id | C00002689 |
---|---|
Name | Apocynin / Acetovanillone |
CAS RN | 498-02-2 |
Standard InChI | InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3 |
Standard InChI (Main Layer) | InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3 |
Phytochemical cluster | |
---|---|
KCF-S cluster | No. 1494 |
By standard InChI | CHEMBL346919 |
---|---|
By standard InChI Main Layer | CHEMBL346919 |
By LinkDB | C11380 |
---|
By CAS RN | C056165 |
---|
class name | count |
---|---|
Liliopsida | 6 |
rosids | 4 |
eudicotyledons | 4 |
asterids | 3 |
family name | count |
---|---|
Iridaceae | 2 |
Apocynaceae | 2 |
Cactaceae | 2 |
Rosaceae | 2 |
Amaryllidaceae | 2 |
Malvaceae | 1 |
Juglandaceae | 1 |
Paeoniaceae | 1 |
Posidoniaceae | 1 |
Plantaginaceae | 1 |
accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|---|
O75496 | Geminin | Unclassified protein | CHEMBL346919 |
CHEMBL2114780
(1)
|
0 / 0 |
P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL346919 |
CHEMBL1794401
(1)
|
0 / 0 |
compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
---|---|---|---|---|---|---|---|
C056165 | 183 |
AGT
ANHU SERPINA8 |
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] |
decreases reaction
/ increases phosphorylation / increases reaction |
protein |
15677497
|
C056165 | 1386 |
ATF2
CRE-BP1 CREB2 HB16 TREB7 |
activating transcription factor 2 (EC:2.3.1.48) | acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein] |
decreases reaction
/ increases phosphorylation |
protein |
22288910
|
C056165 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
20153346
|
C056165 | 6356 |
CCL11
SCYA11 |
chemokine (C-C motif) ligand 11 | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 6362 |
CCL18
AMAC-1 AMAC1 CKb7 DC-CK1 DCCK1 MIP-4 PARC SCYA18 |
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | acetovanillone inhibits the reaction [arsenic trioxide results in increased secretion of CCL18 protein] |
decreases reaction
/ increases secretion |
protein |
18424721
|
C056165 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein] |
decreases reaction
/ increases secretion |
protein |
19158351
|
C056165 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
16845898
|
C056165 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 6352 |
CCL5
D17S136E RANTES SCYA5 SIS-delta SISd TCP228 eoCP |
chemokine (C-C motif) ligand 5 | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 6354 |
CCL7
FIC MARC MCP-3 MCP3 NC28 SCYA6 SCYA7 |
chemokine (C-C motif) ligand 7 | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 948 |
CD36
BDPLT10 CHDS7 FAT GP3B GP4 GPIV PASIV SCARB3 |
CD36 molecule (thrombospondin receptor) | acetovanillone inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] |
decreases reaction
/ increases abundance / increases expression |
mRNA |
19640849
|
C056165 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 2919 |
CXCL1
FSP GRO1 GROa MGSA MGSA-a NAP-3 SCYB1 |
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 2919 |
CXCL1
FSP GRO1 GROa MGSA MGSA-a NAP-3 SCYB1 |
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 3627 |
CXCL10
C7 IFI10 INP10 IP-10 SCYB10 crg-2 gIP-10 mob-1 |
chemokine (C-X-C motif) ligand 10 | acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 3627 |
CXCL10
C7 IFI10 INP10 IP-10 SCYB10 crg-2 gIP-10 mob-1 |
chemokine (C-X-C motif) ligand 10 | acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] |
decreases reaction
/ increases expression |
mRNA |
18322232
|
C056165 | 1536 |
CYBB
AMCBX2 CGD GP91-1 GP91-PHOX GP91PHOX NOX2 p91-PHOX |
cytochrome b-245, beta polypeptide | acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein] |
decreases reaction
/ increases activity / increases expression |
protein |
19878672
|
C056165 | 2033 |
EP300
KAT3B RSTS2 p300 |
E1A binding protein p300 (EC:2.3.1.48) | acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] |
affects binding
/ decreases reaction / increases reaction |
protein |
19281832
|
C056165 | 2335 |
FN1
CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF |
fibronectin 1 | acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein] |
decreases reaction
/ increases secretion |
protein |
15086456
|
C056165 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | acetovanillone inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein] |
decreases reaction
/ increases activity |
protein |
20934533
|
C056165 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20934533
|
C056165 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
protein |
20934533
|
C056165 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | acetovanillone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
protein |
19414066
|
C056165 | 27429 |
HTRA2
OMI PARK13 PRSS25 |
HtrA serine peptidase 2 (EC:3.4.21.108) | [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] |
affects cotreatment
/ affects localization / decreases reaction |
protein |
20153346
|
C056165 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
19632255
|
C056165 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20920494
|
C056165 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
20920494
|
C056165 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 3456 |
IFNB1
IFB IFF IFNB |
interferon, beta 1, fibroblast | acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
18322232
|
C056165 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] |
affects binding
/ decreases reaction / increases reaction |
19281832
|
|
C056165 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein] |
affects localization
/ decreases reaction |
protein |
19281832
|
C056165 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | acetovanillone inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species] |
decreases reaction
/ increases abundance |
protein |
19281832
|
C056165 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] |
decreases reaction
/ increases expression |
protein |
21211511
|
C056165 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA] |
decreases reaction
/ increases expression |
protein |
19281832
|
C056165 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] |
decreases reaction
/ increases expression |
protein |
19281832
|
C056165 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | acetovanillone results in decreased susceptibility to IL1B protein |
decreases response to substance
|
protein |
21211511
|
C056165 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20920494
|
C056165 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of IL8 protein] |
decreases reaction
/ increases expression |
protein |
20920494
|
C056165 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | acetovanillone inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | acetovanillone inhibits the reaction [TNF protein results in increased expression of IL8 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 3684 |
ITGAM
CD11B CR3A MAC-1 MAC1A MO1A SLEB6 |
