Silybum marianum
Species
KNApSAcK Entry
| Organism name | Silybum marianum |
|---|---|
| Genus | Silybum |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Silybum marianum |
|---|---|
| Linked NCBI taxonomy ID | 92921 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (43)
| Species | Activity |
|---|---|
| Silybum marianum (L.) Gaertn. | 5-Lipoxygenase Inhibitor |
| Silybum marianum (L.) Gaertn. | Adrenergic |
| Silybum marianum (L.) Gaertn. | Alterative |
| Silybum marianum (L.) Gaertn. | Antiallergic |
| Silybum marianum (L.) Gaertn. | Antibilious |
| Silybum marianum (L.) Gaertn. | Anticarcinogenic |
| Silybum marianum (L.) Gaertn. | Antidepressant |
| Silybum marianum (L.) Gaertn. | Antidote |
| Silybum marianum (L.) Gaertn. | Antidote, mushroom |
| Silybum marianum (L.) Gaertn. | Antiedemic |
| Silybum marianum (L.) Gaertn. | Antiinflammatory |
| Silybum marianum (L.) Gaertn. | Antileukotriene |
| Silybum marianum (L.) Gaertn. | Antioxidant |
| Silybum marianum (L.) Gaertn. | Antiprostaglandin |
| Silybum marianum (L.) Gaertn. | Antitoxic |
| Silybum marianum (L.) Gaertn. | Antitumor |
| Silybum marianum (L.) Gaertn. | Antiviral |
| Silybum marianum (L.) Gaertn. | Aperient |
| Silybum marianum (L.) Gaertn. | Bitter |
| Silybum marianum (L.) Gaertn. | cAMP-Phosphodiesterase Inhibitor |
| Silybum marianum (L.) Gaertn. | Cholagogue |
| Silybum marianum (L.) Gaertn. | Choleretic |
| Silybum marianum (L.) Gaertn. | Demulcent |
| Silybum marianum (L.) Gaertn. | Depurative |
| Silybum marianum (L.) Gaertn. | Diaphoretic |
| Silybum marianum (L.) Gaertn. | Digestive |
| Silybum marianum (L.) Gaertn. | Emmenagogue |
| Silybum marianum (L.) Gaertn. | Expectorant |
| Silybum marianum (L.) Gaertn. | Glutathionigenic |
| Silybum marianum (L.) Gaertn. | Hemostat |
| Silybum marianum (L.) Gaertn. | Hepatoprotective |
| Silybum marianum (L.) Gaertn. | Hepatoregenerative |
| Silybum marianum (L.) Gaertn. | Hypocholesterolemic |
| Silybum marianum (L.) Gaertn. | Hypolipidemic |
| Silybum marianum (L.) Gaertn. | Lactagogue |
| Silybum marianum (L.) Gaertn. | Laxative |
| Silybum marianum (L.) Gaertn. | Lipolytic |
| Silybum marianum (L.) Gaertn. | Litholytic |
| Silybum marianum (L.) Gaertn. | Peristaltic |
| Silybum marianum (L.) Gaertn. | Stimulant |
| Silybum marianum (L.) Gaertn. | Sunscreen |
| Silybum marianum (L.) Gaertn. | Symphathicolytic |
| Silybum marianum (L.) Gaertn. | Tonic |
Metabolite list (23)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00007247
|
Linolenic acid
/ alpha-Linolenic acid / (Z,Z,Z)-Octadeca-9,12,15-trienoic acid |
D017962
|
22 / 5 |
|
||||
|
C00005190
|
Kaempferol 3-rhamnoside-7-galacturonide
|
No. 1 | No. 15 |
|
||||
|
C00004160
|
Apigenin 7-rhamnosyl-(1->2)-galacturonide
|
No. 1 | No. 15 |
|
||||
|
C00001209
|
Arachidic acid
/ Eicosanoic acid |
CHEMBL1173381
|
C094477
|
No. 184 | No. 68 |
|
||
|
C00001238
|
Stearic acid
|
CHEMBL46403
|
C031183
|
15 / 17 / 19 | 6 / 1 | No. 184 | No. 68 |
|
|
C00001233
|
Palmitic acid
|
CHEMBL82293
|
D019308
|
16 / 8 / 8 | 35 / 1 | No. 184 | No. 68 |
|
|
C00001224
|
Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid |
CHEMBL267476
|
29 / 31 / 28 | No. 367 | No. 68 |
|
||
|
C00001002
|
Silandrin
|
No. 585 | No. 14 |
|
||||
|
C00040306
|
Silychristin B
/ (+)-Silychristin B |
CHEMBL130493
CHEMBL589325 CHEMBL2107543 |
No. 585 | No. 14 |
|
|||
|
C00001004
|
Silychristin
|
CHEMBL130493
CHEMBL589325 CHEMBL2107543 |
C015504
|
No. 585 | No. 14 |
|
||
|
C00001003
|
Silybin
|
CHEMBL9509
CHEMBL431701 CHEMBL245121 CHEMBL592675 CHEMBL1401508 CHEMBL1551617 |
C440975
|
57 / 75 / 91 | 30 / 6 | No. 585 | No. 14 |
|
|
C00040305
|
Silybin B
/ (-)-Silybin B |
CHEMBL9509
CHEMBL431701 CHEMBL245121 CHEMBL592675 CHEMBL1401508 CHEMBL1551617 |
57 / 75 / 91 | No. 585 | No. 14 |
|
||
|
C00039454
|
Isosilybin B
/ (-)-Isosilybin B |
No. 585 | No. 14 |
|
||||
|
C00008376
|
Silyhermin
|
No. 585 | No. 14 |
|
||||
|
C00008377
|
Neosilyhermin A
|
No. 585 | No. 14 |
|
||||
|
C00039453
|
Isosilybin A
/ (+)-Isosilybin A |
No. 585 | No. 14 |
|
||||
|
C00008662
|
Isosilybin
|
C075820
|
No. 585 | No. 14 |
|
|||
|
C00008663
|
Isosilychristin
|
No. 585 | No. 14 |
|
||||
|
C00008378
|
Neosilyhermin B
|
No. 585 | No. 14 |
|
||||
|
C00001211
|
Behenic acid
|
CHEMBL1173474
|
C007547
|
No. 1100 | No. 68 |
|
||
|
C00002422
|
5,7-Dihydroxychromone
/ 5,7-Dihydroxy-4-chromone |
C080094
|
No. 3998 | No. 15 |
|
|||
|
C00008375
|
Silymonin
|
No. 5451 |
|
|||||
|
C00008664
|
Silydianin
|
C015505
|
No. 5451 |
|
Human Protein / Gene in interactions
78 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001003 C00001224 C00001238 C00040305 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001003 C00001224 C00001238 C00040305 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001003 C00001224 C00001238 C00040305 | 3 / 2 |
| P03372 | Estrogen receptor | NR3A1 | C00001003 C00001224 C00001233 C00040305 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001003 C00001224 C00001238 C00040305 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001003 C00001224 C00001233 C00040305 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001003 C00001224 C00001238 C00040305 | 3 / 3 |
| P10275 | Androgen receptor | NR3C4 | C00001003 C00001224 C00001233 C00040305 | 3 / 4 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001003 C00001224 C00001233 C00040305 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001003 C00001224 C00040305 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001224 C00001233 C00001238 | 2 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001003 C00001224 C00040305 | 5 / 3 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00001224 C00001233 C00001238 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001003 C00001224 C00040305 | 2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001003 C00001224 C00040305 | 11 / 10 |
