Myrsine africana
Species
KNApSAcK Entry
| Organism name | Myrsine africana |
|---|---|
| Genus | Myrsine |
| Family | Myrsinaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Myrsine africana |
|---|---|
| Linked NCBI taxonomy ID | 59982 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Primulaceae |
|---|---|
| ID | 4335 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00013859
|
Quercetin 3-glucosyl-(1->4)-rhamnoside-7-rutinoside
/ 3-[(6-Deoxy-4-O-beta-D-glucopyranosyl-alpha-L-mannopyranosyl)oxy]-7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one |
No. 5 | No. 15 |
|
||||
|
C00000555
|
Emodin
|
CHEMBL289277
|
D004642
|
109 / 88 / 91 | 68 / 9 | No. 41 | No. 62 |
|
|
C00002847
|
Norobtusifolin
|
CHEMBL190245
|
C061026
|
No. 41 | No. 62 |
|
||
|
C00013976
|
Myricetin 3-(3'',4''-diacetylrhamnoside)
/ 3-[(3,4-Di-O-acetyl-6-deoxy-alpha-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one |
No. 330 |
|
|||||
|
C00002822
|
Embelin
|
CHEMBL221137
|
C010945
|
29 / 32 / 60 | No. 558 |
|
Human Protein / Gene in interactions
119 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000555 C00002822 | 1 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000555 C00002822 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00000555 C00002822 | 2 / 5 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000555 C00002822 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000555 C00002822 | 7 / 37 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000555 C00002822 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000555 C00002822 | 4 / 3 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000555 C00002822 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000555 C00002822 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000555 C00002822 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000555 C00002822 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000555 C00002822 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000555 C00002822 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000555 C00002822 | 3 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000555 C00002822 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000555 C00002822 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000555 C00002822 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000555 C00002822 | 2 / 3 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000555 C00002822 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000555 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000555 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000555 | 3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000555 | 3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00000555 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00000555 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00000555 | 0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00000555 | 0 / 0 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00000555 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00000555 | 1 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00000555 | 1 / 0 |
| P15311 | Ezrin | Unclassified protein | C00000555 | 0 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000555 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002822 | 2 / 0 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | C00000555 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000555 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002822 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000555 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000555 | 0 / 0 |
| P09769 | Tyrosine-protein kinase Fgr | Src | C00000555 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000555 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000555 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000555 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00000555 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000555 | 0 / 1 |
| P10145 | Interleukin-8 | Secreted protein | C00000555 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00000555 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000555 | 0 / 0 |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | Rskb | C00000555 | 0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | C00000555 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000555 | 1 / 1 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00000555 | 1 / 2 |
| P17252 | Protein kinase C alpha type | Alpha | C00000555 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00000555 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000555 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00002822 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000555 | 0 / 1 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000555 | 5 / 3 |
| Q9H244 | P2Y purinoceptor 12 | Purine receptor | C00000555 | 1 / 1 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00000555 | 0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00000555 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002822 | 2 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00000555 | 0 / 0 |
| P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Enzyme | C00000555 | 9 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002822 | 0 / 0 |
| Q9Y4K4 | Mitogen-activated protein kinase kinase kinase kinase 5 | STE serine/threonine protein kinase KHS subfamily | C00000555 | 0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | C00000555 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002822 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000555 | 1 / 1 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000555 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000555 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000555 | 1 / 1 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | C00000555 | 0 / 0 |
