Engelhardia roxburghiana
Species
KNApSAcK Entry
| Organism name | Engelhardia roxburghiana |
|---|---|
| Genus | Engelhardia |
| Family | Juglandaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Alfaropsis roxburghiana |
|---|---|
| Linked NCBI taxonomy ID | 139932 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Juglandaceae |
|---|---|
| ID | 16714 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (23)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00034390
|
3-epi-Betulinic acid
|
CHEMBL269277
CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635 |
34 / 17 / 14 | No. 23 | No. 51 |
|
||
|
C00029821
|
Sitostenone
/ beta-Sitostenone / Stigmast-4-en-3-one / Stigmast-4-ene-3-one |
CHEMBL66926
|
No. 53 | No. 11 |
|
|||
|
C00034729
|
Tricosyl trans-ferulate
/ n-Tricosyl trans-ferulate |
No. 447 |
|
|||||
|
C00034722
|
Tetracosyl trans-ferulate
|
No. 447 |
|
|||||
|
C00034535
|
Hexacosyl trans-ferulate
/ n-Hexacosyl trans-ferulate |
No. 447 |
|
|||||
|
C00034485
|
Docosyl trans-ferulate
|
No. 447 |
|
|||||
|
C00029961
|
Cinnamic acid
/ .beta-Phenylacrylic acid |
CHEMBL27246
|
C029010
|
5 / 2 / 2 | 16 / 2 | No. 904 | No. 6 |
|
|
C00029515
|
p-Tyrosol
/ 4-(2-Hydroxyethyl)phenol / p-Hydroxyphenethyl alcohol / 2-(4-Hydroxyphenyl)ethanol |
CHEMBL53566
|
C011867
|
6 / 3 / 5 | No. 936 | No. 6 |
|
|
|
C00002683
|
Vanillin
|
CHEMBL13883
|
18 / 8 / 9 | No. 1003 |
|
|||
|
C00002682
|
Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid |
CHEMBL120568
|
D014641
|
5 / 3 / 3 | 5 / 0 | No. 1073 |
|
|
|
C00029476
|
Eudesmic acid
/ Trimethylgallic acid / 3,4,5-Trimethoxybenzoic acid |
CHEMBL377172
|
C005854
|
3 / 2 / 2 | No. 1073 |
|
||
|
C00002689
|
Apocynin
/ Acetovanillone |
CHEMBL346919
|
C056165
|
2 / 0 / 0 | 43 / 10 | No. 1494 |
|
|
|
C00034498
|
Engelhardic acid
|
No. 2025 |
|
|||||
|
C00002657
|
p-Formylphenol
/ 4-Hydroxybenzaldehyde / p-Hydroxybenzaldehyde |
CHEMBL14193
|
C011483
|
3 / 2 / 2 | No. 2076 |
|
||
|
C00000258
|
2,6-Dimethoxy-p-benzoquinone
|
CHEMBL448515
|
C030511
|
22 / 32 / 55 | No. 2517 |
|
||
|
C00034398
|
5-Methoxy-1-naphthalenol
|
No. 3508 |
|
|||||
|
C00034374
|
1-Methoxynaphthalene
|
No. 3508 |
|
|||||
|
C00034393
|
4-(2-Hydroxyphenyl)-4-oxobutyric acid
|
No. 3936 |
|
|||||
|
C00034500
|
Engelharquinone
/ (-)-Engelharquinone |
CHEMBL2204406
|
No. 4494 |
|
||||
|
C00034397
|
5,8-Dihydroxy-4-methoxy-1-tetralone
|
No. 4978 |
|
|||||
|
C00034602
|
Methyl-4-(butyryloxy)benzoate
|
No. 5786 |
|
|||||
|
C00034499
|
Engelharolide
/ (+)-Engelharolide |
No. 5958 |
|
|||||
|
C00034501
|
Engelharquinone epoxide
|
No. 7996 |
|
Human Protein / Gene in interactions
80 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00000258 C00002689 C00029476 C00034390 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000258 C00002689 C00029476 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002682 C00029961 C00034390 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002683 C00034390 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000258 C00002682 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000258 C00034390 | 0 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00002682 C00029961 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000258 C00002683 | 0 / 0 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00002657 C00002683 | 1 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00000258 C00034390 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000258 C00034390 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000258 C00034390 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002683 C00029515 | 0 / 0 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002657 C00002683 | 1 / 1 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00002682 | 1 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00029961 | 1 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002683 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00034390 | 1 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00029515 | 1 / 2 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00002683 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00034390 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00034390 | 0 / 1 |
| P15559 | NAD(P)H dehydrogenase [quinone] 1 | Enzyme | C00034390 | 0 / 0 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00002683 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00034390 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00034390 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000258 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002683 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00034390 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00029961 | 0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00002657 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000258 | 0 / 0 |
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00034390 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002682 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000258 | 2 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00034390 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002683 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00029515 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00029515 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00034390 | 0 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00002683 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00029515 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000258 | 7 / 3 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00034390 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00034390 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00034390 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00034390 | 0 / 0 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00029476 | 2 / 2 |
| P78527 | DNA-dependent protein kinase catalytic subunit | Atypical serine/threonine protein kinase PIKK subfamily | C00002683 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00034390 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00034390 | 0 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00029515 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000258 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00034390 | 0 / 0 |
| P55055 | Oxysterols receptor LXR-beta | NR1H3 | C00034390 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002683 | 2 / 2 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002683 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00034390 | 2 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00034390 | 0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00034390 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00034390 | 11 / 10 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00034390 | 1 / 1 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000258 | 1 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002683 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000258 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002683 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000258 | 4 / 1 |
