KNApSAcK Metabolite C00026537
Metabolite
KNApSAcK Entry
| id | C00026537 |
|---|---|
| Name | Norharman / Carbazoline / beta-Carboline / 2-Azacarbazole / 2,9-Diazafluorene |
| CAS RN | 244-63-3 |
| Standard InChI | InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H |
| Standard InChI (Main Layer) | InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H |
Cluster
| Phytochemical cluster | No. 4 |
|---|---|
| KCF-S cluster | No. 1889 |
Link
ChEMBL
| By standard InChI | CHEMBL275224 |
|---|---|
| By standard InChI Main Layer | CHEMBL275224 |
KEGG
| By LinkDB | C20157 |
|---|
CTD
| By CAS RN | C010262 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Liliopsida | 1 |
Family
| family name | count |
|---|---|
| Araceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Pinellia pedatisecta | 199222 | Araceae | Liliopsida | Viridiplantae |
| Tedania anhelans |
Human Protein / Gene in interaction
50 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL275224 |
CHEMBL1613842
(1)
|
4 / 2 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | CHEMBL275224 |
CHEMBL1930784
(1)
|
0 / 0 |
| O14965 | Aurora kinase A | Aur | CHEMBL275224 |
CHEMBL1963727
(1)
|
0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | CHEMBL275224 |
CHEMBL1963726
(1)
|
0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | CHEMBL275224 |
CHEMBL666137
(1)
|
0 / 0 |
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | CHEMBL275224 |
CHEMBL666138
(1)
|
0 / 0 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | CHEMBL275224 |
CHEMBL1964112
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL275224 |
CHEMBL1614458
(2)
|
0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | CHEMBL275224 |
CHEMBL1670752
(1)
CHEMBL1936791
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL275224 |
CHEMBL2114843
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL275224 |
CHEMBL1794401
(1)
|
0 / 0 |
| O15111 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Other serine/threonine protein kinase | CHEMBL275224 |
CHEMBL694794
(1)
|
1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL275224 |
CHEMBL1614038
(1)
|
2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL275224 |
CHEMBL1738588
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL275224 |
CHEMBL1614211
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL275224 |
CHEMBL1613914
(2)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL275224 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | CHEMBL275224 |
CHEMBL767437
(1)
|
1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 0 |
| P24723 | Protein kinase C eta type | Eta | CHEMBL275224 |
CHEMBL767437
(1)
|
1 / 0 |
| P41743 | Protein kinase C iota type | Iota | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | CHEMBL275224 |
CHEMBL767437
(1)
|
0 / 0 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | CHEMBL275224 |
CHEMBL650075
(1)
|
1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | CHEMBL275224 |
CHEMBL650075
(1)
|
1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | CHEMBL275224 |
CHEMBL650075
(1)
|
1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | CHEMBL275224 |
CHEMBL650075
(1)
|
4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | CHEMBL275224 |
CHEMBL650075
(1)
|
0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | CHEMBL275224 |
CHEMBL650075
(1)
|
1 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | CHEMBL275224 |
CHEMBL772598
(1)
|
0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | CHEMBL275224 |
CHEMBL772598
(1)
|
0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | CHEMBL275224 |
CHEMBL772598
(1)
|
0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | CHEMBL275224 |
CHEMBL659389
(1)
|
0 / 0 |
| P19784 | Casein kinase II subunit alpha' | Ck2 | CHEMBL275224 |
CHEMBL659389
(1)
|
0 / 0 |
| P67870 | Casein kinase II subunit beta | REG serine/threonine protein kinase family | CHEMBL275224 |
CHEMBL659389
(1)
|
0 / 0 |
CTD interaction (9)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C010262 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | CYP1A1 protein affects the metabolism of [norharman co-treated with aniline] |
affects cotreatment
/ affects metabolic processing |
protein |
15279827
|
| C010262 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | CYP1A2 protein affects the metabolism of [norharman co-treated with aniline] |
affects cotreatment
/ affects metabolic processing |
protein |
15279827
|
| C010262 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | CYP1B1 protein affects the metabolism of [norharman co-treated with aniline] |
affects cotreatment
/ affects metabolic processing |
protein |
15279827
|
| C010262 | 1555 |
CYP2B6
CPB6 CYP2B CYP2B7 CYP2B7P CYPIIB6 EFVM IIB1 P450 |
cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) | CYP2B6 protein affects the metabolism of [norharman co-treated with aniline] |
affects cotreatment
/ affects metabolic processing |
protein |
15279827
|
| C010262 | 1565 |
CYP2D6
CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1 |
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) | CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] |
affects cotreatment
/ affects metabolic processing |
protein |
15279827
|
| C010262 | 1571 |
CYP2E1
CPE1 CYP2E P450-J P450C2E |
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | CYP2E1 protein affects the metabolism of [norharman co-treated with aniline] |
affects cotreatment
/ affects metabolic processing |
protein |
15279827
|
| C010262 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] |
affects cotreatment
/ affects metabolic processing |
protein |
15279827
|
| C010262 | 4129 |
MAOB
|
monoamine oxidase B (EC:1.4.3.4) | norharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] |
decreases reaction
/ increases oxidation |
protein |
21554916
|
| C010262 | 4129 |
MAOB
|
monoamine oxidase B (EC:1.4.3.4) | norharman results in decreased activity of MAOB protein |
decreases activity
|
protein |
21554916
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103780 | Alcohol dependence |
P47869
|
| #613630 | Cocoon syndrome |
O15111
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P24723
|
KEGG DISEASE (8)
| KEGG | disease name | UniProt |
|---|---|---|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00882 | Cocoon syndrome |
O15111
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |