| Organism name | Tarenna attenuata | 
|---|---|
| Genus | Tarenna | 
| Family | Rubiaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Tarenna | 
|---|---|
| Linked NCBI taxonomy ID | 58440 | 
| Linked level | genus | 
| Family in NCBI taxonomy | Rubiaceae | 
|---|---|
| ID | 24966 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | asterids | 
|---|---|
| ID | 71274 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00002631   | (+)-Lirioresinol B / (+)-Syringaresinol | CHEMBL361362 CHEMBL402653 | C042192 | 1 / 0 / 0 | No. 38 | No. 21 |   | |
| C00007190   | (+)-Pinoresinol | CHEMBL267963 CHEMBL487611 CHEMBL460862 | C103298 | 7 / 5 / 6 | No. 38 | No. 21 |   | |
| C00039281   | Glycosmisic acid | CHEMBL2346742 | No. 215 | No. 23 |   | |||
| C00033656   | Balanophonin / (-)-Balanophonin | CHEMBL253335 CHEMBL468666 CHEMBL590760 CHEMBL1956166 | No. 215 | No. 23 |   | |||
| C00032977   | Ficusal / (+)-Ficusal | No. 215 | No. 23 |   | ||||
| C00002775   | Sinapaldehyde / Sinapic aldehyde | CHEMBL225067 | C075386 | No. 310 | No. 6 |   | ||
| C00039440   | Isoferulaldehyde | CHEMBL53781 | 2 / 2 / 11 | No. 310 | No. 6 |   | ||
| C00038661   | Buddlenol E | CHEMBL1761717 | No. 428 |   | ||||
| C00038660   | Buddlenol D | No. 428 |   | |||||
| C00038658   | Buddlenol A | CHEMBL221879 | No. 428 |   | ||||
| C00038659   | Buddlenol C | No. 428 |   | |||||
| C00039028   | Dihydrocubebin / (-)-Dihydrocubebin | CHEMBL486597 CHEMBL1477391 | C011228 | 4 / 8 / 4 | No. 629 | No. 21 |   | |
| C00029961   | Cinnamic acid / .beta-Phenylacrylic acid | CHEMBL27246 | C029010 | 5 / 2 / 2 | 16 / 2 | No. 904 | No. 6 |   | 
| C00030463   | Hedyotisol A | CHEMBL388779 CHEMBL1761832 | No. 907 |   | ||||
| C00039300   | Guaiacylglycerol | CHEMBL1078124 | No. 1736 |   | ||||
| C00029477   | beta-Hydroxypropiovanillone / omega-Hydroxypropioguaiacone / 3,4'-Dihydroxy-3'-methoxypropiophenone / 3-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone | CHEMBL485875 | No. 2959 |   | ||||
| C00038323   | 7-O-Ethylguaiacylglycerol / (-)-7-O-Ethylguaiacylglycerol | CHEMBL224843 | No. 5619 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00007190 C00039028 | 0 / 0 | 
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00029961 | 0 / 0 | 
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00007190 | 0 / 0 | 
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00007190 | 0 / 3 | 
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00007190 | 0 / 0 | 
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00029961 | 1 / 1 | 
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00039440 | 1 / 3 | 
| P24385 | G1/S-specific cyclin-D1 | Other cytosolic protein | C00039440 | 1 / 8 | 
| P11387 | DNA topoisomerase 1 | Isomerase | C00002631 | 0 / 0 | 
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00029961 | 0 / 0 | 
| P15121 | Aldose reductase | Enzyme | C00029961 | 0 / 0 | 
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00039028 | 7 / 3 | 
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00007190 | 5 / 3 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00039028 | 1 / 0 | 
| P03372 | Estrogen receptor | NR3A1 | C00029961 | 1 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00039028 | 0 / 1 | 
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00007190 | 0 / 0 | 
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00007190 | 0 / 0 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) | C00029961 | 
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | C00029961 | 
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | C00029961 | 
| 1558 | CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 | cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) | C00029961 | 
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | C00029961 | 
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) | C00029961 | 
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | C00029961 | 
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | C00029961 | 
| 338442 | HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g | hydroxycarboxylic acid receptor 2 | C00029961 | 
| 3284 | HSD3B2, HSD3B, HSDB, SDR11E2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) | C00029961 | 
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | C00029961 | 
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) | C00029961 | 
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) | C00029961 | 
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) | C00029961 | 
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) | C00029961 | 
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) | C00029961 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah | P63092 | 
| %606641 | Body mass index; bmi | P37231 | 
| #609338 | Carotid intimal medial thickness 1 | P37231 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #615363 | Estrogen resistance; estrr | P03372 | 
| #137800 | Glioma susceptibility 1; glm1 | P37231 | 
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 | P37231 | 
| #174800 | Mccune-albright syndrome; mas | P63092 | 
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 | P11802 | 
| #254500 | Myeloma, multiple | P24385 | 
| #601665 | Obesity | P37231 | 
| #166350 | Osseous heteroplasia, progressive; poh | P63092 | 
| #102200 | Pituitary adenoma, growth hormone-secreting | P63092 | 
| #103580 | Pseudohypoparathyroidism, type ia; php1a | P63092 | 
| #603233 | Pseudohypoparathyroidism, type ib; php1b | P63092 | 
| #612462 | Pseudohypoparathyroidism, type ic; php1c | P63092 | 
| #278300 | Xanthinuria, type i | P47989 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00026 | Endometrial Cancer | P03372
                            (marker) | 
| H00036 | Osteosarcoma | P08684
                            (marker) | 
| H00030 | Cervical cancer | P11802
                            (related) | 
| H00038 | Malignant melanoma | P11802
                            (related) | 
| H00042 | Glioma | P11802
                            (related) | 
| H00006 | Hairy-cell leukemia | P24385
                            (related) | 
| H00010 | Multiple myeloma | P24385
                            (related) | 
| H00016 | Oral cancer | P24385
                            (related) P24385 (marker) | 
| H00017 | Esophageal cancer | P24385
                            (related) P35354 (related) | 
| H00031 | Breast cancer | P24385
                            (related) | 
| H00055 | Laryngeal cancer | P24385
                            (related) P24385 (marker) | 
| H00559 | von Hippel-Lindau syndrome | P24385
                            (related) | 
| H00047 | Gallbladder cancer | P24385
                            (marker) | 
| H00025 | Penile cancer | P35354
                            (related) | 
| H00046 | Cholangiocarcinoma | P35354
                            (related) | 
| H00032 | Thyroid cancer | P37231
                            (related) | 
| H00409 | Type II diabetes mellitus | P37231
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P37231
                            (related) | 
| H00192 | Xanthinuria | P47989
                            (related) | 
| H00244 | Pseudohypoparathyroidism | P63092
                            (related) | 
| H00441 | Progressive osseous heteroplasia (POH) | P63092
                            (related) | 
| H00501 | Fibrous dysplasia, polyostotic | P63092
                            (related) |