| O75116 | Rho-associated protein kinase 2 | Rock | C00000555 | 0 / 0 |
| P07948 | Tyrosine-protein kinase Lyn | Src | C00000555 | 0 / 0 |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | C00000555 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00000555 | 4 / 1 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00000555 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000555 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000555 | 0 / 0 |
| P98170 | E3 ubiquitin-protein ligase XIAP | Other cytosolic protein | C00002822 | 1 / 1 |
| O75365 | Protein tyrosine phosphatase type IVA 3 | Tyr | C00000555 | 0 / 0 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | C00000555 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00000555 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000555 | 2 / 2 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000555 | 5 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00000555 | 2 / 0 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00000555 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000555 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002822 | 0 / 0 |
| O43451 | Maltase-glucoamylase, intestinal | Hydrolase | C00000555 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000555 | 3 / 4 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000555 | 0 / 1 |
| P54646 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Ampk | C00000555 | 0 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | C00000555 | 0 / 0 |
| P43405 | Tyrosine-protein kinase SYK | Syk | C00000555 | 0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | C00000555 | 1 / 0 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | C00000555 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000555 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002822 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00000555 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000555 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00002822 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000555 | 3 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00000555 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000555 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000555 | 1 / 4 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00000555 | 0 / 0 |
| P53779 | Mitogen-activated protein kinase 10 | Jnk | C00000555 | 0 / 1 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00000555 | 0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | C00000555 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00000555 | 0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | C00000555 | 0 / 0 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00000555 | 5 / 1 |
| P16234 | Platelet-derived growth factor receptor alpha | Pdgfr | C00000555 | 2 / 1 |
| Q9HCP0 | Casein kinase I isoform gamma-1 | Ck1 | C00000555 | 0 / 0 |
| P48730 | Casein kinase I isoform delta | Ck1 | C00000555 | 1 / 0 |
| P49674 | Casein kinase I isoform epsilon | Ck1 | C00000555 | 0 / 0 |
| P78368 | Casein kinase I isoform gamma-2 | Ck1 | C00000555 | 0 / 0 |
| P48729 | Casein kinase I isoform alpha | Ck1 | C00000555 | 0 / 0 |
68 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 58 | ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3 | actin, alpha 1, skeletal muscle |
C00000555
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000555
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000555
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00000555
|
| 9529 | BAG5, BAG-5 | BCL2-associated athanogene 5 |
C00000555
|
| 51283 | BFAR, BAR, RNF47 | bifunctional apoptosis regulator |
C00000555
|
| 821 | CANX, CNX, IP90, P90 | calnexin |
C00000555
|
| 9133 | CCNB2, HsT17299 | cyclin B2 |
C00000555
|
| 8621 | CDK13, CDC2L, CDC2L5, CHED, hCDK13 | cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22) |
C00000555
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00000555
|
| 1951 | CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1 | cadherin, EGF LAG seven-pass G-type receptor 3 |
C00000555
|
| 10987 | COPS5, CSN5, JAB1, MOV-34, SGN5 | COP9 signalosome subunit 5 |
C00000555
|
| 1509 | CTSD, CLN10, CPSD | cathepsin D (EC:3.4.23.5) |
C00000555
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000555
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000555
|
| 1719 | DHFR, DHFRP1, DYR | dihydrofolate reductase (EC:1.5.1.3) |
C00000555
|
| 3337 | DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
C00000555
|
| 1875 | E2F5, E2F-5 | E2F transcription factor 5, p130-binding |
C00000555
|
| 9538 | EI24, EPG4, PIG8, TP53I8 | etoposide induced 2.4 |
C00000555
|
| 1967 | EIF2B1, EIF2B, EIF2BA | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa |
C00000555
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00000555
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00000555
|
| 2308 | FOXO1, FKH1, FKHR, FOXO1A | forkhead box O1 |
C00000555
|
| 2620 | GAS2 | growth arrest-specific 2 |
C00000555
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00000555
|
| 2947 | GSTM3, GST5, GSTB, GSTM3-3, GTM3 | glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) |
C00000555
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00000555
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00000555
|
| 3440 | IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2 | interferon, alpha 2 |
C00000555
|
| 3708 | ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29 | inositol 1,4,5-trisphosphate receptor, type 1 |
C00000555
|
| 3727 | JUND, AP-1 | jun D proto-oncogene |
C00000555
|