| P10275 | Androgen receptor | NR3C4 | C00002683 | 3 / 4 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00034390 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000258 | 0 / 0 |
| Q2TB90 | Putative hexokinase HKDC1 | Enzyme | C00000258 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002683 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000258 | 7 / 37 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00034390 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00000258 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000258 | 1 / 2 |
| Q9UBT2 | SUMO-activating enzyme subunit 2 | Enzyme | C00034390 | 0 / 0 |
| Q9UBE0 | SUMO-activating enzyme subunit 1 | Unclassified protein | C00034390 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00029961 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00000258 | 2 / 1 |
58 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002682
C00002689
C00029961
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002682
C00029961
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002682
C00029961
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002682
C00029961
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002682
C00029961
|
| 2033 | EP300, KAT3B, RSTS2, p300 | E1A binding protein p300 (EC:2.3.1.48) |
C00002689
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00029961
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00029961
|
| 338442 | HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g | hydroxycarboxylic acid receptor 2 |
C00029961
|
| 3284 | HSD3B2, HSD3B, HSDB, SDR11E2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) |
C00029961
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00029961
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00029961
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00029961
|
| 1558 | CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 | cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) |
C00029961
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00029961
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00029961
|
| 183 | AGT, ANHU, SERPINA8 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
C00002689
|
| 1386 | ATF2, CRE-BP1, CREB2, HB16, TREB7 | activating transcription factor 2 (EC:2.3.1.48) |
C00002689
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002689
|
| 6356 | CCL11, SCYA11 | chemokine (C-C motif) ligand 11 |
C00002689
|
| 6362 | CCL18, AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
C00002689
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002689
|
| 6352 | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP | chemokine (C-C motif) ligand 5 |
C00002689
|
| 6354 | CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7 | chemokine (C-C motif) ligand 7 |
C00002689
|
| 948 | CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 | CD36 molecule (thrombospondin receptor) |
C00002689
|
| 1437 | CSF2, GMCSF | colony stimulating factor 2 (granulocyte-macrophage) |
C00002689
|
| 2919 | CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
C00002689
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00002689
|
| 1536 | CYBB, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX | cytochrome b-245, beta polypeptide |
C00002689
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00029961
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00002689
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00002689
|
| 27429 | HTRA2, OMI, PARK13, PRSS25 | HtrA serine peptidase 2 (EC:3.4.21.108) |
C00002689
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00002689
|
| 3456 | IFNB1, IFB, IFF, IFNB | interferon, beta 1, fibroblast |
C00002689
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00002689
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002689
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002689
|
| 3684 | ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6 | integrin, alpha M (complement component 3 receptor 3 subunit) |
C00002689
|
| 3717 | JAK2, JTK10, THCYT3 | Janus kinase 2 (EC:2.7.10.2) |
C00002689
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00002689
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002689
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002689
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002689
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002689
|
| 4282 | MIF, GIF, GLIF, MMIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) |
C00002689
|
| 4322 | MMP13, CLG3, MANDP1 | matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) |
C00002689
|
| 4481 | MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2 | macrophage scavenger receptor 1 |
C00002689
|
| 653361 | NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox | neutrophil cytosolic factor 1 |
C00002689
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002689
|
| 4973 | OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 | oxidized low density lipoprotein (lectin-like) receptor 1 |
C00002689
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002689
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002689
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00002689
|
| 6772 | STAT1, CANDF7, ISGF-3, STAT91 | signal transducer and activator of transcription 1, 91kDa |
C00002689
|
| 7082 | TJP1, ZO-1 | tight junction protein 1 |
C00002689
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002689
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00002689
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (65)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (83)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
P08581 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
P08581 (related) |
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
12 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003384 | Coxsackievirus Infections |
C00029961
|
| D008545 | Melanoma |
C00029961
|
| D000419 | Albuminuria |
C00002689
|
| D001919 | Bradycardia |
C00002689
|
| D020520 | Brain Infarction |
C00002689
|
| D002310 | Cardiomyopathy, Alcoholic |
C00002689
|
| D003928 | Diabetic Nephropathies |
C00002689
|
| D006331 | Heart Diseases |
C00002689
|
| D006973 | Hypertension |
C00002689
|
| D007022 | Hypotension |
C00002689
|
| D009410 | Nerve Degeneration |
C00002689
|
| D011014 | Pneumonia |
C00002689
|