KCF-S cluster No. 4840 (2 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (2)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	2
rosids	2
Liliopsida	2
eudicotyledons	1

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Cumulative family count

class name	count
Orchidaceae	2
Brassicaceae	2
Polygonaceae	1
Acanthaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (2)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00026982	Indirubin / Indigo red / Couroupitine B / Indigopurpurin	CHEMBL259664 CHEMBL1276127	C027185	16 / 11 / 8	40 / 1
C00048436	Isoindigo	CHEMBL515155	C049010	4 / 0 / 0

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P24941	Cyclin-dependent kinase 2	Cdc2	C00026982 C00048436	0 / 0
P21980	Protein-glutamine gamma-glutamyltransferase 2	Enzyme	C00026982 C00048436	0 / 0
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00026982	0 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00026982	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00026982	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00026982	2 / 3
P17538	Chymotrypsinogen B	S1A	C00026982	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00026982	1 / 1
Q16637	Survival motor neuron protein	Unclassified protein	C00026982	4 / 1
P06493	Cyclin-dependent kinase 1	Cdc2	C00026982	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00026982	4 / 3
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00026982	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00026982	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00026982	0 / 0
P20248	Cyclin-A2	Other cytosolic protein	C00048436	0 / 0
P78396	Cyclin-A1	Other cytosolic protein	C00048436	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00026982	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00026982	0 / 0

40 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
36	ACADSB, 2-MEBCAD, ACAD7, SBCAD	acyl-CoA dehydrogenase, short/branched chain (EC:1.3.8.5)	C00026982
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00026982
378	ARF4, ARF2	ADP-ribosylation factor 4	C00026982
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00026982
10575	CCT4, CCT-DELTA, Cctd, SRB	chaperonin containing TCP1, subunit 4 (delta)	C00026982
1000	CDH2, CD325, CDHN, CDw325, NCAD	cadherin 2, type 1, N-cadherin (neuronal)	C00026982
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00026982
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00026982
1195	CLK1, CLK, CLK/STY, STY	CDC-like kinase 1 (EC:2.7.12.1)	C00026982
9318	COPS2, ALIEN, CSN2, SGN2, TRIP15	COP9 signalosome subunit 2	C00026982
1441	CSF3R, CD114, GCSFR	colony stimulating factor 3 receptor (granulocyte)	C00026982
3577	CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA	chemokine (C-X-C motif) receptor 1	C00026982
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00026982
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00026982
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00026982
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00026982
3491	CYR61, CCN1, GIG1, IGFBP10	cysteine-rich, angiogenic inducer, 61	C00026982
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00026982
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00026982
3281	HSBP1, NPC-A-13	heat shock factor binding protein 1	C00026982
3329	HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13	heat shock 60kDa protein 1 (chaperonin)	C00026982
10808	HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25	heat shock 105kDa/110kDa protein 1	C00026982
3458	IFNG, IFG, IFI	interferon, gamma	C00026982
3484	IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1	insulin-like growth factor binding protein 1	C00026982
3554	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80	interleukin 1 receptor, type I	C00026982
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00026982
3608	ILF2, NF45, PRO3063	interleukin enhancer binding factor 2	C00026982
3688	ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	C00026982
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00026982
4258	MGST2, GST2, MGST-II	microsomal glutathione S-transferase 2 (EC:2.5.1.18)	C00026982
4436	MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2	mutS homolog 2	C00026982
653361	NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox	neutrophil cytosolic factor 1	C00026982
4864	NPC1, NPC	Niemann-Pick disease, type C1	C00026982
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00026982
4735	SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5	septin 2	C00026982
6514	SLC2A2, GLUT2	solute carrier family 2 (facilitated glucose transporter), member 2	C00026982
6688	SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A	spleen focus forming virus (SFFV) proviral integration oncogene	C00026982
6938	TCF12, CRS3, HEB, HTF4, HsT17266, bHLHb20	transcription factor 12	C00026982
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00026982
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00026982

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions