Panax notoginseng
Species
KNApSAcK Entry
| Organism name | Panax notoginseng |
|---|---|
| Genus | Panax |
| Family | Araliaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Panax notoginseng |
|---|---|
| Linked NCBI taxonomy ID | 44586 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Araliaceae |
|---|---|
| ID | 4050 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (64)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00044970
|
Notoginsenoside P
|
No. 11 | No. 51 |
|
||||
|
C00034049
|
Malonyl-ginsenoside Rb1
|
C089027
|
No. 11 | No. 51 |
|
|||
|
C00003518
|
Ginsenoside Re
|
CHEMBL510095
|
C049864
|
2 / 0 / 0 | 0 / 1 | No. 11 | No. 51 |
|
|
C00031120
|
Quinquenoside R1
|
No. 11 | No. 51 |
|
||||
|
C00030864
|
Notoginsenoside T
/ (-)-Notoginsenoside T |
No. 11 | No. 51 |
|
||||
|
C00003535
|
Ginsenoside R1
/ Notoginsenoside R1 |
CHEMBL507115
|
C072936
|
No. 11 | No. 51 |
|
||
|
C00030863
|
Notoginsenoside S
/ (-)-Notoginsenoside S |
No. 11 | No. 51 |
|
||||
|
C00030859
|
Notoginsenoside R6
/ (+)-Notoginsenoside R6 |
CHEMBL494056
|
No. 11 | No. 51 |
|
|||
|
C00030858
|
Notoginsenoside R4
/ (+)-Notoginsenoside R4 |
No. 11 | No. 51 |
|
||||
|
C00030845
|
Notoginsenoside G
/ (+)-Notoginsenoside G |
No. 11 | No. 51 |
|
||||
|
C00029442
|
20-Glucoginsenoside Rf
|
CHEMBL525935
|
No. 11 | No. 51 |
|
|||
|
C00030854
|
Notoginsenoside Q
/ (+)-Notoginsenoside Q |
No. 11 | No. 51 |
|
||||
|
C00030853
|
Notoginsenoside O
/ (+)-Notoginsenoside O |
No. 11 | No. 51 |
|
||||
|
C00030852
|
Notoginsenoside N
|
No. 11 | No. 51 |
|
||||
|
C00030851
|
Notoginsenoside M
|
No. 11 | No. 51 |
|
||||
|
C00030393
|
Ginsenoside Ra3
|
No. 11 | No. 51 |
|
||||
|
C00030394
|
Ginsenoside Rb1
/ Sanchinoside E1 / Sanchinoside Rb1 |
CHEMBL501515
|
2 / 0 / 0 | No. 11 | No. 51 |
|
||
|
C00030395
|
Ginsenoside Rb2
|
CHEMBL449303
CHEMBL507688 CHEMBL452438 |
C048026
|
2 / 0 / 0 | No. 11 | No. 51 |
|
|
|
C00030396
|
Gypenoside IV
/ Ginsenoside Rb3 |
CHEMBL449303
CHEMBL507688 CHEMBL452438 |
C044463
|
2 / 0 / 0 | No. 11 | No. 51 |
|
|
|
C00030397
|
Ginsenoside Rc
|
CHEMBL451702
|
C044462
|
No. 11 | No. 51 |
|
||
|
C00030398
|
Ginsenoside Rd
|
CHEMBL473659
|
C049863
|
2 / 0 / 0 | 0 / 1 | No. 11 | No. 51 |
|
|
C00030850
|
Notoginsenoside L
|
No. 11 | No. 51 |
|
||||
|
C00030849
|
Notoginsenoside K
/ (+)-Notoginsenoside K |
No. 11 | No. 51 |
|
||||
|
C00030847
|
Notoginsenoside I
/ (+)-Notoginsenoside I |
No. 11 | No. 51 |
|
||||
|
C00030846
|
Notoginsenoside H
/ (+)-Notoginsenoside H |
No. 11 | No. 51 |
|
||||
|
C00030445
|
Gypenoside IX
/ Notoginsenoside Fd |
CHEMBL1095009
CHEMBL1733148 |
C077955
|
5 / 0 / 0 | No. 11 | No. 51 |
|
|
|
C00030446
|
Gypenoside XV
|
No. 11 | No. 51 |
|
||||
|
C00030447
|
Gypenoside XVII
|
CHEMBL504441
|
No. 11 | No. 51 |
|
|||
|
C00030837
|
Notoginsenoside A
/ (+)-Notoginsenoside A |
No. 11 | No. 51 |
|
||||
|
C00030838
|
Notoginsenoside B
/ (+)-Notoginsenoside B |
No. 11 | No. 51 |
|
||||
|
C00030839
|
Notoginsenoside C
/ (+)-Notoginsenoside C |
No. 11 | No. 51 |
|
||||
|
C00030840
|
Notoginsenoside D
/ (+)-Notoginsenoside D |
No. 11 | No. 51 |
|
||||
|
C00030841
|
Notoginsenoside E
/ (+)-Notoginsenoside E |
No. 11 | No. 51 |
|
||||
|
C00030842
|
Notoginsenoside Fa
|
CHEMBL447915
|
No. 11 | No. 51 |
|
|||
|
C00030843
|
Notoginsenoside Fc
|
No. 11 | No. 51 |
|
||||
|
C00030844
|
Notoginsenoside Fe
|
No. 11 | No. 51 |
|
||||
|
C00030857
|
Notoginsenoside R3
|
CHEMBL494056
|
No. 11 | No. 51 |
|
|||
|
C00003520
|
Ginsenoside Rg1
|
CHEMBL501637
CHEMBL1977916 |
C035054
|
5 / 6 | No. 32 | No. 51 |
|
|
|
C00003519
|
Ginsenoside Rf
|
CHEMBL1773987
|
C055328
|
1 / 0 | No. 32 | No. 51 |
|
|
|
C00030848
|
Notoginsenoside J
/ (+)-Notoginsenoside J |
No. 32 | No. 51 |
|
||||
|
C00030400
|
Ginsenoside Rg3
|
CHEMBL398412
CHEMBL1095008 CHEMBL1735785 CHEMBL2151041 |
C097367
|
2 / 0 / 0 | 5 / 2 | No. 32 | No. 51 |
|
|
C00030399
|
Panaxoside Rg2
/ Ginsenoside Rg2 |
CHEMBL505747
CHEMBL1095005 CHEMBL1095006 CHEMBL1475728 |
C026474
|
5 / 0 / 0 | 7 / 2 | No. 32 | No. 51 |
|
|
C00030389
|
Ginsenoside F2
|
CHEMBL1095007