| 3880 | KRT19, CK19, K19, K1CS | keratin 19 |
C00000555
|
| 23499 | MACF1, ABP620, ACF7, MACF, OFC4 | microtubule-actin crosslinking factor 1 |
C00000555
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00000555
|
| 4137 | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU | microtubule-associated protein tau |
C00000555
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00000555
|
| 5082 | PDCL, PhLP | phosducin-like |
C00000555
|
| 5289 | PIK3C3, VPS34, hVps34 | phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137) |
C00000555
|
| 8493 | PPM1D, PP2C-DELTA, WIP1 | protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) |
C00000555
|
| 9588 | PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29 | peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) |
C00000555
|
| 5580 | PRKCD, MAY1, PKCD, nPKC-delta | protein kinase C, delta (EC:2.7.10.2 2.7.11.13) |
C00000555
|
| 51495 | PTPLAD1, B-IND1, HACD3, HSPC121 | protein tyrosine phosphatase-like A domain containing 1 (EC:4.2.1.134) |
C00000555
|
| 5894 | RAF1, CRAF, NS5, Raf-1, c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) |
C00000555
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00000555
|
| 5955 | RCN2, E6BP, ERC-55, ERC55, TCBP49 | reticulocalbin 2, EF-hand calcium binding domain |
C00000555
|
| 387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00000555
|
| 6093 | ROCK1, P160ROCK, ROCK-I | Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1) |
C00000555
|
| 9475 | ROCK2, ROCK-II | Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) |
C00000555
|
| 10055 | SAE1, AOS1, HSPC140, SUA1, UBLE1A | SUMO1 activating enzyme subunit 1 |
C00000555
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00000555
|
| 6489 | ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (EC:2.4.99.8) |
C00000555
|
| 10963 | STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L | stress-induced-phosphoprotein 1 |
C00000555
|
| 55578 | SUPT20H, C13, C13orf19, FAM48A, P38IP, SPT20 | suppressor of Ty 20 homolog (S. cerevisiae) |
C00000555
|
| 51347 | TAOK3, DPK, JIK, MAP3K18 | TAO kinase 3 (EC:2.7.11.1) |
C00000555
|
| 6903 | TBCC, CFC | tubulin folding cofactor C |
C00000555
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000555
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00000555
|
| 7186 | TRAF2, MGC:45012, TRAP, TRAP3 | TNF receptor-associated factor 2 |
C00000555
|
| 10381 | TUBB3, CDCBM, CDCBM1, CFEOM3A, TUBB4, beta-4 | tubulin, beta 3 class III |
C00000555
|
| 54957 | TXNL4B, DLP, Dim2 | thioredoxin-like 4B |
C00000555
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000555
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00000555
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00000555
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00000555
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00000555
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00000555
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00000555
|
| 7416 | VDAC1, PORIN, VDAC-1 | voltage-dependent anion channel 1 |
C00000555
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (97)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #615224 | Advanced sleep phase syndrome, familial, 2; fasps2 |
P48730
|
| #103780 | Alcohol dependence |
P14416
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #609821 | Bleeding disorder, platelet-type, 8; bdplt8 |
Q9H244
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P31749
P42336 |
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P31749 P42336 |
| #612918 | Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi |
P42336
|
| #615108 | Cowden syndrome 5; cws5 |
P42336
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #606764 | Gastrointestinal stromal tumor; gist |
P16234
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #114550 | Hepatocellular carcinoma |
P42336
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #607685 | Hypereosinophilic syndrome, idiopathic; hes |
P16234
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #182000 | Keratosis, seborrheic |
P42336
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P04637
|
| #300635 | Lymphoproliferative syndrome, x-linked, 2; xlp2 |
P98170
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #602501 | Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap |
P42336
|
| #603387 | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph |
P42336
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #159900 | Myoclonic dystonia |
P14416
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P42336
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #176920 | Proteus syndrome |
P31749
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (96)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
P42336 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) P15311 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) P09619 (related) P16234 (related) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
P11308 (related) |
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00606 | Early infantile epileptic encephalopathy |
P53779
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P98170
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H01235 | Bleeding disorder platelet-type |
Q9H244
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
9 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001249 | Asthma |
C00000555
|
| D004802 | Eosinophilia |
C00000555
|
| D005317 | Fetal Growth Retardation |
C00000555
|
| D005327 | Fetal Resorption |
C00000555
|
| D020567 | Fetal Weight |
C00000555
|
| D005355 | Fibrosis |
C00000555
|
| D015459 | Leukemia-Lymphoma, Adult T-Cell |
C00000555
|
| D008106 | Liver Cirrhosis, Experimental |
C00000555
|
| D010922 | Placenta Diseases |
C00000555
|