Metabolite

KNApSAcK Entry

id C00002689
Name Apocynin / Acetovanillone
CAS RN 498-02-2
Standard InChI InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3
Standard InChI (Main Layer) InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 1494

Link

ChEMBL

By standard InChI CHEMBL346919
By standard InChI Main Layer CHEMBL346919

KEGG

By LinkDB C11380

CTD

By CAS RN C056165

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein CHEMBL346919 CHEMBL2114780 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL346919 CHEMBL1794401 (1)
0 / 0

CTD interaction (97)

compound gene gene name gene description interaction interaction type form reference
pmid
C056165 183 AGT
ANHU
SERPINA8
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15677497
C056165 1386 ATF2
CRE-BP1
CREB2
HB16
TREB7
activating transcription factor 2 (EC:2.3.1.48) acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein] decreases reaction
/ increases phosphorylation
protein 22288910
C056165 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein] affects cotreatment
/ decreases reaction
/ increases activity
protein 20153346
C056165 6356 CCL11
SCYA11
chemokine (C-C motif) ligand 11 acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 6362 CCL18
AMAC-1
AMAC1
CKb7
DC-CK1
DCCK1
MIP-4
PARC
SCYA18
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) acetovanillone inhibits the reaction [arsenic trioxide results in increased secretion of CCL18 protein] decreases reaction
/ increases secretion
protein 18424721
C056165 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 19158351
C056165 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
mRNA 16845898
C056165 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein] decreases reaction
/ increases expression
protein 22414048
C056165 6352 CCL5
D17S136E
RANTES
SCYA5
SIS-delta
SISd
TCP228
eoCP
chemokine (C-C motif) ligand 5 acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein] decreases reaction
/ increases expression
protein 22414048
C056165 6354 CCL7
FIC
MARC
MCP-3
MCP3
NC28
SCYA6
SCYA7
chemokine (C-C motif) ligand 7 acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 948 CD36
BDPLT10
CHDS7
FAT
GP3B
GP4
GPIV
PASIV
SCARB3
CD36 molecule (thrombospondin receptor) acetovanillone inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] decreases reaction
/ increases abundance
/ increases expression
mRNA 19640849
C056165 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 2919 CXCL1
FSP
GRO1
GROa
MGSA
MGSA-a
NAP-3
SCYB1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 2919 CXCL1
FSP
GRO1
GROa
MGSA
MGSA-a
NAP-3
SCYB1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] decreases reaction
/ increases expression
protein 22414048
C056165 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] decreases reaction
/ increases expression
mRNA 18322232
C056165 1536 CYBB
AMCBX2
CGD
GP91-1
GP91-PHOX
GP91PHOX
NOX2
p91-PHOX
cytochrome b-245, beta polypeptide acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein] decreases reaction
/ increases activity
/ increases expression
protein 19878672
C056165 2033 EP300
KAT3B
RSTS2
p300
E1A binding protein p300 (EC:2.3.1.48) acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases reaction
protein 19281832
C056165 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein] decreases reaction
/ increases secretion
protein 15086456
C056165 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) acetovanillone inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein] decreases reaction
/ increases activity
protein 20934533
C056165 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA] decreases reaction
/ increases expression
mRNA 20934533
C056165 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
protein 20934533
C056165 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) acetovanillone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
protein 19414066
C056165 27429 HTRA2
OMI
PARK13
PRSS25
HtrA serine peptidase 2 (EC:3.4.21.108) [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] affects cotreatment
/ affects localization
/ decreases reaction
protein 20153346
C056165 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 19632255
C056165 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 20920494
C056165 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 20920494
C056165 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 22414048
C056165 3456 IFNB1
IFB
IFF
IFNB
interferon, beta 1, fibroblast acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] decreases reaction
/ increases expression
mRNA 18322232
C056165 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases reaction
19281832
C056165 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein] affects localization
/ decreases reaction
protein 19281832
C056165 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta acetovanillone inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species] decreases reaction
/ increases abundance
protein 19281832
C056165 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] decreases reaction
/ increases expression
protein 21211511
C056165 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 19281832
C056165 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 19281832
C056165 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta acetovanillone results in decreased susceptibility to IL1B protein decreases response to substance
protein 21211511
C056165 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 22414048
C056165 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 20920494
C056165 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 20920494
C056165 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acetovanillone inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 acetovanillone inhibits the reaction [TNF protein results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 22414048
C056165 3684 ITGAM
CD11B
CR3A
MAC-1
MAC1A
MO1A
SLEB6