|
2 / 0 / 0 | No. 32 | No. 51 |
|
||
|
C00029439
|
20(R)-Ginsenoside Rg3
|
CHEMBL398412
CHEMBL1095008 CHEMBL1735785 CHEMBL2151041 |
2 / 0 / 0 | No. 32 | No. 51 |
|
||
|
C00030856
|
Ginsenoside R2
/ Notoginsenoside R2 |
No. 32 | No. 51 |
|
||||
|
C00031282
|
Sanchinoside B1
|
No. 99 |
|
|||||
|
C00030855
|
Notoginsenoside R10
|
No. 99 |
|
|||||
|
C00030865
|
Notopanaxoside A
|
No. 99 |
|
|||||
|
C00030862
|
Notoginsenoside R9
/ (+)-Notoginsenoside R9 |
No. 99 |
|
|||||
|
C00030388
|
Ginsenoside F1
|
CHEMBL584011
|
C055327
|
No. 99 |
|
|||
|
C00030402
|
Ginsenoside Rh1
|
CHEMBL466844
|
C425564
|
8 / 0 | No. 99 |
|
||
|
C00030860
|
Notoginsenoside R7
|
No. 99 |
|
|||||
|
C00030861
|
Notoginsenoside R8
|
No. 99 |
|
|||||
|
C00029440
|
Ginsenoside Rh2
/ 20(R)-Ginsenoside Rh2 |
CHEMBL1783834
CHEMBL1783835 CHEMBL1981496 |
No. 99 |
|
||||
|
C00012778
|
Voleneol
/ Eudesm-4(15)-ene-1beta,6alpha-diol / 1beta,6alpha-Dihydroxyeudesm-4(15)-ene / [1S-(1alpha,2beta,4abeta,5beta,8aalpha)]-Decahydro-4a-methyl-8-methylene-2-(1-methylethyl)-1,5-naphthalenediol |
CHEMBL487595
CHEMBL503863 CHEMBL526915 CHEMBL461400 CHEMBL461399 CHEMBL1814427 |
No. 311 |
|
||||
|
C00019308
|
Doursterol
/ Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside |
CHEMBL197711
CHEMBL506678 CHEMBL2304043 |
C011015
|
5 / 4 / 2 | 0 / 3 | No. 520 |
|
|
|
C00029961
|
Cinnamic acid
/ .beta-Phenylacrylic acid |
CHEMBL27246
|
C029010
|
5 / 2 / 2 | 16 / 2 | No. 904 | No. 6 |
|
|
C00001284
|
Panaxynol
/ Falcarinol / (-)-Falcarinol |
CHEMBL71260
CHEMBL368712 |
C018541
|
0 / 2 | No. 940 | No. 69 |
|
|
|
C00029502
|
3-Hydroxy-4-methoxybenzoic acid
|
CHEMBL88700
|
C045317
|
2 / 1 / 4 | No. 1073 |
|
||
|
C00000149
|
Spathulenol
|
CHEMBL518542
CHEMBL1774433 |
C013258
|
No. 1603 |
|
|||
|
C00030403
|
Ginsenoyne E
|
No. 3682 |
|
|||||
|
C00030922
|
Panaxydol
/ (-)-Panaxydol |
C055778
|
6 / 1 | No. 3682 |
|
|||
|
C00030923
|
Panaxytriol
|
C057682
|
No. 4824 | No. 69 |
|
|||
|
C00032250
|
Succinic acid methyl ester
/ Butanedioic acid 1-methyl ester |
C041105
|
1 / 0 | No. 8237 |
|
Human Protein / Gene in interactions
18 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11387 | DNA topoisomerase 1 | Isomerase | C00003518 C00029439 C00030389 C00030394 C00030395 C00030396 C00030398 C00030399 C00030400 C00030445 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003518 C00029439 C00030389 C00030394 C00030395 C00030396 C00030398 C00030399 C00030400 C00030445 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00030399 C00030445 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00019308 C00029961 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00029961 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00019308 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00019308 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00029961 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00030399 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00029961 | 1 / 1 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00019308 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00030399 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00030445 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00019308 | 4 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00029502 | 0 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00029961 | 1 / 1 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00029502 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00030445 | 0 / 0 |
47 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003520
C00030922
|
| 3757 | KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
C00003519
C00003520
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00003520
|
| 8431 | NR0B2, SHP, SHP1 | nuclear receptor subfamily 0, group B, member 2 |
C00030399
|
| 5105 | PCK1, PEPCK-C, PEPCK1, PEPCKC | phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32) |
C00030399
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00030399
|
| 6794 | STK11, LKB1, PJS, hLKB1 | serine/threonine kinase 11 (EC:2.7.11.1) |
