KCF-S cluster No. 35 (95 metabolites)
Corresponding Phytochemical cluster No. 15
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 155 |
| asterids | 122 |
| Liliopsida | 15 |
| Magnoliophyta | 15 |
| eudicotyledons | 9 |
| Euphyllophyta | 9 |
| Spermatophyta | 2 |
| Embryophyta | 1 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Fabaceae
|
124 |
|
Lamiaceae
|
53 |
|
Asteraceae
|
28 |
|
Zingiberaceae
|
13 |
|
Pteridaceae
|
9 |
|
Acanthaceae
|
8 |
|
Rutaceae
|
7 |
|
Plantaginaceae
|
7 |
|
Boraginaceae
|
6 |
|
Primulaceae
|
6 |
|
Piperaceae
|
5 |
|
Cunoniaceae
|
4 |
|
Annonaceae
|
4 |
|
Bignoniaceae
|
3 |
|
Amaranthaceae
|
3 |
|
Thymelaeaceae
|
3 |
|
Myristicaceae
|
3 |
|
Betulaceae
|
3 |
|
Verbenaceae
|
3 |
|
Lauraceae
|
3 |
KEGG BRITE br08003
Categories (3)
| br08003 Category | # of metabolite |
|---|---|
| Flavones | 3 |
| Flavonols | 1 |
| Isoflavones | 3 |
metabolites link (7)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Flavones | C10029 | C00001028 |
| Flavonols | C10045 | C00001042 |
| Isoflavones | C10199 | C00002507 |
| Isoflavones | C10527 | C00002571 |
| Flavones | C10024 | C00003808 |
| Isoflavones | C16188 | C00009413 |
| Flavones | C14985 | C00013301 |
Metabolite list (95)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001028
|
5,7-Dimethoxyflavone
/ chrysin 5,7-dimethyl ether |
CHEMBL275391
|
C060298
|
14 / 13 / 13 | 2 / 3 |
|
|
C00001042
|
3,5,7-trimethoxyflavone
/ Galangin trimethyl ether / Galangin 3,5,7-trimethyl ether |
CHEMBL75772
|
1 / 0 / 0 |
|
||
|
C00002507
|
Castanin
/ Afromosin / Afrormosin / 7-Hydroxy-6,4'-dimethoxyisoflavone |
CHEMBL464404
|
C080240
|
7 / 14 / 39 | 1 / 0 |
|
|
C00002571
|
Sayanedine
|
|
||||
|
C00003793
|
5,6-Dimethoxyflavone
|
|
||||
|
C00003798
|
6,3'-Dimethoxyflavone
|
|
||||
|
C00003806
|
Baicalein 5,6-dimethyl ether
/ 7-Hydroxy-5,6-Dimethoxyflavone |
|
||||
|
C00003807
|
Mosloflavone
/ 5-Hydroxy-6,7-Dimethoxyflavone |
CHEMBL52676
|
|
|||
|
C00003808
|
Baicalein 5,6,7-trimethyl ether
|
CHEMBL182992
|
|
|||
|
C00003809
|
Norwogonin 5,8-dimethyl ether
/ 7-Hydroxy-5,8-Dimethoxyflavone |
|
||||
|
C00003810
|
Moslosooflavone
/ 7-O-Methylwogonin / 7-O-Methylwogonine / 5-Hydroxy-7,8-dimethoxyflavone |
C035064
|
|
|||
|
C00003811
|
Norwogonin 5,7,8-trimethyl ether
|
|
||||
|
C00003812
|
5-Hydroxy-6,2'-dimethoxyflavone
|
|
||||
|
C00003813
|
5,6,2'-Trimethoxyflavone
|
|
||||
|
C00003814
|
5,6,3'-Trimethoxyflavone
|
|
||||
|
C00003821
|
5,7,4'-Trimethoxyflavone
/ Apigenin 5,7,4'-trimethyl ether |
CHEMBL1087720
|
C103112
|
1 / 1 / 0 | 1 / 0 |
|
|
C00003824
|
6,2',3'-Trimethoxyflavone
|
|
||||
|
C00003828
|
7,3',4'-Trimethoxyflavone
|
CHEMBL13473
|
1 / 1 / 0 |
|
||
|
C00003840
|
Salvigenin
|
CHEMBL376644
|
C014049
|
|
||
|
C00003847
|
7-Hydroxy-5,8,2'-trimethoxyflavone
|
|
||||
|
C00003854
|
5-Hydroxy-7,8,4'-trimethoxyflavone
/ 5-Hydroxy-4',7,8-trimethoxyflavone / Isoscutellarein 7,8,4'-trimethyl ether / 5-Hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
|
||||
|
C00003856
|
Zapotinin
|
|
||||
|
C00003861
|
Noratocarpetin 7,2',4'-trimethyl ether
|
|
||||
|
C00003870
|
Luteolin 7,3',4'-trimethyl ether
/ 5-Hydroxy-7,3',4'-trimethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one |
CHEMBL468876
|
|
|||
|
C00003986
|
6-Methyltectochrysin
/ 5-Hydroxy-7-methoxy-6-methylflavone / 5-Hydroxy-7-methoxy-6-methyl-2-phenyl-4H-1-benzopyran-4-one |
CHEMBL76553
|
2 / 3 / 0 |
|
||
|
C00003994
|
Hoslundal
|
|
||||
|
C00004049
|
Pongone
/ 7-(3-Methoxyphenyl)-5H-furo[3,2-g][1]benzopyran-5-one |
CHEMBL224607
|
1 / 0 / 0 |
|
||
|
C00004050
|
Glabone
|
CHEMBL223067
|
1 / 0 / 0 |
|
||
|
C00004071
|
Grantionin
/ 2-(3,5-Dimethoxyphenyl)-7-hydroxy-6-methoxy-4H-1-benzopyran-4-one |
|
||||
|
C00004086
|
5,7-Dimethoxy-6-C-methylflavone
|
CHEMBL1685069
|
2 / 3 / 0 |
|
||
|
C00004537
|