integrin, alpha M (complement component 3 receptor 3 subunit) | acetovanillone inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA] |
decreases reaction
/ increases expression |
mRNA |
16357311
|
C056165 | 3717 |
JAK2
JTK10 THCYT3 |
Janus kinase 2 (EC:2.7.10.2) | acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] |
decreases reaction
/ increases phosphorylation / increases reaction |
protein |
15677497
|
C056165 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein] |
decreases reaction
/ increases expression / increases phosphorylation |
protein |
22288910
|
C056165 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
22288910
|
C056165 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases abundance / increases phosphorylation |
protein |
21391979
|
C056165 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
22288910
|
C056165 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases abundance / increases phosphorylation |
protein |
21391979
|
C056165 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein] |
decreases reaction
/ increases abundance / increases phosphorylation |
protein |
21391979
|
C056165 | 5601 |
MAPK9
JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK |
mitogen-activated protein kinase 9 (EC:2.7.11.24) | acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein] |
decreases reaction
/ increases abundance / increases phosphorylation |
protein |
21391979
|
C056165 | 4282 |
MIF
GIF GLIF MMIF |
macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) | acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 4322 |
MMP13
CLG3 MANDP1 |
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) | acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] |
decreases reaction
/ increases expression |
protein |
21211511
|
C056165 | 4322 |
MMP13
CLG3 MANDP1 |
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) | acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein] |
decreases reaction
/ increases expression |
protein |
21211511
|
C056165 | 4481 |
MSR1
CD204 SCARA1 SR-A SRA phSR1 phSR2 |
macrophage scavenger receptor 1 | acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
9614211
|
C056165 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
20299304
|
C056165 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
20299304
|
C056165 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of NCF1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
20299304
|
C056165 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
20299304
|
C056165 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | acetovanillone inhibits the reaction [arsenic trioxide affects the localization of NCF1 protein] |
affects localization
/ decreases reaction |
protein |
18424721
|
C056165 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of NCF1 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
19878672
|
C056165 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein] |
affects localization
/ decreases reaction |
protein |
19281832
|
C056165 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
16845898
|
C056165 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | acetovanillone inhibits the reaction [Glucose results in decreased expression of NOS3 protein] |
decreases expression
/ decreases reaction |
protein |
19878672
|
C056165 | 4973 |
OLR1
CLEC8A LOX1 LOXIN SCARE1 SLOX1 |
oxidized low density lipoprotein (lectin-like) receptor 1 | acetovanillone inhibits the reaction [Glucose results in increased expression of OLR1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19878672
|
C056165 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | acetovanillone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein] |
decreases reaction
/ increases expression |
protein |
22288910
|
C056165 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] |
affects binding
/ decreases reaction / increases reaction |
protein |
19281832
|
C056165 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22414048
|
C056165 | 6772 |
STAT1
CANDF7 ISGF-3 STAT91 |
signal transducer and activator of transcription 1, 91kDa | acetovanillone inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
18322232
|
C056165 | 7082 |
TJP1
ZO-1 |
tight junction protein 1 | acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein] |
decreases expression
/ decreases reaction |
protein |
20299304
|
C056165 | 7082 |
TJP1
ZO-1 |
tight junction protein 1 | acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein] |
decreases expression
/ decreases reaction |
protein |
20299304
|
C056165 | 7082 |
TJP1
ZO-1 |
tight junction protein 1 | acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein] |
decreases expression
/ decreases reaction |
protein |
20299304
|
C056165 | 7082 |
TJP1
ZO-1 |
tight junction protein 1 | acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein] |
decreases expression
/ decreases reaction |
protein |
20299304
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide] |
decreases reaction
/ increases abundance |
protein |
19608869
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides] |
decreases reaction
/ increases abundance |
protein |
19608869
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of IL8 protein] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein] |
decreases reaction
/ increases expression |
protein |
21211511
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] |
decreases reaction
/ increases expression |
protein |
22414048
|
C056165 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | acetovanillone results in decreased susceptibility to TNF protein |
decreases response to substance
|
protein |
21211511
|
C056165 | 7412 |
VCAM1
CD106 INCAM-100 |
vascular cell adhesion molecule 1 | acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] |
decreases reaction
/ increases expression |
protein |
19632255
|
C056165 | 7412 |
VCAM1
CD106 INCAM-100 |
vascular cell adhesion molecule 1 | acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19281832
|
C056165 | 7412 |
VCAM1
CD106 INCAM-100 |
vascular cell adhesion molecule 1 | acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] |
decreases reaction
/ increases expression |
protein |
19281832
|
MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
---|---|---|---|---|---|
D000419 | C056165 | Albuminuria |
therapeutic
|
20551625
|
|
D001919 | C056165 | Bradycardia |
therapeutic
|
17448908
|
|
D020520 | C056165 | Brain Infarction |
therapeutic
|
19417757
|
|
D002310 | C056165 | Cardiomyopathy, Alcoholic |
therapeutic
|
22497828
|
|
D003928 | C056165 | Diabetic Nephropathies |
therapeutic
|
20551625
|
|
D006331 | C056165 | Heart Diseases |
therapeutic
|
17217956
|
|
D006973 | C056165 | Hypertension |
therapeutic
|
16053986
16580579 20713914 22431579 |
|
D007022 | C056165 | Hypotension |
therapeutic
|
17448908
|
|
D009410 | C056165 | Nerve Degeneration |
therapeutic
|
20732386
|
|
D011014 | C056165 | Pneumonia |
therapeutic
|
21983654
|