Species

KNApSAcK Entry

Organism name Sargassum crassifolium J.Asgardh
Genus Sargassum
Family Sargassaceae
Kingdom Chromalveolata

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sargassum
Linked NCBI taxonomy ID 3015
Linked level genus

Family

Family in NCBI taxonomy Sargassaceae
ID 3014

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Eukaryota
ID 2759

Plant class

Plant class
ID

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001233 External link 512 Palmitic acid
CHEMBL82293
D019308
16 / 8 / 8 35 / 1 No. 184 No. 68
C00019144 External link 512 Loliolide
/ (-)-Loliolide
CHEMBL227113
CHEMBL446471
C030425
1 / 2 / 2 No. 2667

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001233 C00019144 2 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001233 0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00001233 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00001233 0 / 0
P08183 Multidrug resistance protein 1 drug C00001233 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00001233 0 / 0
O75496 Geminin Unclassified protein C00001233 0 / 0
P12104 Fatty acid-binding protein, intestinal Other cytosolic protein C00001233 0 / 0
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001233 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001233 0 / 1
O60603 Toll-like receptor 2 Membrane receptor C00001233 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00001233 0 / 0
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein C00001233 0 / 0
P03372 Estrogen receptor NR3A1 C00001233 1 / 1
P10275 Androgen receptor NR3C4 C00001233 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001233 0 / 0

35 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00001233
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00001233
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00001233
581 BAX, BCL2L4 BCL2-associated X protein C00001233
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001233
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001233
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00001233
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00001233
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00001233
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00001233
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00001233
3034 HAL, HIS, HSTD histidine ammonia-lyase (EC:4.3.1.3) C00001233
57817 HAMP, HEPC, HFE2B, LEAP1, PLTR hepcidin antimicrobial peptide C00001233
3481 IGF2, C11orf43, IGF-II, PP9974 insulin-like growth factor 2 (somatomedin A) C00001233
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001233
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00001233
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00001233
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001233
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00001233
4493 MT1E, MT1, MTD metallothionein 1E C00001233
4494 MT1F, MT1 metallothionein 1F C00001233
4496 MT1H, MT-0, MT-1H, MT-IH, MT1 metallothionein 1H C00001233
4501 MT1X, MT-1l, MT1 metallothionein 1X C00001233
4502 MT2A, MT2 metallothionein 2A C00001233
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00001233
3651 PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 pancreatic and duodenal homeobox 1 C00001233
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001233
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00001233
29893 PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP PSMC3 interacting protein C00001233
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001233
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00001233
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00001233
23216 TBC1D1, TBC, TBC1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 C00001233
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001233
7351 UCP2, BMIQ4, SLC25A8, UCPH uncoupling protein 2 (mitochondrial, proton carrier) C00001233

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#615363 Estrogen resistance; estrr P03372
#612244 Inflammatory bowel disease 13; ibd13 P08183
#246300 Leprosy, susceptibility to, 3; lprs3 O60603
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275

KEGG DISEASE (8)

KEGG name UniProt
H00344 Leprosy O60603 (related)
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00794 Aromatase excess syndrome P11511 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003072 Cognition Disorders C00001233