3,7-Dimethylgalangin
/ Galangin 3,7-dimethyl ether / 3,7-Dimethoxy-5-hydroxyflavone / 5-Hydroxy-3,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one |
CHEMBL1097683
|
|
|||
|
C00004538
|
Galangin 5,7-dimethyl ether
|
|
||||
|
C00004572
|
Kaempferol 3,5,7-trimethyl ether
|
CHEMBL166029
|
|
|||
|
C00004573
|
3,7,4'-Tri-O-methylkaempferol
/ Kaempferol 3,7,4'-trimethyl ether / 5-Hydroxy-3,7,4'-trimethoxyflavone / 5-Hydroxy-3,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL77686
|
|
|||
|
C00004578
|
3-Hydroxy-7,8,4'-trimethoxyflavone
|
|
||||
|
C00004583
|
Fisetin 7,3',4'-trimethyl ether
|
CHEMBL77198
|
15 / 7 / 2 |
|
||
|
C00005089
|
Karanjin
/ 3-Methoxy-2-phenyl-4H-Furo[2,3-h]-1-benzopyran-4-one |
CHEMBL208484
|
C052068
|
20 / 21 / 18 |
|
|
|
C00005090
|
3,4'-Dimethoxyfurano[2,3:7,8]flavone
|
|
||||
|
C00009398
|
Cladrin
/ 7-Hydroxy-3',4'-dimethoxyisoflavone |
CHEMBL454746
|
13 / 31 / 49 |
|
||
|
C00009405
|
Cabreuvin
/ 7,3',4'-Trimethoxyisoflavone |
CHEMBL273891
|
7 / 10 / 6 |
|
||
|
C00009413
|
7-Hydroxy-2',4',5'-trimethoxyisoflavone
|
CHEMBL455048
|
|
|||
|
C00009414
|
2'-Hydroxy-7,3',4'-trimethoxyisoflavone
|
|
||||
|
C00009415
|
Cladrastin
|
|
||||
|
C00009416
|
7-Hydroxy-8,3',4'-trimethoxyisoflavone
|
|
||||
|
C00009451
|
5,7-Dimethoxyisoflavone
|
CHEMBL308688
|
9 / 23 / 47 |
|
||
|
C00009456
|
5-O-Methylbiochanin A
|
|
||||
|
C00009469
|
7,4'-Di-O-methyltectorigenin
/ 5-Hydroxy-6,7,4'-trimethoxyisoflavone |
|
||||
|
C00009470
|
5-Methoxyafrormosin
/ 7-Hydroxy-5,6,4'-trimethoxyisoflavone |
CHEMBL457449
|
|
|||
|
C00009471
|
Iso-5-methoxyafrormosin
/ 7-Hydroxy-5,8,4'-trimethoxyisoflavone |
|
||||
|
C00009850
|
Alfalone
/ 6-Hydroxy-7,4'-dimethoxyisoflavone |
|
||||
|
C00013292
|
7,8-Dimethoxyflavone
|
CHEMBL441526
|
|
|||
|
C00013294
|
5-Hydroxy-7,2'-dimethoxyflavone
|
|
||||
|
C00013295
|
5,7,2'-Trimethoxyflavone
/ 5,7-Dimethoxy-2-(2-methoxyphenyl)-4H-1-benzopyran-4-one |
|
||||
|
C00013296
|
7,2',4'-Trimethoxyflavone
/ 2-(2,4-Dimethoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one |
|
||||
|
C00013299
|
3',4',5'-Trimethoxyflavone
/ 2-(3,4,5-Trimethoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL307856
|
16 / 7 / 3 |
|
||
|
C00013301
|
6-Hydroxy-5,7,4'-trimethoxyflavone
/ 6-Hydroxy-5,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL77695
|
|
|||
|
C00013302
|
Andrographin
/ 2'-O-Methylskullcapflavone I / Skullcapflavone I 2'-methyl ether / 5-Hydroxy-2',7,8-trimethoxyflavone / 5-Hydroxy-7,8-dimethoxy-2-(2-methoxyphenyl)-4H-1-benzopyran-4-one |
|
||||
|
C00013306
|
5-Hydroxy-7,2',5'-trimethoxyflavone
/ 2-(2,5-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one |
|
||||
|
C00013310
|
5-Hydroxy-7,2',6'-trimethoxyflavone
/ 2-(2,6-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one |
|
||||
|
C00013348
|
3,7-Dimethoxyflavone
/ 3,7-Dimethoxy-2-phenyl-4H-1-benzopyran-4-one |
CHEMBL1449187
|
13 / 23 / 24 |
|
||
|
C00013443
|
Pongaglabol
/ 5-Hydroxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran-4-one |
|
||||
|
C00013444
|
Pinnatin
/ 4-Methoxy-7-phenyl-5H-furo[3,2-g][1]benzopyran-5-one |
CHEMBL395770
|
|
|||
|
C00013445
|
Kanjone
/ 6-Methoxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran-4-one |
|
||||
|
C00013446
|
9-Methoxy-7-phenyl-5H-furo[3,2-g][1]benzopyran-5-one
|
|
||||
|
C00013447
|
2-(2-Methoxyphenyl)-4H-furo[2,3-h]-1-benzopyran-4-one
|
|
||||
|
C00013448
|
Cauliflorin A
/ Pongol methyl ether |
|
||||
|
C00013449
|
2-(4-Methoxyphenyl)-4H-furo[2,3-h]-1-benzopyran-4-one
|
CHEMBL224211
|
1 / 0 / 0 |
|
||
|
C00013453
|
Millettocalyxin C
/ 2-(2,5-Dimethoxyphenyl)-4H-furo[2,3-h]-1-benzopyran-4-one |
|
||||
|
C00013534
|
Ponganone XI
/ 6-Methoxy-7-phenyl-5H-furo[3,2-g][1]benzopyran-5-one |
|
||||
|
C00019014
|
7-Hydroxy-3',5'-dimethoxyisoflavone
|
CHEMBL575075
|
3 / 5 / 3 |
|
||
|