| O00255 | Menin | Unclassified protein | C00001003 C00001238 C00040305 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001003 C00001238 C00040305 | 1 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001003 C00001238 C00040305 | 3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001003 C00001224 C00040305 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001003 C00001224 C00040305 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001003 C00001224 C00040305 | 0 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00001003 C00001233 C00040305 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001003 C00001238 C00040305 | 2 / 3 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001224 C00001233 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001003 C00040305 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001003 C00040305 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00001003 C00040305 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00001003 C00040305 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001003 C00040305 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001003 C00040305 | 2 / 2 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00001003 C00040305 | 1 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001003 C00040305 | 0 / 0 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00001224 C00001233 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001003 C00040305 | 2 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00001003 C00040305 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00001003 C00040305 | 1 / 1 |
| P10145 | Interleukin-8 | Secreted protein | C00001003 C00040305 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00001003 C00040305 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001003 C00040305 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001003 C00040305 | 7 / 3 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001224 C00001238 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001003 C00040305 | 1 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001224 C00001233 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001233 C00001238 | 0 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00001003 C00040305 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00001003 C00040305 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001003 C00040305 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00001003 C00040305 | 2 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00001003 C00040305 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001003 C00040305 | 1 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00001003 C00040305 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001003 C00040305 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00001003 C00040305 | 6 / 4 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00001003 C00040305 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001003 C00040305 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001003 C00040305 | 0 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00001003 C00040305 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00001003 C00040305 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001003 C00040305 | 4 / 3 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001003 C00040305 | 7 / 37 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001003 C00040305 | 1 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001003 C00040305 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001003 C00040305 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001003 C00040305 | 1 / 2 |
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | C00001224 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001238 | 0 / 0 |
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | C00001233 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00001224 | 0 / 0 |
| P13726 | Tissue factor | Membrane receptor | C00001224 | 0 / 0 |
| P12104 | Fatty acid-binding protein, intestinal | Other cytosolic protein | C00001233 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001238 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001224 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001224 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00001233 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00001224 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00001233 | 0 / 0 |
| O60603 | Toll-like receptor 2 | Membrane receptor | C00001233 | 1 / 1 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00001224 | 0 / 0 |
78 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001233
C00001238
C00007247
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00001003
C00001233
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00001233
C00001238
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001233
C00001238
|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00001233
C00001238
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001233
C00001238
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00001233
C00007247
|
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 |
C00001233
C00001238
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001003
C00001233
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001003
C00001233
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00001003
C00001233
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001003
C00007247
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001003
C00001233
