Species

KNApSAcK Entry

Organism name Rumex japonicus
Genus Rumex
Family Polygonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rumex japonicus
Linked NCBI taxonomy ID 174651
Linked level species

Family

Family in NCBI taxonomy Polygonaceae
ID 3615

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005413 External link 512 Rutin
/ Birutan
/ 3-Rutinosylquercetin
/ Quercetin 3-O-rutinoside
/ (+)-Quercetin 3-O-rutinoside
/ Quercetin 3-O-beta-rutinoside
/ (+)-Quercetin 3-O-beta-rutinoside
/ 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside
/ Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
CHEMBL32579
CHEMBL310754
CHEMBL182108
CHEMBL226335
CHEMBL502782
CHEMBL1436093
CHEMBL1532989
D012431
25 / 18 / 16 29 / 8 No. 1 No. 15
C00019490 External link 512 Tormentic acid
/ 2alpha,3beta,19alpha-Trihydroxyurs-12-en-28-oic acid
CHEMBL223484
CHEMBL239077
CHEMBL1270647
2 / 2 / 2 No. 13 No. 51
C00032037 External link 512 Myrianthic acid
CHEMBL515920
No. 13 No. 51
C00000555 External link 512 Emodin
CHEMBL289277
D004642
109 / 88 / 91 68 / 9 No. 41 No. 62
C00000956 External link 512 (-)-Epicatechin
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
85 / 58 / 54 No. 52 No. 14
C00034660 External link 512 Rumejaposide A
/ (+)-Rumejaposide A
No. 826 No. 61
C00034661 External link 512 Rumejaposide B
/ (-)-Rumejaposide B
No. 826 No. 61
C00034662 External link 512 Rumejaposide C
/ (-)-Rumejaposide C
No. 826 No. 61
C00034663 External link 512 Rumejaposide D
/ (-)-Rumejaposide D
No. 826 No. 61
C00034664 External link 512 Rumejaposide E
/ (-)-Rumejaposide E
No. 826 No. 61

Human Protein / Gene in interactions

178 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000555 C00000956 C00005413 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000555 C00000956 C00005413 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000555 C00000956 C00005413 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000555 C00000956 C00005413 3 / 3
P06746 DNA polymerase beta Enzyme C00000555 C00000956 C00005413 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000555 C00000956 C00005413 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000555 C00000956 C00005413 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000555 C00000956 C00005413 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000555 C00000956 C00005413 4 / 3
P03372 Estrogen receptor NR3A1 C00000555 C00005413 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000956 C00005413 0 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000956 C00005413 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000555 C00000956 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000555 C00000956 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000555 C00000956 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00000555 C00000956 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000555 C00000956 1 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000555 C00000956 5 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000555 C00000956 3 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000956 C00005413 1 / 1
O00255 Menin Unclassified protein C00000555 C00000956 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000555 C00000956 1 / 2
Q9Y253 DNA polymerase eta Enzyme C00000555 C00000956 1 / 1
P39748 Flap endonuclease 1 Enzyme C00000555 C00000956 0 / 0
P17252 Protein kinase C alpha type Alpha C00000555 C00000956 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000555 C00000956 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00000555 C00000956 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000555 C00000956 2 / 3
P11388 DNA topoisomerase 2-alpha Isomerase C00000956 C00005413 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00000555 C00005413 1 / 0
P54132 Bloom syndrome protein Enzyme C00000555 C00000956 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000555 C00000956 0 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00000555 C00000956 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000956 C00005413 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00000956 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000555 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00000555 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000956 1 / 2
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005413 0 / 0
P02768 Serum albumin Secreted protein C00000956 0 / 0
P49327 Fatty acid synthase Transferase C00000956 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00000555 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000555 11 / 10
P23443 Ribosomal protein S6 kinase beta-1 p70 C00000555 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00000956 0 / 1
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00000555 0 / 0
P15311 Ezrin Unclassified protein C00000555 0 / 1
Q8N1Q1 Carbonic anhydrase 13 Lyase C00000956 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000555 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000956 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000956 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000956 0 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00000555 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000555 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000956 0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00000956 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00019490 1 / 1
O43570 Carbonic anhydrase 12 Lyase C00000956 1 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000555 0 / 0
P09769 Tyrosine-protein kinase Fgr Src C00000555 0 / 0
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme C00000555 9 / 1
P07998 Ribonuclease pancreatic Enzyme C00000956 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000956 2 / 0
O75496 Geminin Unclassified protein C00000555 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000555 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000555 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00005413 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000956 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000555 0 / 1
P10145 Interleukin-8 Secreted protein C00000555 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000956 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00000555 0 / 0
P08311 Cathepsin G S1A C00000555 0 / 0
P07711 Cathepsin L1 C1A C00000956 0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00000555 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00000555 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005413 0 / 1
P43166 Carbonic anhydrase 7 Lyase C00000956 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00000956 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000956 3 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00000555 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00000555 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00000555 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000956 0 / 0
P00734 Prothrombin S1A C00000956 4 / 2
P04150 Glucocorticoid receptor NR3C1 C00000555 0 / 1
P14679 Tyrosinase Oxidoreductase C00005413 4 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000555 5 / 3
Q9H244 P2Y purinoceptor 12 Purine receptor C00000555 1 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00000555 0 / 0
P06276 Cholinesterase Hydrolase C00005413 0 / 0
P04745 Alpha-amylase 1 Enzyme C00000956 0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00000555 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00000555 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00000956 2 / 3
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000956 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00000956 0 / 1
P56817 Beta-secretase 1 A1A C00000956 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000956 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000956 0 / 1
Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 STE serine/threonine protein kinase KHS subfamily C00000555 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00000555 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005413 2 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000956 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00000555 1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00000956 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000555 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000555 0 / 0
P00374 Dihydrofolate reductase Oxidoreductase C00000956 1 / 1
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00000555 0 / 0
P22303 Acetylcholinesterase Hydrolase C00005413 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000956 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00000555 0 / 0
O75116 Rho-associated protein kinase 2 Rock C00000555 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000956 0 / 0
P07948 Tyrosine-protein kinase Lyn Src C00000555 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000555 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00000555 4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00000555 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000956 3 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00000555 0 / 0
O75365 Protein tyrosine phosphatase type IVA 3 Tyr C00000555 0 / 0
P08246 Neutrophil elastase S1A C00000555 2 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000956 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000555 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000555 2 / 2
P49798 Regulator of G-protein signaling 4 Unclassified protein C00000555 2 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000555 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00000555 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000555 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000555 0 / 0
O43451 Maltase-glucoamylase, intestinal Hydrolase C00000555 0 / 0
P10275 Androgen receptor NR3C4 C00000555 3 / 4
P10828 Thyroid hormone receptor beta NR1A2 C00000555 3 / 1
P06239 Tyrosine-protein kinase Lck Src C00000555 0 / 1
P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 Ampk C00000555 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00000555 0 / 0
P43405 Tyrosine-protein kinase SYK Syk C00000555 0 / 0
P48147 Prolyl endopeptidase S9A C00005413 0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00000555 1 / 0
P22748 Carbonic anhydrase 4 Lyase C00000956 1 / 1
P53778 Mitogen-activated protein kinase 12 p38 C00000555 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00019490 1 / 1
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00000956 0 / 7
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000956 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000956 4 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000956 0 / 0
P40225 Thrombopoietin Unclassified protein C00000555 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00000555 7 / 37
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000956 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00005413 0 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00000555 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00000555 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00000555 1 / 4
Q05513 Protein kinase C zeta type Iota C00000956 0 / 0
Q04759 Protein kinase C theta type Delta C00000956 0 / 1
Q02156 Protein kinase C epsilon type Eta C00000956 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000956 0 / 0
Q05655 Protein kinase C delta type Delta C00000956 0 / 0
P05129 Protein kinase C gamma type Alpha C00000956 1 / 1
P05771 Protein kinase C beta type Alpha C00000956 0 / 0
P24723 Protein kinase C eta type Eta C00000956 1 / 0
P41743 Protein kinase C iota type Iota C00000956 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00000956 0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00000555 0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00000555 0 / 1
P45984 Mitogen-activated protein kinase 9 Jnk C00000555 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00000555 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00000555 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00000555 0 / 0
P09619 Platelet-derived growth factor receptor beta Pdgfr C00000555 5 / 1
P16234 Platelet-derived growth factor receptor alpha Pdgfr C00000555 2 / 1
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 C00000555 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00000555 1 / 0
P49674 Casein kinase I isoform epsilon Ck1 C00000555 0 / 0
P78368 Casein kinase I isoform gamma-2 Ck1 C00000555 0 / 0
P48729 Casein kinase I isoform alpha Ck1 C00000555 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00000956 0 / 0