C00019016
|
Lanceolatin B (flavonoid)
|
CHEMBL224157
|
1 / 0 / 0 |
|
||
|
C00019025
|
5-Hydroxy-7,3',4'-trimethoxyisoflavone
|
|
||||
|
C00019076
|
3,6-Dimethoxyfurano[4'',5'':8,7]flavone
|
|
||||
|
C00019193
|
Pongapinnol A
|
|
||||
|
C00019194
|
Pongapinnol B
|
|
||||
|
C00019195
|
Pongapinnol C
|
|
||||
|
C00019196
|
Pongapinnol D
|
|
||||
|
C00019198
|
Pongaglabol methyl ether
/ 5-Methoxyfurano[8,7-4'',5'']flavone |
|
||||
|
C00019199
|
Pongol
|
|
||||
|
C00019452
|
2'-Hydroxy-7,4'-dimethoxyisoflavone
|
|
||||
|
C00019503
|
Isocladrastin
/ 3'-Hydroxy-6,7,4'-trimethoxyisoflavone |
|
||||
|
C00019505
|
7-Hydroxy-2',4'-dimethoxyisoflavone
|
CHEMBL1087126
|
5 / 5 / 6 |
|
||
|
C00019507
|
7,2',4'-Trimethoxyisoflavone
|
|
||||
|
C00020215
|
6-Methoxyisopongaglabol
|
|
||||
|
C00020219
|
7-Methoxy-2-phenyl-4H-furo[2,3-f][1]benzopyran-9-one
|
|
||||
|
C00020344
|
7,4'-Dimethoxyflavone
|
CHEMBL16442
|
2 / 1 / 1 |
|
||
|
C00020633
|
Isopongaglabol
|
|
||||
|
C00034884
|
Pachycarin D
|
|
||||
|
C00035474
|
2',5'-Dimethoxyflavone
|
|
||||
|
C00035488
|
3',4'-Dimethoxyflavone
|
CHEMBL91153
|
15 / 21 / 19 |
|
||
|
C00035490
|
3'-Hydroxy-4',5'-dimethoxyflavone
|
|
||||
|
C00035969
|
7,2',5'-Trimethoxyflavone
|
|
||||
|
C00036011
|
4',5,7-Trimethoxyisoflavone
|
CHEMBL13097
|
10 / 9 / 8 |
|
||
|
C00038200
|
2,3-Dimethoxyxanthone
|
CHEMBL1434162
|
14 / 16 / 16 |
|
||
|
C00040818
|
3-Hydroxy-5,7,4'-trimethoxyflavone
|
|
Human Protein / Gene in interactions
66 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001028 C00005089 C00009398 C00009451 C00013348 C00019505 C00035488 C00036011 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00005089 C00009398 C00009451 C00013348 C00019505 C00035488 C00036011 | 3 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001028 C00005089 C00009451 C00013348 C00019505 C00035488 C00036011 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001028 C00002507 C00005089 C00009398 C00009405 C00036011 C00038200 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00005089 C00009451 C00013348 C00019505 C00035488 C00036011 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00005089 C00009398 C00009405 C00009451 C00013348 C00035488 | 4 / 3 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00004049 C00004050 C00005089 C00013449 C00019016 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00001028 C00009398 C00009405 C00036011 C00038200 | 1 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00003821 C00003828 C00003986 C00004086 C00035488 | 1 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00001028 C00002507 C00009398 C00009405 C00036011 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00005089 C00009451 C00013348 C00019505 C00035488 | 2 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001028 C00005089 C00009398 C00009405 C00038200 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001028 C00009405 C00036011 C00038200 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001028 C00013348 C00035488 C00038200 | 2 / 5 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00001028 C00002507 C00009398 C00009405 | 4 / 2 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001028 C00013348 C00035488 C00038200 | 1 / 2 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00013348 C00035488 C00038200 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002507 C00009398 C00009451 | 7 / 37 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001028 C00005089 C00038200 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00009451 C00013348 C00035488 | 3 / 1 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00001028 C00003986 C00004086 | 2 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00005089 C00009398 C00035488 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00004583 C00013299 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00004583 C00013299 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00005089 C00009398 | 7 / 3 |