C00030399
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00029961
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00029961
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00029961
|
| 1558 | CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 | cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) |
C00029961
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00029961
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00029961
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00029961
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00029961
|
| 338442 | HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g | hydroxycarboxylic acid receptor 2 |
C00029961
|
| 3284 | HSD3B2, HSD3B, HSDB, SDR11E2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) |
C00029961
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00029961
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00029961
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00029961
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00029961
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00029961
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00029961
|
| 2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00030399
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00003520
|
| 200186 | CRTC2, TORC-2, TORC2 | CREB regulated transcription coactivator 2 |
C00030399
|
| 92579 | G6PC3, SCN4, UGRP | glucose 6 phosphatase, catalytic, 3 (EC:3.1.3.9) |
C00030399
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00003520
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00032250
|
| 174 | AFP, FETA, HPAFP | alpha-fetoprotein |
C00030922
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00030922
|
| 3397 | ID1, ID, bHLHb24 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
C00030922
|
| 3398 | ID2, GIG8, ID2A, ID2H, bHLHb26 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
C00030922
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00030922
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00030400
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00030400
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00030400
|
| 354 | KLK3, APS, KLK2A1, PSA, hK3 | kallikrein-related peptidase 3 (EC:3.4.21.77) |
C00030400
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00030400
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00030402
|
| 3676 | ITGA4, CD49D, IA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
C00030402
|
| 3683 | ITGAL, CD11A, LFA-1, LFA1A | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
C00030402
|
| 3688 | ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
C00030402
|
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00030402
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00030402
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00030402
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00030402
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #601367 | Stroke, ischemic |
P00734
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (8)
| KEGG | name | UniProt |
|---|---|---|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
Diseases related to CTD interactions
18 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006948 | Hyperkinesis |
C00030399
C00003520 C00003518 |
| D003704 | Dementia |
C00003520
|
| D013118 | Spinal Cord Diseases |
C00019308
|
| D002545 | Brain Ischemia |
C00001284
|
| D015427 | Reperfusion Injury |
C00001284
|
| D019970 | Cocaine-Related Disorders |
C00030399
|
| D002493 | Central Nervous System Diseases |
C00019308
|
| D003384 | Coxsackievirus Infections |
C00029961
|
| D008545 | Melanoma |
C00029961
|
| D003072 | Cognition Disorders |
C00019308
|
| D003928 | Diabetic Nephropathies |
C00003520
|
| D007249 | Inflammation |
C00003520
|
| D007859 | Learning Disorders |
C00003520
|
| D008569 | Memory Disorders |
C00003520
|
| D007674 | Kidney Diseases |
C00030398
|
| D006528 | Carcinoma, Hepatocellular |
C00030922
|
| D000647 | Amnesia |
C00030400
|
| D018827 | Carcinoma, Lewis Lung |
C00030400
|