integrin, alpha M (complement component 3 receptor 3 subunit) acetovanillone inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA] decreases reaction
/ increases expression
mRNA 16357311
C056165 3717 JAK2
JTK10
THCYT3
Janus kinase 2 (EC:2.7.10.2) acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15677497
C056165 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein] decreases reaction
/ increases expression
/ increases phosphorylation
protein 22288910
C056165 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 22288910
C056165 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases abundance
/ increases phosphorylation
protein 21391979
C056165 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 22288910
C056165 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases abundance
/ increases phosphorylation
protein 21391979
C056165 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases abundance
/ increases phosphorylation
protein 21391979
C056165 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein] decreases reaction
/ increases abundance
/ increases phosphorylation
protein 21391979
C056165 4282 MIF
GIF
GLIF
MMIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] decreases reaction
/ increases expression
protein 21211511
C056165 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein] decreases reaction
/ increases expression
protein 21211511
C056165 4481 MSR1
CD204
SCARA1
SR-A
SRA
phSR1
phSR2
macrophage scavenger receptor 1 acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] decreases reaction
/ increases expression
mRNA 9614211
C056165 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein] decreases reaction
/ increases phosphorylation
protein 20299304
C056165 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein] decreases reaction
/ increases phosphorylation
protein 20299304
C056165 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of NCF1 protein] decreases reaction
/ increases phosphorylation
protein 20299304
C056165 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein] decreases reaction
/ increases phosphorylation
protein 20299304
C056165 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 acetovanillone inhibits the reaction [arsenic trioxide affects the localization of NCF1 protein] affects localization
/ decreases reaction
protein 18424721
C056165 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of NCF1 protein] decreases reaction
/ increases activity
/ increases expression
protein 19878672
C056165 653361 NCF1
NCF1A
NOXO2
SH3PXD1A
p47phox
neutrophil cytosolic factor 1 acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein] affects localization
/ decreases reaction
protein 19281832
C056165 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16845898
C056165 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) acetovanillone inhibits the reaction [Glucose results in decreased expression of NOS3 protein] decreases expression
/ decreases reaction
protein 19878672
C056165 4973 OLR1
CLEC8A
LOX1
LOXIN
SCARE1
SLOX1
oxidized low density lipoprotein (lectin-like) receptor 1 acetovanillone inhibits the reaction [Glucose results in increased expression of OLR1 mRNA] decreases reaction
/ increases expression
mRNA 19878672
C056165 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) acetovanillone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 22288910
C056165 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases reaction
protein 19281832
C056165 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] decreases reaction
/ increases expression
mRNA 22414048
C056165 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa acetovanillone inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein] decreases reaction
/ increases phosphorylation
protein 18322232
C056165 7082 TJP1
ZO-1
tight junction protein 1 acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein] decreases expression
/ decreases reaction
protein 20299304
C056165 7082 TJP1
ZO-1
tight junction protein 1 acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein] decreases expression
/ decreases reaction
protein 20299304
C056165 7082 TJP1
ZO-1
tight junction protein 1 acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein] decreases expression
/ decreases reaction
protein 20299304
C056165 7082 TJP1
ZO-1
tight junction protein 1 acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein] decreases expression
/ decreases reaction
protein 20299304
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide] decreases reaction
/ increases abundance
protein 19608869
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides] decreases reaction
/ increases abundance
protein 19608869
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein] decreases reaction
/ increases expression
protein 21211511
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] decreases reaction
/ increases expression
protein 22414048
C056165 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor acetovanillone results in decreased susceptibility to TNF protein decreases response to substance
protein 21211511
C056165 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 19632255
C056165 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 19281832
C056165 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 19281832

Related Disease

Diseases related to CTD interactions

10 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000419 C056165 Albuminuria therapeutic
20551625
D001919 C056165 Bradycardia therapeutic
17448908
D020520 C056165 Brain Infarction therapeutic
19417757
D002310 C056165 Cardiomyopathy, Alcoholic therapeutic
22497828
D003928 C056165 Diabetic Nephropathies therapeutic
20551625
D006331 C056165 Heart Diseases therapeutic
17217956
D006973 C056165 Hypertension therapeutic
16053986
16580579
20713914
22431579
D007022 C056165 Hypotension therapeutic
17448908
D009410 C056165 Nerve Degeneration therapeutic
20732386
D011014 C056165 Pneumonia therapeutic
21983654