92 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000555 C00005413
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000555 C00005413
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000555 C00005413
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000555 C00005413
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000555 C00005413
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00005413
821 CANX, CNX, IP90, P90 calnexin C00000555
9133 CCNB2, HsT17299 cyclin B2 C00000555
8621 CDK13, CDC2L, CDC2L5, CHED, hCDK13 cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22) C00000555
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00000555
1951 CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1 cadherin, EGF LAG seven-pass G-type receptor 3 C00000555
10987 COPS5, CSN5, JAB1, MOV-34, SGN5 COP9 signalosome subunit 5 C00000555
1509 CTSD, CLN10, CPSD cathepsin D (EC:3.4.23.5) C00000555
9529 BAG5, BAG-5 BCL2-associated athanogene 5 C00000555
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00000555
1719 DHFR, DHFRP1, DYR dihydrofolate reductase (EC:1.5.1.3) C00000555
3337 DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1 DnaJ (Hsp40) homolog, subfamily B, member 1 C00000555
1875 E2F5, E2F-5 E2F transcription factor 5, p130-binding C00000555
9538 EI24, EPG4, PIG8, TP53I8 etoposide induced 2.4 C00000555
1967 EIF2B1, EIF2B, EIF2BA eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa C00000555
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000555
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000555
2308 FOXO1, FKH1, FKHR, FOXO1A forkhead box O1 C00000555
2620 GAS2 growth arrest-specific 2 C00000555
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00000555
2947 GSTM3, GST5, GSTB, GSTM3-3, GTM3 glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) C00000555
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00000555
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00000555
3440 IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2 interferon, alpha 2 C00000555
3708 ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29 inositol 1,4,5-trisphosphate receptor, type 1 C00000555
3727 JUND, AP-1 jun D proto-oncogene C00000555
3880 KRT19, CK19, K19, K1CS keratin 19 C00000555
23499 MACF1, ABP620, ACF7, MACF, OFC4 microtubule-actin crosslinking factor 1 C00000555
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00000555
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00000555
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000555
5082 PDCL, PhLP phosducin-like C00000555
5289 PIK3C3, VPS34, hVps34 phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137) C00000555
8493 PPM1D, PP2C-DELTA, WIP1 protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) C00000555
9588 PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29 peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) C00000555
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00000555
51495 PTPLAD1, B-IND1, HACD3, HSPC121 protein tyrosine phosphatase-like A domain containing 1 (EC:4.2.1.134) C00000555
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00000555
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000555
5955 RCN2, E6BP, ERC-55, ERC55, TCBP49 reticulocalbin 2, EF-hand calcium binding domain C00000555
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00000555
6093 ROCK1, P160ROCK, ROCK-I Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1) C00000555
9475 ROCK2, ROCK-II Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) C00000555
10055 SAE1, AOS1, HSPC140, SUA1, UBLE1A SUMO1 activating enzyme subunit 1 C00000555
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00000555
6489 ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (EC:2.4.99.8) C00000555
10963 STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L stress-induced-phosphoprotein 1 C00000555
55578 SUPT20H, C13, C13orf19, FAM48A, P38IP, SPT20 suppressor of Ty 20 homolog (S. cerevisiae) C00000555
51347 TAOK3, DPK, JIK, MAP3K18 TAO kinase 3 (EC:2.7.11.1) C00000555
6903 TBCC, CFC tubulin folding cofactor C C00000555
58 ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3 actin, alpha 1, skeletal muscle C00000555
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00000555
7186 TRAF2, MGC:45012, TRAP, TRAP3 TNF receptor-associated factor 2 C00000555
10381 TUBB3, CDCBM, CDCBM1, CFEOM3A, TUBB4, beta-4 tubulin, beta 3 class III C00000555
54957 TXNL4B, DLP, Dim2 thioredoxin-like 4B C00000555
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000555
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000555
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000555
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000555
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000555
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000555
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000555
7416 VDAC1, PORIN, VDAC-1 voltage-dependent anion channel 1 C00000555
177 AGER, RAGE advanced glycosylation end product-specific receptor C00005413
51283 BFAR, BAR, RNF47 bifunctional apoptosis regulator C00000555
581 BAX, BCL2L4 BCL2-associated X protein C00005413
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00005413
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00005413
847 CAT catalase (EC:1.11.1.6) C00005413
873 CBR1, CBR, SDR21C1, hCBR1 carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) C00005413
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00005413
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00005413
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00005413
2936 GSR glutathione reductase (EC:1.8.1.7) C00005413
3458 IFNG, IFG, IFI interferon, gamma C00005413
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00005413
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00005413
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00005413
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00005413
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00005413
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00005413
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00005413
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00005413
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00005413
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00005413
7039 TGFA, TFGA transforming growth factor, alpha C00005413
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (128)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#609821 Bleeding disorder, platelet-type, 8; bdplt8 Q9H244
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#114480 Breast cancer P31749
P42336
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P31749
P42336
P84022
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#615108 Cowden syndrome 5; cws5 P42336
#615109 Cowden syndrome 6; cws6 P31749
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P16234
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P08581
P42336
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#182000 Keratosis, seborrheic P42336
#601626 Leukemia, acute myeloid; aml P09619
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P42336
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#176920 Proteus syndrome P31749
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (112)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P10415 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
P10415 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
P08581 (related)
P10415 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P42336 (related)
H00028 Choriocarcinoma P04637 (related)
P10415 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P27487 (marker)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
P15311 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
P10415 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
P09619 (related)
P16234 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P08581 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00100 Neutropenic disorders P08246 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
P11308 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00030 Cervical cancer P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H01235 Bleeding disorder platelet-type Q9H244 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

17 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001249 Asthma C00000555
D004802 Eosinophilia C00000555
D005317 Fetal Growth Retardation C00000555
D005327 Fetal Resorption C00000555
D020567 Fetal Weight C00000555
D005355 Fibrosis C00000555
D015459 Leukemia-Lymphoma, Adult T-Cell C00000555
D008106 Liver Cirrhosis, Experimental C00000555
D010922 Placenta Diseases C00000555
D001424 Bacterial Infections C00005413
D003092 Colitis C00005413
D004409 Dyskinesia, Drug-Induced C00005413
D015212 Inflammatory Bowel Diseases C00005413
D007674 Kidney Diseases C00005413
D028361 Mitochondrial Diseases C00005413
D010243 Paralysis C00005413
D013276 Stomach Ulcer C00005413