| P07437 | Tubulin beta chain | Structural | C00004583 C00013299 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00013348 C00035488 | 0 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00004583 C00013299 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00009398 C00019014 | 5 / 3 |
| Q13509 | Tubulin beta-3 chain | Structural | C00004583 C00013299 | 2 / 1 |
| P37840 | Alpha-synuclein | Unclassified protein | C00036011 C00038200 | 4 / 2 |
| P68371 | Tubulin beta-4B chain | Structural | C00004583 C00013299 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002507 C00036011 | 0 / 0 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00004583 C00013299 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00013348 C00038200 | 6 / 4 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00004583 C00013299 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00004583 C00013299 | 1 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00004583 C00013299 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001028 C00038200 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00009451 C00035488 | 4 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00005089 C00038200 | 0 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00004583 C00013299 | 0 / 0 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00004583 C00013299 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00004583 C00013299 | 1 / 1 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002507 C00038200 | 2 / 2 |
| P04350 | Tubulin beta-4A chain | Structural | C00004583 C00013299 | 2 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00004583 C00013299 | 1 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002507 | 1 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00013299 | 0 / 1 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00019014 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00005089 | 1 / 1 |
| P06280 | Alpha-galactosidase A | Enzyme | C00035488 | 1 / 1 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00001028 | 2 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00005089 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00038200 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00013348 | 2 / 3 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00005089 | 0 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00009398 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00005089 | 0 / 3 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00020344 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00005089 | 3 / 2 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005089 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00019014 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001042 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00020344 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00005089 | 1 / 0 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001028
C00003821
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001028
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00002507
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (76)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #133239 | Esophageal cancer |
P04637
|
| #301500 | Fabry disease |
P06280
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #211980 | Lung cancer |
P04637
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
P37840 |
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (82)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
P16473 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
P37840 (related) |
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|