHEMBL1772553 (1)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL27246 CHEMBL984565 (1) CHEMBL1942675 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL27246 CHEMBL1941568 (1) CHEMBL1941569 (1)
1 / 1

CTD interaction (17)

compound gene gene name gene description interaction interaction type form reference
pmid
C029010 1586 CYP17A1
CPT7
CYP17
P450C17
S17AH
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) cinnamic acid analog results in decreased activity of CYP17A1 protein decreases activity
protein 15072549
C029010 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) cinnamic acid analog results in decreased activity of CYP2A6 protein decreases activity
protein 15072549
C029010 1557 CYP2C19
CPCJ
CYP2C
P450C2C
P450IIC19
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) cinnamic acid analog results in decreased activity of CYP2C19 protein decreases activity
protein 15072549
C029010 1558 CYP2C8
CPC8
CYPIIC8
MP-12/MP-20
cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) cinnamic acid analog results in decreased activity of CYP2C8 protein decreases activity
protein 15072549
C029010 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) cinnamic acid analog results in decreased activity of CYP2C9 protein decreases activity
protein 15072549
C029010 1565 CYP2D6
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) cinnamic acid analog results in decreased activity of CYP2D6 protein decreases activity
protein 15072549
C029010 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) cinnamic acid analog results in decreased activity of CYP2E1 protein decreases activity
protein 15072549
C029010 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) cinnamic acid analog results in decreased activity of CYP3A4 protein decreases activity
protein 15072549
C029010 338442 HCAR2
GPR109A
HCA2
HM74a
HM74b
NIACR1
PUMAG
Puma-g
hydroxycarboxylic acid receptor 2 cinnamic acid binds to HCAR2 protein affects binding
protein 21167710
C029010 3284 HSD3B2
HSD3B
HSDB
SDR11E2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) cinnamic acid analog results in decreased activity of HSD3B2 protein decreases activity
protein 15072549
C029010 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) cinnamic acid results in increased expression of NOS3 mRNA increases expression
mRNA 15740983
C029010 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) TYR protein results in increased oxidation of cinnamic acid increases oxidation
protein 20685355
C029010 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) [TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione decreases abundance
/ increases oxidation
protein 20685355
C029010 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of cinnamic acid increases glucuronidation
protein 15117964
C029010 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of cinnamic acid increases glucuronidation
protein 15117964
C029010 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of cinnamic acid increases glucuronidation
protein 15117964
C029010 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of cinnamic acid increases glucuronidation
protein 15117964

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#615363 Estrogen resistance; estrr P03372
#278300 Xanthinuria, type i P47989

KEGG DISEASE (2)

KEGG disease name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00192 Xanthinuria P47989 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003384 C029010 Coxsackievirus Infections therapeutic
20460981
D008545 C029010 Melanoma therapeutic
20685355