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001003
C00007247
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00001233
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001003
|
| 11200 | CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1 | checkpoint kinase 2 (EC:2.7.11.1) |
C00001003
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00001003
|
| 835 | CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 | caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) |
C00001003
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00001003
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00001003
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00001003
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00001003
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00001003
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00001003
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00001003
|
| 110357 |
C00001003
|
||
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001003
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00001003
|
| 8795 | TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 | tumor necrosis factor receptor superfamily, member 10b |
C00001003
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001003
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00001003
|
| 54578 | UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F | UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) |
C00001003
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00001003
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00001003
|
| 7364 | UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9 | UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) |
C00001003
|
| 8647 | ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
C00007247
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00001003
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00007247
|
| 1591 | CYP24A1, CP24, CYP24, HCAI, P450-CC24 | cytochrome P450, family 24, subfamily A, polypeptide 1 (EC:1.14.13.126) |
C00007247
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00007247
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00007247
|
| 3992 | FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12 | fatty acid desaturase 1 (EC:1.14.19.-) |
C00007247
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00007247
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00007247
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00007247
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00007247
|
| 3827 | KNG1, BDK, BK, KNG | kininogen 1 |
C00007247
|
| 9971 | NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 | nuclear receptor subfamily 1, group H, member 4 |
C00007247
|
| 100136658 |
C00007247
|
||
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00007247
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00007247
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00007247
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00007247
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00007247
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00001233
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00001233
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00001233
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001003
|
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) |
C00001233
|
| 57817 | HAMP, HEPC, HFE2B, LEAP1, PLTR | hepcidin antimicrobial peptide |
C00001233
|
| 3481 | IGF2, C11orf43, IGF-II, PP9974 | insulin-like growth factor 2 (somatomedin A) |
C00001233
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001233
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00001233
|
| 4493 | MT1E, MT1, MTD | metallothionein 1E |
C00001233
|
| 4494 | MT1F, MT1 | metallothionein 1F |
C00001233
|
| 4496 | MT1H, MT-0, MT-1H, MT-IH, MT1 | metallothionein 1H |
C00001233
|
| 4501 | MT1X, MT-1l, MT1 | metallothionein 1X |
C00001233
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00001233
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00001233
|
| 3651 | PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 | pancreatic and duodenal homeobox 1 |
C00001233
|
| 29893 | PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP | PSMC3 interacting protein |
C00001233
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001233
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00001233
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00001233
|
| 23216 | TBC1D1, TBC, TBC1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 |
C00001233
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001233
|
| 7351 | UCP2, BMIQ4, SLC25A8, UCPH | uncoupling protein 2 (mitochondrial, proton carrier) |
C00001233
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (78)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #246300 | Leprosy, susceptibility to, 3; lprs3 |
O60603
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (94)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00344 | Leprosy |
O60603
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
12 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003072 | Cognition Disorders |
C00001238
C00001233 |
| D008175 | Lung Neoplasms |
C00001003
|
| D056486 | Drug-Induced Liver Injury |
C00001003
|
| D006943 | Hyperglycemia |
C00001003
|
| D007674 | Kidney Diseases |
C00001003
|
| D008106 | Liver Cirrhosis, Experimental |
C00001003
|
| D058186 | Acute Kidney Injury |
C00001003
|
| D001930 | Brain Injuries |
C00007247
|
| D003866 | Depressive Disorder |
C00007247
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00007247
|
| D007249 | Inflammation |
C00007247
|
| D009422 | Nervous System Diseases |
C00007247
|