PCIDB

KCF-S cluster No. 1494 (7 metabolites)

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00000171 External link 512 3-Acethyl-6-methoxybenzaldehyde
C00002689 External link 512 Apocynin
/ Acetovanillone
CHEMBL346919
C056165
2 / 0 / 0 43 / 10
C00002693 External link 512 3',4'-Dihydroxyacetophenone
CHEMBL243161
C032940
1 / 0
C00002704 External link 512 Paeonol
CHEMBL1079227
C013638
4 / 2 / 3
C00032617 External link 512 2,5-Dihydroxy-4-methylacetophenone
C00032695 External link 512 Acetoisovanillone
/ Isoacetovanillone
C085119
C00033340 External link 512 Resacetophenone
CHEMBL243374
C078634
1 / 0 / 0

Human Protein / Gene in interactions

7 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9HAS3 Solute carrier family 28 member 3 Unclassified protein C00033340 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002704 0 / 0
O75496 Geminin Unclassified protein C00002689 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002689 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002704 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002704 2 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002704 0 / 1

44 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002693
183 AGT, ANHU, SERPINA8 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) C00002689
1386 ATF2, CRE-BP1, CREB2, HB16, TREB7 activating transcription factor 2 (EC:2.3.1.48) C00002689
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002689
6356 CCL11, SCYA11 chemokine (C-C motif) ligand 11 C00002689
6362 CCL18, AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) C00002689
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002689
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00002689
6354 CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7 chemokine (C-C motif) ligand 7 C00002689
948 CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 CD36 molecule (thrombospondin receptor) C00002689
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00002689
2919 CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) C00002689
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00002689
1536 CYBB, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX cytochrome b-245, beta polypeptide C00002689
2033 EP300, KAT3B, RSTS2, p300 E1A binding protein p300 (EC:2.3.1.48) C00002689
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00002689
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00002689
27429 HTRA2, OMI, PARK13, PRSS25 HtrA serine peptidase 2 (EC:3.4.21.108) C00002689
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002689
3456 IFNB1, IFB, IFF, IFNB interferon, beta 1, fibroblast C00002689
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00002689
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002689
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002689
3684 ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6 integrin, alpha M (complement component 3 receptor 3 subunit) C00002689
3717 JAK2, JTK10, THCYT3 Janus kinase 2 (EC:2.7.10.2) C00002689
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00002689
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002689
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002689
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00002689
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00002689
4282 MIF, GIF, GLIF, MMIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) C00002689
4322 MMP13, CLG3, MANDP1 matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) C00002689
4481 MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2 macrophage scavenger receptor 1 C00002689
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00002689
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00002689
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002689
4973 OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 oxidized low density lipoprotein (lectin-like) receptor 1 C00002689
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002689
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002689
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00002689
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00002689
7082 TJP1, ZO-1 tight junction protein 1 C00002689
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002689
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002689

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#119900 Digital clubbing, isolated congenital P15428
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428

KEGG DISEASE (3)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000419 Albuminuria C00002689
D001919 Bradycardia C00002689
D020520 Brain Infarction C00002689
D002310 Cardiomyopathy, Alcoholic C00002689
D003928 Diabetic Nephropathies C00002689
D006331 Heart Diseases C00002689
D006973 Hypertension C00002689
D007022 Hypotension C00002689
D009410 Nerve Degeneration C00002689
D011014 Pneumonia C00002689